The document discusses Sofosbuvir, a breakthrough drug approved by the FDA in 2013 to treat hepatitis C. Sofosbuvir directly targets the hepatitis C virus, attaching to its RNA to stop it from multiplying in the liver. It is effective against genotypes 1-4 of the virus and offers all-oral treatment options without interferon for some genotypes. A 400mg dose of Sofosbuvir has been found effective in combination therapies lasting 12-24 weeks.
- Androgens like testosterone and synthetic analogs cause male secondary sex characteristics. Testosterone is produced in testes and adrenals and binds to androgen receptors.
- Testosterone has androgenic effects like development of male reproductive tract and secondary sex characteristics. It also has anabolic effects like muscle building.
- Androgens are used to treat conditions like hypogonadism and wasting diseases. Synthetic anabolic steroids have higher anabolic effects. Anti-androgens like danazol and cyproterone acetate are used to treat conditions like endometriosis by inhibiting androgen action.
This document discusses the causes and treatment of cough. It notes that cough is a protective reflex triggered by receptors in the throat and lungs. The most common causes of acute, sub-acute, and chronic cough are then outlined. The document proceeds to categorize cough as either non-productive or productive and discusses appropriate suppression treatments. It then examines various classes of antitussive medications including opioids, non-opioids, antihistamines, bronchial secretion enhancers, mucolytics, and common cough syrup formulations.
General anesthesia results in reversible depression of the central nervous system, causing loss of response to external stimuli. It provides benefits like sedation, lack of awareness, muscle relaxation, suppression of reflexes, and analgesia. No single agent provides all benefits, so several drugs are used in combination for optimal anesthesia. Factors like organ function and concurrent medications must be considered when choosing anesthetic drugs to safely induce, maintain, and recover the patient from anesthesia.
The document discusses the gastrointestinal system and acid secretion process. It summarizes the anatomy and functions of the stomach, including the three parts (fundus, body, antrum) and cell types. It describes the three phases of acid secretion and factors involved like gastrin and histamine. Common acid-related disorders are explained like GERD, reflux esophagitis, peptic ulcers, and their symptoms. Causes of increased acid levels are outlined as well as complications. Treatment options for acid suppression include antacids, H2 blockers, and proton pump inhibitors, though antacids have limitations.
Skeletal muscle relaxants work by either depolarizing or competitively blocking nicotinic acetylcholine receptors in the neuromuscular junction. Succinylcholine is a depolarizing agent that causes initial muscle fasciculation and prolonged depolarization before hydrolysis by plasma cholinesterase. Non-depolarizing agents like atracurium and vecuronium are competitive antagonists that bind nicotinic receptors without activating them. They vary in onset, duration and route of elimination depending on whether they are short, intermediate or long acting. Pancuronium and pipecuronium have longer durations due to renal elimination while mivacurium and rapacuronium are shorter acting due to
This presentation includes basic concepts about pharmacodynamics. It discusses about:
Definition of Pharmacodynamics
Types of drug tragets
Stay tuned for more!
- Androgens like testosterone and synthetic analogs cause male secondary sex characteristics. Testosterone is produced in testes and adrenals and binds to androgen receptors.
- Testosterone has androgenic effects like development of male reproductive tract and secondary sex characteristics. It also has anabolic effects like muscle building.
- Androgens are used to treat conditions like hypogonadism and wasting diseases. Synthetic anabolic steroids have higher anabolic effects. Anti-androgens like danazol and cyproterone acetate are used to treat conditions like endometriosis by inhibiting androgen action.
This document discusses the causes and treatment of cough. It notes that cough is a protective reflex triggered by receptors in the throat and lungs. The most common causes of acute, sub-acute, and chronic cough are then outlined. The document proceeds to categorize cough as either non-productive or productive and discusses appropriate suppression treatments. It then examines various classes of antitussive medications including opioids, non-opioids, antihistamines, bronchial secretion enhancers, mucolytics, and common cough syrup formulations.
General anesthesia results in reversible depression of the central nervous system, causing loss of response to external stimuli. It provides benefits like sedation, lack of awareness, muscle relaxation, suppression of reflexes, and analgesia. No single agent provides all benefits, so several drugs are used in combination for optimal anesthesia. Factors like organ function and concurrent medications must be considered when choosing anesthetic drugs to safely induce, maintain, and recover the patient from anesthesia.
The document discusses the gastrointestinal system and acid secretion process. It summarizes the anatomy and functions of the stomach, including the three parts (fundus, body, antrum) and cell types. It describes the three phases of acid secretion and factors involved like gastrin and histamine. Common acid-related disorders are explained like GERD, reflux esophagitis, peptic ulcers, and their symptoms. Causes of increased acid levels are outlined as well as complications. Treatment options for acid suppression include antacids, H2 blockers, and proton pump inhibitors, though antacids have limitations.
Skeletal muscle relaxants work by either depolarizing or competitively blocking nicotinic acetylcholine receptors in the neuromuscular junction. Succinylcholine is a depolarizing agent that causes initial muscle fasciculation and prolonged depolarization before hydrolysis by plasma cholinesterase. Non-depolarizing agents like atracurium and vecuronium are competitive antagonists that bind nicotinic receptors without activating them. They vary in onset, duration and route of elimination depending on whether they are short, intermediate or long acting. Pancuronium and pipecuronium have longer durations due to renal elimination while mivacurium and rapacuronium are shorter acting due to
This presentation includes basic concepts about pharmacodynamics. It discusses about:
Definition of Pharmacodynamics
Types of drug tragets
Stay tuned for more!
This document discusses various vasodilators used to treat conditions like hypertension, heart failure, and peripheral vascular disease. It describes different classes of vasodilators including direct-acting vasodilators like calcium channel blockers and drugs that increase cyclic nucleotides, and indirect vasodilators that interfere with the sympathetic nervous system or renin-angiotensin system. Specific vasodilators discussed in detail include nitroglycerin, hydralazine, minoxidil, diazoxide, nitric oxide, and natriuretic peptides. Their mechanisms of action, pharmacological effects, uses, and adverse effect profiles are summarized.
1. Adrenergic receptor antagonists include alpha and beta blockers. Alpha blockers are further divided into non-selective, alpha1-selective, and alpha2-selective types.
2. Common uses of alpha blockers include treatment of hypertension, benign prostatic hyperplasia, and phaeochromocytoma. They work by blocking alpha-adrenergic receptors to cause vasodilation and reduce blood pressure.
