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8. TRANSPORT IN HUMANS
Why do we need a Transport System?
Picture this…
Why do we need a Transport System?
Picture this…
• Nutrients  transported to
cells
• Waste products  transported
out of cell  out of body
• Can Diffusion be the only way
to go?...
NO!
Why do we need a Transport System?
• We need a transport system to:
– Transport nutrients and oxygen to the various
organs/ cells
– Remove waste product efficiently
The Circulatory Fluid: Blood
• Our blood transports:
Centrifuge Machine
Centrifuged Blood Samples
The Circulatory Fluid: Blood
• Our blood transports:
The Circulatory Fluid: Blood
Cellular Elements
• Red blood cells:
– Circular and biconcave with the centre portion
much thinner than the edge.
– This allows cells to be bent out of shape as they
squeeze through capillaries which are narrower
than themselves.
The Circulatory Fluid: Blood
Cellular Elements
– Mature red blood cells lack nucleus which allows
them to contain more haemoglobin.
– Relatively short life span of only three months.
– Replacement cells are produced by bone marrow.
The Circulatory Fluid: Blood
Cellular Elements
• White blood cells:
– All leucocytes have a nucleus.
The Circulatory Fluid: Blood
Cellular Elements
• White blood cells:
– The creeping movement of the white blood cell
enables it:
– To squeeze through pores in capillary walls in
order to reach the sites of infection, and
– To carry out phagocytosis in order to remove
bacteria or damaged cells.
Lets see it in action…
The Circulatory Fluid: Blood
Cellular Elements
• White blood cells:
– During phagocytosis, cell processes surround and
engulf bacteria or damaged cells.
– Enzymes are then secreted into the vacuole formed
to digest it.
The Circulatory Fluid: Blood
Cellular Elements
• White blood cells:
– Inflammatory response:
– Injured cells release chemicals causing nearby
blood vessels to leak fluid into the tissue, causing
it to swell;
– This dilutes the toxins & brings extra oxygen as
well as platelets and clotting proteins to the
injured site;
– The chemicals also attract phagocytes which
engulf bacteria.
The Circulatory Fluid: Blood
Cellular Elements
• White blood cells:
– Inflammatory response:
The Circulatory Fluid: Blood
Cellular Elements
• White blood cells:
– Antibody production:
– Produced by lymphocytes;
– Antibodies will recognise antigen present on a
foreign body and bind with and deactivate that
specific antigen;
– Each antibody responds to a specific antigen;
– Some become memory cells for vaccination.
The Circulatory Fluid: Blood
Cellular Elements
• White blood cells:
– Antibody production:
The Circulatory Fluid: Blood
Cellular Elements
• Platelets:
– Smallest of the formed elements of blood.
– Between 250 000 to 400 000 platelets per mm3
of blood.
– Can live between five to eight days before being
destroyed by patrolling phagocytes.
– Used for formation of blood clot (platelet plug),
thereby preventing blood loss.
– Are highly adhesive to rough surfaces.
The Circulatory Fluid: Blood
Cellular Elements
• Platelets:
Damaged tissues
& platelets
*thrombokinase
(enzyme)
release
prothrombin
(inactive plasma protein)
*thrombin
(active enzyme)Ca2+
fibrinogen
(soluble plasma protein)
fibrin threads
(insoluble mesh)
Substances in blood clotting
The Circulatory Fluid: Blood
Cellular Elements
• Platelets:
– Once the clot has
formed, it shrinks
and presses out
most of the fluid
serum.
– Clot hardens and
stops further
bleeding.
The Blood Vessels
• Three kinds of blood vessels are present in the human
circulatory system:
bloodVESSELS - artery
Structure:
•thick and elastic muscular walls to
withstand the high blood pressure
• elasticity enables artery wall to stretch &
recoil
• do not contain valves
Function:
•carry oxygeneated (except pulmonary
artery) blood away from the heart at high
pressure
Middle layer
(smooth muscle &
elastic fibres)
External layer
(connective tissue)
Small
lumen
bloodVESSELS - vein
Structure:
• relatively thin, less muscular
walls
• valves present to prevent the
backflow of blood
Function:
• usually carry deoxygenated
blood (except pulmonary vein)to
the heart at lower blood
pressure
Blood flow in veins
Artery Vein Capillary
-Thick, muscular and
elastic walls to withstand
the high blood pressure in
artery.
