BPH, or benign prostatic hyperplasia, is a non-cancerous enlargement of the prostate gland caused by changes in hormone balance and cell growth as men age. It occurs when the prostate blocks part of the urethra, causing problems with urination. Symptoms range from mild to serious and include frequent, urgent, and interrupted urination. Diagnosis involves exams, tests to check urine and rule out infection or cancer. Treatment options include lifestyle changes, medications like alpha-blockers to relax the prostate or 5-alpha-reductase inhibitors to shrink the prostate, and surgery for severe cases. While not cancer, left untreated BPH can damage the kidneys.
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. Symptoms may include frequent urination, trouble starting to urinate, weak stream, inability to urinate, or loss of bladder control.
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. Symptoms may include frequent urination, trouble starting to urinate, weak stream, inability to urinate, or loss of bladder control.
Interstitial cystitis is a long-term
(chronic) inflammation of the bladder wall.
Treatment results vary. Some people respond well to simple treatments
and dietary changes. Others may require extensive treatments or surgery.
Urolithiasis is a common disease that is estimated to
produce medical costs of $2.1 billion per year in the United States alone.
Renal colic affects approximately 1.2 million people
each year in USA and accounts for approximately 1% of
all hospital admissions.
Most active emergency departments (EDs) manage
patients with acute renal colic every day.
Benign prostatic hyperplasia is an enlargement of the prostate gland resulting from an increase in the number of epithelial cells and stromal tissue and developing upward into the bladder and obstructing the outflow of urine.
Interstitial cystitis is a long-term
(chronic) inflammation of the bladder wall.
Treatment results vary. Some people respond well to simple treatments
and dietary changes. Others may require extensive treatments or surgery.
Urolithiasis is a common disease that is estimated to
produce medical costs of $2.1 billion per year in the United States alone.
Renal colic affects approximately 1.2 million people
each year in USA and accounts for approximately 1% of
all hospital admissions.
Most active emergency departments (EDs) manage
patients with acute renal colic every day.
Benign prostatic hyperplasia is an enlargement of the prostate gland resulting from an increase in the number of epithelial cells and stromal tissue and developing upward into the bladder and obstructing the outflow of urine.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
A benign (not cancer) condition in which an overgrowth of prostate tissue pushes against the urethra and the bladder, blocking the flow of urine. Also called benign prostatic hyperplasia and BPH.
Announcement about my previous presentations - Thank youAreej Abu Hanieh
ANNOUNCEMENT Thank you for all of you, my followers who sent me messages with a lot of love and appreciations, I finally graduated after 6 years of studying in Birzeit University , In doctor of Pharmacy department I hope all of you benefited from all the presentations posted before Thank you a new PharmD GraduatedAreej ^^
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. WHAT IS BPH?
It is an enlarged prostate gland.
The prostate gland surrounds the urethra. As the
prostate gets bigger, it may squeeze or partly block
the urethra, which causes problems with urinating.
It is also known as benign prostatic hypertrophy.
3. ANATOMY
The prostate: is a gland that forms
part of the male reproductive system.
It is a conduit between the bladder
and the urethra.
It is composed of several zones.
(Peripheral, central, anterior
fibromuscular stroma, and transition
zones).
BPH originates in the transition zone,
which surrounds the urethra.
4. BPH
oThe main function of the prostate
gland is to secrete an alkaline fluid
that comprises 70% of the seminal
volume.
oThe secretions produce:
lubrication and nutrition for the
sperm.
liquefaction of the seminal plug.
neutralize the acidic vaginal
environment.
5. CAUSES OF BPH
• BPH is probably a normal part of the aging process
in men.
• Changes in hormone balance.
• Changes in cell-growth factors.
• Genetics (may also play a role).
6. PATHOPHYSIOLOGY
oProstatic enlargement depends on the potent
androgen dihydrotestosterone (DHT). In the prostate
gland, type II 5-alpha-reductase metabolizes circulating
testosterone into DHT, which works locally, not
systemically.
oDHT binds to androgen receptors in the cell nuclei,
potentially resulting in BPH.
7. PATHOPHYSIOLOGY
vitro studies have shown that large numbers of alpha-1-
adrenergic receptors are located in the smooth muscle of
the stroma and capsule of the prostate. Stimulation of
these receptors causes an increase in smooth-muscle tone,
which can worsen LUTS.
Microscopically, BPH is characterized as a hyperplastic
process. The hyperplasia results in enlargement of the
prostate that may restrict the flow of urine from the
bladder, resulting in clinical manifestations of BPH.
The prostate enlarges with age in a hormonally
dependent manner.
Notably, castrated males (e.g: who are unable to make
testosterone) do not develop BPH.
8. SIGN AND SYMPTOMS
• Many men with BPH have no symptoms.
