PPT on cancer treatment from natural products

1. Cancer treatment by natural products

3. Malignant – cancerous have spread to other areas (metastasis)What is Cancer?

4. Benzene and other chemicals Drinking excess alcohol Smoking Environmental toxins, such as certain poisonous mushrooms & aflatoxins Excessive sunlight exposure Genetic problems Obesity Radiation Viruses What causes cancer?

5. Surgery Chemotherapy - pill or intravenously (IV) Radiation Therapy Biologic or Targeted Therapy Natural products Treatment for cancer

6. Fatigue GI toxicity Radiation therapy – mutagenic Nausea Vomiting Loss of appetite Hair loss etc Complications of chemotherapy & radiation therapy

7. Natural products for treatment of cancer WHO estimates that 80% of world population relies on plant-based medicines for primary healthcare Safer More natural Holistic Symptom relief (pain, nausea)

8. Antibiotic that is derived from the livers of dogfish perform a powerful anti-angiogenesis function Blocks blood vessel growth in tumors - Starves tumors Lung cancer Squalamine

9. Scutellariabaicalensis Anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines inhibits cellular growth Chinese skullcap

10. Targeting tumors with peptides from natural sources Sujit K. Bhutia and Tapas K. Mai, IIT Natural products that contained necrotic peptides, apoptotic peptides, function-blocking peptides, anti-angiogenic peptides, and immunostimulatory peptides in the context of their ability to induce tumor regression Indian scenario – usage of natural products for cancer cure

11. Indian Americans pioneering cancer research from herbal extracts January 11, 2011 Orally administering 12 grams per day for three months, curcumin was found to inhibit proliferation of cells. no side-effects in the animals

12. Curcumin (diferuloyl methane) is the active compound in the spice Tumeric. It has potent irreversible anti-proliferative effects against a variety of cancer cell lines Curcumin is believed to directly induce cancer cell apoptosis Bharat Aggarwal, professor of cancer medicine at Texas University research on tumeric Foreign scenario– usage of natural products for cancer cure

13. The Hollings Cancer Institute at the University of South Carolina has conducted a study on a group of 500 cervical cancer patients Ellagic acid is causing so-called G-arrest within 48 hours (inhibiting and stopping mitosis-cancer cell division) and apoptosis in several cancer types This is found in different foods. Ellagic Acid

14. Green Tea: A recent study from Japan demonstrates that green tea goes way beyond it's role as a well-known antioxidant. One of the factors that sets cancer cells apart from normal cells is that they have telomerase, an enzyme that maintains telomeres on the ends of DNA. Most normal cells do not have telomerase to maintain their telomeres. Every time a normal cell divides, telomeres are lost. ECGC – telomerase inhibitor Destroy cancer cells Several other natural products are explored for effective cancer treatment in future! FUTURE

15. http://www.alternative-cancer.net/78_alternatives.htm http://www.sciencedirect.com/science/article/pii/S016777990800053X http://nccam.nih.gov/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560162/ Further reading:

16. THANK YOU