-Elasticity allows artery
wall to stretch & recoil to
push the blood in spurts
along the artery.
-Thin, slightly muscular
and have less elastic tissue
as blood move more slowly
and smoothly in the vein at
low pressure.
- Very thin, only one-cell
thick wall to allow
exchange of substances to
take place between the
blood and surrounding
tissue.
-Valves are absent -Valves are present to
prevent backflow of blood
-No valves
-Always transport blood
away from the heart to the
rest of the body
-Transport oxygenated
blood(except for
pulmonary artery and
umbilical artery)
-Always transport blood
from body to the heart
-Transport deoxygenated
blood (except for
pulmonary vein & umbilical
vein)
-Always carry blood from
arterioles to venules
-Allow exchange of
substances between blood
and tissue fluid.
Blood pressure differences across
blood vessels
Formation of tissue fluid
tissueFLUID (pure)
plasma
direction of
blood flow
movement of oxygen and
dissolved food substances
movement of excretory
waste products
blood capillary wall
white blood cell squeezing
through capillary wall
tissueFLUID (pure)
• Tissue cells are bathed in tissue fluid (interstitial
fluid)
• Tissue fluid allows the diffusion of dissolved
substances between the tissue cells and the blood
capillaries.
• Dissolved food substances and oxygen diffuse out
from the blood capillaries into the tissue fluid then
into the cells
• Excretory products diffuse out from the cells into
the tissue fluid and then through the capillary walls
into the blood.
8.9 Blood Groups
Types of Blood Group
• There are 4 human blood groups:
 A, B, AB and O
• Classification is based on the types of antigens and
antibodies present in the blood:
 Antigens represented by capital letters A & B
 Antibodies represented by small letters a & b
Types of Blood Group
Are ‘blood agglutination’ and ‘blood clotting’
similar?
Blood clotting is the formation of an enmeshed network
of fibrin that traps RBCs and seal the wound from further
blood loss.
Blood agglutination is the clumping of RBC when natural
antibodies in the recipient’s body react with the antigens
on the donor’s red blood cells.
microQuestion (p8.24 of Bio Notes)
Answers:
(a) X : Blood group B
Y : Blood group AB
Z : Blood group O
(b) Antibody b in the serum reacts with antigen B on the red blood
cells, causing clumping of the red blood cells from X.
(c) Blood group O
(d) Blood groups A and AB
(e) Such a person’s red blood cells do not contain any antigens, so
this person’s blood can be donated to any blood group without
causing clumping of the recipient’s red blood cells.
The Heart
The Heart!
Double Circulation in Mammals
• In mammals, blood flows through the heart
twice in one complete circuit.
Systemic Circulation Pulmonary Circulation
A
B
C
D
E
F
G
H
I
A
B
C
D
E
F
G
H
I
Right Atrium
Right Ventricle
Tricuspid Valve
Aorta
Pulmonary
Artery
Left Atrium
Bicuspid Valve
Left Ventricle
Median Septum
Semi-lunar Valves
Did You Know That?!
• The muscular walls of the right ventricle is
thinner than the left? Why?
-The left ventricle pumps
blood from the heart to
the rest of the body, thus
requiring a more muscular
wall.
-The right ventricle pumps
blood to the lungs, which
is nearer to the heart, thus
have a thinner muscular
wall
Right
Ventricle
Left
Ventricle
Aorta distributes oxygenated blood to
different parts of the body. For example...
Lungs
Liver
Small intestine
Kidney
Limbs
Aorta
Hepatic
artery
Renal
artery
Hepatic
vein
Hepatic
portal vein
Renal
vein
Interactive heart
The Cardiac Cycle pg8.17
The Cardiac Cycle
1
The atria contracts, forcing blood into the
relaxed . This causes a slight
increase in both the atrial pressure and
ventricular pressure
1
ventricles.
