This document provides an overview of organic reactions, including the different types of organic reactions and how reaction mechanisms are used to describe the steps involved in organic reactions. It discusses several key aspects of organic reactions, including: 1) the common types of organic reactions such as addition, elimination, substitution, and rearrangement reactions, 2) how reaction mechanisms are used to describe the individual steps that occur in organic reactions, from reactants to products, and 3) the different types of steps that can be involved in reaction mechanisms, including the formation and breaking of covalent bonds. It also provides examples of reaction mechanisms, such as the addition of HBr to ethylene.
The anomeric effect was discovered in 1955 with the work of J.T. Edward, N.-J. Chu, and R.U. Lemieux.
Contributed by: Cody F. Bender, Charles E. Price (Undergraduates), University of Utah, 2016
The anomeric effect was discovered in 1955 with the work of J.T. Edward, N.-J. Chu, and R.U. Lemieux.
Contributed by: Cody F. Bender, Charles E. Price (Undergraduates), University of Utah, 2016
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Nature of coordination compounds, coordination sphere, coordination number, oxidation state of central metal atom, lewis acids, types of ligands, types of complex(cationic and anionic), Valance bond theory, crystal field theory, werner theory of coordination compounds, Nomenclature of coordination compounds.Eg and t2g ,CFSE, Degeneracy, Application of coordination compounds, Charge of the coordination sphere.
Spatial arrangements, inner and outer orbital complexes, low and high spin complex, spin pair and spin free complexes, isomerism, types of isomerism.
Carbocations and factors affecting their stabilitykoskal
A carbocation is a species where a carbon atom bonds to three carbon atoms and has a positive charge. Carbocations are electron deficient species and therefore very reactive and unstable. Anything which donates electron density to the electron-deficient center will help to stabilize them.
CONTENTS
INTRODUCTION
CONCEPTS OF WALSH DIAGRAM
APPLICATION IN TRIATOMIC MOLECULES
[IN AH₂ TYPE OF MOLECULES(BeH₂,BH₂,H₂O)]
INTRODUCTION
Arthur Donald Walsh FRS The introducer of walsh diagram (8 August 1916-23 April 1977) was a British chemist, professor of chemistry at the University of Dundee . He was elected FRS in 1964. He was educated at Loughborough Grammar School.
Walsh diagrams were first introduced in a series of ten papers in one issue of the Journal of the Chemical Society . Here, he aimed to rationalize the shapes adopted by polyatomic molecules in the ground state as well as in excited states, by applying theoretical contributions made by Mulliken .
These slides are especially made to understand the postulates of quantum mechanics or chemistry better. easily simplified and at one place you will find each of relevant details about the 5 postulates. so go through it & trust me it will help you a lot if you are chemistry or a science student.
well done
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Nature of coordination compounds, coordination sphere, coordination number, oxidation state of central metal atom, lewis acids, types of ligands, types of complex(cationic and anionic), Valance bond theory, crystal field theory, werner theory of coordination compounds, Nomenclature of coordination compounds.Eg and t2g ,CFSE, Degeneracy, Application of coordination compounds, Charge of the coordination sphere.
Spatial arrangements, inner and outer orbital complexes, low and high spin complex, spin pair and spin free complexes, isomerism, types of isomerism.
Carbocations and factors affecting their stabilitykoskal
A carbocation is a species where a carbon atom bonds to three carbon atoms and has a positive charge. Carbocations are electron deficient species and therefore very reactive and unstable. Anything which donates electron density to the electron-deficient center will help to stabilize them.
CONTENTS
INTRODUCTION
CONCEPTS OF WALSH DIAGRAM
APPLICATION IN TRIATOMIC MOLECULES
[IN AH₂ TYPE OF MOLECULES(BeH₂,BH₂,H₂O)]
INTRODUCTION
Arthur Donald Walsh FRS The introducer of walsh diagram (8 August 1916-23 April 1977) was a British chemist, professor of chemistry at the University of Dundee . He was elected FRS in 1964. He was educated at Loughborough Grammar School.
Walsh diagrams were first introduced in a series of ten papers in one issue of the Journal of the Chemical Society . Here, he aimed to rationalize the shapes adopted by polyatomic molecules in the ground state as well as in excited states, by applying theoretical contributions made by Mulliken .
These slides are especially made to understand the postulates of quantum mechanics or chemistry better. easily simplified and at one place you will find each of relevant details about the 5 postulates. so go through it & trust me it will help you a lot if you are chemistry or a science student.
well done
Organic Reaction Mechanism : This topic is very-very important for CSIR-NET, GATE, IIT-JAM and other Competitive exams for Chemistry and Chemical Sciences.
