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NATURAL PESTICIDES
Presented By
K.Sudheer Kumar
Asst.Proff, Dept.of, Pharmacognosy.
Chilkur Balaji College of Pharmacy, Hyderabad.
A pesticide is  a  substance  that  disrupts  or  kills  organisms  that  we  consider  to 
be pests such as weeds, damaging insects, or microbes that cause disease. 
Any  substance  or  mixture  of  substances,  intended  for  preventing,  destroying,  or 
mitigating any pest, or intended for use as a plant growth regulator, defoliant or 
desiccant.
Pest- it is any animal, plant or microorganism that trouble, injuries or cause 
destruction of crop.
Methods of pest control-
They have two types- natural and artificial pest control.
Natural pest control- they are prepared in nature due to prey- predator 
relationships.
Beneficial insects are those insects which prey on harmful insects or their larvae.
Artificial pest control-  these are man mede methods to control pest. 
They have following types
In  agricultural  production  the  synthetic  pesticides  are  used  which  has  got 
sometimes carcinogenic, teratogenic and residual toxic effects.
The excessive use of it also causes serious health hazards to live stocks, human life, 
wild life, fishes, birds and animals.
mechanical- manual or mechanical method  for collection  or destruction of pest. 
Eg.handpicking, pruning, trapping, burning for destruction of eggs, larvae, pupae, 
insects
Agriculture control- these methods are used to destroy life cycle of pest 
eg deep ploughing for eradication of  weeds, alternate crop rotation, hybrid pest 
resistance crop species
Chemical control-  these are chemicals used to kill pest 
eg. insecticides, paraciticides
Biological control- Living organisms are used to control pest. 
Eg microorganisms may be used to kill by causing fatal disease in insects
Classification of pesticides
Pesticides are classified according to the pest they control
Insecticides (Ants, moths, cockroaches)
Herbicides (Weeds) 
Fungicides (Control fungal diseases) 
Rodenticides (Rats)
Characteristics of ideal pesticide
-should have high margin of safety for plants and animals
-easy to handle and apply
-should not be toxic for warm blooded animals
-should not be inflammable or explosive
 should be available easily at affordable cost 
Advantages:
• 1. They are cheap (They are economical)
• 2.They are less harmful to the human beings and more effective against pest
• 3. They are more stable and can be kept for prolonged period (Degradation is 
less)
• 4.They can be used to control the carriers of vector borne diseases like malarial, 
sleeping sickness and dengue fever.
Dis- advantages:
• The onset of action is slow
• The quantity of  pesticide required may be more due to crude components
Herbicides, also commonly known as weed killers, 
These are pesticides used to kill unwanted plants. Selective herbicides kill specific 
targets, while leaving the desired crop relatively unharmed. Some of these act by 
interfering  with  the  growth  of  the weed and  are  often  synthetic  mimics  of 
natural plant hormones.
Some  plants  produce  natural  herbicides,  action  of  natural  herbicides,  and  other 
related chemical interactions, is called allelopathy.
The most frequent application of herbicides occurs in row-crop farming, where they 
are applied before or during planting to maximize crop productivity by minimizing 
other vegetation(weed)
Fungicides- they are used to control fungal diseases of plants and food crops.
Fungi  can  cause  serious damage  in agriculture, resulting in  critical losses of yield, 
quality, and profit
Fungicides can either be contact, translaminar or systemic. Contact fungicides are 
not  taken  up  into  the  plant  tissue,  and  protect  only  the  plant  where  the  spray  is 
deposited; translaminar  fungicides redistribute  the  fungicide  from  the  upper, 
sprayed leaf surface to the lower, unsprayed surface; systemic fungicides are taken 
up and redistributed through the xylem vessels. Few fungicides move to all parts of a 
plant. Some are locally systemic, and some move upwardly
Fumigation is  a  method  of pest  control that  completely  fills  an  area  with 
gaseous pesticides—or fumigants—to suffocate or poison the pests within. It 
is  used  to  control  pests  in  buildings (structural fumigation), soil,  grain,  and 
produce,  and  is  also  used  during  processing  of  goods  to  be  imported  or 
exported to prevent transfer of exotic organisms. 
