This document discusses beats and stationary waves. It defines beats as the periodic alternation of sound between constructive and destructive interference from two sounds of slightly different frequencies. The frequency of beats is equal to the difference between the two original frequencies. Stationary waves occur when two waves of the same frequency travel in opposite directions, resulting in points of no displacement (nodes) and maximum displacement (antinodes). The document also describes the modes of vibration in open and closed organ pipes, explaining how the end conditions determine which harmonics are present.
Professor Iaccarino provides a window into intriguing physical phenomena, the challenges of extreme-scale computations and simulations illustrating the fascinating beauty of fluid turbulence.
Topics:
1. Introduction to Fluid Dynamics
2. Surface and Body Forces
3. Equations of Motion
- Reynold’s Equation
- Navier-Stokes Equation
- Euler’s Equation
- Bernoulli’s Equation
- Bernoulli’s Equation for Real Fluid
4. Applications of Bernoulli’s Equation
5. The Momentum Equation
6. Application of Momentum Equations
- Force exerted by flowing fluid on pipe bend
- Force exerted by the nozzle on the water
7. Measurement of Flow Rate
a). Venturimeter
b). Orifice Meter
c). Pitot Tube
8. Measurement of Flow Rate in Open Channels
a) Notches
b) Weirs
Professor Iaccarino provides a window into intriguing physical phenomena, the challenges of extreme-scale computations and simulations illustrating the fascinating beauty of fluid turbulence.
Topics:
1. Introduction to Fluid Dynamics
2. Surface and Body Forces
3. Equations of Motion
- Reynold’s Equation
- Navier-Stokes Equation
- Euler’s Equation
- Bernoulli’s Equation
- Bernoulli’s Equation for Real Fluid
4. Applications of Bernoulli’s Equation
5. The Momentum Equation
6. Application of Momentum Equations
- Force exerted by flowing fluid on pipe bend
- Force exerted by the nozzle on the water
7. Measurement of Flow Rate
a). Venturimeter
b). Orifice Meter
c). Pitot Tube
8. Measurement of Flow Rate in Open Channels
a) Notches
b) Weirs
This is a summary of the topic "Kinetic model of matter" in the GCE O levels subject: Physics. Students taking either the combined science (chemistry/physics) or pure Physics will find this useful. These slides are prepared according to the learning outcomes required by the examinations board.
Review of Basic Fluid Mechanics Continuity, momentum and energy equation,
units and dimensions, Types of flow, compressibility, Mach number regimes
Description of Fluid Motion Euler and Lagrangian descriptions, Control volume
approach to continuity and momentum equations, Pathlines Streamlines and
Streaklines Angular velocity, Vorticity, Circulation, Stream function, Velocity
potential and Relationship between them
Schrodinger equation and its applications: Chapter 2Dr.Pankaj Khirade
Wave function and its physical significance, Schrodinger time dependent equation, Separation in time dependent and time independent parts, Operators in quantum Mechanics, Eigen functions and Eigen values, Particle in one dimensional and three dimensional box (Energy eigen values). Qualitative analysis of potential barrier Tunneling effect). Simple Harmonic Oscillator (Qualitative analysis of Zero point energy)
This is a summary of the topic "Kinetic model of matter" in the GCE O levels subject: Physics. Students taking either the combined science (chemistry/physics) or pure Physics will find this useful. These slides are prepared according to the learning outcomes required by the examinations board.
Review of Basic Fluid Mechanics Continuity, momentum and energy equation,
units and dimensions, Types of flow, compressibility, Mach number regimes
Description of Fluid Motion Euler and Lagrangian descriptions, Control volume
approach to continuity and momentum equations, Pathlines Streamlines and
Streaklines Angular velocity, Vorticity, Circulation, Stream function, Velocity
potential and Relationship between them
Schrodinger equation and its applications: Chapter 2Dr.Pankaj Khirade
Wave function and its physical significance, Schrodinger time dependent equation, Separation in time dependent and time independent parts, Operators in quantum Mechanics, Eigen functions and Eigen values, Particle in one dimensional and three dimensional box (Energy eigen values). Qualitative analysis of potential barrier Tunneling effect). Simple Harmonic Oscillator (Qualitative analysis of Zero point energy)
In this learning object, we track the motion of two points on a standing wave and analyze and interpret the results. We discuss nodes and antinodes and end with a brief quiz.