3. Beta blockers are also classified as non-selective or cardio-selective. They work by competitively blocking beta receptors and reducing the effects of catecholamines. Common uses include treatment of hypertension, heart failure, and cardiac arrhythmias.
NSAIDs are a group of drugs that relieve pain, fever, and inflammation by inhibiting prostaglandin synthesis. They can be classified based on their action on COX enzymes or their chemical structure. Their mechanism of action involves blocking COX pathways to prevent the formation of prostaglandins. Common adverse effects include gastric irritation and impaired healing. NSAIDs should be used cautiously in patients with conditions like peptic ulcer or impaired kidney function.
Skeletal muscle relaxants are drugs that affect skeletal muscle function by decreasing muscle tone. There are two main types: neuromuscular blockers that interfere with transmission at the neuromuscular junction and have no central nervous system activity, often used during surgery; and centrally-acting muscle relaxants that are used to alleviate musculoskeletal pain and spasms by acting in the central nervous system. Anemia is a condition in which the number of red blood cells or their oxygen-carrying capacity is insufficient, defined as a hemoglobin level below 13 g/dL for men and 12 g/dL for non-pregnant women. Anemia can be caused by blood loss, decreased red blood cell production, or increased red
Adrenergic agonists and antagonists act on adrenergic receptors. Agonists like epinephrine and norepinephrine directly stimulate receptors, whereas antagonists like prazosin competitively block receptor activation. These drugs have widespread effects throughout the body due to the sympathetic nervous system's role in functions like heart rate, blood pressure, bronchodilation and uterine contraction. Care must be taken with certain drugs that can cause severe side effects like hypotension or bronchospasm.
Pharmacology (Corticosteroids Lecture)Ashfaq Ahmad
This document discusses adrenocortical hormones and corticosteroids. It begins by describing how corticosteroids are derived from cholesterol and the different zones of the adrenal cortex that produce glucocorticoids, mineralocorticoids, and androgens. It then covers the mechanisms of action of glucocorticoids like cortisol via glucocorticoid receptors, their therapeutic uses to treat inflammatory and autoimmune disorders, and their potential side effects. The document also discusses mineralocorticoids like aldosterone, their effects on sodium reabsorption, and synthetic alternatives like fludrocortisone. Inhibitors of corticosteroid synthesis and antagonists of mineralocorticoid receptors
Dopamine receptor agonists are important in the treatment of Parkinson's disease as they have fewer side effects than levodopa therapy. Key points:
- Dopamine agonists work directly on dopamine receptors and do not require metabolic conversion like levodopa. This avoids toxic metabolites.
- They are effective as initial therapy for mild Parkinson's and can be used alongside levodopa to smooth fluctuations and reduce dyskinesias in advanced disease.
- Common side effects include nausea, hypotension, hallucinations, impulse control disorders and sleep attacks. Ergot derivatives like bromocriptine and pergolide also carry risks of fibrosis and cardiac side effects.
- Apomorphine injections provide temporary
The document discusses opioids, including their definition, sources, receptors, history of use, classifications, mechanisms of action, pharmacological effects, adverse effects, toxicity, and therapeutic uses. It describes the three main opioid receptors (mu, kappa, delta), the effects of receptor activation, and different classifications of opioids based on their receptor actions (agonists, partial agonists, antagonists, mixed). It covers the absorption, distribution, metabolism and excretion of opioids. The major pharmacological actions discussed are analgesia, sedation, respiratory depression, nausea, constipation, and dependence/withdrawal. Therapeutic uses include management of severe pain and obstetrical labor pain. Risks/cautions with impaired organ function and certain patient populations
This document discusses serotonin receptors and their agonists and antagonists. It begins by describing the sources and chemistry of serotonin in the body. It then details the seven main families of serotonin receptors, their locations and functions. The document outlines various pathophysiological roles of serotonin. Finally, it examines several classes of drugs that act as agonists or antagonists at serotonin receptors, describing their mechanisms, indications, and side effects.
This document discusses drug metabolism and biotransformation. It describes how drugs are structurally modified inside the body through Phase I and Phase II metabolic pathways. Phase I metabolism involves oxidation, reduction and hydrolysis reactions by cytochrome P450 enzymes and flavin monooxygenases. This makes the drugs more hydrophilic but can also activate some drugs. Phase II conjugation reactions like glucuronidation and sulfation catalyzed by transferase enzymes further increases hydrophilicity and promotes excretion of drug metabolites. The liver is the major site of drug metabolism though other tissues also play a role. Enzyme induction and inhibition can impact drug metabolism.
Antipsychotic drugs, also known as neuroleptics, are used to treat psychotic disorders like schizophrenia. There are two main types - first generation "typical" antipsychotics that are associated with more extrapyramidal side effects, and second generation "atypical" antipsychotics that have fewer of these motor side effects. Antipsychotics work by blocking dopamine receptors in the brain, particularly in the mesolimbic pathway. They can have various adverse effects involving the cardiovascular, nervous, endocrine and other body systems. Proper management of these drugs requires monitoring for potential toxic reactions and drug interactions.
Diuretics
Pharmacology
Katzung
Abnormalities in fluid volume and electrolyte composition are common and important clinical disorders. Drugs that block specific transport functions of the renal tubules are valuable clinical tools in the treatment of these disorders. Although various agents that increase urine volume (diuretics) have been described since antiquity, it was not until 1937 that carbonic anhydrase inhibitors were first described and not until 1957 that a much more useful and powerful diuretic agent (chlorothiazide) became available. Technically, a “diuretic” is an agent that increases urine volume, whereas a “natriuretic” causes an increase in renal sodium excretion and an “aquaretic” increases excretion of solute-free water. Because natriuretics almost always also increase water excretion, they are usually called diuretics. Osmotic diuretics and antidiuretic hormone antagonists (see Agents That Alter Water Excretion) are aquaretics that are not directly natriuretic.
Progesterone is a hormone that prepares the uterus for pregnancy and maintains pregnancy. It is produced naturally by the ovaries and placenta during pregnancy. Synthetic progestins are also used as contraceptives and for hormone replacement therapy. Progestins work by converting the estrogen-primed endometrium to a secretory state and maintaining it to support pregnancy. They also have other effects throughout the body. Mifepristone is a progesterone antagonist that is used to terminate early pregnancies by blocking the effects of progesterone and causing abortion.
This document provides an overview of pharmacokinetic principles including definitions of pharmacology and pharmacokinetics. It describes how drugs are absorbed, distributed, and eliminated in the body. Key points include how drugs pass through membranes via passive diffusion, active transport, or vesicles. Distribution depends on plasma protein binding, tissue binding, and physicochemical properties. The liver and kidneys aid in drug metabolism and excretion from the body. Factors like pH, blood flow, dosage form, and route of administration influence drug absorption and disposition.
