for the treatment of BPH.

1. GENKOMAX SCIENCES PVT LTD
TAMLINTAMSULOSIN 0.4 MG

2. Benign prostatic hyperplasia
Benign prostatic hyperplasia (BPH) — also called
prostate gland enlargement — is a common condition as
men get older. An enlarged prostate gland can cause
uncomfortable urinary symptoms, such as blocking the
flow of urine out of the bladder. It can also cause
bladder, urinary tract or kidney problems.
There are several effective treatments for prostate gland
enlargement, including medications, minimally invasive
therapies and surgery.

3. Symptoms
The severity of symptoms in people who have prostate
gland enlargement varies, but symptoms tend to gradually
worsen over time. Common signs and symptoms of BPH
include:-
1) Frequent or urgent need to urinate
2)Increased frequency of urination at night (nocturia)
3)Difficulty starting urination
4)Weak urine stream or a stream that stops and starts
5)Dribbling at the end of urination
6)Inability to completely empty the bladder
Less common signs and symptoms include:
Urinary tract infection.
Inability to urinate.
Blood in the urine.

4. Other possible causes of urinary symptoms
Conditions that can lead to symptoms similar to those
caused by enlarged prostate include:-
1) Urinary tract infection.
2)Inflammation of the prostate (prostatitis).
3)Narrowing of the urethra (urethral stricture).
4)Scarring in the bladder neck as a result of previous
symptoms.
5)Bladder or kidney stones.
6)Problems with nerves that control the bladder.
7)Cancer of the prostate or bladder.

5. Causes
The prostate gland is located beneath your bladder. The
tube that transports urine from the bladder out of your
penis (urethra) passes through the center of the
prostate. When the prostate enlarges, it begins to block
urine flow.
Most men have continued prostate growth throughout
life. In many men, this continued growth enlarges the
prostate enough to cause urinary symptoms or to
significantly block urine flow.

6. Mechanism of Action
Tamsulosin is a selective α1 receptor antagonist that has
preferential selectivity for the α1A receptor in the prostate
versus the α1Breceptor in the blood vessels.
When alpha 1 receptors in the bladder neck and the prostate
are blocked, this causes a relaxation in smooth muscle and
therefore less resistance to urinary flow. Due to this, the pain
associated with BPH can be reduced.

7.  Adverse Reactions
Headache
Dizziness
Infection
Abnormal ejaculation
Back pain
Diarrhea
Chest pain
Cough increased
Nausea
Blurred vision

8.  Overdose and treatment
Overdose can lead to hypotension.
Treat by supporting CV system.
Keep patient in supine position, and administer I.V.
fluids if needed.
Give vasopressors, if needed, and monitor renal
function, supporting as needed.
Dialysis is unlikely to be beneficial.

9.  Drug Interactions
Some products that may interact with this drug
include: other alpha blocker drugs (such
as prazosin, terazosin).
If you are also taking a drug to treat erectile
dysfunction-ED or pulmonary
hypertension (such as sildenafil, tadalafil),
your blood pressure may get too low which can
lead to dizziness or fainting.

10. Tamsulosin Dosage-
Tamsulosin is usually taken once a day in a dose of
0.4 milligrams (mg), 30 minutes after eating.
For best results, try to take tamsulosin at the same
time each day.
After your doctor evaluates your condition, he or
she may increase the dose of your tamsulosin up
to 0.8 mg per day.

11. Missed Dose of Tamsulosin-
If you miss a dose of tamsulosin, try to take it as soon
as you remember as long as it's not too close to bedtime
or to the usual time of taking your next dose.
However, if it's almost time for the next dose, skip the
missed dose and resume your regular dosing schedule.
Don't double up to make up for a missed dose.
If you've missed a few doses of tamsulosin and normally
take 0.8 mg a day, your doctor may need to lower your
dose.