Rodenticides,  rat poison, are pest control chemicals intended to kill rodents.
Rodenticides  are  controversial,  due to  secondary  poisoning and  their  risks  to 
children, pets and wildlife.
Single feed baits are  chemicals  sufficiently  dangerous  that  the  first  dose  is 
sufficient to kill.
 rodents will eat a small bit of something and wait, and if they do not get sick, they 
continue. An  effective rodenticides must  be  tasteless  and  odorless  in  lethal 
concentrations, and have a delayed effect.
Tobacco
Synonym : Tobacco
Biological source : Tobacco consist of dried leaves of Nicotiona tabacum belonging to 
the family Solanaceae.
Tobacco is a whole stout ever green viscid annual, 1 to 3 meters in height. 
Erect with few branches. 
Bears 20 leafs and each leaf is 80 cm in length. 
Flowers are white or pink in color, 
fruits are capsules, elliptic, ovoid. 
Seeds are spherical and brown in color with 0.5 mm in size. 
Types 
Bidi tobacco
Cigar tobacco
Chewing tobacco
Hookah tobacco
Color : green to slightly brown
Odour : characteristic 
Taste : bitter and acrid
Mode  of  action. In  both  insects  and  mammals,  nicotine  is  an  extremely  fast-
acting nerve toxin. It competes with acetylcholine, the major neurotransmitter, by 
bonding  to  acetylcholine  receptors  at  nerve  synapses  and  causing  uncontrolled 
nerve  firing.  This  disruption  of  normal  nerve  impulse  activity  results  in  rapid 
failure of those body systems that depend on nervous input for proper functioning. 
In  insects,  the  action  of  nicotine is  fairly  selective,  and  only  certain  types  of 
insects are affected.
Chemical constituents
Consists of pyridine , piperidine type of alkaloids among them 1-10% nicotine,
nornicotine, anabasine
Uses
Insecticidal
free base of nicotine is more toxic than sulphate,
Mostly effective against minute soft body insects like aphides, white flies, fruit tree 
borers, termites, cabbage butterfly larvae
Nicotine preparations are safer, easier to handle, less toxic to warm blooded animals
Pyrethrum
Synonym
Insect flowers, pyrethrum flowers
Biological source :It consist of dried unexpanded flower-heads of Chrysanthemum
cinerariaefolium belonging  to  the family Compositae, consists  of  NLT    0.7  % 
pyrethrins.
Macroscopic study :
Color : cream to straw coloured 
Odour : aromatic
Taste : bitter to Numbness
Size : 10 to 15 mm in diameter
Shape : flower head is flat with convex receptacle.
Peduncle is short and longitudinal striated. Ray florets s are 15-23 in number. Disc 
florets 200-300 ( hermaphrodite) 5 lobed, yellow colored corolla is present.
Before drying flower heads are non toxic to insects
Mode of action. Pyrethrins exert their toxic effects by disrupting the sodium and 
potassium ion exchange process in insect nerve fibers and interrupting the normal 
transmission of nerve impulses. Pyrethrins insecticides are extremely fast acting 
and  cause  an  immediate  “knockdown”  paralysis  in  insects.  Despite  their  rapid 
toxic action, however, many insects are able to metabolize (break down) pyrethrins 
quickly. After a brief period of paralysis, these insects may recover rather than die. 
To prevent insects from metabolizing pyrethrins and recovering from poisoning, 
most products containing pyrethrins also contain the synergist, piperonyl butoxide 
(PBO). Without PBO the effectiveness of pyrethrins is greatly reduced.
 “pyrethrins” refers to the six related insecticidal compounds that occur naturally in 
the  crude  material,  the  pyrethrum  flowers.  They  are  extracted  from  crude 
pyrethrum dust as a resin that is used in the manufacture of various insecticidal 
products.
Chemical constituents
Esters Pyrethrin- I,II, Jasmolin,- I ,II , cinerin- I,II, triterpine alcohol, pyrethrol, 
lactone, pyrethrocin.  Other pyretol,pyrethrotoxic  acid,chrysanthemine, 
chrysanthemumic acid
Uses
Domestic and agriculture insecticidal 
It  act  on  nervous  system  of  insects  resulting  in  muscular  excitation,  convulsion, 
paralysis occurs. 
