Anemia Causes, Types, Symptoms, Diet, and Treatment Dr Medical
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Anemia is a condition that develops when your blood lacks enough healthy red blood cells or hemoglobin. Hemoglobin is a main part of red blood cells and binds oxygen. If you have too few or abnormal red blood cells, or your hemoglobin is abnormal or low, the cells in your body will not get enough oxygen.
Anemia Causes, Types, Symptoms, Diet, and Treatment Dr Medical
https://userupload.net/0gv9ijneu7hf
Anemia is a condition that develops when your blood lacks enough healthy red blood cells or hemoglobin. Hemoglobin is a main part of red blood cells and binds oxygen. If you have too few or abnormal red blood cells, or your hemoglobin is abnormal or low, the cells in your body will not get enough oxygen.
Megaloblastic anaemia is a red blood cell disorder due to the inhibition of DNA synthesis during erythropioesis.
Mitotically, the inhibition of the DNA synthesis impaires the progression of the cell cycle development from G2 to (M) stage.
Megaloblastic anaemia is a red blood cell disorder due to the inhibition of DNA synthesis during erythropioesis.
Mitotically, the inhibition of the DNA synthesis impaires the progression of the cell cycle development from G2 to (M) stage.
Anemia is a reduction in RBCs
which in turn decreases the oxygen
carrying capacity of blood.
Anemia is not a specific
disease state but a sign of an
underlying disorder.
Rbcs & its clinical implications. Dr. Amit Suryawanshi .Oral & Maxillofacial ...All Good Things
Hi. This is Dr. Amit T. Suryawanshi. Oral & Maxillofacial surgeon from Pune, India. I am here on slideshare.com to share some of my own presentations presented at various levels in the field of OMFS. Hope this would somehow be helpful to you making your presentations. All the best & your replies are welcomed!
Rbcs & its clinical implications by Dr. Amit T. Suryawanshi, Oral Surgeon, P...All Good Things
Hi. This is Dr. Amit T. Suryawanshi. Oral & Maxillofacial surgeon from Pune, India. I am here on slideshare.com to share some of my own presentations presented at various levels in the field of OMFS. Hope this would somehow be helpful to you making your presentations. All the best.
The blood, Thrombosis, Plasma substitutes, AnemiaSivabalanKumar2
The Blood:
Blood is a vital fluid that circulates throughout the human body, delivering essential substances like oxygen and nutrients to cells and removing waste products. It plays a crucial role in various physiological processes, including transportation, defense, and regulation. Blood is composed of different components, including red blood cells (RBCs), white blood cells (WBCs), platelets, and plasma.
Red blood cells (RBCs) are responsible for carrying oxygen to tissues and organs. They contain a protein called hemoglobin that binds to oxygen and gives blood its characteristic red color. White blood cells (WBCs) are a crucial part of the immune system, defending the body against infections and foreign substances. Platelets are essential for blood clotting, preventing excessive bleeding when there is an injury.
Plasma is the liquid component of blood, making up about 55% of its volume. It is a yellowish fluid composed mainly of water, along with proteins, electrolytes, hormones, antibodies, and various other substances. Plasma carries nutrients, hormones, and waste products throughout the body and also plays a significant role in maintaining the body's pH balance and regulating body temperature.
Thrombosis:
Thrombosis refers to the formation of a blood clot within a blood vessel, obstructing normal blood flow. It occurs when there is an imbalance in the clotting mechanism, leading to the formation of an excessive or inappropriate clot. Thrombosis can occur in both veins and arteries, and its severity can range from mild to life-threatening, depending on the location and size of the clot.
When a clot forms in a vein, it is called venous thrombosis. This can manifest as deep vein thrombosis (DVT), where the clot forms in the deep veins of the legs or arms, or as pulmonary embolism (PE), where a clot travels to the lungs and blocks blood flow. Arterial thrombosis occurs when a clot forms in an artery, leading to a reduction or blockage of blood supply to vital organs or tissues.
Thrombosis can be caused by various factors, including prolonged immobility, surgery, trauma, certain medical conditions (such as cancer or autoimmune disorders), hormonal changes, and genetic predisposition. Treatment for thrombosis typically involves blood thinners (anticoagulants) to prevent further clotting and measures to dissolve or remove existing clots.
