The cubital fossa is a triangular space at the front of the elbow, bordered by the brachioradialis and pronator teres muscles, with a base formed by a line between the humeral epicondyles. The fossa contains critical structures including the median nerve, brachial artery, tendon of the biceps brachii, and radial nerve, along with important veins such as the median cubital vein. Clinically, the median cubital vein is commonly used for intravenous injections, and blood pressure is measured using the brachial artery located in the fossa.