This document discusses Taxus bark and pine bark. Taxus bark comes from yew trees and contains the active compound paclitaxel, which is used to treat cancers. It works by stabilizing microtubules to block cell proliferation. Side effects include low blood counts and nerve pain. Pine bark contains proanthocyanidins, catechins, and acids that have anti-inflammatory and antioxidant effects and is used to treat inflammation and fragility. It is stable under processing conditions.
Tannins are one of the most widely occuring group of natural substances in different families of higher plants. They are of two types-
1. Hydrolysable
2. Condensed
The catechu is an example of hydrolysable tannins which gets easily hydrolysed by action of enzymes and acids.
The presentation covers microscopic characteristics of Rauwolfia. The transverse section, powder microscopy, micro-chemical tests and chemical tests of Rauwolfia are discussed in video lecture. It is useful for preparation of competitive examinations like GPAT.
Hey,
I am a B.Pharma. student. This is my personal notes on the topic called Tannins, a topic from Unit 2 i.e. Secondary metabolites from the subject Pharmacognosy and Phytochemistry II from Semester 5th. Syllabus of this subject is according to GTU. Hope this will be much helpful for your reading.
Thank you.
Tannins are one of the most widely occuring group of natural substances in different families of higher plants. They are of two types-
1. Hydrolysable
2. Condensed
The catechu is an example of hydrolysable tannins which gets easily hydrolysed by action of enzymes and acids.
The presentation covers microscopic characteristics of Rauwolfia. The transverse section, powder microscopy, micro-chemical tests and chemical tests of Rauwolfia are discussed in video lecture. It is useful for preparation of competitive examinations like GPAT.
Hey,
I am a B.Pharma. student. This is my personal notes on the topic called Tannins, a topic from Unit 2 i.e. Secondary metabolites from the subject Pharmacognosy and Phytochemistry II from Semester 5th. Syllabus of this subject is according to GTU. Hope this will be much helpful for your reading.
Thank you.
a complete description on medically important plant taxus Wallachiana
its transverse section , microscopic characters, macroscopic characters,
and its medical uses
Unit II Introduction to secondary metabolite
Volatile oils
Mentha, Clove, Cinnamon, Fennel, Coriander.
For video lecture suscribe yutube channel snehal chakorkar
Adulteration of Crude Drug and Evaluation Methods Vandana Janghel
Different factor and cause of adulteration with common examples, different types of adulteration with examples, different types of quality control methods for detection of adulteration (physical , chemical, biological, morphological and microscopic methods of detection of adulterstion with examples of each evaluation parameter)
A pesticide is a substance that disrupts or kills organisms that we consider to be pests such as weeds, damaging insects, or microbes that cause disease.
Any substance or mixture of substances, intended for preventing, destroying, or mitigating any pest, or intended for use as a plant growth regulator, defoliant or desiccant.
Pest- it is any animal, plant or microorganism that trouble, injuries or cause destruction of crop.
Methods of pest control-
They have two types- natural and artificial pest control.
Natural pest control- they are prepared in nature due to prey- predator relationships.
Beneficial insects are those insects which prey on harmful insects or their larvae.
Artificial pest control- these are man mede methods to control pest.
They have following types
In agricultural production the synthetic pesticides are used which has got sometimes carcinogenic, teratogenic and residual toxic effects.
The excessive use of it also causes serious health hazards to live stocks, human life, wild life, fishes, birds and animals.
mechanical- manual or mechanical method for collection or destruction of pest. Eg.handpicking, pruning, trapping, burning for destruction of eggs, larvae, pupae, insects
Agriculture control- these methods are used to destroy life cycle of pest
eg deep ploughing for eradication of weeds, alternate crop rotation, hybrid pest resistance crop species
Chemical control- these are chemicals used to kill pest
eg. insecticides, paraciticides
Biological control- Living organisms are used to control pest.
