Introduction about the mineral metabolism, function, classification, Role of minerals in life process such as calcium, potassium, phosphorous, chloride, magnesium, zinc, iodine, copper, cobalt some of the trace minerals. uses and their deficiency diseases and disorders. source of water, execration and water balance water process in life. acid-base balance, osmosis, concept of pH, concept of buffer, concept of electrolytes.
Are most abundantly distributed organic compounds.
70 kg man= protein weight constitute 12 kg
Skeleton and connective tissue contains half
Body protein and other half is intracellular.
Digestion and absorption of lipids ppt
what is lipid ppt
digestion of lipid ppt
phase of digestion and absorption ppt
phases of lipids ppt
digestion in mouth and stomach ppt
digestion in small intestine ppt
secretion of lipids ppt
enzyme involved in lipid digestion ppt
transportation phases of lipids ppt
principles of lipid digestion ppt
The chemistry of digestion is simple because, in the case of all three major types of food (carbohydrates, proteins and fats), the same basic process of hydrolysis is involved. The only difference lies in the types of enzymes required to promote the hydrolysis reactions for each type of food.
Introduction about the mineral metabolism, function, classification, Role of minerals in life process such as calcium, potassium, phosphorous, chloride, magnesium, zinc, iodine, copper, cobalt some of the trace minerals. uses and their deficiency diseases and disorders. source of water, execration and water balance water process in life. acid-base balance, osmosis, concept of pH, concept of buffer, concept of electrolytes.
Are most abundantly distributed organic compounds.
70 kg man= protein weight constitute 12 kg
Skeleton and connective tissue contains half
Body protein and other half is intracellular.
Digestion and absorption of lipids ppt
what is lipid ppt
digestion of lipid ppt
phase of digestion and absorption ppt
phases of lipids ppt
digestion in mouth and stomach ppt
digestion in small intestine ppt
secretion of lipids ppt
enzyme involved in lipid digestion ppt
transportation phases of lipids ppt
principles of lipid digestion ppt
The chemistry of digestion is simple because, in the case of all three major types of food (carbohydrates, proteins and fats), the same basic process of hydrolysis is involved. The only difference lies in the types of enzymes required to promote the hydrolysis reactions for each type of food.
describes the structure of hb, its variants in detail. Oxygen dissociation curve is explained with graph. Hemoglobinopathy is explained with diagram. myoglobin is also explained.
Hemoglobin and myoglobin are two important proteins involved in the transport...tekalignpawulose09
1. Hemoglobin:
• Hemoglobin is found in red blood cells and is responsible for carrying oxygen from the lungs to the tissues and organs of the body.
• It consists of four protein subunits, each containing a heme group with an iron atom that binds to oxygen.
• Hemoglobin also helps in the transport of carbon dioxide from tissues back to the lungs for exhalation.
• The function of hemoglobin is vital for the body's oxygen transport system and overall metabolism.
2. Myoglobin:
• Myoglobin is a protein found in muscle tissues and serves as an oxygen reservoir for muscle cells.
• It contains a single heme group that binds to oxygen, similar to hemoglobin.
• Myoglobin stores oxygen in muscle cells and releases it when needed, helping in the supply of oxygen during muscle activity.
• This protein helps muscles sustain aerobic metabolism and endurance during physical activities.
HEMOGLOBIN - STRUCTURE IN RELATION TO FUNCTIONMuunda Mudenda
Hemoglobin (Haemoglobin) is one of the most widely studied proteins in biology. It also stands as the first protein to have been crystallized and its structure elucidated. Apart from that, hemoglobin gave scientists a better understanding of the structure to function phenomenon in proteomics. This document discusses hemoglobin including the types and mechanism of action in its roles of oxygen and carbon dioxide transportation. Please note that this document is for academic purposes and does not, in any way, claim to be exhaustive. However, if you would like to understand the subject in more depth, write me an email and we can discuss the subject together. Enjoy the read.
