The oral cavity hosts a complex ecology of microbial populations that compete for available nutrients. While most oral bacteria grow best at a narrow pH range, some aciduric bacteria can grow at low pH levels and are favored in acidic environments. Sugar is the main energy source, but some bacteria can use other substrates like carboxylic acids. Key bacterial adaptations include maintaining metabolism at low pH, rapidly transporting sugars, and producing extracellular and intracellular polysaccharides. Major cariogenic bacteria associated with dental caries include Streptococcus mutans, Lactobacillus, Actinomyces, and Veillonella. Dental caries results from the net acid production of the overall plaque microflora through multiple bacterial interactions, competitions,