Plasma Substitutes:
Plasma substitutes are solutions or products used to temporarily replace or supplement the function of plasma when it is unavailable or insufficient. These substitutes are mainly employed in emergency situations or during medical procedures where blood loss or volume expansion is required. Plasma substitutes can be categorized into two broad groups: colloid and crystalloid solutions.
Colloid solutions contain large molecules that remain within the blood vessels for a longer duration, exerting an osmotic effect and helping to maintain fluid balance. Examples of colloid solutions include a
Basic Life Support, or BLS, generally refers to the type of care that first-responders, healthcare providers and public safety professionals provide to anyone who is experiencing cardiac arrest, respiratory distress or an obstructed airway.
The Advanced Cardiovascular Life Support (ACLS) algorithm is a systematic, evidence-based approach designed to guide healthcare providers in the urgent treatment of: Cardiac arrest. Arrhythmias. Stroke. Other life-threatening cardiovascular emergencies.
Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar), which leads over time to serious damage to the heart, blood vessels, eyes, kidneys and nerves. The most common is type 2 diabetes, usually in adults, which occurs when the body becomes resistant to insulin or doesn't make enough insulin. In the past 3 decades the prevalence of type 2 diabetes has risen dramatically in countries of all income levels. Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which the pancreas produces little or no insulin by itself. For people living with diabetes, access to affordable treatment, including insulin, is critical to their survival. There is a globally agreed target to halt the rise in diabetes and obesity by 2025.
Levels of Organization
1
An Introduction to the Human Body
2
The Chemical Level of Organization
3
The Cellular Level of Organization
4
The Tissue Level of Organization
Support and Movement
Regulation, Integration, and Control
Fluids and Transport
Energy, Maintenance, and Environmental Exchange
Human Development and the Continuity of Life
Anatomy refers to the internal and external structures of the body and their physical relationships, whereas physiology refers to the study of the functions of those structures.
Communicable diseases, including HIV/AIDS, tuberculosis (TB), malaria, viral hepatitis, sexually transmitted infections and neglected tropical diseases (NTDs), are among the leading causes of death and disability in low-income countries and marginalized populations.
Nursing Mangement on occupational and industrial disorders [Autosaved].pptxDR .PALLAVI PATHANIA
What are the 5 types of occupational disease?
Occupational diseases in this registry system including Occupational lung diseases, occupational skin diseases, noise-induced hearing loss, diseases caused by chemical agents (poisoning), diseases caused by biological agents, occupational cancers and other occupational diseases
Acyanotic heart disease is where the blood contains enough oxygen but it's pumped abnormally around the body. Babies born with acyanotic heart disease may not have any apparent symptoms but, over time, the condition can cause health problems.
Congenital heart disease, also called a defect, refers to one or more problems with the heart structure that are present at birth. These abnormalities occur when the heart or blood vessels don't form correctly in utero. At least eight out of every 1000 infants born in the US each year have a heart defect.
Dialysis is a treatment for people whose kidneys are failing. When you have kidney failure, your kidneys don't filter blood the way they should. As a result, wastes and toxins build up in your bloodstream. Dialysis does the work of your kidneys, removing waste products and excess fluid from the blood
Urinary disorders with congenital anomalies of Kidney, ureter. UTIs are common infections that happen when bacteria, often from the skin or rectum, enter the urethra, and infect the urinary tract. The infections can affect several parts of the urinary tract, but the most common type is a bladder infection (cystitis).
Genitourinary disorders are conditions that affect the genitourinary system, which includes the urinary and reproductive systems. Some are congenital, and others are acquired later in life.
Large numbers of patients suffer from a variety of diseases in the genitourinary system, which is composed of kidneys, ureters, bladder, urethra, and genital organs. Genitourinary diseases include congenital abnormalities, iatrogenic injuries, and disorders such as cancer, trauma, infection, and inflammation.
The genitourinary system, or urogenital system, are the organs of the reproductive system and the urinary system. These are grouped together because of their proximity to each other, their common embryological origin and the use of common pathways, like the male urethra.
lymphatic system, a subsystem of the circulatory system in the vertebrate body that consists of a complex network of vessels, tissues, and organs. The lymphatic system helps maintain fluid balance in the body by collecting excess fluid and particulate matter from tissues and depositing them in the bloodstream
The musculoskeletal system is made up of bones, cartilage, ligaments, tendons and muscles, which form a framework for the body. Tendons, ligaments and fibrous tissue bind the structures together to create stability, with ligaments connecting bone to bone, and tendons connecting muscle to bone.