When symptoms (lower urinary tract symptoms) occur, they
may range from mild to serious and disruptive.
• The amount of Prostate enlargement is not always related to
the severity of the symptoms.
• Your symptoms may become worse during cold weather or
as a result of physical or emotional stress.
9. SIGNS AND SYMPTOMS
The symptoms of BPH may involve problems
emptying the bladder or problems
with bladder storage, they include:
• Urinary frequency
• Urinary urgency
• Incomplete bladder emptying
• Decreased force of stream
• Difficulty initiating the urinary stream;
interrupted, weak stream
• Straining - The need strain or push to initiate
and maintain urination in order to more fully
evacuate the bladder
• Dribbling - The loss of small amounts of
urine due to a poor urinary stream
10. PROGNISIS
Chronic BOO secondary to BPH may lead to:
Urinary retention
Renal insufficiency
Recurrent UTI
Gross hematuria
Bladder calculi
11. IS BPH A TYPE OF CANCER?
No!
BPH is completely benign. It is not a precursor
to prostate cancer.
But prostate cancer may cause symptoms similar to
those of BPH.
13. TESTS THAT ARE OFTEN DONE :
Digital rectal exam. The doctor inserts a finger into
the rectum to check your prostate for enlargement.
Urine test and urine culture. Analyzing a sample of
your urine can help identifying an infection or
other conditions that can cause similar symptoms.
14. TESTS THAT ARE OFTEN DONE :
A prostate-specific antigen (PSA) test helps check
for prostate cancer, which can cause the same
symptoms as BPH.
15. TESTS THAT ARE USED AS NEEDED
A blood creatinine test checks how well
your kidneys are working.
Post-void residual urine test (PVR) measures the
amount of urine left in the bladder after urination
using ultrasound or a small tube (catheter) put
into the bladder through the urethra.
16. TESTS THAT ARE USED AS NEEDED
Pressure flow studies measure pressure in the bladder
while urinating .
Cystometrogram measures the bladder's pressure,
compliance, and capacity during urinary storage. Like
a uroflowmetry test, which measures how fast the
urine flows out of the bladder.
18. NON PHARMACOLOGICAL
TREATMENT
Limiting the amount of fluids you drink in
situations where needing to go to the toilet may
be inconvenient.
Avoiding drinks that are diuretics because they
increase the amount of urine released by the
body.
19. NON PHARMACOLOGICAL
TREATMENT
Using double-voiding technique when you urinate :
after urinating, you wait a moment and try again to
see if more urine comes out.
Doing exercises to train your bladder to hold
more urine.
21. DRUGS USED FOR BPH
α1-adrenoceptor-blocking agents
5α-reductase inhibitors
22. Α1-ADRENERGIC ANTAGONIST
Terazosin, Doxazosin, Tamsulosin, Alfuzosin, &
Silodosin
Mechanism of Action
They block the α1(A) and α1(B) receptors in
the prostate, causing prostatic smooth muscle
relaxation, which leads to improved urine
flow.
23. Doxazosin, Terazosin,& Alfuzosin block α1(A)
and α1(B) receptors, which decrease
peripheral vascular resistance and lower
arterial BP by causing relaxation of both
arterial and venous smooth muscle.
Tamsulosin & silodosin, are more selective for
the α1(A) receptors and have less effect on BP.
24. ADVERSE EFFECTS
oDizziness, a lack of energy, nasal congestion,
headache, drowsiness and orthostatic
hypotentsion.
oTachycardia, vertigo, and sexual dysfunction.
oInhibition of ejaculation and retrograde
ejaculation.
oTamsulosin has a caution about “floppy iris
syndrome”, a condition in which the iris billows in
response to intraoperative surgery.
26. TAMSULOSIN (FLOMAX®)
S/E: (anemia, nausea & vomiting, weakness,
headache … ).
Preparations: 0.4mg Cap.
Dosing:
The dose may be increased after 2-4 weeks if the
response is not adequate.
27. 5-Α REDUCTASE INHIBITORS
Finasteride & Dutasteride
Mechanism of Action
They inhibit the enzyme 5-α rductase, which is
responsible for converting testosterone to the more
active dihydrotestosterone (DHT). DHT is an androgen
that stimulates prostate growth. By reducing it, the
prostate shrinks and urine flow improves.
28. ADVERSE EFFECTS
o Sexual side effects ..( decreased ejaculate,
decreased libido, ED, gynecomastia, &
oligospermia).
o They have teratogenic potential.. (Causing birth
defects involving genitalia in a male fetus).
29. FENASTERIDE (PROSCAR®)
S/E: ( impotence, decreased libido, confusion, …).
Preparations: 1,5 mg TAB. .
Dosing:
For 6-12 months
to notice a benefit.