This document provides information about proton pump inhibitors (PPIs). It discusses what a proton pump is and how PPIs work by inhibiting proton pumps in the stomach. It lists commonly used PPIs like omeprazole, lansoprazole, and pantoprazole. It describes the mechanism of action of PPIs in blocking acid production and their pharmacokinetics. Potential adverse effects with short and long term use are outlined as well as common medical and therapeutic uses to treat conditions like ulcers and GERD. A comparison of pantoprazole to other PPIs in terms of bioavailability, effects duration, and drug interactions is also provided.
This document discusses emetics and antiemetics. It summarizes that emesis is a protective reflex to rid the body of toxins, and describes the neuronal pathway and receptors involved. Common emetics like apomorphine and ipecacuanha are outlined. The document then provides a detailed overview of various classes of antiemetics including anticholinergics, antihistamines, neuroleptics, prokinetic drugs, 5-HT3 antagonists, NK1 receptor antagonists, and adjuvant antiemetics. Specific drugs within each class are discussed, along with their mechanisms of action, indications, pharmacokinetics, and adverse effects.
This document discusses GABA modulators. It begins by introducing GABA as the major inhibitory neurotransmitter in the mammalian central nervous system. It then discusses the three main types of GABA receptors: GABAA, GABAB, and GABAC. The GABAA receptor is an ionotropic receptor that opens chloride channels, while the GABAB receptor is a metabotropic G protein-coupled receptor. The document outlines the biosynthesis and mechanism of action of the different GABA receptor subtypes. It also discusses several drugs that act on GABA receptors, including benzodiazepines, barbiturates, baclofen, vigabatrin, tiagabine, valproate
Gout is a metabolic disorder caused by high levels of uric acid in the blood that can precipitate in the joints, kidneys, and soft tissues. Drugs used to treat gout include NSAIDs for acute flares, colchicine as an anti-inflammatory, and uricosurics or xanthine oxidase inhibitors like allopurinol or febuxostat for chronic treatment to lower uric acid levels. Rheumatoid arthritis is an autoimmune disease involving joint inflammation, damage to cartilage and bone. Disease-modifying antirheumatic drugs (DMARDs) like methotrexate and sulfasalazine aim to reduce symptoms and slow disease progression. Biological DMARDs that
Progestogens are steroid hormones that are synthesized and secreted by the corpus luteum under the influence of LH. Their main function is the preparation of the uterus for implantation and maintenance of pregnancy. They are classified based on their structure and include natural progesterone as well as synthetic derivatives. Common therapeutic uses include oral contraceptives, hormone replacement therapy, dysfunctional uterine bleeding, and endometriosis. Adverse effects may include breast tenderness, headaches, and mood changes. Newer antiprogestins like mifepristone and ulipristal are used for emergency contraception and medical abortion.
This document discusses the pharmacology of the nervous system. It begins by classifying the nervous system into the central nervous system (CNS) and peripheral nervous system (PNS). Within the PNS it describes the autonomic nervous system (ANS) including the sympathetic and parasympathetic divisions. It then discusses key topics such as neurotransmitters, the process of synaptic transmission, and drugs that act on different parts of the nervous system including CNS depressants, stimulants, analgesics, and drugs acting on the PNS including adrenergic and anticholinergic drugs.
Benign prostatic hyperplasia - symptomes and treatmentAreej Abu Hanieh
BPH, or benign prostatic hyperplasia, is a non-cancerous enlargement of the prostate gland caused by changes in hormone balance and cell growth as men age. It occurs when the prostate blocks part of the urethra, causing problems with urination. Symptoms range from mild to serious and include frequent, urgent, and interrupted urination. Diagnosis involves exams, tests to check urine and rule out infection or cancer. Treatment options include lifestyle changes, medications like alpha-blockers to relax the prostate or 5-alpha-reductase inhibitors to shrink the prostate, and surgery for severe cases. While not cancer, left untreated BPH can damage the kidneys.
The document discusses benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate gland that is common in aging men. It describes the anatomy and function of the prostate, defines and provides the incidence and risk factors of BPH. The clinical manifestations, diagnostic tests, management including lifestyle changes, medications, minimally invasive procedures and surgeries are summarized. Nursing management focuses on facilitating urinary elimination, relieving pain, and addressing risks like urinary retention and deficient fluid volume.
This document discusses various vasodilators used to treat conditions like hypertension, heart failure, and peripheral vascular disease. It describes different classes of vasodilators including direct-acting vasodilators like calcium channel blockers and drugs that increase cyclic nucleotides, and indirect vasodilators that interfere with the sympathetic nervous system or renin-angiotensin system. Specific vasodilators discussed in detail include nitroglycerin, hydralazine, minoxidil, diazoxide, nitric oxide, and natriuretic peptides. Their mechanisms of action, pharmacological effects, uses, and adverse effect profiles are summarized.
1. Adrenergic receptor antagonists include alpha and beta blockers. Alpha blockers are further divided into non-selective, alpha1-selective, and alpha2-selective types.
2. Common uses of alpha blockers include treatment of hypertension, benign prostatic hyperplasia, and phaeochromocytoma. They work by blocking alpha-adrenergic receptors to cause vasodilation and reduce blood pressure.
3. Beta blockers are also classified as non-selective or cardio-selective. They work by competitively blocking beta receptors and reducing the effects of catecholamines. Common uses include treatment of hypertension, heart failure, and cardiac arrhythmias.
NSAIDs are a group of drugs that relieve pain, fever, and inflammation by inhibiting prostaglandin synthesis. They can be classified based on their action on COX enzymes or their chemical structure. Their mechanism of action involves blocking COX pathways to prevent the formation of prostaglandins. Common adverse effects include gastric irritation and impaired healing. NSAIDs should be used cautiously in patients with conditions like peptic ulcer or impaired kidney function.
Skeletal muscle relaxants are drugs that affect skeletal muscle function by decreasing muscle tone. There are two main types: neuromuscular blockers that interfere with transmission at the neuromuscular junction and have no central nervous system activity, often used during surgery; and centrally-acting muscle relaxants that are used to alleviate musculoskeletal pain and spasms by acting in the central nervous system. Anemia is a condition in which the number of red blood cells or their oxygen-carrying capacity is insufficient, defined as a hemoglobin level below 13 g/dL for men and 12 g/dL for non-pregnant women. Anemia can be caused by blood loss, decreased red blood cell production, or increased red
Adrenergic agonists and antagonists act on adrenergic receptors. Agonists like epinephrine and norepinephrine directly stimulate receptors, whereas antagonists like prazosin competitively block receptor activation. These drugs have widespread effects throughout the body due to the sympathetic nervous system's role in functions like heart rate, blood pressure, bronchodilation and uterine contraction. Care must be taken with certain drugs that can cause severe side effects like hypotension or bronchospasm.
