The document provides information about Ahmed Metwaly's academic positions and areas of research interest which include oligosaccharides, their classification, structure, properties and examples. It then discusses specific oligosaccharides in more detail including reducing and non-reducing disaccharides, their structures, sources and uses. Further sections cover topics such as glycosidic bond formation, enzymatic hydrolysis of glycosides, and potential applications of oligosaccharides.
Introduction to Carbohydrates and its ChemistryDHANANJAY PATIL
A Comprehensive Introduction to Carbohydrates its chemistry, classification, qualitative tests an disorders related to its metabolism. This will give readers a overall insight to this topic. All types of queries and suggestions are most welcome
Introduction to Carbohydrates and its ChemistryDHANANJAY PATIL
A Comprehensive Introduction to Carbohydrates its chemistry, classification, qualitative tests an disorders related to its metabolism. This will give readers a overall insight to this topic. All types of queries and suggestions are most welcome
WHAT IS CARBOHYDRATE? CLASSIFICATION OF CARBOHYDRATE? WHAT IS MONOSACCHARIDE? CLASSIFICATION OF MONOSACCHARIDE. PHYSICAL PROPERTY. CHEMICAL PROPERTY. ATRUCTURAL FORMULA. METABOLISM . IMPORTANCE OF MONOSACCHARIDE. IMPORTANT FACT RELATED TO MONOSACCHARIDE. DISORDER OF MONOSACCHARIDE CONCLUSION. REFRANCES
Monosaccharides are simple sugar molecules. These molecules have different configurations due to which various isomeric forms are formed. The structure of monosaccharides help to understand the positions of H and OH in the structure and the aldehyde and keto groups.
This ppt explains the properties of monosaccharides, polysaccharides. the properties like mutarotation, reduction, optical activity, caramerlization, osazone is given in the ppt. Also the determination of ring size of the monosaccharide is explained/
WHAT IS CARBOHYDRATE? CLASSIFICATION OF CARBOHYDRATE? WHAT IS MONOSACCHARIDE? CLASSIFICATION OF MONOSACCHARIDE. PHYSICAL PROPERTY. CHEMICAL PROPERTY. ATRUCTURAL FORMULA. METABOLISM . IMPORTANCE OF MONOSACCHARIDE. IMPORTANT FACT RELATED TO MONOSACCHARIDE. DISORDER OF MONOSACCHARIDE CONCLUSION. REFRANCES
Monosaccharides are simple sugar molecules. These molecules have different configurations due to which various isomeric forms are formed. The structure of monosaccharides help to understand the positions of H and OH in the structure and the aldehyde and keto groups.
This ppt explains the properties of monosaccharides, polysaccharides. the properties like mutarotation, reduction, optical activity, caramerlization, osazone is given in the ppt. Also the determination of ring size of the monosaccharide is explained/
Deoxy sugars, 6-Deoxy-hexoses
(methyl pentoses or hexomethyloses)
alpha-L-Rhamnose (6-deoxy-L-mannose),D-Digitoxose
a component of the sugar part of Digitalis glycosides
Keller Killiane test ,DISACCHARIDES, Maltose (malt sugar)
Lactose (milk sugar) LACTULOSE, Polysaccharide
About carbohydrates, its types, physical and chemical properties, isomers and isomeric properties, important carbohydrates, medical use of some carbohydrates.
The brief classification, types, physical properties, chemical properties, mucopolysaccherides type, disorders related to GAG.
the Topic covered with the interest of MBBS, BDS, BPT, Nursing, Bsc and MSc Biochemistry and MLT students
Mass- 3rd lecture
Ionization methods
Electron Impact (EI),
Chemical Ionization (CI),
Field Desorption (FD),
Fast Atom Bombardment (FAB),
Plasma Desorption (PD),
Matrix assisted laser desorption (MALDI),
Thermospray Mass and
Electrospray(ESI)
Analysis techniques
Magnetic Sector
Quadrupole
Ion Trap
Time-of-Flight (TOF)
Fourier Transform (FT)
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
1. Associate Professor of Pharmacognosy , Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
•Associate Professor, City of Scientific Research and Technological Applications (SRTA-City), Alexandria,
Egypt
•Senior research fellow, Liaoning University of Traditional Chinese Medicine, China (20118-2019)
•Visiting scholar, School of Pharmacy, University of Mississippi, USA (2012-2014)
Ahmed Metwaly
Oligosaccharides
2. ▪ They are crystalline and soluble in water.
▪ They are hydrolysable by acids or specific enzymes to yield from 2-10 molecules of
monosaccharides.
▪ The monosaccharide units are linked through glycosidic linkages.
▪ They are subclassified on the basis of the number of sugar molecules into di-, tri- or
tetrasaccharides and so on.
▪ The two sugar units are linked through their reducing groups, the resultant disaccharide will be non-
reducing e.g. sucrose (a1 glucose -b 2 fructose). Theoretically, there are four possible forms: a1-a 2, a 1-b 2,
b1-a2, or b1-b2.
