Penicillin is obtained from the fungus Penicillium chrysogenum and contains a beta-lactam ring that provides its antibacterial activity. It works by inhibiting the final step in bacterial cell wall synthesis mediated by transpeptidases, preventing cross-linking of peptidoglycan strands and leading to cell lysis. While penicillin G has a narrow spectrum mostly against gram-positive bacteria, subsequent penicillins were developed with improved spectra, stability, and resistance to beta-lactamases. Their mechanisms of resistance include inactivation by beta-lactamases or modifications of penicillin-binding proteins. Beta-lactamase inhibitors can restore the activity of penicillins against bacteria producing
This ppt deals with the sulfonamide group of drugs with classification, mechanism, spectrum, resistance, uses and adverse effects discussed in detail. It also discusses in detail about Cotrimoxazole
Definition
History
Chemistry
Properties
Classification & its Generation
Pharmacokinetics
Mechanism of action
Indication
Contraindication
Therapeutic use
Adverse effect
Resistance
Comparison with penicillin
Market preparation
Tetracyclines slide contains full information about uses, adverse effect, marketed preparation, precaution, route of drug administration, antimicrobial spectrum, mechanism of action, pharmacokineticks and pharmacodynamics of tetracyclines. This slide is very helpful for pharmacy and pharmacology student for the study about tetracyclines.
This ppt deals with the sulfonamide group of drugs with classification, mechanism, spectrum, resistance, uses and adverse effects discussed in detail. It also discusses in detail about Cotrimoxazole
Definition
History
Chemistry
Properties
Classification & its Generation
Pharmacokinetics
Mechanism of action
Indication
Contraindication
Therapeutic use
Adverse effect
Resistance
Comparison with penicillin
Market preparation
Tetracyclines slide contains full information about uses, adverse effect, marketed preparation, precaution, route of drug administration, antimicrobial spectrum, mechanism of action, pharmacokineticks and pharmacodynamics of tetracyclines. This slide is very helpful for pharmacy and pharmacology student for the study about tetracyclines.
Pharmacology of Penicllins (Beta lactam antibiotics), description of their mechanism of action, mechanism of resistance, classification, indications and adverse effects
It include introduction and history of penicillin, mechanism of action of penicillin, classification of penicillin, structural activity relationship of penicillin, adverse effects of penicillin and therapeutic uses of penicillin.
this presentation cover medicinal chemistry of penicillin.
Broad spectrum antibiotics chloramphenicol, anaerobic,soil bacteria. Description includes Physicochemical Properties,Mechanism of action-50S ribosome ,Inhibits Bacterial protein synthesis,Resistance,Interactions,Indications of chloramphenicol-Pyogenic meningitis.
Anaerobic infections.
Intraocular infections.
Enteric fever
Drug of choice in some conditions.
Urinary tract infections
Topically In conjunctivitis & external ear Infections. Snehal chakorkar
Pharmacology of Penicllins (Beta lactam antibiotics), description of their mechanism of action, mechanism of resistance, classification, indications and adverse effects
It include introduction and history of penicillin, mechanism of action of penicillin, classification of penicillin, structural activity relationship of penicillin, adverse effects of penicillin and therapeutic uses of penicillin.
this presentation cover medicinal chemistry of penicillin.
Broad spectrum antibiotics chloramphenicol, anaerobic,soil bacteria. Description includes Physicochemical Properties,Mechanism of action-50S ribosome ,Inhibits Bacterial protein synthesis,Resistance,Interactions,Indications of chloramphenicol-Pyogenic meningitis.
Anaerobic infections.
Intraocular infections.
Enteric fever
Drug of choice in some conditions.
Urinary tract infections
Topically In conjunctivitis & external ear Infections. Snehal chakorkar
Explanation on the industrial production of penicillin covering the history, fermentors, specific conditions required for penicillin production, how to increase yield amongst others.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
This is lecturer notes on pharmacology & toxicology for B.V.Sc & A.H. Seventh semester students.This may useful for other institute veterinary students.Please send your comment and suggestion;jibachhashah@gmail.com,mob.9845024121
Beta lactam antibiotics, First antibiotic by Scottish scientist , Alexander Fleming in 1928 (seen fungus and bacteria can not grow together)
PCN was isolated from fungus Penicillium notatum
ß-lactum antibiotics
Active against Gram +ve bacteria (Staphylococci and Streptococci) not against gram –ve except at high dose
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. Penicillin
Obtained from fungus Penicllium chrysogenum.
Sulfur containing thiazolidine ring fused with b-
lactam ring to which a side chain is attached at
position -6 (-NHCOR).
Activity is due to the 6-amino penicillanic acid (6-
APA), hence named β-lactam antibiotics.
2
3. Mechanism of action
Interfere with synthesis of bacterial cell wall.
Cell wall composed of peptidoglycan, glycon consist of two
amino sugars;
1)N-acetylmuramic acid (NAcM).
2)N-acetylglucosamine(NAcG).
Peptidoglycan residues are linked together forming long strands
&UDP is split off.
Final step is cleavage of terminal D-alanine of the peptide by
transpeptidase, process known as transpeptidation.
