it contain all the details of of tetracycline

1. PRESENTED BY: ARJITA SRIVASTAVA
ROLL NO. :1355250005
SUBMITTED TO: Mr.ARUN KR. TIWARI
(Asst.Professor,CSSCP)

2.  Introduction
 Classification and there structures
 Mechanism of action
 Spectrum of activity
 Mechanism of Resistance
 Pharmacokinetics
 Administration
 Adverse Drug Reactions of tetracycline antibiotics
 Uses and Drug Interaction
 Storage

3.  Tetracyclines are a class of antibiotic,which
are chemical substances produced by a
microorganism that are able to kill other
microorganisms without being toxic to the
person,animal or plant.
 Tetracyclines are derived directly from a
bacterium known as Streptomyces
coelicolor.
 Tetracycline were discovered in 1940.

4. Tetracyclines
(according to
duration of
action)
Short acting
(half life is 6-
8hrs)
Tetracycline
Oxytetracycline
Intermediate-
acting
(half-life 12hrs)
Demeclocycline
Methacycline
Long acting
(half-life 16hrs)
Doxycycline
Minocycline

6.  Tetracyclines are specific inhibitors of bacterial
protien synthesis.
 They bind to the 30s ribosomal subunit and
thereby prevent the binding of aminoacyl
tRNA to the mRNA ribosome complex.
 Tetracyclines also inhibit protein synthesis
in the host,but are less likely to reach the
concentration required because eukaryotic
cells do not have a tetracycline uptake
mechanism.

8. Tetracyclines are broad spectrum
antibiotics,active against Gram positive
and Gram negative
bacteria,spirochetes,mycoplasma,rickettsie
and chalmydiae.

9. Cell become resistance to tetracycline 3
mechanisms
 Enzymatic rarest type of resistance,where an
acetyl group is added to the molecule,causing
inactivation of drug.
 Efflux resistance gene encodes a membrane
protien that actively pumps tetracycline out of
cell.
 Ribosomal protection which blocking
tetracycline from binding to the ribosome.

12. Oral capsules is the dosage form in
which tetracyclines are most commonly
administered.
The capsule should be taken 1/2hr before
or 2hr after food.
 Not recommended for i.m. route of
administration.

15. Tetracycline is used to treat wide
variety of infections,including
acne.It is an antibiotic that works by
stopping the growth of bacteria.
 Venerel disease
 Atypical pneumonia
 Cholera
 Relapsing fever
 Rickettsial infections,plague

16. Tetracycline may interact with other
medicine.Effects of one or both of drugs
may change or rick of side effect may
be greater.
 Calcium supplements
 Mineral supplements
 Mutivitamine
 Cholestrol lowering drugs
 Penicillin compounds

17. Keep at room temperature 68 and 77
degreeF.
Keep away from heat,moisture and
light.