This document provides information on compartment syndromes, including:
- The pathophysiology of increased pressure within closed muscle compartments leading to reduced blood flow and tissue ischemia.
- Risk factors, signs and symptoms including disproportionate pain and elevated compartment pressures measured via needle technique.
- Diagnosis is clinical with compartment pressures helping to confirm.
- Treatment involves urgent surgical fasciotomy to decompress all affected compartments before irreversible muscle and nerve damage occurs.
- Post-fasciotomy care and complications are also discussed.
Seminar presentation by 4th year medical student of Lincoln University College, supervised by HRPZ Orthopedic's specialist.
Reference were from reliable medical websites and also from texttbook; Apley and Solomon's Concise System of Orthopaedics and Trauma, 4th Ed.
An increased pressure within enclosed
osteofascial space that reduces capillary per-
fusion below level necessary for tissue
viability; the underlying mechanism is:
- increased volume within space
- decreased space for contents
- combination of both
Seminar presentation by 4th year medical student of Lincoln University College, supervised by HRPZ Orthopedic's specialist.
Reference were from reliable medical websites and also from texttbook; Apley and Solomon's Concise System of Orthopaedics and Trauma, 4th Ed.
An increased pressure within enclosed
osteofascial space that reduces capillary per-
fusion below level necessary for tissue
viability; the underlying mechanism is:
- increased volume within space
- decreased space for contents
- combination of both
This presentation deals with the causes, signs, symptoms and management of compartment syndrome. It also briefly deals with abdominal comaprtment syndrome
Complication on avf play significant number of hospitalization & morbidity. Despite fistula first campaign are still beneficial for most patient, gathering knowlege to prevent complication are important.
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As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
3. Increase in hydrostatic pressure in closed osteofascial
space resulting in decreased perfusion of muscle
and nerves within compartment
4. • RAISED PRESSURERAISED PRESSURE
WITHIN A CLOSEDWITHIN A CLOSED
SPACESPACE with a potential to
cause irreversible damageirreversible damage
to the contents of the
closed space
5. Richard Von Volkmann, 1881
• “For many years I have noted on occasion, following the
use of bandages too tightly appliedbandages too tightly applied, the occurrence of
paralysis and contraction of the limb, NOT … due toparalysis and contraction of the limb, NOT … due to
thethe paralysis of the nerve by pressureparalysis of the nerve by pressure, but as a quick and
massive disintegration of the contractile substance and
the effect of the ensuing reaction and degeneration.”
8. Pathophysiology
• A continuous increase in
pressure within a
compartment occurs until
the low intramuscularlow intramuscular
arteriolar pressure isarteriolar pressure is
exceededexceeded and blood
cannot enter the
capillaries
10. Pathophysiology
• Autoregulatory mechanisms may compensate:
– Decrease in peripheral vascular resistance
– Increased extraction of oxygen
• As system becomes overwhelmed:
– Critical closing pressure is reached
– Oxygen perfusion of muscles and nerves decreases
16. Nerve Ischemia
• 1 hour - normal conduction
• 1- 4 hours - neuropraxic damage
reversible
• 8 hours - axonotmesis and
irreversible change
Hargens et al. JBJS 1979
17. Pathophysiology:
• CAUSES:
• Increased Volume - internal :Increased Volume - internal : hemmorhage, fractures, swelling
from traumatized tissue, increased fluid secondary to burns, post-
ischemic swelling
• Decreased volume - external:Decreased volume - external: tight casts, dressings
• Most common cause of hemmorhage into a compartment:Most common cause of hemmorhage into a compartment:
fractures of the tibia, elbow, forearm or femur
20. Arterial Injuries
• Secondary toSecondary to
revascularizationrevascularization:
• Ischemia causes damage
to cellular basement
membrane that results in
edema
• With reestablishment of
flow, fluid leaks into the
compartment increasing
the pressure
22. Difficult Diagnosis
• Classic signs of the 5 P’s - ARE NOT RELIABLE:
– pain
– pallor
– paralysis
– pulselessness
– paresthesias
• These are signs of an ESTABLISHED compartment
syndrome where ischemic injury has already taken place
• These signs may be present in the absence of
compartment syndrome.