Toxic effect of pyrethrum on human are irritation to eyes, mucosa.
 maximum permissible atmospheric concentration is up to 5 mg per cubic meter.
Insecticide, sometimes mixed with synthetic products such as D.D.T.
scabicide for human beings , ectoparasiticide in veterinary medicine
These compounds make a unique insecticide because they are relatively non-toxic to 
humans  and  warm  blooded  animals  pyrethrins  are  quickly  broken  down  into 
inactive forms, and pass from the body quickly
NEEMNEEM
The  NEEM  tree  (Azadirachta indica belonging  to  the  family Meliaceae)  is  a 
tropical evergreen tree native to India and is also found in other southeast countries. 
In India, neem is known as “the village pharmacy” because of its healing versatility, 
and it has been used in Ayurvedic medicine for more than 4,000 years due to its 
medicinal properties. In the first millennium BC the neem tree was called the "Sarva 
Roga Nivarini" (one that could cure all ailments and ills).
Description : Leaves are imparipinnate, alternate, exstipulate, 3-6 cm long on long 
slender petioles; leaflets 7-17; alternate or opposite, very shortly stalked, 1-1.5 cm 
long. Apex: ovate-lanceolate, attenuate, bases are  unequal, Smooth in touch and 
dark green in color, odour is typical, and taste is bitter in nature. Fruits are  Ovoid, 
bluntly  pointed,  smooth  drupe,  appear  in  Green  (Young  and  unripe);  Yellow  to 
brown (Mature and ripe) in color. Shows Very scanty pulp and hard bony endocarp. 
Solitary  with  a  thick  testa  and  embryo  with  foliaceous  cotyledons  in  the  axis  of 
scanty endocarp.
1. Leaves:
i. Nimbin, 6- desacetylnimbinene.
ii. Nimbinene, Nimbandiol, nimbolide.
iii. Quercetin, β-sitosterol.
iv. Ascorbic acid, n-hexacosanol, nonacosane 
and amino acid.
Nimbin & Nimbidinin
Chemical Constituents
Fruits:
i. Gedunin.
ii. 7-deacetoxy-7α- hydroxygedunin.
iii. Azadiredione, azadirone, nimbiol.
iv. 17-epiazadiradione.
Seeds:
i. Tetranortriterpenoids; 1, 2-
diepoxyazadiradiradione,
ii. 7-acetylneotrichilenone, 7-desacetyl-7-
benzoyIgedunin
iii. Azadirachtin.
Oils:
i. Fatty acid: Myristic acid, palmitic acid, 
stearic acid, oleic acid and linoleic acid.
ii. Glycerides: Oleopalmitostearin, 
oleodistearin, odiolein and linoleodiolein.
iii. Bitter principle: Nimbidin, nimbidinin, 
Nimbin, nimbinin and nimbidol.
The product known as “neem oil” is more like a vegetable or horticultural oil and 
acts to suffocate insects. Neem and neem oil are often confused.
Mode of action. Neem is a complex mixture of biologically active materials, and it 
is difficult to pinpoint the exact modes of action of various extracts or preparations. 
In insects, neem is most active as a feeding deterrent, but in various forms it also 
serves  as  a  repellent,  growth  regulator,  oviposition  (egg  deposition)  suppressant, 
sterilant, or toxin.
As a repellent, neem prevents insects from initiating feeding. As a feeding deterrent, 
it  causes  insects  to  stop  feeding.  As  a  feeding,  either  immediately  after  the  first 
“taste” (due to the presence of deterrent taste factors), or at some point soon after 
ingesting  the  food  (due  to  secondary  hormonal  or  physiological  effects  of  the 
deterrent  substance).   As  a  growth  regulator,  neem  is  thought  to  disrupt  normal 
development interfering with chitin synthesis. Susceptibility to the various effects of 
neem differs by species.
Uses 
Neem  oil  is  extracted  from  the  seeds  of  the  neem  tree  and  has  insecticidal  and 
medicinal properties due to which it has been used in pest control in cultivation. 