Eg microorganisms may be used to kill by causing fatal disease in insects
Classification of pesticides
Pesticides are classified according to the pest they control
Insecticides (Ants, moths, cockroaches)
Herbicides (Weeds)
Fungicides (Control fungal diseases)
Rodenticides (Rats)
Unit II Introduction to secondary metabolite
Steroids, Cardiac Glycosides & Triterpenoids:
Liquorice, Dioscorea, Digitalis
For video lecture suscribe youtube channel snehal chakorkar.
Title: Almond Oil- Mandel- Badam
• Description: In this video the viewers will come to know about ALMOND OIL that is one of the Lipid containing crude drugs obtained from the various plant sources. Almond oil is a fixed oil obtained by expression from the seeds of Prunus amygdalus (Rosaceae) var. dulcis (sweet almonds) or P. amygdalus var. amara (bitter almonds). This drug becomes important since it is obtained from nut source. Here the synonyms, biological sources (scientific names & Family), geographical sources (what are the countries where it can be collected), chemical constituents, identification tests and uses has been discussed in brief.
Portion explained:
1. Synonyms of Almond oil
2. Biological Sources of ALMOND OIL
3. Geographical Sources of ALMOND OIL
4. Preparation of ALMOND OIL
5. Description of ALMOND OIL
6. Chemical Constituents of Almond oil
7. Chemical Test of ALMOND OIL
8. Uses of Almond oil
Synonyms:- Vinca rosea, Catharanthus, Madagascar,periwinkle.
Barmasi.
Biological Source:- Vinca is the dried entire plant of Catharanthus roseus Linn .belonging to family Apocynaceae
Geographical Source:- The plant is a native of Madagascar and is found in manytropical and subtropical countries especially in India, Australia,South Africa and North and South America. The plant is cultivated as garden plant in Europe and India.
Cloves are the aromatic flower buds of a tree in the family Myrtaceae, Syzygium aromaticum. They are native to the Maluku Islands in Indonesia, and are commonly used as a spice. Cloves are commercially harvested primarily in Indonesia, India, Madagascar, Zanzibar, Pakistan, Sri Lanka and Tanzania.
a complete description on medically important plant taxus Wallachiana
its transverse section , microscopic characters, macroscopic characters,
and its medical uses
Unit II Introduction to secondary metabolite
Volatile oils
Mentha, Clove, Cinnamon, Fennel, Coriander.
For video lecture suscribe yutube channel snehal chakorkar
Adulteration of Crude Drug and Evaluation Methods Vandana Janghel
Different factor and cause of adulteration with common examples, different types of adulteration with examples, different types of quality control methods for detection of adulteration (physical , chemical, biological, morphological and microscopic methods of detection of adulterstion with examples of each evaluation parameter)
A pesticide is a substance that disrupts or kills organisms that we consider to be pests such as weeds, damaging insects, or microbes that cause disease.
Any substance or mixture of substances, intended for preventing, destroying, or mitigating any pest, or intended for use as a plant growth regulator, defoliant or desiccant.
Pest- it is any animal, plant or microorganism that trouble, injuries or cause destruction of crop.
Methods of pest control-
They have two types- natural and artificial pest control.
Natural pest control- they are prepared in nature due to prey- predator relationships.
Beneficial insects are those insects which prey on harmful insects or their larvae.
Artificial pest control- these are man mede methods to control pest.
They have following types
In agricultural production the synthetic pesticides are used which has got sometimes carcinogenic, teratogenic and residual toxic effects.
The excessive use of it also causes serious health hazards to live stocks, human life, wild life, fishes, birds and animals.
mechanical- manual or mechanical method for collection or destruction of pest. Eg.handpicking, pruning, trapping, burning for destruction of eggs, larvae, pupae, insects
Agriculture control- these methods are used to destroy life cycle of pest
eg deep ploughing for eradication of weeds, alternate crop rotation, hybrid pest resistance crop species
Chemical control- these are chemicals used to kill pest
eg. insecticides, paraciticides
Biological control- Living organisms are used to control pest.