Interference of light refers to the redistribution of light energy due to superposition of two light waves. This superposition leads to a pattern of alternate dark and bright fringes. These dark and bright fringes are called as minima and maxima respectively.
Informal Fallacies, Introduction, Explanation, Types of Fallacies,
Formal Fallacy: affirming the consequent, denying the antecedent.
Classification of Fallacies:
Fallacies of relevance: appeal to the populace, fallacy of straw man, the red herring, appeal to force, argument against the person, appeal to emotion, missing the point.
Fallacies of defective induction: appeal to ignorance, appeal to inappropriate, hasty generalization, false cause.
Fallacy of Presumption: beginning the question, complex question, accident.
Fallacies of ambiguity: Equivocation, Composition, Division, Amphiboly, Accent.
Avoidance, strategies, and factors of fallacies
Dilemma in Logic, Definition, Informal fallacies, Ambiguity of fallacies, Avoidance of fallacies, Examples of Dilemma, Types of dilemma, Quantitative, Qualitative, and Ethical dilemma.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
4. BEATS:
Definition : The periodic alternation of sound between constructive and
destructive interference of sound are called beats.
Example: Tuning fork.
A= 32HZ ; B= 32HZ
A= 32HZ ; B= 30HZ
5. This fading in and out will occur repetitively.
In the example above, we can see that the period for the
wave to go from loud to soft and back to loud is 1waves.
This is true in general: two waves with frequencies f1 and f2,
when added together, will pulse or beat with a frequency
equal to the difference between the two original frequencies,
f1 and f2. Since this frequency should always be a positive
number.
6. Beat caused due to superposition of two waves.
Two waves of slightly different frequencies.
One rise and one fall make one beat.
At the start the two waves are in phase, At this point they add together
constructively.
if we look at the figure above, this is not so for waves of different
frequencies: after about five oscillations, we see that the waves are definitely
out-of-phase: when one is a maximum the other is a minimum. So, at this
point, there will be destructive interference.
If we listened to this wave, we would first hear the sound normally as it
started with constructive interference.
The sound would then fade away as it went through destructive
interference, and then come back again.
7. f beat = |f1 – f2|.
For example, if we play two notes, one at 500 Hz and one at
502 Hz, they will beat together with a frequency of 2 Hz.
1 beat = ¼ seconds.
4 beats = 1 seconds.
When the difference between the frequencies of two sounds is
more than 10 HZ, then it becomes difficult to recognize the
beats.
No of beats = difference between frequencies.
FORMULA: No. of beats = n= fA – fB
where fA and fB of tuning forks A and B and n is the number of
beats per second.
RESULT: The number of beats per second is equal to
difference between the frequencies of the tuning forks.
9. DEFINITION: The stationary waves are produced by the
superposition of two waves having same frequency and
travelling in the opposite direction.
Examples are:
Waves produce in Organ pipes
Waves produce in a string
10. Characteristics of Stationary Waves
The points of zero displacement in the stationary waves are
called nodes.
The points of maximum displacement in the stationary waves
are called antinodes.
No energy is transferred from particle to particle in stationary
waves.
Particles, except nodes, perform SHM with the same period as
the component waves.
Distance between the two consecutive nodes or anti-nodes is
equal to λ/2.
Distance between node and its neighboring anti-nodes is equal
to λ/4.