The skin is the largest organ of the body, with a total area of about 20 square feet. ... Skin has three layers: The epidermis, the outermost layer of skin, provides a waterproof barrier and creates our skin tone. The dermis, beneath the epidermis, contains tough connective tissue, hair follicles, and sweat glands.
Professional development is learning to earn or maintain professional credentials such as academic degrees to formal coursework, attending conferences, and informal learning opportunities situated in practice. It has been described as intensive and collaborative, ideally incorporating an evaluative stage.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
2. INDEX
SR.NO CONTENT
1) Introduction
2) Anatomy and physiology of blood
3) RBC Disorders
4) WBC Disorders
5) Platelets Disorders
6) Summarization
7) Conclusion
8) Assignment
9) Bibliography
3. INTRODUCTION
Hematology is the study of blood in health
and disease. It includes problems with the red
blood cells, white blood cells, platelets, blood
vessels, bone marrow, lymph nodes, spleen,
and the proteins involved in bleeding and
clotting (hemostasis and thrombosis).
4. BLOOD
William Harvey- father of physiology discovered
blood circulated through the body in 1628.
It is a fluid connective tissue which transports
substance from one part of the body to another.
It provides nutrients and hormones to the tissues
and removes their waste products.
5. CHARACTERISTICS OF BLOOD:
Color: blood is red in color. Arterial
blood is scarlet red and venous blood
is purple
Volume: Average volume of blood in
a normal adult is 5 liter
In females it is slightly less
and it is about 4.5 liter
6. Cont…
Reaction and pH: Blood is slightly alkaline
its pH in normal conditions is 7.4
Specific gravity:
Total blood: 1.052 to 1.06
Blood cells: 1.092 to 1.101
Plasma: 1.022 to 1.026
Viscosity: blood is five times more viscous than
water.
8. 1. PLASMA
It is Straw colored, nonliving part of blood.
Blood plasma is a mixture of proteins,
enzymes, nutrients, wastes, hormones and
gases.
It contains : 91% Water
9% Solids
that comprises :1% inorganic molecules:
Na+,Ca2+,Cl-, HCO3-,K+,Mg2+
9. 2. Protein
Normal value: 6.4 -8.3 gm%
Albumin: 55% (3-5gm% )
it helps substances dissolve in the plasma by
binding to them, hence playing an important
role in plasma transport of substances such as
drugs, hormones and fatty acids.
10. 3.Nutrients:
These include glucose, amino acids, fats,
cholesterol, phospholipids, vitamins and minerals.
Gases: O2 & Co2
Electrolytes: Most abundant Sodium.
Amino Acids
Nitrogenous Waste
Urea
Uric Acid
Creatinine
12. 1) Red blood cell
The most abundant blood cells are the red
blood cells (RBCs), which account for
99.9 percent of the formed elements
In adult males ,4.5–6.3 million per 1
cubic ml
females, 4.2–5.5 million per 1 cubic ml
13. Cont..
HAEMOGLOBIN:
◦ Normal values: At birth: 23gm/dl
◦ At the end of 3 months: 10.5gm/dl
◦ At the end of 1 year 12.5gm/dl
◦ Adults- males: 14-18gm/dl
◦ females: 12-15 gm/dl
14. RED BLOOD CELL DISODERS
1. Erythrocytosis
2. Polycythaemia vera
3. Anaemia
I. Iron deficiency anaemia
II. Anaemia owing to heamolysis
III. Sickle cell anaemia
IV. Thalassemia
V. Pernicious anaemia
VI. Aplastic anaemia
15. 1.Erythrocytosis:
A conditions with an increase in
circulating red blood cells (RBCs),
characterized by a increased
hemoglobin level.
It is of two type:
Relative
erythrocytosis
Absolute
erythrocytosis
16. Relative Erythrocytosis:
• It is apparent rise of erythrocytes
level in the blood the underlying
cause is:
• with hemoconcentration of cells.
• as a result of loss of fluid
• vomiting,
• diarrhea
• lossof electrolytes with
accompanying loss of water.
17. Absolute erythrocytosis:
This is due to increased erythropoiesis and
can be primary or secondary.
Primary erythrocytosis :
It can be a familial disorders or neoplastic.
• True idiopathic increase in the number
of circulating RBC and of the
hemoglobin level.
18. Cont..
Secondary erythrocytosis :
• The exact cause is not known.
• Absolute increased in RBC mass resultant to
enhanced production of RBC .