24. Diagnosis
• Palpable pulses are usually present in acute
compartment syndromes unless an arterial
injury occurs
• Sensory changes and paralysisSensory changes and paralysis do not occur
until ischemia has been present for about 11
hour or morehour or more
25. Diagnosis
• The most importantmost important
symptomsymptom of an impending
compartment syndrome is
PAINPAIN
DISPROPORTIONATEDISPROPORTIONATE
TO THAT EXPECTEDTO THAT EXPECTED
FOR THE INJURYFOR THE INJURY
26. Signs & Symptoms
• Pain
–Passive muscle stretching
–Out of proportion
–Progressive
–Not relieved by immobilization
27. Signs & Symptoms
• Pain
–May be worse with elevation
–Patient will not initiate motion on
own
• Be careful with coexisting nerve
injury
28. Signs & Symptoms
• Parasthesia
–Secondary to nerve ischemia
• Must be differentiated from nerve
injury
31. Tissue Pressure
• Normal tissue pressure
– 0-4 mm Hg
– 8-10 with exertion
• Absolute pressure theory
– 30 mm Hg - Mubarak
– 45 mm Hg - Matsen
• Pressure gradient theory
– < 20 mm Hg of diastolic pressure – Whitesides
– < 30 mm Hg of diastolic pressure McQueen, et al
32. Tissue-Pressure: Principles
• Originally, fasciotomies for tissue-pressures greater-than
30mmHg
• Whitesides et al in 1975Whitesides et al in 1975 was the first to suggest that the
significance of tissue pressures was in their relation torelation to
diastolic blood pressurediastolic blood pressure.
• McQueen et al: absolute compartment pressure is anabsolute compartment pressure is an
UNRELIABLE indication for the need for fasciotomies.UNRELIABLE indication for the need for fasciotomies. BUT,
pressures within 30mmHg of DP indicate compartment
syndrome
33. Tissue-Pressure: Principles
• Heckman et al demonstrated that
pressure within a givenpressure within a given
compartment is not uniformcompartment is not uniform
• They found tissue pressures to be
highest at the site or within 5cmhighest at the site or within 5cm
of the injuryof the injury
• 3 of their 5 patients requiring
fasciotomies had sub-critical
pressure values 5cm from the site
of highest pressure
37. Diagnosis
• The presence of an open fracture does NOT rule out the presenceopen fracture does NOT rule out the presence
of a compartment syndromeof a compartment syndrome
• 6-9% of open tibial fractures are associated with compartment
syndromes
• McQueen et al found no significant differences in compartmentno significant differences in compartment
pressures between open and closed tibial fracturespressures between open and closed tibial fractures
• No significant difference in pressures between tibial fracturesNo significant difference in pressures between tibial fractures
treated with IM Nails and those treated with Ex-Fixtreated with IM Nails and those treated with Ex-Fix
39. Needle Infusion Technique-Historical
• Needle inserted into muscle, tube
with air/saline interval kept at this
height, manometer indicates
pressure
• Air injected by syringe via 3-way
stopcock
• When the pressure of the injected
air exceeds the compartment
pressure pressure, the saline interval
moves in the tube
• AT this point, the second personthe second person
reads the pressure from thereads the pressure from the
manometermanometer
NEED 2 PEOPLE !NEED 2 PEOPLE !