11. Types of Organ Pipe
There are two types of organ pipes:
(i) Closed Pipe (ii) Open Pipe
Closed Pipe
If one end of the organ pipe is closed, it is called closed
pipe.
Open Pipe
If both ends of the organ pipe are open, it is called open
pipe.
12. The phenomenon of stationary waves in air column.
Stationary waves can be set in air column, such as in
case of organ pipe. The relationship between
the incident wave and the reflected wave depends on
whether the reflecting end is open or close.
If the reflecting end is open, as in case of open
organ pipe, the air molecule has complete freedom of
motion and this behaves as an anti-node.
If the reflecting end is closed, as in case of close
organ pipe, the motion of the air molecules is
restricted and it behaves as a node.
13. Modes of vibrations in an Open Air Column
Let a vibrating tuning fork be held at
the mouth of an open pipe of length L.
If the pipe is open at both ends, then
its ends behaves as anti-nodes.
First Harmonic
If f1 and λ1 be the frequency and the
wavelength of the stationary wave for
the case of first harmonic, then from
figure:
L= λ1/2 λ1=2L
If v is the speed of the wave, then
v=f1λ1=f1(2L)
f1=v/2L
Second Harmonic
If f2 and λ2 be the frequency and
the wavelength of the stationary
wave for the case of second
harmonic, then from figure:
L=2(λ2 /2) λ2 =L
If v is the speed of the wave, then
v=f2λ2=f2(L)
f2=v/L=2(v/2L)=2f1
14. Third Harmonic
If f3 and λ3 be the frequency and
the wavelength of the stationary
wave for the case of third
harmonic, then from figure:
L=3(λ3/2) λ3=2L/3
If v is the speed of the wave,
then
v=f3λ3=f3(2L/3)
f3=3(v/2L)=3f1
Generalization
Similarly for the nth harmonic,
fn=nf1
Where n=1,2,3,4,…..
Hence, it is proved that all harmonics
are present in an open organ pipe.
15. Modes of vibrations in a Close Air Column
Let a vibrating tuning fork be held at the
mouth of an open pipe of length L. If the pipe
is close at one end and open at the other, the
close end acts as node while the open end
behaves as anti-nodes.
First Harmonic
If f1 and λ1 be the frequency and the
wavelength of the stationary wave for the
case of first
harmonic, then from figure:
L=λ1/4 λ1=4L
If v is the speed of the wave, then
v=f1λ1=f1(4L)
f1=v/4L
Second Harmonic
If f and λ2 be the frequency and the
wavelength of the stationary wave for
the case of second harmonic, then from
figure:
L=3(λ2/4) λ2=4L/3
If v is the speed of the wave, then
v=f2λ2=f2(4L/3)
f2= 3(v/4L)=3f1
16. Third Harmonic
If f3 and λ3 be the frequency and the wavelength
of the stationary wave for the case of third
harmonic, then from figure:
L=5(λ3/2) λ3=2L/5
If v is the speed of the wave, then
v=f3λ3=f3(2L/5)
f3=5(v/2L)=5f1
Generalization
Similarly for the nth harmonic,
fn= nf1
where n= 1,2,3,…..
Hence, it is proved that only the odd harmonics
are present in a close organ pipe.
17.
18. A closed organ pipe (closed at one end) is excited so as to support the third
overtone. It is then found that there are in the pipe
1) Three nodes and three antinodes 2) Three nodes and four
antinodes
3). Four nodes and three antinodes 4). Four nodes and four
antinodes
The number of beats produced per second is equal to
1) the sum of the frequencies of two tuning forks 2) the
difference of the frequencies of two tuning forks 3)the ratio of
the frequencies of two tuning forks 4) the frequency of either
of the two tuning forks.
Beats are the results of
1) diffraction of sound waves 2)constructive and destructive
interference 4) polarization
3)destructive interference.
In open organ pipe
1)only even harmonics are present 2) only odd harmonics
are present 3) selected harmonics are present 4)both even
and odd harmonics are