THE PERICYCLIC REACTION THE MOST COMMON TOPIC INCLUDE THE SYLLABUS OF MANY SCIENCE STUDY INCLUDING BSC, MSC , PHARMA STUDY, AND MORE HENCE WE ARE COVERED ALL THE DATA OF IT HOPE THIS WILL MAKE READER EASY.
Organic reactions are chemical reactions involving organic compounds. Organic reactions are used in the construction of new organic molecules. The production of many man-made chemicals such as drugs, plastics, food additives, fabrics depend on organic reactions.
In this webinar you will understand the guidelines of physical activity and how it can be incorporated into your lifestyle. You will also learn how to use the FITT principle in your exercise to achieve your fitness goals. The active use of body's fuel and the importance of nutrition before, during, and after exercise will also be discussed.
You will learn how to calculate body mass index (BMI) when given height and weight information, and describe the health implications of any given BMI value. You will also learn how to calculate yout total daily energy expenditure (TDEE) , and describe the roles of basal metabolic rate (BMR) and several other factors in determining an individual’s daily energy needs. The role of hormones that control your weight and strategies to "fix' those hormones will also be explored
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
MARUTI SUZUKI- A Successful Joint Venture in India.pptx
Chapter 05 an overview of organic reactions.
1. 1
6. An Overview of
Organic Reactions
Dr. Wong Yau Hsiung CHEM 221
2. 2
6.1 Kinds of Organic Reactions
In general, we look at what occurs and try to learn how it
happens
Common patterns describe the changes
Addition reactions – two molecules combine
Elimination reactions – one molecule splits into two
Substitution – parts from two molecules exchange
Rearrangement reactions – a molecule undergoes
changes in the way its atoms are connected
3. 3
6.2 How Organic Reactions Occur:
Mechanisms
In a clock the hands move but the mechanism behind
the face is what causes the movement
In an organic reaction, we see the transformation that
has occurred. The mechanism describes the steps
behind the changes that we can observe
Reactions occur in defined steps that lead from
reactant to product
4. 4
Steps in Mechanisms
We classify the types of steps in a sequence
A step involves either the formation or breaking of a
covalent bond
Steps can occur in individually or in combination with
other steps
When several steps occur at the same time they are
said to be concerted
5. 5
Types of Steps in Reaction
Mechanisms
Formation of a covalent bond
Homogenic or heterogenic
Breaking of a covalent bond
Homogenic or heterogenic
Oxidation of a functional group
Reduction of a functional group
6. 6
Homogenic Formation of a Bond
One electron comes from each fragment
No electronic charges are involved
Not common in organic chemistry
7. 7
Heterogenic Formation of a Bond
One fragment supplies two electrons
One fragment supplies no electrons
Combination can involve electronic charges
Common in organic chemistry
8. 8
Homolytic Breaking of Covalent
Bonds
Each product gets one electron from the bond
Not common in organic chemistry
9. 9
Heterolytic Breaking of Covalent
Bonds
Both electrons from the bond that is broken become
associated with one resulting fragment
A common pattern in reaction mechanisms
10. 10
Indicating Steps in Mechanisms
Curved arrows indicate breaking
and forming of bonds
Arrowheads with a “half” head
(“fish-hook”) indicate homolytic
and homogenic steps (called
‘radical processes’)
Arrowheads with a complete head
indicate heterolytic and
heterogenic steps (called ‘polar
processes’)
11. 11
Radicals
Alkyl groups are abbreviate “R” for radical
Example: Methyl iodide = CH3I, Ethyl iodide =
CH3CH2I, Alkyl iodides (in general) = RI
A “free radical” is an “R” group on its own:
CH3 is a “free radical” or simply “radical”
Has a single unpaired electron, shown as: CH3
.
Its valence shell is one electron short of being
complete
12. 12
6.3 Radical Reactions and How
They Occur
Note: Polar reactions are more common
Radicals react to complete electron octet of valence
shell
A radical can break a bond in another molecule
and abstract a partner with an electron, giving
substitution in the original molecule
A radical can add to an alkene to give a new
radical, causing an addition reaction
13. 13
Steps in Radical Substitution
Three types of steps
Initiation – homolytic formation of two reactive
species with unpaired electrons
Example – formation of Cl atoms form Cl2 and
light
Propagation – reaction with molecule to generate
radical
Example - reaction of chlorine atom with
methane to give HCl and CH3
.
Termination – combination of two radicals to form
a stable product: CH3
.
+ CH3
.