saline
41. • Needle
– 18 gauge
– Side ported
• Catheter
– wick
– slit
• Performed within 5 cm
of the injury if
possible-Whitesides,
Heckman
Side port
Pressure Measurement
42. • Unit and needle set
• Assemble unit and prime
• Hold at angle to measure
• Zero machine
• Test each of 4 compartments
– Keep calf off of bed
43. Most Common Locations
• Leg: deep posterior and thedeep posterior and the
anterioranterior compartmentscompartments
• Forearm: volar compartmentvolar compartment,
especially in the deep flexor area
52. Perifibular Fasciotomy
• One incision
• Head of fibula to proximal tip of lateral malleolus
• Incise fascia between soleus and FHL distally and
extended proximally to origin of soleus from fibula
• Deep posterior compartment released off of the
interosseous membrane, approached from the interval
between the lateral and superfical posterior
compartments
58. Double Incision
• 2 vertical incisions separated by a skin bridge of
at least 8 cm
• Anterolateral Incision: from knee to ankle,
centered over interval between anterior and lateral
compartments
59. Double Incision
• Posteromedial Incision: centered 1-2cm behind
posteromedial border of tibia
• Soleus must be detached from tibia in order to
adequately decompress proximal portion of deep
posterior compartment
60. Thigh
• Rare
• Crush injury with femur fracture
• Over distraction
– relative under distraction
62. Treatment
• Based upon involvement
• Usually Quadriceps and
Hamstrings
• Usually, a single lateral incision
will suffice
63. Compartments of the Forearm
• Forearm can be divided into 3
compartments: Dorsal, Volar and “Mobile
Wad”
• Mobile Wad: Brachioradialis, ECRL, ECRB
• Dorsal: EPB, EPL, ECU, EDC
• Volar: FPL, FCR, FCU, FDS, FDP, PQ
64. Henry Approach
• Incision begins proximal to antecubital
fossa and extends across carpal tunnel
• Begins lateral to biceps tendon, crosses
elbow crease and extends radially, then
it is extended distally along medial
aspect of brachioradialis and extends
across the palm along the thenar crease
• Alternatively, a straight incision from
lateral biceps to radial styloid can be
used.
66. Henry Approach
• Brachioradialis and superficial
radial n. are retracted radially and
FCR and radial artery are retracted
ulnar to expose the deep volar
muscles
• Fascia of each of the deep muscles
is then incised
67. Post Fasciotomy…
• Must get bone stability
– IMN
– exfix
• ~48hrs after procedure patient should be
brought back to OR for further debridement
• Delayed skin closure or skin-grafting 3-7
days after the fasciotomies
69. Remember…
• Fasciotomies are not benign
• Complications are real >25%
– Chronic swelling
– Chronic pain
– Muscle weakness
– Iatrogenic NV injury
– Cosmetic concerns
*** BUT if they are needed do not come up with*** BUT if they are needed do not come up with
excuses to not do them !!!excuses to not do them !!!
73. Conclusion
• Very important to make diagnosis
• Missed compartment is devastating
• Physical exam
• Re-examine patient!
Editor's Notes
Normal resting muscle tissue pressure is up to 4 mm Hg and 8-10 with exertion. Exercise induced CS may have a resting based line of 10-15 mmHg. Many studies utilizing clinical evaluations and animal models by Whitesides, Mubarak, Matsen, Heckman, Heppenstall and Matava have help to establish a better understanding of the pathophysiology and thresholds of ischemia. Two schools of though prevail: 1. The Absolute Pressure Theory of Murbarak and Matsen who suggest surgical decompression in CS with pressures that reach or exceed these thresholds. 2. The Perfusion Theory of Whitesides who demonstrated in animal models and human subjects the relationship of tissue perfusion and diastolic blood pressure. His group recommends surgical decompression when the tissue pressure is within 20mm Hg of the DBP. McQueen suggested a differential &lt;30mmHg of the diastolic pressure and the intramuscular pressure as a threshold for release as being more reliable. Mean arterial pressure can also serve as a benchmark with a release suggested when intramuscular pressure is within 45 mm Hg. Caution must be exercised in traumatized tissue and especially in hypotensive patients
Whitesides described the use of a 3-way stop cock connected to a mercury manometer(now against JCAH rules-biohazard)
An arterial line using a large bore needle hooked up to a transducer and monitor in any ICU, OR or the recovery room will work. Remember that a standard needle will give higher results than a side port (Srtyker) or wick catheter. (Moed and Thorderson, JBJS(A), 1993) The stryker device is one of the more commonly used portable hand-held devices used for the tissue pressure measurements and since the redesign of the side port needle is very accurate. All devices must have the transducer at the level of the needle to be zeroed for an accurate reading.
Whitesides et al have demonstrated that the pressure measurements should be done within 5 cm of the fracture (tibia) to obtain a true pressure reading within the suspected compartment.