1) Geographic Information Systems (GIS) allow users to visualize and analyze spatial data by linking geographical features to tabular data. 2) Pioneered in the 1960s, GIS has since become a valuable tool for epidemiology by allowing disease data to be mapped and analyzed in relation to environmental, demographic, and other spatial factors. 3) Key functions of GIS in spatial epidemiology include disease mapping, cluster detection, and risk analysis to better understand patterns and associations between disease occurrence and location.