Eg microorganisms may be used to kill by causing fatal disease in insects
Classification of pesticides
Pesticides are classified according to the pest they control
Insecticides (Ants, moths, cockroaches)
Herbicides (Weeds)
Fungicides (Control fungal diseases)
Rodenticides (Rats)
Unit II Introduction to secondary metabolite
Steroids, Cardiac Glycosides & Triterpenoids:
Liquorice, Dioscorea, Digitalis
For video lecture suscribe youtube channel snehal chakorkar.
Title: Almond Oil- Mandel- Badam
• Description: In this video the viewers will come to know about ALMOND OIL that is one of the Lipid containing crude drugs obtained from the various plant sources. Almond oil is a fixed oil obtained by expression from the seeds of Prunus amygdalus (Rosaceae) var. dulcis (sweet almonds) or P. amygdalus var. amara (bitter almonds). This drug becomes important since it is obtained from nut source. Here the synonyms, biological sources (scientific names & Family), geographical sources (what are the countries where it can be collected), chemical constituents, identification tests and uses has been discussed in brief.
Portion explained:
1. Synonyms of Almond oil
2. Biological Sources of ALMOND OIL
3. Geographical Sources of ALMOND OIL
4. Preparation of ALMOND OIL
5. Description of ALMOND OIL
6. Chemical Constituents of Almond oil
7. Chemical Test of ALMOND OIL
8. Uses of Almond oil
Synonyms:- Vinca rosea, Catharanthus, Madagascar,periwinkle.
Barmasi.
Biological Source:- Vinca is the dried entire plant of Catharanthus roseus Linn .belonging to family Apocynaceae
Geographical Source:- The plant is a native of Madagascar and is found in manytropical and subtropical countries especially in India, Australia,South Africa and North and South America. The plant is cultivated as garden plant in Europe and India.
Cloves are the aromatic flower buds of a tree in the family Myrtaceae, Syzygium aromaticum. They are native to the Maluku Islands in Indonesia, and are commonly used as a spice. Cloves are commercially harvested primarily in Indonesia, India, Madagascar, Zanzibar, Pakistan, Sri Lanka and Tanzania.
Studies that examined the therapeutic potential of plants leaf extracts
Plant Scientific Name Common Name Type of extraction Proposed active material
1. Solanum viarum Tropical Soda Apple Ether Solasodine glycoalkaloid
2. Acanthus illicifolious Harkucha Kanta Methanol Triterpenoids,Flavonoids,
Alkaloids
3. Annona squamosa Custard Apple Ethyl acetate Acetogenins,Alkaloids,
Dofamine
4 Alstonia scholaris. Chatium Methanol Alkaloids,Flavonoids
5. Calotropis gigantea Akanda Ethanol Triterpenoids,Flavonol
Glycosides
It describes the basics of Plant classification, morphological, anatomical, palynological, embryological, chemical and cytological evidences of classification
Mass- 3rd lecture
Ionization methods
Electron Impact (EI),
Chemical Ionization (CI),
Field Desorption (FD),
Fast Atom Bombardment (FAB),
Plasma Desorption (PD),
Matrix assisted laser desorption (MALDI),
Thermospray Mass and
Electrospray(ESI)
Analysis techniques
Magnetic Sector
Quadrupole
Ion Trap
Time-of-Flight (TOF)
Fourier Transform (FT)
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
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The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
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A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
2. Taxus bark.
1. Origin.
2. Macroscopical properties.
3. Active constituents.
4. Uses.
5. Mechanism of action.
6. Side effects
Pine bark
1. Origin.
2. Macroscopical properties.
3. Active constituents.
4. Uses.
5. Chemical test.
3. Dried stem bark of Taxus brevifolia, Family: taxaceae.
Syn. Pacific (western) Yew
4. Small trees or shrubs in the
yew family. They are relatively
slow-growing and can be very
long-lived.