This cross bridging provide neccessry strength to bacterial cell
wall.
β-lactam ABs inhibit the transpeptidase so that cross-linking
does not take place.
This will cause cell wall deficient forms of bacteria are produced
3
4. Cont…..
This cross bridging provide neccessry strength to
bacterial cell wall.
β-lactam ABs inhibit the transpeptidase so that cross-
linking does not take place.
This will cause cell wall deficient forms of bacteria are
produced
Thus shows bactericidal action.
4
5. Penicillin G
Narrow spectrum antibiotic.
Primarily to gram positive bacteria and few others,
active against….
Cocci-Streptococci (except group D), Staph.aureus ;
gram negative N.gonorrheoe and N.meningitis.
Bacilli-majority of B.anthracis, Corynebacterium
diptheriae etc
5
6. Uses
Strptococcal infections-Pharyngitis, otitis
media,scarlet fever
Syphillis- T.pallidum does not show any resistance,
drug of choice.
Diptheria-Antitoxin therapy.
6
7. Adverse Effects
Local irritancy and direct toxicity; pain at i.m injection
site nausea on oral ingestion and thrombophlebitis of
injected vein.
Hypersensitivity-rashes,itching,urticaria
Contact dermatitis and Jarisch-Herxheimer reaction
7
8. Drawbacks of Penicillin G
Poor oral efficacy.
Susceptibility to penicillinase
Narrow spectrum of activity.
Hypersensitivity.
Destroyed by acid
“To overcome these problems, developed new
penicillins and classified according to the anti
microbial spectrum”.
Refernce; K.D.Tripathi.pg.no 658,6th edition
8
13. Narrow spectrum, β-lactamase
resistant group
Similar to penicillin-G, additionally effective against B-
lactamase producing staphylococcal hence named
anti-staphylococcal penicillins.
Methicillin no use –due to –nephrotoxicity.
Nafcillin is preferred for parenteral use,while
cloxacillin and dicloxacillin-orally.
Used to treat osteomyelittis, septicaemia,
endocarditis.
13
14. Extended spectrum penicillins
All penicillins are β-lactamase sensitive, but
Ampicillin and amoxicillin –acid stable .
Carbenicillin, ticarcillin and piperacillin are acid labile
can be given by I.V or I.M.
Food decreases the bioavailability of ampicillin but
does not happen in case of Amoxycillin.
Ampicillin & amoxycillin are effective against
Streptococcus viridans, and enterococci(SABE)
14
15. Penicillin Units
Activity of natural penicillins (e.g penicillin) is defined
in terms of units.
Crystalline sodium penicillin G contains 1600 units per
mg.
Semi-synthetic penicillins are prescribed by weight
basis rather than units, e.g amoxycillin 500 mg 8
hourly orally.
15
16. Resistance to penicillins
Inactivation of β-lactam ring by Beta-lactamase
S.aureus, haemophilus influenza and E.coli
These bacteria produce beta- lactamase which can
hydrolyze penicillins .
Psedomonas, Enterbacter, Neisseria gonorrhoeae
and Moraxella catarrhalis have a broader degradative
activity
16
17. Cont…
Resistance due to modification of penicillin
binding proteins-resistance bacteria like Methicillin
resistant Staphylococcal aureus (MRSA), Streptococcus
pneumoniae and Enterococcus produce mutant PBPs
which have low affinity to penicillins.
Reduction of penicillin permeability to reach
PBPs-bacteria reduce the antibiotic access to PBPs
through porin channels.e.g Pseudomonas aeruginosa,
the porin mutant block the penicillin transfer across
the outer membrane.
17
18. β- lactamase inhibitors
Resemble to beta-lactam antibiotics only structurally
but do not possess any significant antimicrobial
action.
Drug include –Clavulanic acid and sulbactam.
Bind irreversibly to catalytic site of susceptible β-
lactamases ( produced by bacteria) to prevent
hydrolysis of penicillins.
Can inhibit plasmid mediated β-lactamases which are
responsible for transferred drug resistance like MSRH.
G.I intolerance,stomatitis and rashes are recorded
18
19. Drug interactions
Antagonistic combination;
Oral penicillins;
antagonised by bacteriostatic antibiotics such
tetracyclines, chlramphenicol, erythromycin.
Penicillin and aminoglycosides should not mixed in
the same syringe ,inactivate each other.
Hydrocortisone inactivates ampicillin if mixed in the
I.V fluid.
19
20. Cont….
Synergistic combinations;
Probenecid prolongs the action of penicillin by
decreasing its tubular secretion.
Beta –lactamase inhibitors extend the spectrum of
penicillins against beta lactamase producing bacteria.
A fixed dose combination of ampicillin or amoxycillin
250 mg with cloxacillin 250 mg has been promoted as
synergistic combination useful in postoperative and
respiratory infection.
20
21. REFERNCE
Sharma KK, “ Principle of Pharmacology” 2nd edition
2011 721-742
Tripathi K.D. “ Essentials of Medical Pharmacology”,
6th edition, 2011
www.wikipedia.com
21