B-cell disorders account for approximately two-thirds of all genetic primary immunodeficiency disorders (PIDD) and may result in decrease or dysfunction of one or more isotypes of immunoglobulin, leading to increased susceptibility to infection, particularly bacterial infections.

1. B CELL
DEFFICINCIES

2.  THE FIRST TYPE RESULTS FROM LACK
OF DIFFERENTIATION OF B-CELL
PERCURSORS INTO MATURE B CELLS.
 PLASMA CELLS ARE LACKING,
GERMINAL CENTRES FROM ALL
LYMPHATIC TISSUE DISAPPEARS
 COMPLETE LACK OF ANTIBODY
PRODUCTION AGAINST INVADING
BACTERIA.

3. 1. SEX LINKED AGAMMAGLOBULINEMIA
 ALL THE ANTIBODIES DISAPPEAR
FROM THE BLOOD
 SEVERE INFECTION SOON AFTER
BIRTH
 DIAGNOSIS IS MADE BY THE MARKED
DEFICIENCY OR COMPLETE ABSENCE
OF ALL SERUM IMMUNOGLOBULINS

4.  MANAGEMENT
 IV IMMUNOGLOBULIN
 ANTIBIOTIC OR ANTIMICROBIAL
THERAPY TO PREVENT
COMPLICATIONS

5.  2. COMMON VARIABLE
IMMUNODEFICINCY
 B CELL DEFICIENCY RESULTS FROM A
LACK OF DIFFERENTIATION OF B
CELLS INTO PLASMA CELLS
 DIMINISHED ANTIBODIES ARE
PRODUCED
 SYNDROME IS CALLED
HYPOGAMMAGLOBULINEMIA

6.  IMMUNOGLOBULIN A
DEFICIENCY- ONLY PLASMA
CELLS ARE LACKING
 PANHYPOGLOBULINEMIA

7. SIGN AND SYMPTOMS
PERNICIOUS ANEMIS
LYMPHOID HYPERPLASIA
OF THE SMALL INTESTINE
AND SPLEEN
GASTRIC ATROPHY
AUTOIMMUNE DISEASES-
ARTHRITIS
HYPOTHYROIDISM

8.  CHRONIC LUNG DISEASE
 HEPATITIS GASTRIC CANCER
 MALABSORPTION
 ADVERSE REACTIONS TO BLOOD
TRANSFUSIONS OR
IMMUNOGLOBULINS

9.  DIAGNOSIS
 HISTORY
 QUANTIFICATION OF THE B CELL
ACTIVITY
 SERUM IMMUNOGLOBULIN LEVEL
 ANTIBODY TITRE

10.  MANAGEMENT
 METRONIDAZOLE
 VITAMIN B 12
 ANTIMICROBIAL THERAPY
 QUINACRINE HCL