Pharmacology (Corticosteroids Lecture)Ashfaq Ahmad
This document discusses adrenocortical hormones and corticosteroids. It begins by describing how corticosteroids are derived from cholesterol and the different zones of the adrenal cortex that produce glucocorticoids, mineralocorticoids, and androgens. It then covers the mechanisms of action of glucocorticoids like cortisol via glucocorticoid receptors, their therapeutic uses to treat inflammatory and autoimmune disorders, and their potential side effects. The document also discusses mineralocorticoids like aldosterone, their effects on sodium reabsorption, and synthetic alternatives like fludrocortisone. Inhibitors of corticosteroid synthesis and antagonists of mineralocorticoid receptors
Dopamine receptor agonists are important in the treatment of Parkinson's disease as they have fewer side effects than levodopa therapy. Key points:
- Dopamine agonists work directly on dopamine receptors and do not require metabolic conversion like levodopa. This avoids toxic metabolites.
- They are effective as initial therapy for mild Parkinson's and can be used alongside levodopa to smooth fluctuations and reduce dyskinesias in advanced disease.
- Common side effects include nausea, hypotension, hallucinations, impulse control disorders and sleep attacks. Ergot derivatives like bromocriptine and pergolide also carry risks of fibrosis and cardiac side effects.
- Apomorphine injections provide temporary
The document discusses opioids, including their definition, sources, receptors, history of use, classifications, mechanisms of action, pharmacological effects, adverse effects, toxicity, and therapeutic uses. It describes the three main opioid receptors (mu, kappa, delta), the effects of receptor activation, and different classifications of opioids based on their receptor actions (agonists, partial agonists, antagonists, mixed). It covers the absorption, distribution, metabolism and excretion of opioids. The major pharmacological actions discussed are analgesia, sedation, respiratory depression, nausea, constipation, and dependence/withdrawal. Therapeutic uses include management of severe pain and obstetrical labor pain. Risks/cautions with impaired organ function and certain patient populations
This document discusses serotonin receptors and their agonists and antagonists. It begins by describing the sources and chemistry of serotonin in the body. It then details the seven main families of serotonin receptors, their locations and functions. The document outlines various pathophysiological roles of serotonin. Finally, it examines several classes of drugs that act as agonists or antagonists at serotonin receptors, describing their mechanisms, indications, and side effects.
This document discusses drug metabolism and biotransformation. It describes how drugs are structurally modified inside the body through Phase I and Phase II metabolic pathways. Phase I metabolism involves oxidation, reduction and hydrolysis reactions by cytochrome P450 enzymes and flavin monooxygenases. This makes the drugs more hydrophilic but can also activate some drugs. Phase II conjugation reactions like glucuronidation and sulfation catalyzed by transferase enzymes further increases hydrophilicity and promotes excretion of drug metabolites. The liver is the major site of drug metabolism though other tissues also play a role. Enzyme induction and inhibition can impact drug metabolism.
Antipsychotic drugs, also known as neuroleptics, are used to treat psychotic disorders like schizophrenia. There are two main types - first generation "typical" antipsychotics that are associated with more extrapyramidal side effects, and second generation "atypical" antipsychotics that have fewer of these motor side effects. Antipsychotics work by blocking dopamine receptors in the brain, particularly in the mesolimbic pathway. They can have various adverse effects involving the cardiovascular, nervous, endocrine and other body systems. Proper management of these drugs requires monitoring for potential toxic reactions and drug interactions.
Diuretics
Pharmacology
Katzung
Abnormalities in fluid volume and electrolyte composition are common and important clinical disorders. Drugs that block specific transport functions of the renal tubules are valuable clinical tools in the treatment of these disorders. Although various agents that increase urine volume (diuretics) have been described since antiquity, it was not until 1937 that carbonic anhydrase inhibitors were first described and not until 1957 that a much more useful and powerful diuretic agent (chlorothiazide) became available. Technically, a “diuretic” is an agent that increases urine volume, whereas a “natriuretic” causes an increase in renal sodium excretion and an “aquaretic” increases excretion of solute-free water. Because natriuretics almost always also increase water excretion, they are usually called diuretics. Osmotic diuretics and antidiuretic hormone antagonists (see Agents That Alter Water Excretion) are aquaretics that are not directly natriuretic.
Progesterone is a hormone that prepares the uterus for pregnancy and maintains pregnancy. It is produced naturally by the ovaries and placenta during pregnancy. Synthetic progestins are also used as contraceptives and for hormone replacement therapy. Progestins work by converting the estrogen-primed endometrium to a secretory state and maintaining it to support pregnancy. They also have other effects throughout the body. Mifepristone is a progesterone antagonist that is used to terminate early pregnancies by blocking the effects of progesterone and causing abortion.
This document provides an overview of pharmacokinetic principles including definitions of pharmacology and pharmacokinetics. It describes how drugs are absorbed, distributed, and eliminated in the body. Key points include how drugs pass through membranes via passive diffusion, active transport, or vesicles. Distribution depends on plasma protein binding, tissue binding, and physicochemical properties. The liver and kidneys aid in drug metabolism and excretion from the body. Factors like pH, blood flow, dosage form, and route of administration influence drug absorption and disposition.
This document provides information about proton pump inhibitors (PPIs). It discusses what a proton pump is and how PPIs work by inhibiting proton pumps in the stomach. It lists commonly used PPIs like omeprazole, lansoprazole, and pantoprazole. It describes the mechanism of action of PPIs in blocking acid production and their pharmacokinetics. Potential adverse effects with short and long term use are outlined as well as common medical and therapeutic uses to treat conditions like ulcers and GERD. A comparison of pantoprazole to other PPIs in terms of bioavailability, effects duration, and drug interactions is also provided.
This document discusses emetics and antiemetics. It summarizes that emesis is a protective reflex to rid the body of toxins, and describes the neuronal pathway and receptors involved. Common emetics like apomorphine and ipecacuanha are outlined. The document then provides a detailed overview of various classes of antiemetics including anticholinergics, antihistamines, neuroleptics, prokinetic drugs, 5-HT3 antagonists, NK1 receptor antagonists, and adjuvant antiemetics. Specific drugs within each class are discussed, along with their mechanisms of action, indications, pharmacokinetics, and adverse effects.