Neem  seed  cake  (residue  of  neem  seeds  after  oil  extraction)  when  used  for  soil 
amendment or added to soil, not only enriches the soil with organic matter but also 
lowers nitrogen losses by inhibiting nitrification. 
It also works as a nematicide. 
Neem leaves are used as green leaf manure and also in preparation of litter compost. 
Neem leaves are also used in storage of grains. 
Twigs of neem when tender is used as green manure after decomposing and widely 
incorporated in rice cultivation fields. 
Neem (leaf and seed) extracts have been found to have insecticidal properties.
has anti-bacterial, anti-fungal and anti-nematicidalproperties and positive effect in 
combating several diseases
  DERRIS
Biological source: It consists of dried root and rhizomes of Derris elliptica and Derris
malaccensis belonging into the family Leguminosae
Tubli is a rambling climber, with branches covered with brown hairs. Leaves are 
pinnate and 30 to 50 centimeters long. Leaflets are usually oblong, 9 to 13, when 
matured smooth above, and subglaucous and silky beneath, 10 to 15 centimeters 
long, and about half as broad. Racemes are lax, 15 to 30 centimeters in length, 
with  reddish  flowers  in  stalked  clusters.  Pods  are  5  to  8  centimeters  long  and 
contain 1 to 3 seeds, flat and reniform, olive, brown or black.
Synonym: Tubli
Mode of action
Mode of action of rotenone is a respiratory enzyme inhibitor, acting between NAD+ 
(a  coenzyme  involved  in  oxidation  and  reduction  in  metabolic  pathways)  and 
coenzyme Q (a respiratory enzyme responsible for carrying electrons in some electron 
transport chains), resulting in failure of the respiratory functions. 
Acute  toxicity: Local  effects  on  the  body  include  conjunctivitis,  dermatitis,  sore 
throat,  and  congestion.  Ingestion  produces  effects  ranging  from  mild  irritation  to 
vomiting.  Inhalation  of  high  doses  can  cause  increased  respiration  followed  by 
depression and convulsions. The compound can cause a mild rash in humans and is a 
strong eye irritant to rabbits .
Chronic toxicity: Growth retardation and vomiting resulted from chronic exposures 
of rats and dogs. The compound is nontoxic to bees. However, it is toxic to bees when 
used in combination with pyrethrum.
Chemical constituents: It contains isoflavonoid derivative  Rotenone, Tephrosin, 
Toxicarol, Degnelin.
Uses : 
1. It is a Contact poison
2.Used in the form of spray for killing vegetable insects during harvesting time such as 
leaf hopper 
3. Insecticidal from the rotenone in the roots.
4.Rotenone has also been found effective against plant lice, leaf beetles, aphids, flies, 
caterpillars, ticks, chicken lice, red spiders and other insects. 
5.It has been reported to be more effective than potassium cyanide or nicotine and 
equally effective as pyrethrum, Because of toxicity, rotenone as insecticidal is being 
phased out in many eco-conscious countries.
SABADILLA  synonym:  stickweed 
Biological  source:  It  consists  of  dried  ripe  seeds  of Schoenocaulon officinale
belonging to the family Liliaceae, it is a perennial plant growing up to 1 metre tall 
from an underground bulb. 
The plant is used locally as an insecticide. 
Brushy  or  grassy  slopes,  usually  in  pine  or  oak  forest,  mostly  in  rather  dry  and 
exposed places, sometimes on moist or wet slopes, chiefly at elevations of 500 - 
2,000 metresThe seeds are 4 - 6 mm. long, wrinkled, black or dark brown outside, 
whitish within, hard, inodorous, and have an exceedingly acrid, burning taste. They 
contain veratrin and other alkaloids, and are poisonous.
They formerly constituted an official drug of the British Pharmacopoeia.The seeds 
have  emetic-cathartic  properties,  operating  sometimes  with  great  violence,  and 
overdoses  produce  death.  They  were  formerly  used  to  some  extent  to  expel 
tapeworms
Mode of action. In insects, sabadilla’s toxic alkaloids affect nerve cell membrane 
action, causing loss of nerve cell membrane action, causing loss of nerve function, 
paralysis and death. Sabadilla kills insects of some species immediately, while 
others may survive in a state of paralysis for several days before dying.