Thin, dark reddish or purplish
scales shed off the trunk and
expose a rose-coloured
underbark.
5. The Taxaceae is a small family with one main
genus, Taxus, which has an ancient reputation
as a toxic and magical plant. The yew tree was
used in ancient Greece and Rome to produce
weapons.
An alkaloidal Taxus fraction, which was named
“taxine” by Lucas (1856), is highly cardiotoxic
and has been implicated in many stock
poisonings and human poisonings.
6. In 1966 Dr. Monroe Wall isolated the active
principle, paclitaxol. Molecular structure of
paclitaxol was published in 1971; it is a
complex diterpenoidal alkaloid with an ester
side chain and a unique oxetane ring.
the approval of TAXOL® (Paclitaxel) for
marketing in December of 1992 was the
result of 30 years of work that began with
the collection of Taxus brevifolia in
Washington state in 1962.”
9. The plant need to be mature( about I00 years)
to be large enough for exploitation of its
bark. At this age the tree will be some 6-9 m
high, and have a trunk of about 25 cm in
diameter.
It requires the bark from about three mature
100-year-old trees to provide one gram of
taxol.
And a course of treatment may needs 2 gms of
taxol.
10. Taxol is now the best known and most studied
member of the taxane diterpenoidal
alkaloids, or taxoids.
It is only one of over 350 members of this
compound class.
The reported taxol yield was 0.02% from dried
bark of T. brevifolia
Taxol was also reported to be present in other
Taxus species, including T. baccata and T.
cuspidata.
12. Researchers determined that
Paclitaxel binds to
microtubules, stabilizes
them against
depolymerisation and thus
blocks cell proliferation.
Complex of α, β tubulin subunits
and paclitaxel. Paclitaxel is showed
as yellow stick.
13. Today, paclitaxel is obtained either from
Tissue cultures of variousTaxus species or
Semisynthesis from baccatin III and 10-
deacetylbaccatin III, which can be extracted in
sufficient amounts from leaves and twigs of the
common yew ( T. baccata), a tree that grows
much faster than T. brevifolia.
Other approaches have involved the use of
endophytic fungal fermentation.
Docetaxel (Taxotere®) is a side-chain analogue
of taxol, more water-soluble and slightly more
active than paclitaxel. It can be produced
semisynthetically from10-deacetylbaccatin III.
14.
15. Taxol is given as an injection or infusion into the
vein (intravenous, IV).
There is no pill form of Taxol.
Taxol is an irritant. An irritant is a chemical that
can cause inflammation of the vein through
which it is given.
Because severe allergic reactions have occurred
in some people taking Taxol, patient will be
asked to take medications to help prevent a
reaction.
Taxol is given over various amounts of times and
in various schedules.
16. Low blood counts.
Hair loss.
Arthralgias and myalgias, pain in the joints
and muscles.
Peripheral neuropathy (numbness and
tingling of the hands and feet)
Nausea and vomiting (usually mild)
Diarrhea.
Mouth sores.
teratogenicity.
17.
18. Dried stem bark of pinus pinaster,
family pinaceae
Synonym: Pinus maritima
19. is a medium-size, reaching 20–35 m
tall and with a trunk diameter of up to 1.2.
is orange-red, thick and deeply
fissured at the base of the trunk, somewhat
thinner in the upper crown.
20. proanthocyanidins
Flavonoids like catechin, epicatechin
phenolic acids (such as ferulic acid and
caffeic acid)
the patented extract called "Pycnogenol®"
22. Anti-inflammatory
Antioxidant
Antimicrobial
Capillary Fragility treatment
Some researches reported an antidiabetic
activity for "Pycnogenol®"
23. Pine bark extract is found to be very stable
under thermal conditions and comparatively
stable under acidic conditions. Thus, pine
bark extract is easier to handle during
processing or manufacturing steps and
remains stable when exposed to the human
digestive tract.