This document discusses GABA modulators. It begins by introducing GABA as the major inhibitory neurotransmitter in the mammalian central nervous system. It then discusses the three main types of GABA receptors: GABAA, GABAB, and GABAC. The GABAA receptor is an ionotropic receptor that opens chloride channels, while the GABAB receptor is a metabotropic G protein-coupled receptor. The document outlines the biosynthesis and mechanism of action of the different GABA receptor subtypes. It also discusses several drugs that act on GABA receptors, including benzodiazepines, barbiturates, baclofen, vigabatrin, tiagabine, valproate
Gout is a metabolic disorder caused by high levels of uric acid in the blood that can precipitate in the joints, kidneys, and soft tissues. Drugs used to treat gout include NSAIDs for acute flares, colchicine as an anti-inflammatory, and uricosurics or xanthine oxidase inhibitors like allopurinol or febuxostat for chronic treatment to lower uric acid levels. Rheumatoid arthritis is an autoimmune disease involving joint inflammation, damage to cartilage and bone. Disease-modifying antirheumatic drugs (DMARDs) like methotrexate and sulfasalazine aim to reduce symptoms and slow disease progression. Biological DMARDs that
Progestogens are steroid hormones that are synthesized and secreted by the corpus luteum under the influence of LH. Their main function is the preparation of the uterus for implantation and maintenance of pregnancy. They are classified based on their structure and include natural progesterone as well as synthetic derivatives. Common therapeutic uses include oral contraceptives, hormone replacement therapy, dysfunctional uterine bleeding, and endometriosis. Adverse effects may include breast tenderness, headaches, and mood changes. Newer antiprogestins like mifepristone and ulipristal are used for emergency contraception and medical abortion.
This document discusses the pharmacology of the nervous system. It begins by classifying the nervous system into the central nervous system (CNS) and peripheral nervous system (PNS). Within the PNS it describes the autonomic nervous system (ANS) including the sympathetic and parasympathetic divisions. It then discusses key topics such as neurotransmitters, the process of synaptic transmission, and drugs that act on different parts of the nervous system including CNS depressants, stimulants, analgesics, and drugs acting on the PNS including adrenergic and anticholinergic drugs.
Benign prostatic hyperplasia - symptomes and treatmentAreej Abu Hanieh
BPH, or benign prostatic hyperplasia, is a non-cancerous enlargement of the prostate gland caused by changes in hormone balance and cell growth as men age. It occurs when the prostate blocks part of the urethra, causing problems with urination. Symptoms range from mild to serious and include frequent, urgent, and interrupted urination. Diagnosis involves exams, tests to check urine and rule out infection or cancer. Treatment options include lifestyle changes, medications like alpha-blockers to relax the prostate or 5-alpha-reductase inhibitors to shrink the prostate, and surgery for severe cases. While not cancer, left untreated BPH can damage the kidneys.
The document discusses benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate gland that is common in aging men. It describes the anatomy and function of the prostate, defines and provides the incidence and risk factors of BPH. The clinical manifestations, diagnostic tests, management including lifestyle changes, medications, minimally invasive procedures and surgeries are summarized. Nursing management focuses on facilitating urinary elimination, relieving pain, and addressing risks like urinary retention and deficient fluid volume.
The document provides an overview of benign prostatic hyperplasia (BPH), including its definition, epidemiology, risk factors, signs and symptoms, pathophysiology, diagnosis, treatment options and recent advances. It discusses how BPH involves the non-cancerous enlargement of the prostate gland which can squeeze the urethra and cause problems with urination. Risk factors include aging, family history, ethnicity and lifestyle factors. Treatment involves lifestyle changes, medications like alpha-blockers and 5-alpha-reductase inhibitors, and surgeries for more severe cases.
The prostate gland is located below the bladder and surrounds the urethra. It secretes fluid that protects and nourishes sperm. The size and shape of the prostate can change with age due to conditions like benign prostatic hyperplasia (BPH) and prostate cancer. BPH involves noncancerous growth of the prostate and commonly causes urinary symptoms in older men. Prostate cancer develops from cells in the prostate and risks include family history and diet. Investigation may include a digital rectal exam and PSA testing while treatment options depend on cancer stage and severity of symptoms.
The document summarizes benign prostatic hyperplasia (BPH), a common condition where the prostate gland enlarges with age. It describes the anatomy of the prostate, risk factors for BPH, potential symptoms including frequent urination, and diagnostic tests. Treatment options discussed include drug therapies, minimally invasive procedures like microwave therapy and surgery to remove obstructing prostate tissue. Post-operative nursing care focuses on airway, vital signs, pain management and preventing complications.
Tamsulosin is a medication used to treat benign prostatic hyperplasia (BPH), a common condition in aging men where the prostate gland enlarges and can cause urinary symptoms. It works by blocking alpha-1 receptors in the prostate and bladder neck to relax muscles and improve urine flow. Common side effects include headache, dizziness, and abnormal ejaculation. Overdose can cause low blood pressure and should be treated by supporting the cardiovascular system. Tamsulosin may interact with other alpha blockers or erectile dysfunction medications. It is usually taken once daily in a 0.4 mg dose with food.
This document provides an overview of benign prostatic hyperplasia (BPH), a common urological condition among aging men. It discusses the incidence and risk factors of BPH and its clinical manifestations. Diagnostic methods including physical exam, PSA levels, and urodynamics are outlined. Medical management includes alpha blockers and 5-alpha-reductase inhibitors to shrink the prostate, while surgical options include transurethral resection of the prostate (TURP), photovaporization of the prostate (PVP), and placement of urethral stents. Post-operative care after TURP is also reviewed.
Benign prostatic hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland that occurs in many men as they age. It is caused by hormonal changes that lead to increased cell growth in the prostate. BPH causes compression of the urethra and urinary symptoms like frequent urination, weak stream, and incomplete emptying. Treatment options include watchful waiting for mild symptoms, medication to reduce symptoms, or surgery for more severe cases. Surgical options range from minimally invasive procedures to more invasive options like transurethral resection of the prostate (TURP).
An enlarged prostate, also called benign prostatic hyperplasia (BPH), causes frequent and difficult urination in many men over 50 as the prostate gland grows larger with age. Symptoms range from frequent urination to inability to urinate. Treatment options include watchful waiting, lifestyle changes, medications to relax the bladder or shrink the prostate, minimally invasive procedures, and surgery. Left untreated, BPH can lead to permanent kidney damage.
