The cold chain is a system used to store and transport vaccines at the proper temperatures from manufacturers to recipients. It includes cold chain equipment like walk-in cold rooms, deep freezers, ice-lined refrigerators, cold boxes, vaccine carriers, and day carriers. Proper cold chain storage and transportation is crucial because some vaccines like polio and measles must be kept at very cold temperatures to maintain their efficacy. Nurses play an important role in maintaining the cold chain by arranging and transporting vaccines safely using the appropriate equipment and temperatures.