Omeprazole, a proton pump inhibitor marketed as Prilosec, is available in various forms including packets, tablets, and suspensions, with dosages tailored for different age groups. It works by irreversibly blocking gastric acid secretion and is prescribed for conditions such as peptic ulcers, GERD, H. pylori infections, and Zollinger-Ellison syndrome. Common side effects include headache, abdominal pain, and diarrhea, with varying safety and efficacy based on patient demographics.

1. Omeprazole
Prepared by: Abdulaziz M.shahbaz

2. omeprazole
• Generic name: omeprazole
• Brand names: PriLOSEC
• Dosage forms:
– Packet: 2.5mg , 10mg
– Suspension: 2mg/ml
– Tablet/capsule: 10mg, 20mg, 40mg
– Oral disintegrating tablets: 20mg
• Drug class: Proton pump inhibitors
• Rout of administration:
• Orally
• capsule
• Powder for oral suspension
• Intravenously , infusion

3. Mechanism of action
Omeprazole inhibits secretion of gastric acid
by irreversibly blocking the enzyme system of
hydrogen/potassium adenosine
triphosphatase, the “proton pump” of the
gastric parietal cell.
resulting in suppression of gastric acid
secretion

4. uses
1. Peptic ulcer
2. GERD
3. H pylori infection
4. NSAID induced ulcer
5. Reflux esophagitis
6. Zollinger-Ellison syndrome
7. Prophylaxis for ulcers

5. Uses
• GERD:
–<1 year: Safety and efficacy not established
–5-10 kg: 5 mg PO qDay
–10-20 kg: 10 mg PO qDay
–>20 kg: 20 mg PO qDay

6. Uses
• Erosive Esophagitis
• <1 month: Safety and efficacy not established
• Aged 1 month to <1 year
• 3 to <5 kg: 2.5 mg qDay
• 5 to <10 kg: 5 mg qDay
• ≥10 kg: 10 mg qDay
• May treat for up to 6 weeks
• Aged 1-16 years
• 5 to <10 kg: 5 mg PO qDay
• 10 to <20 kg: 10 mg PO qDay
• ≥20 kg: 20 mg PO qDay
• May treat for 4-8 weeks

7. Adverse Effects
• Headache (7%)
• Abdominal pain (5%)
• Diarrhea (4%)
• Nausea (4%)
• Vomiting (3%)
• Flatulence (3%)
• Dizziness (2%)
• Upper respiratory infection (2%)
• Acid regurgitation (2%)
• Constipation (2%)
• Rash (2%)
• Cough (1%)