We are all aware of the fact that our urine takes out all the toxic waste from our body. What if our urine gets blocked or does not come out properly or it requires force to urinate? These conditions are mostly encountered in old age. If you are going through these problems, you should better consult the physician. It may be because you are suffering from BPH (benign prostatic hyperplasia). The prostate is the gland, which is located below the bladder and in front of the rectum. It surrounds the urethra, a tube that carries urine from the bladder.
Guide on improving prostate health for a better urinary stream.docxRichard Smith
Chapter 1: Introduction
The importance of prostate health cannot be overstated, as the prostate gland plays a crucial role in the male reproductive system and overall well-being. Here are some key points highlighting its significance:
Reproductive Function: The prostate is responsible for producing seminal fluid, which nourishes and transports sperm during ejaculation. A healthy prostate is essential for fertility and successful reproduction.
Urinary Function: The prostate surrounds the urethra, the tube that carries urine from the bladder out of the body. When the prostate is healthy, it doesn't obstruct the urethra, allowing for normal urine flow. Prostate problems, such as enlargement (BPH), can obstruct the urethra, leading to urinary issues like weak flow, frequent urination, and difficulty emptying the bladder.
Quality of Life: Prostate issues, if left untreated, can significantly impact a man's quality of life. Symptoms like urinary urgency, nocturia (frequent nighttime urination), and discomfort can disrupt daily activities, sleep, and overall well-being.
Cancer Risk: Prostate cancer is one of the most common cancers in men. Regular screenings and early detection are vital for successful treatment. Maintaining prostate health can reduce the risk of developing prostate cancer or catching it in its early stages when it's more treatable.
Aging and Hormones: Prostate health is closely tied to hormonal changes, especially with age. An imbalance in hormones, particularly the male sex hormone testosterone, can affect prostate growth and function. Understanding these hormonal dynamics is essential for maintaining prostate health.
Preventative Measures: Proactive measures, including a healthy diet, regular exercise, and avoiding known risk factors (like smoking and excessive alcohol consumption), can promote prostate health. Awareness of family history and risk factors also helps in early intervention.
The document summarizes information about the prostate gland and benign prostatic hyperplasia (BPH). It discusses the anatomy and function of the prostate gland. It describes how the size of the prostate increases with age due to BPH in many men. Common symptoms of BPH include frequent urination and weak urine stream. Treatment options for BPH include watchful waiting, medications, and surgery. The risk of prostate cancer also increases with age and it is a major health concern for older men.
As a part of my M.Sc. Nursing course, I have prepared PPT on Bengin Prostate Hyperplasia, which is an important topic from clinical as well as exam point of view. I hope this material will be helpful to the prospect nursing student. However, refer books for the better understanding of the topic.
This document provides an overview of the prostate gland, including its anatomy, physiology, common conditions like prostatitis and benign prostatic hyperplasia (BPH), associated risk factors, diagnostic criteria and treatment options. Key points:
- The prostate gland produces fluid that nourishes sperm. It surrounds the urethra below the bladder.
- Common conditions are prostatitis (inflammation) and BPH (enlargement). Prostatitis has acute bacterial and chronic types.
- BPH is age-related and causes urinary symptoms due to prostate enlargement blocking urine flow.
- Diagnosis involves exams, tests and symptom scores. Treatment options range from watchful waiting to medications
Benign prostatic hyperplasia (BPH) is a noncancerous enlargement of the prostate gland that is common in aging men. It is caused by hormonal changes that lead to increased cell growth in the prostate, compressing the urethra and causing urinary symptoms. Treatment options range from watchful waiting for mild symptoms to medications and surgery for more severe cases. Transurethral resection of the prostate (TURP) is generally the gold standard surgical treatment, providing long-term relief but also risks side effects like retrograde ejaculation and erectile dysfunction.
Benign prostatic hyperplasia (BPH) is a common condition in aging men that involves enlargement of the prostate gland. It often causes bothersome lower urinary tract symptoms (LUTS) such as frequent urination and weak urine flow. BPH-LUTS refers to these urinary symptoms linked to an enlarged prostate. Treatment involves medications like alpha-blockers and 5-alpha-reductase inhibitors to shrink the prostate and relieve symptoms. For men with larger prostates or those where medications fail, surgery such as transurethral resection of the prostate (TURP) may be considered, though it carries risks like incontinence or sexual side effects.
The prostate gland secretes fluid that nourishes and protects sperm. It normally enlarges with age due to a balance between cell growth and death being disrupted. The main cause of enlargement is benign prostatic hyperplasia (BPH), where cells multiply faster than they die. BPH symptoms include frequent urination and weak urine stream. Diagnosis involves exams and ruling out other causes. Mild cases are treated with lifestyle changes while moderate-severe cases may require medicines or surgery like transurethral resection of the prostate (TURP).
Calcium and phosphorus levels in the blood are tightly regulated through the actions of parathyroid hormone (PTH), calcitonin, and vitamin D. When blood calcium levels drop, PTH levels rise to promote calcium absorption from the intestine and kidneys and release from bones. Calcitonin acts in opposition to PTH by lowering calcium levels through inhibiting bone resorption and promoting calcium excretion by the kidneys. Vitamin D aids in intestinal calcium absorption and renal reabsorption. Together this hormonal system maintains blood calcium levels within a narrow range through balancing calcium exchange between the blood, bones, intestine and kidneys.
Time Management presentation discusses the importance of time management and provides tips. It defines time management as the process of organizing time commensurate with one's daily schedule. Time is explained as a non-renewable resource, with each day providing 86,400 seconds that cannot be carried over. The most effective time management tips include doing the most important tasks first, maintaining an organized to-do list, focusing on one task at a time, and knowing when to change activities or say no.
This document provides information about osteoporosis including goals of education, personal stories, statistics, risk factors, prevention methods, bone density testing, and treatment options. The goal is to increase awareness of osteoporosis, risk factors, prevention, diagnosis, and treatment. Prevention methods discussed include maintaining sufficient calcium and vitamin D intake through diet and supplements, engaging in weight bearing exercise, avoiding smoking and excessive caffeine/alcohol, and addressing other controllable risk factors. Bone density testing and medications are also covered as part of a comprehensive approach.
This document discusses techniques for effective time management. It outlines benefits like better work-life balance, increased productivity, and avoidance of stress. Some key tips include prioritizing tasks by importance and urgency, setting goals and deadlines, creating daily schedules, identifying and reducing time wasters, and regularly reviewing pending tasks. The overall message is that proper time management allows one to focus on important activities and achieve more in less time.