Transport of cabon dioxide in the bloodmed_students0
At the end of this session, the student should be able to:
Describe the forms in which carbon dioxide is transported in the blood.
Describe the importance of the chloride shift in the transport of carbon dioxide by blood and the changes caused by this shift.
Describe carbon dioxide dissociation curves and how it is affected by oxygen binding to hemoglobin.
Discuss respiratory acidosis and alkalosis, and their compensatory role (revise).
Define respiratory exchange ratio and mention the significance of its estimation.
GUYTON & HALL Textbook of Medical Physiology, 12th edition, page: 502-504.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
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Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
3. Blood performs three major
functions:
transport through the body of
oxygen and carbon dioxide
food molecules (glucose, lipids, amino acids)
ions (e.g., Na+, Ca2+, HCO3−)
wastes (e.g., urea)
hormones
defense of the body against infections and other foreign
materials. All the WBCs participate in these defenses.
Homeostatic functions
- heat
- water- salt balance
- Acid – base balance
4.
5. Red Blood Cells (erythrocytes)
The most numerous type in the blood .
•Features:
•The erythrocytes doesn’t contain nucleus, chromatine
•The erythrocytes doesn’t contain mytochondrias, thus АТP
producing due to the anaerobic glycolisis till to the lactate
(∼90%).
•The glycolisis has features. During it the 2,3 BPG will be
produced, not 1,3 BPG. This compound need for joining О2 to
hemoglobin: low concentration of 2,3 BPG will increase the
affinity hemoglobin (Нв) to О2.
• The PPP is the main path for producing of reductive
equivalents NADPН2 for taking part in glycolisis
6. Red blood cells are responsible for the
transport of oxygen and carbon dioxide.
In adult humans the
hemoglobin (Hb) molecule
consists of four
polypeptides:
two alpha (α) chains of
141 amino acids and
two beta (β) chains of
146 amino acids
Each of these is attached
the prosthetic group heme.
There is one atom of iron at
the center of each heme.
One molecule of oxygen
can bind to each heme.
The reaction is reversible.
7.
8.
9.
10.
11.
12. The iron atom may either
be in the Fe2+ or Fe3+
state, but ferrihemoglobin
(methemoglobin) (Fe3+)
cannot bind oxygen. In
binding, oxygen
temporarily oxidizes Fe to
(Fe3+), so iron must exist
in the +2 oxidation state in
order to bind oxygen. The
body reactivates
hemoglobin found in the
inactive (Fe3+) state by
reducing the iron center.
13.
14.
15.
16.
17. Carbon Dioxide Transport
Carbon dioxide (CO2) combines with water forming
carbonic acid, which dissociates into a hydrogen ion
(H+) and a bicarbonate ions:
CO2 + H2O ↔ H2CO3 ↔ H+ + HCO3−
95% of the CO2 generated in the tissues is carried in
the red blood cells:
It probably enters (and leaves) the cell by diffusing
through transmembrane channels in the plasma
membrane. (One of the proteins that forms the
channel is the D antigen that is the most important
factor in the Rh system of blood groups.)
Once inside, about one-half of the CO2 is directly
bound to hemoglobin (at a site different from the one
that binds oxygen).
18. The rest is converted — following the equation above —
by the enzyme carbonic anhydrase into
bicarbonate ions that diffuse back out into the plasma
and
hydrogen ions (H+) that bind to the protein portion of
the hemoglobin (thus having no effect on pH).
Only about 5% of the CO2 generated in the tissues
dissolves directly in the plasma.
When the red cells reach the lungs, these reactions are
reversed and CO2 is released to the air of the alveoli.
