This document provides guidance on performing a clinical examination of cattle. It outlines examining the animal's signalment and history, general appearance, vital signs, and performing a systems-based physical exam. The systems examined include cardiovascular, respiratory, gastrointestinal, urogenital, lymphatic, musculoskeletal, nervous, skin, and head and neck. Basic examination techniques are described for evaluating posture, gait, ears, eyes, body condition, and specific regions of the animal. The goal of the clinical exam is to develop a differential diagnosis and plan appropriate tests, treatment, and information for the owner.