CH3CH3
14. 14
6.4 Polar Reactions and How They
Occur
Molecules can contain local unsymmetrical electron
distributions due to differences in electronegativities
This causes a partial negative charge on an atom
and a compensating partial positive charge on an
adjacent atom
The more electronegative atom has the greater
electron density
15. 15
Electronegativity of Some
Common Elements
The relative electronegativity is indicated
Higher numbers indicate greater electronegativity
Carbon bonded to a more electronegative element
has a partial positive charge (δ+)
16. 16
Polarizability
Polarization is a change in electron distribution as a
response to change in electronic nature of the
surroundings
Polarizability is the tendency to undergo polarization
Polar reactions occur between regions of high
electron density and regions of low electron density
17. 17
Generalized Polar Reactions
An electrophile, an electron-poor species, combines
with a nucleophile, an electron-rich species
An electrophile is a Lewis acid
A nucleophile is a Lewis base
The combination is indicate with a curved arrow from
nucleophile to electrophile
18. 18
6.5 An Example of a Polar Reaction:
Addition of HBr to Ethylene
HBr adds to the π part of C-C double bond
The π bond is electron-rich, allowing it to function as
a nucleophile
H-Br is electron deficient at the H since Br is much
more electronegative, making HBr an electrophile
H
Br
δ+
19. 19
Mechanism of Addition of HBr to
Ethylene
HBr electrophile is attacked by π electrons of
ethylene (nucleophile) to form a carbocation
intermediate and bromide ion
Bromide adds to the positive center of the
carbocation, which is an electrophile, forming a C-Br
σ bond
The result is that ethylene and HBr combine to form
bromoethane
All polar reactions occur by combination of an
electron-rich site of a nucleophile and an electron-
deficient site of an electrophile
20. 20
6.6 Using Curved Arrows in Polar
Reaction Mechanisms
Curved arrows are a way to keep track of changes in
bonding in polar reaction
The arrows track “electron movement”
Electrons always move in pairs
Charges change during the reaction
One curved arrow corresponds to one step in a
reaction mechanism
21. 21
Rules for Using Curved Arrows
The arrow goes from the nucleophilic reaction site to
the electrophilic reaction site
The nucleophilic site can be neutral or negatively
charged
The electrophilic site can be neutral or positively
charged
22. 22
Changes in Energy
Free energy changes (∆Gº) can be divided into
a temperature-independent part called entropy
(∆Sº) that measures the change in the amount of
disorder in the system
a temperature-dependent part called enthalpy
(∆Hº) that is associated with heat given off
(exothermic) or absorbed (endothermic)
23. 23
6.8 Describing a Reaction: Bond
Dissociation Energies
Bond dissociation energy (D): Heat change that
occurs when a bond is broken by homolysis
The energy is mostly determined by the type of bond,
independent of the molecule
The C-H bond in methane requires a net heat
input of 105 kcal/mol to be broken at 25 ºC.
Table 5.3 lists energies for many bond types
Changes in bonds can be used to calculate net
changes in heat
24. 24
Calculation of an Energy Change from Bond
Dissociation Energies
Addition of Cl-Cl to CH4 (Table 5.3)
Breaking: C-H D = 438 kJ/mol
Cl-Cl D = 243 kJ/mol
Making: C-Cl D = 351 kJ/mol
H-Cl D = 432 kJ/mol
Energy of bonds broken = 438 + 243 = 681 kJ/mol
Energy of bonds formed = 351 + 432 = 783 kJ/mol
∆Hº = 681 – 783 kJ/mol = -102 kJ/mol
25. McMurry Organic Chemistry 6th edition Chapter 5
(c) 2003
25
6.9 Describing a Reaction: Energy Diagrams
and Transition States
The highest energy
point in a reaction step
is called the transition
state
The energy needed to
go from reactant to
transition state is the
activation energy (∆G)
26. 26
First Step in Addition
In the addition of HBr
the (conceptual)
transition-state
structure for the first
step
The π bond between
carbons begins to
break
The C–H bond
begs to form
The H–Br bond
begins to break
27. 27
6.10 Describing a Reaction:
Intermediates
If a reaction occurs in more than one step, it must
involve species that are neither the reactant nor the
final product
These are called reaction intermediates or simply
“intermediates”
Each step has its own free energy of activation
The complete diagram for the reaction shows the free
energy changes associated with an intermediate
28. 28
Formation of a Carbocation
Intermediate
HBr, a Lewis acid, adds to
the π bond
This produces an
intermediate with a positive
charge on carbon - a
carbocation
This is ready to react with
bromide
29. 29
Carbocation Intermediate Reactions
with Anion
Bromide ion adds an
electron pair to the
carbocation
An alkyl halide produced
The carbocation is a
reactive intermediate
30. 30
Reaction Diagram for Addition of HBr
to Ethylene
Two separate steps,
each with a own
transition state
Energy minimum
between the steps
belongs to the
carbocation reaction
intermediate.
31. 31
Biological Reactions
Reactions in living organisms follow reaction
diagrams too
They take place in very controlled conditions
They are promoted by catalysts that lower the
activation barrier
The catalysts are usually proteins, called enzymes
Enzymes provide an alternative mechanism that is
compatible with the conditions of life