Tooth decay, also known as dental caries is an epidemic, microbiological contagious disease of the teeth that ends in localized dissolution and damage of the calcified structure of the teeth. ... The time factor is significant for the commencement and development of caries in teeth.
Dental Plaque
Soft deposits that form the biofilm adhering to the tooth surface or other hard surfaces in the oral cavity, including removable & fixed restorations”
Bowen , 1976
Bacterial aggregations on the teeth or other solid oral structures
Lindhe, 2003
Describe relationship between plaque and oral diseases
Describe role of plaque in development of caries
Define Dental Caries
Describe the aetiology and the role different factors play in ini4a4on and progression of the disease
Describe the role played by different microorganisms
Introduction
Prevention of caries
Brief introduction about types of Immunity
Causative factors of dental caries
Virulance of S mutans
Natural immune barriers
Salivary secretion and its composition
Natural barriers
Innate immune responses of dental pulp to caries
Acquisition of oral microbes
Factors affecting oral microbial colonization
Innate salivary factors found in oral cavity
Adaptive immunity
Secretary IgA
Types of Immunization
Routes of Immunization
Conclusion
Dental Plaque
Soft deposits that form the biofilm adhering to the tooth surface or other hard surfaces in the oral cavity, including removable & fixed restorations”
Bowen , 1976
Bacterial aggregations on the teeth or other solid oral structures
Lindhe, 2003
Describe relationship between plaque and oral diseases
Describe role of plaque in development of caries
Define Dental Caries
Describe the aetiology and the role different factors play in ini4a4on and progression of the disease
Describe the role played by different microorganisms
Introduction
Prevention of caries
Brief introduction about types of Immunity
Causative factors of dental caries
Virulance of S mutans
Natural immune barriers
Salivary secretion and its composition
Natural barriers
Innate immune responses of dental pulp to caries
Acquisition of oral microbes
Factors affecting oral microbial colonization
Innate salivary factors found in oral cavity
Adaptive immunity
Secretary IgA
Types of Immunization
Routes of Immunization
Conclusion
This seminar includes classifcation,etiopathogenesis,Various theories of dental caries,caries patterns in primary and permanent teeth,Caries pattern in adolescets followed by caries risk assessment,CAMBRA,Differences between nursing bottle and rampant cariess,diagnosis which included the advanced digital diagnostic methods like diagnodent,QLF,etc and management with age specific management and flouride therapy age wise .
Dental attrition is a type of tooth wear caused by tooth-to-tooth contact, resulting in loss of tooth tissue, usually starting at the incisal or occlusal surfaces. Tooth wear is a physiological process and is commonly seen as a normal part of aging.
Tooth discoloration is abnormal tooth color, hue or translucency. External discoloration is accumulation of stains on the tooth surface. Internal discoloration is due to absorption of pigment particles into tooth structure.
Dentine, unlike enamel, has the ability to react to the progression of caries due to the presence of odontoblasts. Odontoblasts can respond to irritation by depositing minerals in the dentinal tubules
Minimal intervention dentistry vs g.v blackEdward Kaliisa
Minimal Intervention Dentistry (MID) is a response to the traditional, surgical manner of managing dental caries, that is based on the operative concepts of G.V. Black of more than a century ago. MID is a philosophy that attempts to ensure that teeth are kept functional for life
Tooth resorption is the progressive loss of dentine and cementum by the action of osteoclasts. This is a physiological process in the exfoliation of the primary dentition, caused by osteoclast differentiation due to pressure exerted by the erupting permanent tooth
Nutrition and dental caries. Promotion of sound dietary practices is an essential component of caries management, along with fluoride exposure and oral hygiene practices. ... Fermentable carbohydrates interact dynamically with oral bacteria and saliva, and these foods will continue to be a major part of a healthful diet.
Dentinogenesis imperfecta (DI) is a genetic disorder of tooth development. This condition is a type of dentin dysplasia that causes teeth to be discolored (most often a blue-gray or yellow-brown color) and translucent giving teeth an opalescent sheen.
SEQUELAE. Most dental pain occurs as a result of caries. Initially, caries presents as a painless white spot (decalcification of the enamel, which may be reversible), followed by cavitation and brownish discoloration. ... Untreated caries can progress through the dentine to the pulp, which becomes inflamed (pulpitis)
Dental radiographs are commonly called X-rays. Dentists use radiographs for many reasons: to .... Detect any presence or position of unerupted teeth.2-D Conventional radiographs provide excellent images for most dental radiographic needs. Their primary use is to supplement the clinical examination by providing insight into the internal structure of teeth and supporting bone to reveal caries, periodontal and periapical diseases, and other osseous conditions.