• Bone marrow anoxia– pulmonary dysfunction, high
altitude, CO poisoning.
19. Causes:
Smoking
A lack of oxygen, such as from
lung diseases or being in high
altitudes.
Tumors
Medications such as steroids and
diuretics
24. Cont…
Aspirin. Taking low doses of
this everyday pain reliever may
help prevent blood clots.
Medications that lower RBC
production.
These include:
Hydroxyurea (hydrea),
Busulfan (myleran)
Interferon.
25. 2.Polycythemia vera
• Chronic stem cell disorder with an insidious
onset characterized as a pan hyperplastic,
malignant and neoplastic marrow disorder.
• Absolute increase in the number of
circulating RBC and in the total blood
volume because of uncontrolled RBC
production.
26. Causes:
Causes of polycythaemia are primary or
secondary.
1. Primary polycythemia : Abnormalities in
red blood cell production cause an increase
in red cell count.
2. Secondary polycythemia : Factors
external to red blood cell production (for
example, hypoxia, sleep apnea, certain
tumors) result in polycythemia
31. 3.ANEMIA
• It can also be defined as a
lowered ability of the blood
to carry oxygen.
32. Etiology: Classification of anemia
Blood loss:
1.Acute Post haemorrhagic
2.Chronic blood loss
Deficiency of Hemopoietic factors:-
1.Iron deficiency
2.Folate and vitamin b12deficiency
3.Protein deficiency.
Bone marrow aplasia:-
1.Aplastic anaemia
2.Pure red cell aplasia
33. Cont…
Anemia due to systemic infections:
1.Due to chronic infection
2.Due to chronic renal disease
3.Due to chronic liver disease
4.Endocrinal diseases
Anemia due to bone marrow infiltration
1.Leukemia’s
2.Lymphomas
3.Myelofibrosis
4.Multiple myeloma
5.Congenital sideroblastic anemia
Anemia due to increased red cell destruction:
1.Intra-corpuscular defect
2. Extra-corpuscular defect
35. 1.Iron deficiency anemia
• Iron deficiency is defined as a
reduction in total body iron to an
extent that iron stores are fully
exhausted and some degree of tissue
iron deficiency is present.
• Females are mostly affected.
36. Etiology:
• Chronic blood loss
• Inadequate dietary intake
• Faulty iron absorption for iron- infancy, childhood,
• Increased requirements pregnancy.
37.
38. Clinical manifestations:
• Chronic fatigue
• Pallor of the conjunctiva, lips, and oral mucosa
• Brittle nails with spooning, cracking,
• Splitting of nail beds, koilonychia
• Palmar creases
41. Laboratory findings:
• Health history
• Physical examination
• RBC- 3,000,000-4,000,000/cubic
mm
• Low hemoglobin
• Low serum iron and ferritin with
an elevated total iron binding
capacity (TIBC)
43. Oral Health Considerations
• Low hemoglobin levels - physician
consultation prior to surgical treatment.
• If Hemoglobin is less than 8 gm/dL,
general anesthesia should be avoided.
• Narcotic use should be limited.
• Increased risk for ischemic heart disease
44. II. Anemia Owing to Hemolysis:
• Normal RBC life span - 90 to 120 days.
• Hemolytic diseases result in anemia if the
bone marrow is not able to replenish
adequately the prematurely destroyed RBCs.
• Either inherited or acquired.
45. Cont…
3 mechanism for accelerated
destruction of RBCs:
1. Molecular defect inside the red
cell
2. Abnormality in membrane
structure and function
3. Environmental factor- mechanical
trauma
46. Clinical Manifestations:
1. Acute back pain
2. Breathlessness
3. Renal failure.
4. . Loss of stamina
5. Tachycardia
6. Haemoglobinuria
49. III. SICKLE CELL DISEASES
Sickle cell disease is a disorders that
affects the red blood cells, which use a
protein called hemoglobin to transport
oxygen from the lungs to the rest of the
body.
These rigid, sticky cells can get stuck in
small blood vessels, which can slow or
block blood flow and oxygen to parts of
the body.
50. Causes:
It is caused by a mutation in the gene
In sickle cell anemia, the abnormal
hemoglobin causes red blood cells to
become rigid, sticky and misshapen.
52. Symptoms:
• Anemia
• Episodes of pain
• Swelling of hand and feet
• Frequent infections
• Delayed growth or puberty
• Vision problems
• infection
• Dizziness
• Fatigue
53. Laboratory finding:
• Health history
• RBC- may reach a level of 1,000,000 cells per
cubic mm.