19. Hb Equilibrium
H+, CO2,
ab BPG
α β
b a O2 β α
R T
(low affinity)
(high affinity)
20. The ability of hemoglobin to release oxygen, is affected by pH, CO2
and by the differences in the oxygen-rich environment of the lungs and
the oxygen-poor environment of the tissues. The pH in the tissues is
considerably lower (more acidic) than in the lungs. Protons are
generated from the reaction between carbon dioxide and water to form
bicarbonate:
CO2 + H20 -----------------> HCO3- + H+
This increased acidity serves a two fold purpose.
- First, protons are lower the affinity of hemoglobin for oxygen,
allowing easier release into the tissues. As all four oxygens
are released, hemoglobin binds to two protons. This helps to
maintain equilibrium towards the right side of the equation.
This is known as the Bohr effect, and is vital in the removal of
carbon dioxide as waste because CO2 is insoluble in the
bloodstream. The bicarbonate ion is much more soluble, and
can thereby be transported back to the lungs after being
bound to hemoglobin.
- If hemoglobin couldn’t absorb the excess protons, the
equilibrium would shift to the left, and carbon dioxide couldn’t
be removed
21. In the lungs, this effect works in the reverse
direction. In the presence of the high oxygen
concentration in the lungs, lead to the proton
affinity decreasing. As protons are shed, the
reaction is driven to the left, and CO2 forms as
an insoluble gas to be expelled from the lungs.
The proton poor hemoglobin now has a greater
affinity for oxygen, and the cycle continues.
24. Effect of BPG
BPGEffect BPG is the main
Hb alone player in Hb
100
cooperativity.
80
60
Hb + BPG High altitude
40 increases BPG,
20
pushing curve
0
pO2 vs p50=8
pO2 vs p50=26 further to right
0 20 40 60 80 100 120 140 160
pO2 (mm Hg)
25. Cooperativity
Oxygen binding to one subunit of Hb,
increases the affinity of the other subunits
for additional oxygens. In other words, the
first one is the hardest, the rest are easy.
Anaemia
Anaemia is a shortage of RBCs and/or the
amount of haemoglobin in them.
26. Myoglobin and Hemoglobin
Mb is monomer, Hb is a tetramer (ex. a2b2).
Hb subunits are structurally similar to Mb, with 8
a-helical regions, no b-strands and no interior
water.
Both contain one heme prosthetic group per
chain.
Both Mb and Hb contain proximal and distal
histidines.
Affinity of Mb for oxygen is high, affinity of Hb for
oxygen is lower and more variable.
27.
28. Sickle cell hemoglobin (HbS)
-
G lu
G lu
-
αβ αβ
αβ
βα βα
-
βα
G lu H bS H bS
H bA (h e te ro z y g o u s ) (h o m o zy g o u s)
1
S ic k le c e ll tra it S ic k le c e ll d is e a s e
29. Polymerization of HbS
αβ αβ
αβ
α β βαβα
αβ βα
αβ βα Association shown in
αβ βα previous figure is
βα repeated over and over
to produce large, rod-like
βα aggregates that bind
oxygen poorly and distort
shape of erythrocytes.
30. Sickle cell trait is usually asymptomatic, but
strenuous exercise at altitude could elicit
sickling and destruction of erythrocytes.
This lowers serum Hb and hematocrit, while
raising Hb breakdown products such as
bilirubin, which can accumulate to form
gallstones.
31. α Thalassemias
Rare, since α gene is duplicated (four genes per diploid
chromosome set).
Usually more severe than β thalassemia because
there is no substitute for α gene in adults.
Almost all α thalassemias are deletions
In α thalassemia intermedia (αoα/αοαo) -
appearance of HbH (β4)
In α thalassemia major (αoαο/αoαo), Hb Bart’s
(γ4) is predominant (usually lethal).
BPG is ineffective in HbH & Hb Bart’s.
32. β Thalassemias
More common, since β gene is present in only
one copy per chromosome.
Less severe than α thalassemia, since δ chain
can effectively substitute in adults.
The γ chain can also persist into adulthood
(HPFH).
In βδ thalassemia major (βδ0/βδ0) excess α
chains do not form soluble homotetramers.