Phagocyte bactericidal dysfunction refers to a class of medical conditions where phagocytes have a diminished ability to fight bacterial infection. Examples include: Hyperimmunoglobulin E syndrome. Chédiak–Higashi syndrome. Chronic granulomatous disease.

1. PHAGOCYTIC
DYSFUNCTION

2.  Genetic in origin
 Affect the innate immune system
 Neutrophils are impaired and cannot
exit the circulation and travel to the
sites on infection
 Cannot produce a normal
inflammatory response against the
pathogens.

3.  S/s
 Increased incidence of bacterial , fungal
and viral infection
 Cutaneous abscess
 Chronic eczema
 Bronchitis, pneumonia
 Chronic otitis media, sinusitis
 Neutropenia
 Painful mouth ulcers

4.  gingivitis
 Stomatitis
 cellulitis

5.  Diagnosis
 History
 Sign & symptoms
 Laboratory analysis of the cytocidal
activity of the cells

6.  MANAGEMENT
 Early diagnosis of the disease and
treatment
 Granulocyte transfusions
 Trating with granulocyte macrophage or
granulocyte colony stimulating factor
 It will draw nonlymphoid stem cells from
the bone marrow and hasten their
maturation