• Decreased hemoglobin level.
• High reticulocyte count-Anemia
• Increased marrow response.
• Elevated lactic dehydrogenase and decreased
levels of hepatoglobin- confirms hemolysis
54. Radiographic features:
• HAIR – ON – END: in iron deficiency anaemia and
cyanotic congenital heart disease. Hair‐on‐end
appearance of the skull is a characteristic feature of
chronic haemolysis usually seen in patients with
thalassaemia and sickle cell anaemia.
56. MANAGEMENT OF SICKLE CELL ANEMIA
ANTIBIOTIC e.g.
PENICILLIN
BLOOD
TRANSFUSION
NITRIC OXIDE
(Keep blood vessels open)
BONE MARROW
TRANSPLANT
GENE THERAPY
57. V.Thalassemia:
It is an inherited blood
disorder in which the body
makes an abnormal form of
hemoglobin. Hemoglobin is
the protein molecule in red
blood cells that carries
oxygen.
58. Types of thalassemia:
There are three main types of thalassemia
(and four subtypes):
Beta thalassemia, it occur when a gene
defect affect production of beta globin
protein.
Alpha thalassemia: it occur when a gene
defect affect production of alpha globin
protein.
59. Cont..
Thalassemia minor: in this the
defective gene received from one
parents
Thalassemia major: in this the
defective gene received from both
parents
60. Causes of thalassemia:
Mutations in the DNA
Family history of thalassemia.
Certain ancestry. Thalassemia occurs most
often in African Americans and in people of
Mediterranean and southeast Asian descent.
66. VI. Anemia owing to decreased production of
RBCs
Megaloblastic (Pernicious) anemia and
vitamin B12 (Cobalamin deficiency:It
is adult form of anemia that is
associated with gastric atrophy and a
loss of intrinsic factor production in
gastric secretions.
67. Cont…
• Autoimmune disease resulting from
autoantibodies directed against intrinsic
factor (a substance needed to absorb
vitamin B12 from the gastrointestinal
tract) and gastric parietal cells.
• Vitamin B12 → erythrocyte – maturing
factor.
68. Causes:
Deficiencies of vitamin B-12:it is a
nutrient found in some foods like:
◦ Meat
◦ Fish
◦ Eggs
◦ milk.
Megaloblastic anemia caused by vitamin
B-12 deficiency is referred to
as pernicious anemia.
.
71. Sign and symptoms :
• Shortness of breath
• Muscle weakness
• Abnormal paleness of the skin
• Glossitis (swollen tongue)
• Loss of appetite/weight loss
72. Cont…
• Diarrhea
• Nausea
• Fast heartbeat
• Smooth or tender tongue
• Tingling in hands and feet
• Numbness in extremities
73. Oral manifestation:
Burning sensation in the tongue, lips,
buccal mucosa, and other mucosal sites.
‘beefy red’
Hunter’s glossitis or Moeller’s glossitis.
Dysphagia and taste alterations have been
reported.
74. Laboratory findings:
• SERUM: Indirect bilirubin may be elevated.
serum lactic dehydrogenase is
markedly increased.
↓- serum potassium,
cholesterol and alkaline phosphatase
• BONE MARROW-hypercellular and show
trilineage differentiation.
75. Treatment:
Weekly intramuscular injections of 1,000
μg of vitamin B12 for the initial 4 to 6
weeks, followed by 1,000 μg per week
indefinitely.
• Delayed treatment permits progression
of the anemia and neurological
complication
76. VII. APLASTIC ANEMIA:
• Aplastic anemia (AA) is a rare blood
dyscrasia in which peripheral blood
pancytopenia results from reduced or
absent blood cell production in the bone
marrow and normal hematopoietic tissue
in the bone marrow has been replaced by
fatty marrow.
77. CAUSES:
Radiation and chemotherapy treatments.
Exposure to toxic chemicals
Use of certain drugs
Autoimmune disorders
A viral infection
Pregnancy
80. PREVENTION
There's no prevention for most cases of
aplastic anemia. Avoiding exposure to
insecticides, herbicides, organic solvents,
paint removers and other toxic chemicals
might lower your risk of the disease.