▪ The reducing group of the first molecule
e.g. C-1 of an aldose is linked to C-2, C-3,
C-4, or C-6 of another aldose; the
reducing group of the second molecule is
thus free and the resultant disaccharide will
be reducing. The common disaccharides
are linked through C1-C4,
3. The anomeric hydroxyl and a hydroxyl of another sugar or some other compound can join together, splitting out
water to form a glycosidic bond:
R-OH + HO-R' → R-O-R' + H2O
e.g., Methanol reacts with the anomeric OH on glucose to form methyl glucoside (methyl-glucopyranose).
O
H
HO
H
HO
H
OH
OH
H
H
OH
a-D-glucopyranose
O
H
HO
H
HO
H
OCH3
OH
H
H
OH
methyl-a-D-glucopyranose
CH3-OH
+
methanol
H2O
4. ▪ a-glycosides are hydrolyzed by a-glycosidases (e.g. maltase obtained from barley) and
▪ b-glycosides by b-glycosidases (e.g. emulsin obtained from bitter almond).
6. REDUCING DISACCHARIDES
MALTOSE (MALT SUGAR)
▪ Sources: It is the main constituent of malt and germinating cereals.
▪ Structure:
▪ It consists of two glucose units, linked by α1-4. It is hydrolyzed by maltase enzyme (α-glucosidase).
▪ It exists in two anomeric forms α-maltose and β-maltose, which undergo mutarotation.
▪ Properties
▪ It reduces Fehling’s solution but does not reduce Barfoed’s solution.
▪ It forms a characteristic osazone (rosettes of plates or broad needles).
▪ Preparation
▪ Maltose is prepared from starch by partial acid hydrolysis, or by using α -amylase enzyme isolated
from green malt.
▪ Uses: Nutrient.
O
CH2OH
O
O
CH2OH
O
HO
HO
O
OH
OH
O
HO
OH
OH
OH
1 4
1 4
Maltose
4-O-(a-Dglucopyranosyl)-D-glucopyranose
Glu-a1-4-Glu
7. LACTOSE (MILK SUGAR)
▪Sources:
▪ Lactose is the principal sugar of mammalian milk. It is not present in higher plants.
▪Structure:
▪ It consists of galactose and glucose, linked by a b 1— 4 linkage. It is hydrolyzed by
emulsin enzyme.
▪ Properties
▪
It reduces Fehling’s solution but does not reduce Barfoed’s solution.
It forms a characteristic osazone (needles aggregated in clusters or tufts).
▪ Preparation
▪ Lactose is obtained from whey
(a by-product from cheese manufacture)
after concentration, upon which deposits of lactose crystallize out.
▪Uses:
▪ Nutrient in infant food.
▪ Diluents in tablets.
O
O
HO
OH
OH
OH
O
CH2OH
O
OH
HO
OH
OH
O O
CH2OH
Lactose
4-O-b-(D-galactopyranosyl)-D-glucopyranose
Gal-b1-4 Glu
1
4
1
4
9. ▪ Invert sugar:
Sucrose is (d, +) with [a]20
d = +66.50. On hydrolysis by dil. acids or by invertase enzyme from yeast, it yields
mixture of (+)d-glucose (+52.50)and (-)d-fructose (-920). Because of high negative rotation of the fructose, the final
sign of the solution [a]20
d of the mixture (- 20.40) is changed from (+) to (-). that is why it is called invert sugar
or inversion.
Uses:
▪Sweetening agent as it is more sweet than sucrose.
▪Adulteration of honey.
▪It can be detected by test for cl-
22. LACTULOSE
▪ Galactose-b-(1,4)-fructose
▪ A semi-synthetic disaccharide (not naturally occurring)
▪ Not absorbed in the GI tract
▪ Used either as a laxative in constipation and for hepatic encephalopathy
Mechanism
• Lactulose is not absorbed in the small intestine nor broken down by human enzymes, thus
stays in the digestive bolus through most of its course, causing retention of water through
osmosis leading to softer, easier-to-pass stool.
• Fermented by the gut flora, producing metabolites which have osmotic powers and
peristalsis-stimulating effects (such as acetate), but also methane associated with flatulence.
• Lactulose is metabolized in the colon by bacterial flora into lactic acid and acetic acid.
These partially dissociate, acidifying the colonic contents the formation of the nonabsorbable
NH4 from NH3, trapping NH3 in the colon and effectively reducing plasma NH3 concentrations.
(hepatic encephalopathy)
• There have also been studies demonstrating the capacity for lactulose to minimize the
formation of gallstones.
• Anticancer potentiality owing to its ability to bind galactin carbohydrates involved in
various tumor progressions
24. ▪ These are crystalline substances obtained from starch by the action of specific enzymes.
▪ They are differentiated into : a , b and g cyclodextrins with 6, 7 and 8-glucopyranose units respectively.
▪ They are arranged in cylindrical macro-rings with a hydrophobic central cavity (central core) and a
hydrophilic outer surface.
▪ Uses
Cyclodextrins are of great pharmaceutical importance. They are used as “drug enclosures” in order to:
▪ Reduce side effects,
▪ Mask unpleasant taste,
▪ Allow drug stabilization and avoid drug-interaction and
▪ Enhance drug solubilization.