this ppt is very simple and has immence importance in physical pharmacy. it has been prepared based on the syllabus of WBUT & consists of informations of elimentary label...
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
INCLUDES SPREADING COEFFICIENT AND ITS THEORY AND ALSO FEW OF ITS APPLICATION IN PHARMACEUTICAL FIELD
WILL BE HELPFUL FOR B PHARMACY STUDENTS
INCLUDES HOW IT IS DERIVED AND ALSO HOW IT IS RELATED TO SPREADING OF A CREAM OR OINTMENT ON OUR SKIN
IMPORTANCE OF SPREADING COEFFICIENT
States of matter and properties of matterJILSHA123
States of matter and properties of matter, latent heat, vapour pressure, aerosols - inhalers, sublimation critical point, eutectic mixtures, gas laws, Gibbs phase rule, crystalline structures, 3rd b.pharmacy, sanjo college of pharmaceutical studies, palakkad, kerala
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems. Solubility
of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions)
Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature . Distribution law, its limitations and applications
In this presentation:
Surface Tension
Interfacial Tension
Definition of inerfacial tension in different ways
Measurement of interfacial and surface tesion
Surface and Interfacial tension [Part-3(a)](Measurement of Surface and Inter...Ms. Pooja Bhandare
MEASUREMENT OF SURFACE AND INTERFACIAL TENSION
Capillary Rise Method, Drop Count and Weight Method.
Wilhelmy Plate Methods ,The DuNouy Ring Method.
Capillary Rise Method: Upward force due to surface tension: Drop count and Weight method Downward Force: Drop weight method: Drop count method
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
Solubility of liquids in liquids, The term miscibility refers to the mutual solubility of the component of liquid - liquid system, Raoult’s Law, Raoult’s law may be mathematically expressed as: Ideal solution, Real solution
INCLUDES SPREADING COEFFICIENT AND ITS THEORY AND ALSO FEW OF ITS APPLICATION IN PHARMACEUTICAL FIELD
WILL BE HELPFUL FOR B PHARMACY STUDENTS
INCLUDES HOW IT IS DERIVED AND ALSO HOW IT IS RELATED TO SPREADING OF A CREAM OR OINTMENT ON OUR SKIN
IMPORTANCE OF SPREADING COEFFICIENT
States of matter and properties of matterJILSHA123
States of matter and properties of matter, latent heat, vapour pressure, aerosols - inhalers, sublimation critical point, eutectic mixtures, gas laws, Gibbs phase rule, crystalline structures, 3rd b.pharmacy, sanjo college of pharmaceutical studies, palakkad, kerala
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems. Solubility
of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions)
Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature . Distribution law, its limitations and applications
In this presentation:
Surface Tension
Interfacial Tension
Definition of inerfacial tension in different ways
Measurement of interfacial and surface tesion
Surface and Interfacial tension [Part-3(a)](Measurement of Surface and Inter...Ms. Pooja Bhandare
MEASUREMENT OF SURFACE AND INTERFACIAL TENSION
Capillary Rise Method, Drop Count and Weight Method.
Wilhelmy Plate Methods ,The DuNouy Ring Method.
Capillary Rise Method: Upward force due to surface tension: Drop count and Weight method Downward Force: Drop weight method: Drop count method
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
Solubility of liquids in liquids, The term miscibility refers to the mutual solubility of the component of liquid - liquid system, Raoult’s Law, Raoult’s law may be mathematically expressed as: Ideal solution, Real solution
Discussion on the 2 kinds of Disperse Systems 1. Suspensions 2. Emulsions. The principles of emulsification, types and examples of emulsifying agents used.
What is a Dentifrice?
According to American Dental Association, Council on Dental Therapeutics:-
“ A dentifrices is a substance used with a toothbrush for the purpose of cleaning the accessible surface of the teeth”
“Webster” described the term Dentifrices as derived from “Dens” (tooth ) and “fricare” ( to rub ) .
Function of a dentifrice:-
Forms of dentifrices:-
General Formulation:-
Recent Modifications:-
References
Diabetes mellitus is a metabolic disease, characterized by high glucose level in blood (hyperglycaemia).
Insulin-dependent diabetes mellitus (IDDM)
Juvenile-onset diabetes
Type1 diabetes is characterized by the presence of antibodies in blood.
Glutamic Acid Decarboxylase antigen (GAD)
Insulin autoantibodies (IAAs),
Islet cell autoantibodies (ICAs).
These are the markers of the immune destruction of the ß cell.
Therefore, those with more than one autoantibody(i.e., ICA, IAA, GAD etc.) are at high risk.
It is a Project on Industrial Vocational Training at Pasteur laboratories PVT. LTD. It mainly comprises of the Management overviews of a Pharmaceutical as well as a production eligible industry. Workplace training, also known as trade or industry training, involves learning and earning money while you work. Apprenticeships are one type of workplace training. You can do workplace training in a range of hands-on industries. Workplace training usually combines on-the-job and off-the-job training. You'll have to:
1. attend all courses that are part of the industry training – these may be block courses, evening courses or day release classes, and are offered by a polytechnic or other education provider
2. Complete on-the-job assessments to show you are competent doing practical tasks, and to work towards your national certificate
3. Complete off-the-job assessments to work towards completing your qualification.
The Industry Training Authority is a provincial government agency in the province of British Columbia, Canada. Established in 2004, to replace the Industry, Training and Apprenticeship Commission (ITAC), its mandate is to facilitate training in the trades and industry occupations in the province.