82. LEUKOCYTES (WBCS)
Leukocytes found in blood in the following
proportions:
Granulocytes–WBC with granules in their
cytoplasm
60% Neutrophils
1-4% Eosinophils
<1% Basophils
Agranulocytes–lack visible cytoplasmic
granules
20 - 40% Lymphocytes
2 - 8% Monocytes
83. Cont..:
TLC: At birth is 20000/ ul In adults is 4000-11000/
ul
Leukopenia : decreases less than 4000/ cumm
Causes:
starvation
Typhoid fever
Viral/ protozoal infection
85. NEUTROPHILS
Size: 10-12 diameter
Nucleus: Multilobed (2-6)-PMNL
Functions:
Phagocytosis : whenever the body gets
invaded by bacteria, neutrophils are the
first to seek out to ingest and kill bacteria.
(First line defense)
86. EOSINOPHIL
Size: 10-12 diameter
Nucleus : Bilobed spectacle appearance
Functions:
Mild phagocytic
Anti-allergic effect: collect at the site of the tissues where
allergic reactions occur by degrading the effects of mediators
(histamine, bradykinin)
87. BASOPHIL
Size: 10-12 m Nucleus : Bilobed
Functions:
Liberates Histamine and ECF-A: which
leads to allergic manifestations
Liberates Heparin : which acts as
Anticoagulant and keeps the blood in fluid
state
88. MONOCYTE
It is a Largest WBC
Size :12-18 diameter
Functions :
Active Phagocytosis and also a second line
defence
Enter the tissues to become tissue
macrophage .
89. LYMPHOCYTES
It is of 2 types:
Large Lymphocyte : 10-14 diam,
Small Lymphocyte : 7-10 diameter
Functions –
1. Produce antibodies and hence responsible for
Immunity
2. Humoral Immunity: Antibodies which are -
globulins produced by B-Lymphocytes
3. Cell-mediated Immunity: Due to T-Lymphocytes
90. Life span of WBC
Neutrophils : 2-4 days
Eosinophils : 8-12 days (Last through GIC or Resp.
tract)
Monocyte : 1 day in circulation
B-Lymphocytes : Few days or weeks
T-Lymphocytes : 2-4 years
92. 1.Lymphoma:
DEFINITION:
Lymphoma is cancer that begins in infection-fighting cells of
the immune system, called lymphocytes. These cells are in the
lymph nodes, spleen, thymus, bone marrow, and other parts of
the body.
93. Types :
There are two main types of lymphoma:
Most people with lymphoma have this type.
Non-
Hodgkin
Hodgkin
94. Hodgkin lymphoma :
Hodgkin’s disease: Hodgkin lymphoma,
also known as Hodgkin's disease, is a type
of lymphoma, a cancer of the lymphatic
system.
Hodgkin lymphoma is marked by the
presence of Reed-Sternberg cells, which a
physician can identify using a microscope.
95. Causes:
The exact cause is not known, but the following have been implicated:
Hodgkin lymphoma: 15 and 40 or older than 55
Gender: male, may be more common in females
weak immune system : -HIV/AIDS, Organ transplant,
Epstein-Barr,
Hepatitis C, or (HTLV-1)
98. Sign and symptoms:
Hodgkin's lymphoma may include:
Painless swelling of lymph nodes in your
neck, armpits or groin
Persistent fatigue
Fever
Night sweats
Pain following alcohol consumption
99. Diagnostic evaluation:
A physical exam
Blood tests
Imaging tests
X ray
PET scan
Removing a lymph node for testing
Removing a sample of bone marrow for
testing
101. Cont…
The most effective combination
chemotherapeutic regimen for Hodgkin
lymphoma is ABVD:
A adriamycin,
B bleomycin,
V vinblastin
D dacarbazine).
102. Cont….
MOPP regimen of
M (Mustargen) nitrogen mustard
O (Oncovin), vincristine
P procarbazine (Matulane),
P prednisone.
103. 2.Non-Hodgkin lymphoma:
Non-Hodgkin lymphoma is also a
malignancy of lymphocytes and can be
derived from B cells or T cells.
In non-Hodgkin lymphoma of Reed-
Sternberg cells are not present.
Non-Hodgkin lymphoma is more
common than Hodgkin lymphoma.
Non-Hodgkin lymphoma may arise in
lymph nodes anywhere in the body
104. Risk factors:
Non-Hodgkin lymphoma :more than 60s or
older
Some factors that may increase the risk of
non-Hodgkin's lymphoma include:
Medications that suppress your immune
system.