Amelogenesis imperfecta is a disorder of tooth development. This condition causes teeth to be unusually small, discolored, pitted or grooved, and prone to rapid wear and breakage
The traditional method of detecting dental caries in clinical practice is a visual‐tactile examination often with supporting radiographic investigations.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. Objectives
Introduction
To define dental caries
To describe the normal flora of the mouth
To describe the chemoparasitic theory
To describe specific and non specific plaque
hypothesis.
To describe role of plaque in caries
Streptococcus mutans in caries development
BDS
3. Introduction
Dental caries is the most common chronic
diseases in the world
Has affected humans since prehistoric times
Its prevalence has increased greatly in
modern times world wide, an increase
strongly associated with dietary changes.
Loesche in 1986, described it as the most
expensive infection that most individuals have
to contend with during life. This statement
remains correct today world wide
BDS
4. Dental
caries
Dental caries is microbial
disease of the calcified
tissues of teeth (enamel,
dentine &cementum)
characterized by
demineralization of the
inorganic portion and
destruction of organic
substance of the tooth
which often leads to
cavitation.
BDS
6. Chemicoparasitic theory(1890)
Proposed in 1890 by W. D. Miller in his book
‘’microorganisms of the human mouth" based upon the
work done in Robert Koch’s laboratory in Berlin
Acid and parasite
showed that the degradation of carbohydrate-containing
foods resulted in acid formation and was able to
demonstrate this process in vitro with isolated oral
bacteria and extracted teeth.
Concluded that dental caries was caused by multiple
species of oral bacteria
No specific bacteria was implicated
Proper prevention is therefore is to remove or minimize
multiple bacterial species
BDS
7. Specific and non specific plaque
hypothesis in plaque pathogenicity
Non specific plaque hypothesis:
It assumes that all plaque is pathogenic
It therefore requires a therapeutic goal that completely
eliminates plaque in patients.
This goal is unrealistic and not achievable even in most
dedicated patients
•Specific plaque hypothesis
Recognizes plaque as pathogenic only when signs of
associated disease are present.
Treatment is aimed at eliminating specific pathogenic
organisms (cariogenic plaque) but not total plaque
elimination.
Provides new scientific basis of caries treatment based on
medical model.
BDS
8. The specific plaque hypothesis
and dental caries.
In 1924, Clark isolated streptococci from human carious
lesions, and named Streptococcus mutans
In 1960, Keyes showed that ‘caries-free’ hamsters
develop dental caries only when caged together with
caries-active’ hamsters
The bacteria previously referred to as S. mutans are
actually seven distinct species now called mutans
MS are the principal etiological agents of dental caries
BDS
9. Role of plaque in caries
Plaque is a soft, non mineralized, bacterial deposit which
forms on a teeth that are not adequately cleaned
Important component of dental plaque is acquired
pellicle just prior or concomitantly with bacterial
colonization and may facilitate plaque formation
Microbial in dental plaque
streptococci
actinomycetes
veillonella
Strep. mutans chief etiological agent of dental caries
BDS
10. Microbial etiology of caries
Strep. mutans
Requires a relatively high proportion (2-10%) of mutans
streptococci within dental plaque.
Possess adherence activity to tooth surface (wall associated
protein A and Glucan binding protein A&C)
Produce higher amounts of acid(lactate) from sugars than
other bacterial types, and possess acid tolerance (aciduric)
Produce extracellular polysaccharides (glucans,fructans) from
sucrose
Lactobacilli
Dentin, root caries, acidogenic, aciduric
● Actinomyces viscosus
Root caries, acidogenic and aciduric
BDS
11. The metabolism of s.mutans
The fermentation of these carbohydrates is the principal
source of energy for S. mutans
Genome sequence shows that S. mutans can metabolize
a wider variety of carbohydrates than any other G(+)
microorganism
The glycolytic pathway leads to the production of
pyruvate, which is converted to lactic acid (by LDH
activity), formate, ethanol and acetate
The acidic environments are responsible for the damage
of
tooth structure
Acid tolerant – based on a membrane-bound, acid stable,
proton-translocating ATPase
BDS
12. Virulence of s.mutans
Production of
Acid
Adhesins
Wall-associated protein A (WapA)
Glucan-binding proteins A and C
BDS
13. Methods of attachment
Sucrose independent –using ionic and lectin like
interaction
Adhere to salivary agglutinin glycoprotein (SpaP:
Streptococcal protein antigen P.
Adhere to other bacteria, the extracellular matrix and
epithelial
cell-surface receptors
Sucrose dependent
Adhere to tooth surface by synthesizing glucans by
glucosyltransferases
Glucan promotes cell-cell aggregation by interacting with
surface-associated glucan binding protein
BDS
