Taking history of animals is the most important part of the clinical examination as animals cannot describe their own symptoms. The veterinarian must carefully examine the animal and assess the accuracy of the owner's history. It is essential to handle the owner with diplomacy and use non-technical language, as livestock owners may not understand technical terms. Relevant history includes the owner's name, species/breed, disease history, present illness details, previous exposure, previous disease, and management history including nutrition, breeding, housing and handling. The goal is to determine if any changes preceded the disease appearance.
History taking
In veterinary medicine, history taking is most important from a clinical point of view because animals are unable to describe their pain and problems (symptoms).
History taking
In veterinary medicine, history taking is most important from a clinical point of view because animals are unable to describe their pain and problems (symptoms).
Respiration, types of respiration, examination of mucous membrane, changes of color , examination of lymph-nodes, examination of skin and associated structures
For vets especially importance of physical examination in any animal diagnosis can be well understand. No short cuts! to any treatment as we always say.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Today there exists a wide spectrum of views on this subject, ranging from those concerned with animal 'rights' to those who view animals only as a resource to be exploited.
All of thThe five freedoms were originally developed from a UK Government report on livestock husbandry in 1965 (Prof.Roger Brambell) then by Farm Animal Welfare Council (FAWC) In July 1979
Freedom from hunger or thirst by ready access to fresh water and a diet to maintain full health and vigour .
Freedom from discomfort by providing an appropriate environment including shelter and a comfortable resting area .
Freedom from pain, injury or disease by prevention or rapid diagnosis and treatment.
Freedom to express (most) normal behaviour by providing sufficient space, proper facilities and company of the animal's own kind.
Freedom from fear and distress by ensuring conditions and treatment which avoid mental suffering.
Respiration, types of respiration, examination of mucous membrane, changes of color , examination of lymph-nodes, examination of skin and associated structures
For vets especially importance of physical examination in any animal diagnosis can be well understand. No short cuts! to any treatment as we always say.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Today there exists a wide spectrum of views on this subject, ranging from those concerned with animal 'rights' to those who view animals only as a resource to be exploited.
All of thThe five freedoms were originally developed from a UK Government report on livestock husbandry in 1965 (Prof.Roger Brambell) then by Farm Animal Welfare Council (FAWC) In July 1979
Freedom from hunger or thirst by ready access to fresh water and a diet to maintain full health and vigour .
Freedom from discomfort by providing an appropriate environment including shelter and a comfortable resting area .
Freedom from pain, injury or disease by prevention or rapid diagnosis and treatment.
Freedom to express (most) normal behaviour by providing sufficient space, proper facilities and company of the animal's own kind.
Freedom from fear and distress by ensuring conditions and treatment which avoid mental suffering.
Dr. Robert Tauxe - Human Health Viewpoint and Setting the Tone for the Antibi...John Blue
Human Health Viewpoint and Setting the Tone for the Antibiotic Symposium - Dr. Robert Tauxe, Deputy Director, Division of Foodborne, Waterborne and Environmental Diseases, Center for Disease Control and Prevention (CDC), from the 2015 NIAA Antibiotic Symposium - Stewardship: From Metrics to Management, November 3-5, 2015, Atlanta, Georgia, USA.
More presentations at http://swinecast.com/2015-niaa-symposium-antibiotics-stewardship-from-metrics-to-management
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
3. History taking
• In veterinary medicine, history-taking is often the most
important of the three aspects of a clinical examination.
Animals are unable to describe their clinical symptoms
They vary widely in their reaction to handling and
examination.
A wide range of normality must be permitted in the
criteria used in a physical examination.
4. It is essential that the veterinarian assesses the accuracy
of the history by careful examination.
5. HISTORY-TAKING METHOD
The owner or attendant must be handled with diplomacy and
tact.
The use of nontechnical terms is essential, since livestock
owners are likely to be confused by technical expressions or
reluctant to express themselves.
6. PATIENT HISTORY
An animal's previous history can be referred to, the disease
status of a herd can be examined, specimens for laboratory
examination can be dispatched with the knowledge that the
results can be related to the correct patient.
The relevant data include: Owner's name and initials.
Species type or breed (or estimate of parentage in a crossbred)
name of owner or number, bodyweight.
7. DISEASE HISTORY
History-taking will vary considerably depending on whether
one animal or a group of animals is involved in the disease
problem under examination. It is often rewarding to examine
the remainder of a group and find animals that are in the
early stages of the disease.
8. Present disease
Attempts should be made to elicit the details of the clinical
abnormalities observed by the owner in the sequence in which
they occurred. If more than one animal is affected, a typical case
should be chosen and the variations in history in other cases
should then be noted.
Morbidity, case fatality and population mortality rates
The morbidity rate is usually expressed as the percentage of
animals that are clinically affected compared with the total
number of animals exposed to the same risks. The case fatality
rate is the percentage of affected animals that die. The population
mortality rate is the percentage of all exposed animals that die.
9. Previous exposure
The history of the group relative to additions is of
particular importance.if the affected animal an
established member of the group, or has it been
introduced how long ago? If the affected animal has
been in the group for some time, have there been recent
additions? If the herd is 'closed herd' or are animals
introduced at frequent intervals? Herd may be immune
but fail to new area due to different strains of
causative agents or have no resistance to disease of
area where imported.
10. Previous
disease
Information elicited by questioning on previous history
of illness may be helpful. If there is a history of previous
illness, inquiries should be made on the usual lines, including
clinical observations, necropsy findings, morbidity, fatality
rates, the treatments and control measures used and the
results obtained.
11. HISTORY
MANAGEMENT
The management history includes nutrition,
breeding policy and practice, housing, transport
and general handling.
It is most important to learn whether or not
there has been any change in the prevailing
practice prior to the appearance of disease.
The major objective in the examination of the
nutritional history is to determine how the
quantity and quality of the diet which the
animals have been receiving compares with
the nutrient requirements that have been
recommended for a similar class of animal.