Infection with certain viruses and bacteria
Chemicals
Older age
106. Symptoms:
• Swollen glands (lymph nodes),
often in the neck, armpit, or groin
or throughout the body that are
painless
• Cough
• Shortness of breath
• Fever
• Night sweats
• Fatigue
• Weight loss
• Itching
108. Treatment:
The main treatments for NON-HODGKIN LYMPHOMA are:
1. Chemotherapy
2. Radiation therapy:
3. Immunotherapy
4. Targeted therapy
109. 2.Leukemia:
Cancer of the blood cells,
usually the white blood cells.
Leukemic cells look different
than normal cells and do not
function properly.
110. Risk factors:
1. exact causes is unknown
2. Previous cancer treatment
3. Genetic disorders
4. Exposure to certain
chemical
5. Smoking
6. Family history of leukemia
111. Types of leukemia:
Acute leukemia - The new
or immature cells, called
blasts, remain very immature
and cannot perform their
functions. The blasts increase
in number rapidly, and the
disease progresses quickly.
112. CONT..
Chronic leukemia - There are some
blast cells present, but they are more
mature and are able to perform some
of their functions. The cells grow
more slowly, and the number
increases less quickly, so the disease
progresses gradually.
113. LEUKEMIA IS CLASSIFIED INTO ONE
OF THE FOUR MAIN TYPES OF
LEUKEMIA
1. Acute myelogenous leukemia (AML)
2. Chronic myelogenous leukemia (CML)
3. Acute lymphocytic leukemia (ALL)
4. Chronic lymphocytic leukemia (CL
114. 1.Acute myelogenous leukaemia (AML)
AML is a common type of leukemia. It occurs in
children and adults. AML is the most common
type of acute leukemia in adults.
The word "acute" in acute myelogenous
leukemia denotes the disease's rapid progression.
It's called myelogenous leukemia because it
affects a group of white blood cells called the
myeloid cells,
115. Cont..
2.Chronic myelogenous leukemia
(CML). This type of leukemia mainly affects
adults. A person with CML may have few or
no symptoms for months or years before
entering a phase in which the leukemia cells
grow more quickly.
120. Diagnosis:
Physician examination
Blood tests and laboratory tests
Bone marrow aspiration and biopsy
Lymph node biopsy
Spinal tap
Imaging procedures, such as x-ray,
ultrasound, and computed tomography (CT)
121. Treatment:
Chemotherapy
Radiation therapy
Bone marrow stem cell transplantation
Biological therapy
Platelet transfusion
Red blood cell transfusion
Medications to prevent or treat damage to other systems of
the body caused by leukemia treatment
123. CAUSES:
exposure to cancer treatments, such as
chemotherapy and radiation.
exposure to toxic chemicals, such as
tobacco, benzene and pesticides.
exposure to heavy metals, such as
lead.
127. Treatment:
The goals of therapy are to control symptoms,
improve quality of life, improve overall
survival, and decrease progression to AML.
Chemotherapy with the hypomethylating
agents to retard the progression of MDS to
AML
130. PLATELETS
(THROMBOCYTES)
Structure : It is smallest blood cells,
colorless & disc shaped (in activated from) to
sphere shaped (activated) granulated bodies.
Size : 2-5 m in diameter
Normal count: 1.5 to 4 lacs /cumm (average
2.59 lac/cumm)
Life span : 8-12 days
Destruction : Mainly in spleen
131. 1.THROMBOCYTHEMIA
it is a myeloproliferative blood disorder.
It is characterized by the production of
too many platelets in the bone marrow.
Too many platelets make normal clotting
of blood difficult
132. Etiology:
Etiology is idiopathic
The bone marrow makes too many cells
that create platelets. It's not clear what
causes this to happen.
About 90 percent of people with the
disorder have an acquired gene mutation
contributing to the disease.
133.
134. Diagnosis
Complete medical history
Physical examination
Blood counts and elevated platelet levels
Bone-marrow biopsy
137. Bone marrow transplantation :
BMT is a special therapy for
patients with cancer.
A bone marrow transplant
involves taking cells that are
normally found in the bone marrow
(stem cells), filtering those cells,
and giving them back either to the
patient or to another person.
138. 2. Idiopathic Thrombocytopenic Purpura
(ITP)
Idiopathic thrombocytopenic purpura is an immune disorder in
which the blood doesn’t clot normally. This condition is now
more commonly referred to as immune thrombocytopenia (ITP).
