The document discusses T cell deficiencies leading to opportunistic infections, highlighting conditions such as DiGeorge syndrome and chronic mucocutaneous candidiasis. DiGeorge syndrome is characterized by thymic hypoplasia linked to chromosomal abnormalities, with symptoms appearing shortly after birth, while chronic candidiasis has an autoimmune component and presents with chronic infections and hypocalcemia. Management for both conditions includes thymus transplantation, bone marrow reconstitution, antifungal agents, and immunoglobulin therapy.

1. T CELL DEFFICIENCIES

2. • DEFECTS IN T CELLS LEAD TO
OPPORTUNISTIC INFECTIONS.
• GENETIC IN ORIGIN
• INCREASED SUSCEPTIBILITY TO
INFECTION
• S/S DEPENDS UPON THE TYPE OF
T CELLS AFFECTED

3. • 1. THYMIC HYPOPLASIA[
DIGEORGE SYNDROME]
• ABSENCE OF SEVERAL GENES
ON CHROMOSOME 22
• THYMUS GLAND FAILS TO
DEVELOP NORMALLY DURING
EMBRYOGENESIS
• SYMPTOMS PRESENT ALMOST
SOON AFTER BIRTH

4. • SIGN AND SYMPTOM
• HYPOTHYROIDISM WITH
HYPOCALCEMIA
• CONGENITAL HEART DISEASE
• RENAL ABNORMALITIES
• ABNORMAL FACES
• TETANY
• CONVULSIONS

5. • DIAGNOSIS
• T CELLS EVALUATION-
PERIPHERAL BLOOD
LYMPHOCYTE COUNT
• WILL FIND LYMPHOPENIA

6. • MANAGEMENT
• THYMUS TRANSPLANTATION
• HUMAN LEUKOCYTE ANTIGEN
MATCHED BONE MARROW TO THE
RECONSTITUTION OF
PERMANENT T CELL IMMUNITY

7. • 2. CHRONIC MUCOCUTANEOUS
CANDIDIASIS
• AUTOSOMAL RECESSIVE
INHERITANCE
• AUTOIMMUNE DISORDER IN
WHICH THE THYMUS AND OTHER
ENDOCRINE GLANDS ARE
INVOLVED IN AUTOIMMUNE
PROCESS
• EXTENSIVE MORBIDITY DUE TO

8. • S/S
• CHRONIC CANDIDAL INFECTION
• HYPOCALCEMIA
• TETANY SECONDARY TO THE
HYPOFUNCTION OF THE
PARATHYROID GLAND
• ADDISON’S DISEASE

9. • DIAGNOSIS IS DONE BY THE
DERMAL SENSITIZATION OF THE
PATIENT
•
• MANAGEMENT-
• ANTIFUNGAL AGENT
• IVIG