This document summarizes information about the drug sodium valproate, including its chemical properties, history of use, indications, dosing, mechanisms of action, side effects, contraindications, and considerations for special populations. Some key points are:
- Sodium valproate is an anticonvulsant and mood stabilizer derived from valproic acid that is used to treat epilepsy and bipolar disorder.
- It was first isolated in 1882 and first used clinically in 1964, gaining approval in various countries in the late 1960s and 1970s.
- Its mechanisms of action involve increasing GABA transmission and blocking voltage-gated sodium channels.
- Common side effects include weight gain,
This document discusses sodium valproate and valproic acid, which are used to treat epilepsy, bipolar disorder, and migraine headaches. Sodium valproate is converted to valproic acid in the body. Valproic acid increases GABA levels in the brain through inhibiting GABA-degrading enzymes. It may also affect potassium channels. Common side effects include weight gain, tremors, and liver injury. Therapeutic drug monitoring is important due to its narrow therapeutic window. It is generally dosed at 10-15 mg/kg/day for epilepsy, 250 mg twice daily for migraines, and up to 750 mg/day for bipolar mania.
The document provides information on human anatomy and physiology, with a focus on the digestive system. It describes the structure and functions of the cells, tissues, organs and body systems. It then discusses the layers, organs and functions of the digestive system in detail. This includes the mouth, salivary glands, esophagus, stomach, small intestine, large intestine, liver and pancreas. It also covers the mechanisms of acid secretion in the stomach and factors that regulate gastric juice production. Finally, it provides an overview of acid peptic disorders like gastritis, GERD, peptic ulcers, and their causes and treatments.
This document lists 8 vaccines recommended in India along with the diseases they protect against and the ages at which they should be administered. The vaccines protect against tuberculosis, diphtheria, pertussis, tetanus, hepatitis B, Hib, polio, pneumococcal diseases, measles, rubella, Japanese encephalitis, and tetanus and diphtheria during pregnancy. They are administered according to a schedule between birth and 15 months, with some boosters later in life.
Toxicology is the study of the harmful effects of chemicals on living organisms. All substances can be toxic depending on dose, with even something essential like vitamin A becoming poisonous at high enough levels. Common routes chemicals enter the body include ingestion, inhalation, and dermal contact. Factors like dose, formulation, and individual susceptibility determine a substance's toxicity. Pesticides aim to control pests but can also harm nontarget species like humans if exposed, so their use requires minimizing risks to human and environmental health.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
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Osteoporosis is an increasing cause of morbidity among the elderly.
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2. Prostate Glands
• The prostate (or prostate gland) is part of a man’s reproductive
and urinary systems lies below the urinary bladder and is
located in front of the rectum.
• It is about the size of a walnut in younger men, but it starts to
get larger when men reach their late 40s and early 50s.
• The seminal vesicles are located at the base of the prostate.
3. • The prostate gland is a pyramid-shaped organ with apex
(contact to the urethra and directed downward) and basis
(contact to the bladder and directed upward).
• Most men have continued prostate growth throughout life.
• In many men, this continued growth enlarges the prostate
enough to cause urinary symptoms or to significantly block
urine flow.
4.
5. Seminal vesicles
• The seminal vesicles are glands found on each side of the prostate.
• They make most of the fluid in semen.
The prostate is divided into the following areas.
The peripheral zone is the largest area of the prostate.
The transition zone surrounds the part of the urethra that passes
through the prostate (called the prostatic urethra). This zone gets
bigger as men age, a condition called benign prostatic hyperplasia
(BPH).
The central zone lies behind the transition zone and surrounds the
ejaculatory ducts, which run from the seminal vesicles to the
prostatic urethra.
6.
7. Function
Prostatic secretion
The main function of the prostate is to make prostatic fluid.
Prostatic fluid is rich in enzymes, proteins and minerals that
help protect and nourish sperm.
When a man is sexually aroused, the prostate pushes
prostatic fluid through the ducts and into the urethra.
Prostatic fluid mixes with sperm and other fluids in the
urethra and is ejaculated as semen.
8. Control of urine or semen flow
• The prostate acts as a kind of valve, preventing urine flow
during the ejaculation and or permitting urine flow in between.
9.
10. BPH
Prostate gland enlargement is a common condition as men get
older. Also called benign prostatic hyperplasia (BPH), prostate
gland enlargement can cause bothersome urinary symptoms.
Untreated, prostate gland enlargement can block the flow of
urine out of the bladder and cause bladder, urinary tract or
kidney problems.
There are several effective treatments for prostate gland
enlargement, including medications, minimally invasive
therapies and surgery.
11. Symptoms
The severity of symptoms in people who have prostate gland
enlargement varies, but symptoms tend to gradually worsen over
time. Common signs and symptoms of BPH include:
Frequent or urgent need to urinate
Increased frequency of urination at night (nocturia)
Difficulty starting urination
Weak urine stream or a stream that stops and starts
Straining while urinating
Inability to completely empty the bladder
Less common signs and symptoms include:
Urinary tract infection
Inability to urinate
Blood in the urine
12. Risk factors for prostate gland
enlargement include:
Aging. Prostate gland enlargement rarely causes signs and symptoms in
men younger than age 40. About one-third of men experience moderate to
severe symptoms by age 60, and about half do so by age 80.
Family history. Having a blood relative, such as a father or brother, with
prostate problems means you're more likely to have problems.
Ethnic background. Prostate enlargement is less common in Asian men
than in white and black men. Black men might experience symptoms at a
younger age than white men.
Diabetes and heart disease. Studies show that diabetes, as well as heart
disease and use of beta blockers, might increase the risk of BPH.
Lifestyle. Obesity increases the risk of BPH, while exercise can lower your
risk.
13. Complications
Sudden inability to urinate (urinary retention). need to have a tube
(catheter) inserted into your bladder to drain the urine. Some men
with an enlarged prostate need surgery to relieve urinary retention.
Urinary tract infections (UTIs). Inability to fully empty the bladder
can increase the risk of infection in urinary tract.
Bladder stones. These are generally caused by an inability to
completely empty the bladder. Bladder stones can cause infection,
bladder irritation, blood in the urine and obstruction of urine flow.
Bladder damage. A bladder that hasn't emptied completely can
stretch and weaken over time. As a result, the muscular wall of the
bladder no longer contracts properly, making it harder to fully
empty your bladder.