The Cardiac Cycle
2
2
The Ventricles contract. This is called
ventricle systole. The ventricle pressure
increases. This causes the atrioventricular
valves (Tricuspid & Bicuspid valves) to
close, producing a loud “lub” sound and
prevents the backflow of blood into the
atria.
The Cardiac Cycle
3
3
The pressure in the ventricles becomes
higher than that of the aorta and
pulmonary artery. The semi-lunar valves
open and blood flows into the aorta and
pulmonary artery.
The Cardiac Cycle
4
4
The ventricles relax. This
is called ventricular
diastole. The drop in
pressure in the ventricles
causes the semi-lunar
valves to close, producing
a soft “dub” sound. This
prevents the backflow of
blood into the ventricles.
The Cardiac Cycle
5
5
The pressure in the
ventricle continues to
decrease as they relax.
6
6
The atrioventricular
valves opens as pressure
in the ventricle becomes
lower than that in the
atria.
7
7
The pressure in the
ventricles gradually
increases as blood
continues to enter the
ventricle from the atria
Heart Disease
• Coronary artery (supplies blood to the heart)
lie on the outside of the heart and supply
oxygenated blood to the muscles in the wall
of the cell.
• Taking in too much cholesterol and
polysaturated fat can cause fatty substance to
be deposited on the inner surface of the
coronary arteries.
Did You Know That?!
Atherosclerosis
Atherosclerosis
• This results in the occlusion/ blockage of the
coronary arteries and reducing the supply of
oxygenated blood & nutrients to the heart
muscles.
• Heart muscles eventually dies heart failure
Fatty deposits
Heart
Attack!
Buzz Time!
Can a thin person develop arteriosclerosis?
Polyunsaturated
fats
Effect of tobacco smoke
Substance Effect
nicotine increases blood pressure and the risk of
blood clotting in the coronary arteries.
carbon
monoxide
increase the risk of fatty deposits
(atherosclerosis) on the inner surfaces of
arteries.
Prepared by, Ms Wong Fui Yen
Examples of Famous People with Heart Disease
• Bill Clinton – quadruple
bypass surgery in 2004
• David Letterman -
quadruple bypass surgery
in 2000
• Larry King - heart attack
and bypass surgery in
1987
• Michael Jackson – died of
cardiac arrest 2009
Coronary Bypass Surgery to replace the blocked coronary arteries
Prevention

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Chapter 8 transport in humans

  • 2. Why do we need a Transport System? Picture this…
  • 3. Why do we need a Transport System? Picture this… • Nutrients  transported to cells • Waste products  transported out of cell  out of body • Can Diffusion be the only way to go?... NO!
  • 4. Why do we need a Transport System? • We need a transport system to: – Transport nutrients and oxygen to the various organs/ cells – Remove waste product efficiently
  • 5. The Circulatory Fluid: Blood • Our blood transports:
  • 8. The Circulatory Fluid: Blood • Our blood transports:
  • 9. The Circulatory Fluid: Blood Cellular Elements • Red blood cells: – Circular and biconcave with the centre portion much thinner than the edge. – This allows cells to be bent out of shape as they squeeze through capillaries which are narrower than themselves.
  • 10. The Circulatory Fluid: Blood Cellular Elements – Mature red blood cells lack nucleus which allows them to contain more haemoglobin. – Relatively short life span of only three months. – Replacement cells are produced by bone marrow.
  • 11. The Circulatory Fluid: Blood Cellular Elements • White blood cells: – All leucocytes have a nucleus.
  • 12. The Circulatory Fluid: Blood Cellular Elements • White blood cells: – The creeping movement of the white blood cell enables it: – To squeeze through pores in capillary walls in order to reach the sites of infection, and – To carry out phagocytosis in order to remove bacteria or damaged cells.
  • 13. Lets see it in action…
  • 14. The Circulatory Fluid: Blood Cellular Elements • White blood cells: – During phagocytosis, cell processes surround and engulf bacteria or damaged cells. – Enzymes are then secreted into the vacuole formed to digest it.