The seeds are black, shining, flat, shrivelled and winged, odourless, with a bitter, 
acrid,  persistent  and  disagreeable  taste,  the  pale  grey,  amorphous  powder  being 
errhine and violently sternutatory.
Chemical Constituents---Sabadilla contains several alkaloids, the most important 
being Cevadine, yielding cevine on hydrolysis; Veratrine, obtained from the syrupy 
liquor  from  which  the  cevadine  has  crystallized;  and  Cevadilline  or  Sabadillie, 
obtained after the extraction of the veratrine with ether.
Two other alkaloids have been isolated: Sabadine, which is less sternutatory than 
veratrine, and Sabadinine, which is not sternutatory. Sabadilla yields about 0.3 per 
cent of veratrine. The seeds also contain veratric acid, cevadic acid, fat and resin.
Uses: 
It is an insecticide used to kill house flies and bugs in the form of spray or dust.
• Uses: 
• Spinal cord stimulant.
• In cases of neurasthenia (excessive fatigue of neurotic origin).
• As a circulatory stimulant.
• Nerve and sex tonic.
• Bitter Stomachic (strengthening of stomach and promoting its action).
RYANIA
Biological source: It consists of dried root and stems of Ryania speciosa belonging 
to the family Flacourtiaceae.
Ryania is a botanical insecticide made from the ground stems of Ryania speciosa, a 
native  plant  of  tropical  America.  The  principal  alkaloid  in  this  stem  extract  is 
ryanodine, which makes up approximately 0.2% of the product. Ryania is highly 
toxic to the fruit moth, coddling moth, corn earworm, European corn borer, and 
citrus thrips, but it is ineffective against the cabbage maggot, cauliflower worm, 
and boll weevil. Ryania is a complex mixture of many compounds; thus, no single 
structure would represent it.
Mode of action. Ryania is a slow-acting stomach poison. Although it does not 
produce rapid knockdown  paralysis, it does cause insects to stop feeding soon 
after ingesting it. Little has been published concerning its exact mode of action in 
insect systems
The most active compound in ryania is the alkaloid ryanodine, which constitutes 
approximately 0.2% of the dry weight of stem wood.
Citrus Oil Extracts: Limonene and Linalool
Crude  citrus  oils  and  the  refined  compounds  d-limonene  (hereafter  referred  to 
simply as limonene) and linalool are extracted from orange and other citrus fruit 
peels.
Limonene,  a  terpene,  constitutes  about  90%  of  crude  citrus  oil,  and  is  purified 
from the oil by steam distillation. 
Linalool, a terpene alcohol, is found in small quantities in citrus peel and in over 
200 other herbs, flowers, fruits, and woods.
Terpenes  and  terpene  alcohols  are  among  the  major  components  of  many  plant 
volatiles  or  essential  oils.  Other  components  of  essential  oils  are  ketones, 
aldehydes, esters, and various alcohols. Essential oils are the volatile compounds 
responsible for most of the tastes and scents of plants. Many of the essential oils 
also have some physiological activity.
Mode of action. The modes of action of limonene and linalool in insects are not 
fully  understood.  Limonene  is  thought  to  cause  an  increase  in  the  spontaneous 
activity of sensory nerves. This heightened activity sends spurious information to 
motor nerves and results in twitching, lack of coordination, and convulsions. The 
central nervous system may also be affected, resulting in additional stimulation of 
motor nerves. Massive over stimulation of motor nerves leads to rapid knockdown 
paralysis.
Essential oils are volatile, odorous oils derived from plant sources. Although they are 
used mainly as flavorings and fragrances in foods, cosmetics, soaps, and perfumes, 
some of them also have insect repellent or insecticidal properties. Many essential oils 
have GRAS (Generally Regarded As Safe) status; however, when applied topically 
at high concentrations they tend to be irritating to skin and mucous membranes. They 
are sometimes used as topical counterirritant to relieve or mask pain. Many of the 
essential oils that have low dermal toxicity may be toxic by ingestion.
The most common essential oils used as repellents are the oils of cedar, lavender, 
eucalytus
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