Kidney damage. Pressure in the bladder from urinary retention can
directly damage the kidneys or allow bladder infections to reach the
kidneys.
14. Medication
Medication is the most common treatment for mild to moderate symptoms of prostate
enlargement. The options include:
Alpha blockers. These medications relax bladder neck muscles and muscle fibers in the
prostate, making urination easier. Alpha blockers — which include alfuzosin
(Uroxatral), doxazosin (Cardura), tamsulosin (Flomax), and silodosin (Rapaflo) —
usually work quickly in men with relatively small prostates.
5-alpha reductase inhibitors. These medications shrink our prostate by preventing
hormonal changes that cause prostate growth. These medications — which include
finasteride (Proscar) and dutasteride (Avodart) — might take up to six months to
be effective. Side effects include retrograde ejaculation.
Combination drug therapy. taking an alpha blocker and a 5-alpha reductase inhibitor
at the same time if either medication alone isn't effective.
Tadalafil (Cialis). this medication, which is often used to treat erectile dysfunction, can
also treat prostate enlargement. However, this medication is not routinely used for BPH
and is generally prescribed only to men who also experience erectile dysfunction.
16. ?
Receptor
a receptor is a protein molecule that receives
chemical signals from outside a cell
a molecule on the cell surface within a cell,
that recognizes and binds with specific molecules,
producing some effect in the cell.
17. There are 3 types of alpha-1 receptors
alpha-1 (α1) adrenergic receptor
1. Alpha 1A
2. Alpha 1B
3. Alpha 1D
18. Alpha-1A and 1D receptors
• Found in the bladder, ureters, and prostate
• Stimulating alpha-1A and 1D receptors inhibits urine flow
Alpha-1B receptors
• Found in arteries and veins
• Stimulating alpha-1B receptors causes vasoconstriction and raises blood
pressure
19. Alpha blockers differ by which types of alpha-1 receptors they block:
Antihypertensive Drugs
• Doxazosin - nonselective (blocks all alpha receptors)
• Terazosin - nonselective (blocks all alpha receptors)
• Prazosin - nonselective (blocks all alpha receptors)
• Prostate Relaxation
• Silodosin - selective for Alpha-1A and Alpha-1D
• Tamsulosin - selective for Alpha-1A and Alpha-1D
• Alfuzosin - selective for Alpha-1A and Alpha-1D
• Doxazosin
• Terazosin
21. The dynamic component of BPH is associated with prostatic smooth muscle
tone.. Excessive stimulation of postsynaptic α1-adrenergic receptors causes
the smooth muscle of the prostate, prostatic capsule, bladder neck, and
proximal urethra to contract, and causes a decrease in the urethral lumen.
Resultant obstructive voiding
symptoms include difficulty in urination, a decreased force of urinary
stream, urinary hesitancy,
straining to void, incomplete bladder emptying, urinary dribbling, and
intermittent urinary
Administration of α1-blockers relaxes both the bladder
neck and prostatic smooth muscle, thus decreasing
pressure in the bladder and urethra and improving
urinary flow.20 These agents are more effective at
improving obstructive symptoms than irritative symptoms
22. There are two commonly associated male
physiological events that have a similar etiology.
Enlarged prostate or benign prostatic hyperplasia (BPH) and
male pattern baldness are both related to the enzyme 5-
reductase.
Hirsutism (Hirsutism is the presence of excess hair in
women.)in women is also related to this enzyme.
An excess in activity of 5- reductase has been
shown to be responsible for enlarged prostate and
male pattern baldness, as well as hirsutism in
women
23. 5α-reductase, which is an enzyme responsible
for conversion of testosterone to
dihydrotestosterone.
Inhibition of such conversion maintains prostate health.
5- Reductase catalyzes the conversion of testosterone to
5 dihydrotestosterone (5 DHT).
5DHT:- Responsible for Prostate
enlargement
24. Two isoenzymes of 5AR exist:
Type 1 and Type 2
• Type 1 is most abundant in the liver and skin,
but is found, to a lesser degree, in the prostate
as well.
• It is also the dominant isoform in sebaceous
glands.
25. Type 2
Type 2 is the dominant isoenzyme in the prostate,
and is minimally present in the liver and skin.
Their primary function is to convert testosterone
to DHT.
Finasteride has proven to selectively inhibit the
Type 2 isoenzyme whereas dutasteride
competitively inhibits both forms of the enzyme.
26. The guidelines state that the 5α-reductase inhibitors
finasteride and dutasteride are appropriate and
effective treatments for patients with LUTS
associated with demonstrable prostatic enlargement,
but they are not appropriate treatments for men with
LUTS who do not have evidence of prostatic
enlargement.
27. • patients exhibiting symptomatic prostatic
enlargement but without an impact on their daily
life
• 5α-reductase inhibitor could prevent progression
of the disease.
33. • US FDA has approved Sofosbuvir under the
brand name Sovaldi for the treatment
chronic HCV infection in6 December, 2013.
34. • Sofosbuvir—a breakthrough medicine that
directly targets the hepatitis C (Hep C) virus.
Combination therapy with SOFOSBUVIR has
been shown to be effective for people with
Hep C genotypes 1, 2, 3, and 4.
35. • What is a genotype?
• Just as there are different blood types, there
are also different types of Hep C, called
genotypes. There are 6 main genotypes.
SOFOSBUVIR has been shown to work in
genotypes 1, 2, 3, and 4. SOFOSBUVIR
combination therapy is the first all-oral
treatment for genotypes 2 and 3.
36. • What the Hep C virus does ?
• The Hep C virus infects a liver cell. Then, it
uses the cell to create new copies of itself.
These copies then leave the cell and move on
to infect other liver cells, creating more copies
37. • What Sofosbuvir does?
• Sofosbuvir directly targets the Hep C virus to
stop it from making copies of itself in the
liver. Sofosbuvir attaches itself to the genetic
information, called RNA, to block the virus
from multiplying.
38. • A dose of 400 mg of sofosbuvir has been
found to be most effective, with treatment
durations ranging from 12 to 24 weeks, in
various combinations of PEG-IFN and
ribavirin
39. • Sofosbuvir is a promising therapy for chronic
HCV infection, as it offers several advantages
over the existing therapies, particularly in
dealing with patients with decompensated
liver disease and patients who cannot tolerate
interferon-containing therapies.
Editor's Notes
is part of the male reproductive system of many vertebrates; these vasa transport sperm from the epididymis to the ejaculatory ducts in anticipation of ejaculation ( From Testes)
Seminal vesicles are located within the pelvis. They secrete fluid that partly composes the semen.