  • 15. The Circulatory Fluid: Blood Cellular Elements • White blood cells: – Inflammatory response: – Injured cells release chemicals causing nearby blood vessels to leak fluid into the tissue, causing it to swell; – This dilutes the toxins & brings extra oxygen as well as platelets and clotting proteins to the injured site; – The chemicals also attract phagocytes which engulf bacteria.
  • 16. The Circulatory Fluid: Blood Cellular Elements • White blood cells: – Inflammatory response:
  • 17. The Circulatory Fluid: Blood Cellular Elements • White blood cells: – Antibody production: – Produced by lymphocytes; – Antibodies will recognise antigen present on a foreign body and bind with and deactivate that specific antigen; – Each antibody responds to a specific antigen; – Some become memory cells for vaccination.
  • 18. The Circulatory Fluid: Blood Cellular Elements • White blood cells: – Antibody production:
  • 19. The Circulatory Fluid: Blood Cellular Elements • Platelets: – Smallest of the formed elements of blood. – Between 250 000 to 400 000 platelets per mm3 of blood. – Can live between five to eight days before being destroyed by patrolling phagocytes. – Used for formation of blood clot (platelet plug), thereby preventing blood loss. – Are highly adhesive to rough surfaces.
  • 20. The Circulatory Fluid: Blood Cellular Elements • Platelets:
  • 21. Damaged tissues & platelets *thrombokinase (enzyme) release prothrombin (inactive plasma protein) *thrombin (active enzyme)Ca2+ fibrinogen (soluble plasma protein) fibrin threads (insoluble mesh)
  • 23. The Circulatory Fluid: Blood Cellular Elements • Platelets: – Once the clot has formed, it shrinks and presses out most of the fluid serum. – Clot hardens and stops further bleeding.
  • 24. The Blood Vessels • Three kinds of blood vessels are present in the human circulatory system:
  • 25. bloodVESSELS - artery Structure: •thick and elastic muscular walls to withstand the high blood pressure • elasticity enables artery wall to stretch & recoil • do not contain valves Function: •carry oxygeneated (except pulmonary artery) blood away from the heart at high pressure Middle layer (smooth muscle & elastic fibres) External layer (connective tissue) Small lumen
  • 26. bloodVESSELS - vein Structure: • relatively thin, less muscular walls • valves present to prevent the backflow of blood Function: • usually carry deoxygenated blood (except pulmonary vein)to the heart at lower blood pressure
  • 27. Blood flow in veins
  • 28. Artery Vein Capillary -Thick, muscular and elastic walls to withstand the high blood pressure in artery. -Elasticity allows artery wall to stretch & recoil to push the blood in spurts along the artery. -Thin, slightly muscular and have less elastic tissue as blood move more slowly and smoothly in the vein at low pressure. - Very thin, only one-cell thick wall to allow exchange of substances to take place between the blood and surrounding tissue. -Valves are absent -Valves are present to prevent backflow of blood -No valves -Always transport blood away from the heart to the rest of the body -Transport oxygenated blood(except for pulmonary artery and umbilical artery) -Always transport blood from body to the heart -Transport deoxygenated blood (except for pulmonary vein & umbilical vein) -Always carry blood from arterioles to venules -Allow exchange of substances between blood and tissue fluid.
  • 29. Blood pressure differences across blood vessels
  • 31. tissueFLUID (pure) plasma direction of blood flow movement of oxygen and dissolved food substances movement of excretory waste products blood capillary wall white blood cell squeezing through capillary wall
  • 33. • Tissue cells are bathed in tissue fluid (interstitial fluid) • Tissue fluid allows the diffusion of dissolved substances between the tissue cells and the blood capillaries. • Dissolved food substances and oxygen diffuse out from the blood capillaries into the tissue fluid then into the cells • Excretory products diffuse out from the cells into the tissue fluid and then through the capillary walls into the blood.
  • 35. Types of Blood Group
  • 36. • There are 4 human blood groups:  A, B, AB and O • Classification is based on the types of antigens and antibodies present in the blood:  Antigens represented by capital letters A & B  Antibodies represented by small letters a & b
  • 37. Types of Blood Group
  • 38. Are ‘blood agglutination’ and ‘blood clotting’ similar? Blood clotting is the formation of an enmeshed network of fibrin that traps RBCs and seal the wound from further blood loss. Blood agglutination is the clumping of RBC when natural antibodies in the recipient’s body react with the antigens on the donor’s red blood cells.
