The oral cavity contains hundreds of bacterial species that form complex biofilm communities on teeth and gums. Two key pathogens associated with dental caries are Streptococcus mutans and Lactobacillus casei. These bacteria produce acids by fermenting sugars that demineralize tooth enamel over time, leading to cavities. While everyone harbors caries-causing bacteria like S. mutans, dental caries only develops when there is an imbalance in the microbial community that allows these pathogens to dominate and lower the pH. Studying the oral microbiome provides insights into the pathogenesis of oral diseases and opportunities for prevention and treatment strategies.