139. Types of thrombocytopenic purpura
1)Acute thrombocytopenic purpura :
Most common in young children, the
symptoms may follow a virus infection
and disappears within a year - usually
disorder does not recur.
140. Cont..
2)Chronic thrombocytopenic purpura:
Onset of the disorder can happen at any age,
and symptoms can last six months or longer.
Adults have this form more often than
children, and females have it 3 times more
often than males.
141. Cause:
The exact cause is unknown
Infection
Immune disorders
Medications - including over-the-
counter
144. Cont…
Blood in the urine
Blood in the stool
Abnormally heavy menstruation
Prolonged bleeding from cuts
Profuse bleeding during surgery
Some people with ITP have no symptoms.
148. 3.Hemophilia:
Persons with hemophilia lack the
ability to stop bleeding because of
the low levels, or complete absence,
of specific proteins, called
"factors," in their blood that are
necessary for clotting.
149. Types of Hemophilia:
Hemophilia A Or classic hemophilia : it is occur due to
deficiency of factor VIII deficiency
Hemophilia B or Christmas disease: : it is occur due to
deficiency of factor IX deficiency
Hemophilia C : : it is occur due to deficiency of factor XI
deficiency
Hegeman’s disease:: it is occur due to deficiency of factor XII
deficiency.
152. Symptoms:
Excessive, uncontrollable bleeding
Bleeding may occur even if there is no
injury.
Often occurs in the joints and in the
head.
Bruising
Bleeds easily - Tendency to bleed.
Bleeding into a joint
Heavy menstrual bleeding
153.
154. Diagnosis test:
Complete medical history
Physical examination
Clotting factor levels
Complete blood count (CBC)
Assessment of bleeding times
DNA testing.
157. 4.Von Willebrand disease:
Von Willebrand disease (VWD) is a
genetic disorder caused by missing or
defective von Willebrand factor (VWF),
a clotting protein. VWF binds factor
VIII, a key clotting protein, and platelets
in blood vessel walls, which help form a
platelet plug during the clotting process.
158. Causes:
Family history
If you have the gene for von Willebrand
disease, you have a 50% chance of transmitting
this gene to your children.
159. Symptoms :
If you have von Willebrand disease, you might have:
Excessive bleeding from an injury or after surgery
or dental work
Nosebleeds that don't stop within 10 minutes
Heavy or long menstrual bleeding
Blood in your urine or stool
Easy bruising or lumpy bruises
163. Cont..
Oral contraceptives: For women, these
can be useful for controlling heavy bleeding
during menstrual periods. The estrogen
hormones in birth control pills can boost von
Willebrand factor and factor VIII activity.
164. Cont..
Clot- stabilizing medication:
These anti-fibrinolytic medications :
Aminocaproic acid (amicar)
Tranexamic acid (Cyklokapron, Lysteda)
These can help stop bleeding by slowing the
breakdown of blood clots
165. 4.Disseminated intravascular coagulation (DIC)
DEFINITION:
Disseminated intravascular
coagulation (DIC) is a
serious disorder in which the
proteins that control blood
clotting become overactive.
166. Risk factors :
Blood transfusion reaction
Cancer, especially certain types of
leukemia
Pancreatitis
Infection in the blood
Liver disease
Pregnancy complications (such as placenta
that is left behind after delivery)
169. Chronic DIC
Signs of deep venous or arterial
thrombosis or embolism
Superficial venous thrombosis,
especially without varicose veins
Multiple thrombotic sites at the same
time
Serial thrombotic episodes
Cont…
170. DIAGNOSTIC EVALUATION:
LABORATORY TEST FINDINGS
Platelet count Markedly decreased
Prothrombin time Increased
Activated partial
thromboplastine time
Increased
Fibrin degradation products Markedly Increased
Fibrinogen Normal or decreased
Protein C Markedly decreased
174. Conclusion:
I conclude that the blood is a important
component in our body . Blood is a body
fluid in humans and other animals that
delivers necessary substances such as
nutrients and oxygen to the cells and
transports metabolic waste products away
from those same cells . Blood deficiency
cause many problem
175.
176. BIBLIOGRAPHY:
Suddharth’s & brunner Textbook of medical
surgical nursing published by Wolters Kluwer
edition south Asian page no.-1170-1194
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177.
178. Assignment
1. Write the nursing management of thalassemia.
2. Write the nursing management of leukemia.