  • 40. Answers: (a) X : Blood group B Y : Blood group AB Z : Blood group O (b) Antibody b in the serum reacts with antigen B on the red blood cells, causing clumping of the red blood cells from X. (c) Blood group O (d) Blood groups A and AB (e) Such a person’s red blood cells do not contain any antigens, so this person’s blood can be donated to any blood group without causing clumping of the recipient’s red blood cells.
  • 41.
  • 44. Double Circulation in Mammals • In mammals, blood flows through the heart twice in one complete circuit. Systemic Circulation Pulmonary Circulation
  • 45. A B C D E F G H I A B C D E F G H I Right Atrium Right Ventricle Tricuspid Valve Aorta Pulmonary Artery Left Atrium Bicuspid Valve Left Ventricle Median Septum Semi-lunar Valves
  • 46. Did You Know That?! • The muscular walls of the right ventricle is thinner than the left? Why? -The left ventricle pumps blood from the heart to the rest of the body, thus requiring a more muscular wall. -The right ventricle pumps blood to the lungs, which is nearer to the heart, thus have a thinner muscular wall Right Ventricle Left Ventricle
  • 47. Aorta distributes oxygenated blood to different parts of the body. For example... Lungs Liver Small intestine Kidney Limbs Aorta Hepatic artery Renal artery Hepatic vein Hepatic portal vein Renal vein
  • 50. The Cardiac Cycle 1 The atria contracts, forcing blood into the relaxed . This causes a slight increase in both the atrial pressure and ventricular pressure 1 ventricles.
  • 51. The Cardiac Cycle 2 2 The Ventricles contract. This is called ventricle systole. The ventricle pressure increases. This causes the atrioventricular valves (Tricuspid & Bicuspid valves) to close, producing a loud “lub” sound and prevents the backflow of blood into the atria.
  • 52. The Cardiac Cycle 3 3 The pressure in the ventricles becomes higher than that of the aorta and pulmonary artery. The semi-lunar valves open and blood flows into the aorta and pulmonary artery.
  • 53. The Cardiac Cycle 4 4 The ventricles relax. This is called ventricular diastole. The drop in pressure in the ventricles causes the semi-lunar valves to close, producing a soft “dub” sound. This prevents the backflow of blood into the ventricles.
  • 54. The Cardiac Cycle 5 5 The pressure in the ventricle continues to decrease as they relax. 6 6 The atrioventricular valves opens as pressure in the ventricle becomes lower than that in the atria. 7 7 The pressure in the ventricles gradually increases as blood continues to enter the ventricle from the atria
  • 55. Heart Disease • Coronary artery (supplies blood to the heart) lie on the outside of the heart and supply oxygenated blood to the muscles in the wall of the cell.
  • 56. • Taking in too much cholesterol and polysaturated fat can cause fatty substance to be deposited on the inner surface of the coronary arteries. Did You Know That?! Atherosclerosis
  • 57. Atherosclerosis • This results in the occlusion/ blockage of the coronary arteries and reducing the supply of oxygenated blood & nutrients to the heart muscles. • Heart muscles eventually dies heart failure Fatty deposits Heart Attack!
  • 58. Buzz Time! Can a thin person develop arteriosclerosis? Polyunsaturated fats
  • 59. Effect of tobacco smoke Substance Effect nicotine increases blood pressure and the risk of blood clotting in the coronary arteries. carbon monoxide increase the risk of fatty deposits (atherosclerosis) on the inner surfaces of arteries.
  • 60. Prepared by, Ms Wong Fui Yen Examples of Famous People with Heart Disease • Bill Clinton – quadruple bypass surgery in 2004 • David Letterman - quadruple bypass surgery in 2000 • Larry King - heart attack and bypass surgery in 1987 • Michael Jackson – died of cardiac arrest 2009
  • 61. Coronary Bypass Surgery to replace the blocked coronary arteries