We are thankful to Pasteur laboratories Pvt. Ltd., for conducting this training program during our undergraduate course in pharmacy & also for their precious knowledge & guidance throughout the training.
We are highly grateful as this knowledge would be an enormous help to our career in future days.
I, Diptarco Singha from GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE & TECHNOLOGY, PANIHATI, KOLKATA is representing this project after successfully completing our vocational training at Pasteur Laboratories Pvt. Ltd.
I am highly grateful to Pasteur Laboratories Pvt. Ltd. for complete guidance and supervision. It was a treat to work and learn under the guidance of Mr. Tuhin Saha. His vast knowledge regarding the subject was immensely helpful and gave a clear view about the path in future.
Normal Heart & Angina
Angere= Inflammation
Pectus= Chest
Angina Pectoris commonly known as Angina, characterised by chest pain due to imbalance between O2 supply & O2 demand in cardiac muscle or tissue due to the defect or blockage in the coronary artery.
Also known as CAD
A) Classical Angina/Stable Angina
Atheroma Deposition
Defect in coronary artery
Excessive exercise(O2 D )
Stress & tension
Predictable
Coronary Artery blocks
Blood supply to heart decreases
Heart unable to consume sufficient O2
O2 demand increases rather than supply
Antihyperlipidemic should be given.
to fat deposition on coronary
artery wall.
Antiplatelet & Thrombolytic are given.
to thrombin/platelet aggregation.
Calcium channel blockers (CCBs) are given.
to vasoconstriction.
Introduction:
SEDATIVES CNS depressant drugs , reduce excitement & tension, & produce calmness & relaxation.
HYPNOTICS drugs that produce sleep similar to that of natural arousal sleep.
Both sedative & hypnotic action may reside in the same drug.
A small dose may act as sedative, whereas a large dose of the same drug may act as a hypnotic.
SAR of Benzodiazepine:
Presence of phenyl ring / pyridyl ring promotes sedative-hypnotic activity at C5-position.
If presence of electron withdrawing group like –Cl or –NO2 (Lorazepam, Clonazepam) at R2’ position, then sedative-hypnotic activity .
Presence of electron withdrawing group like –Cl,
-F, –NO2 at C7 position, activity.
Substitution at 6,8,9 position of carbon atom, activity.
Shifting of double bond present between –N4 & C5 or saturation of double bond activity.
R3 = alkyl group, activity & R3 = -OH or –COOH activity & R1 = -CH3 ,if larger group is present activity.
Sleep is mainly loss of consciousness. Sleep is an architectured cyclic process.
These drugs maintains the sleep-wake cycle.
Insomnia is a symptom & its proper treatment depends on finding the cause of sleeplessness. To treat this type of patient, use sedative-hypnotics.
High dose of the drugs may lead to coma or death.
This ppt is very simple and has immence importance in dispensing pharmacy. it has been prepared based on the syllabus of WBUT & consists of informations of elimentary label...WHAT IS A “PRESCRIPTION” ?
A Prescription is a written order from a Registered Medical Practitioner, or any other Licensed Practitioner, such as Dentists, Veterinarian etc.
ABBREVIATIONS:-
It represents a problem in understanding the parts of a prescribing order & therefore leads to confusion…
NAME OF THE DRUG
There are certain drugs whose name look or sound like those of other drugs…
INSTRUCTIONS FOR THE PATIENTS
It essential to mention the instructions like quantity of the drug to be taken, the frequency & timing of administration in order to avoid confusion…
INCOMPATIBILITIES
It is essential to check that there are no Pharmaceutical or Therapeutic incompatibility in a prescription…
(07.03.2014) on zinc oxide ointment (chemistry) by Diptarco SinghaDiptarco Singha
this ppt is very simple and has immence importance in physical pharmacy & pharmaceutics. it has been prepared based on the syllabus of WBUT & consists of informations of elimentary label...
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Mammalian Pineal Body Structure and Also Functions
4th (30.10.2014) on eutectic mixture by Diptarco Singha
1.
2.
3. Melts below
the melting
point of
individual
component…
The melting
point is
always
fixed…
During
formation, the
components
are miscible
in liquid state
but
immiscible in
solid state…
4. Below the eutectic
temperature the mixture of
the two substances will exist
as a solid.
While above it the mixture
will convert into a liquid.
(e- Eutectic point)
Point ‘e’ is the lowest melting
point.
5. It is necessary to adjust the ratio of the
components in the mixture.
It is also necessary to closely control
the components for impurities.
6. The components must be miscible in a liquid state & mostly
immiscible in solid state…
The molecules which are in accordance to modified VantHoff’s
equation can form eutectic mixtures…
The components should have chemical groups that can interact
to form physical bonds such has intermolecular hydrogen
bonding etc…
7. Eutectic Mixtures are commonly used in drug designing and delivery
processes for various routes of administration…
Other uses are:-
For the identification of the compounds having similar
melting points.
Local anesthetics in case of children (used topically).