Cloning involves creating an exact genetic copy of an organism, with all of its DNA being identical. Genetic modification involves altering the genes of an organism using biotechnology, usually targeting one or a few specific genes to change a trait. While cloning aims to replicate an organism entirely, genetic modification allows targeted changes to traits through gene addition or replacement. The document discusses how scientists in Jurassic Park cloned dinosaurs using ancient DNA preserved in amber, but had to use frog DNA to fill in missing segments, showing how cloning and genetic modification techniques can be combined.