The kidneys filter waste from the bloodstream and regulate water, electrolyte, and acid-base balance. They remove urea and other waste through urine while producing hormones like erythropoietin and renin. The kidneys contain nephrons which filter blood in the glomerulus and reabsorb nutrients in the tubules. Urine is transported by the ureters to the bladder, then exits through the urethra. The urinary system develops from intermediate mesoderm through pronephros, mesonephros, and metanephros stages, with the metanephros becoming the adult kidneys.
Consists of liver, biliary tree, gall bladder
Liver is the largest gland in the body
Multiple functions
Disease of the liver and biliary tree influences drug actions
Every anesthetic drugs are metabolized by the liver
So liver is very much important for anesthetists
location, length, and relation of right an left ureter, raletion of male an female ureter, n physiological site of ureteric constriction, bloo supply an inerve supply of ureter, clinical sinificance of ureter with hysteriectpomy
Anatomy of urinary bladder. surfaces, border of urinary bladder its relation , ligament support, peritoneal relation in male and females, pouches, blood supply of bladder, nerve supply of bladder, true and false ligament of urinary bladder,
gross Anatomy of kidney, description of external and internal structure of kidney, the relation of right and left kidney. difference between right and left kidney, and some clinical abnormalities relate to kidney,
Consists of liver, biliary tree, gall bladder
Liver is the largest gland in the body
Multiple functions
Disease of the liver and biliary tree influences drug actions
Every anesthetic drugs are metabolized by the liver
So liver is very much important for anesthetists
location, length, and relation of right an left ureter, raletion of male an female ureter, n physiological site of ureteric constriction, bloo supply an inerve supply of ureter, clinical sinificance of ureter with hysteriectpomy
Anatomy of urinary bladder. surfaces, border of urinary bladder its relation , ligament support, peritoneal relation in male and females, pouches, blood supply of bladder, nerve supply of bladder, true and false ligament of urinary bladder,
gross Anatomy of kidney, description of external and internal structure of kidney, the relation of right and left kidney. difference between right and left kidney, and some clinical abnormalities relate to kidney,
Various waste products are formed in our body as a result of many
metabolic activities taking place inside the body. These waste substances if
accumulated would poison cells or slow down their metabolism. Hence, the body must
get rid of these unwanted substances.The metabolic wastes to be excreted include
CO2, H2O, fat, ammonia, urea and uric acid.
The nourishment coming from food that is simplified or processed by digestion is consumed by the blood and conveyed all through the body. When this absorbed food is broken down in the tissues and many toxic and poisonous substances are produced which should be removed as they may be fatal if present beyond a certain concentration. The removal of these substances is known as excretion. Excretion and osmoregulation, both are interconnected processes and occur side by side. in higher vertebrates like humans, kidneys perform both the functions, excretion as well as osmoregulation.The system responsible for these function is known as the excretory system or urinary system
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The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
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Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
2. The Functions of Kidneys
Excretion & Elimination:
removal of organic wastes products from body fluids
(urea, creatinine, uric acid)
Homeostatic regulation:
Water -Salt Balance
Acid - base Balance
Endocrine function:
Productions of some hormones
A)
B)
C)
3. B) Homeostatic
Functions
Regulate blood volume and blood pressure:
by adjusting volume of water lost in urine
releasing renin from the juxtraglomerular apparatus
• Regulate plasma ion concentrations:
– sodium, potassium, and chloride ions (by controlling quantities lost in urine)
– calcium ion levels
1) Water –electrolytes balance
The kidneys control this by excreting H+ ions and reabsorbing
HCO3 (bicarbonate).
2) Acid-Base Balance (Help stabilize blood pH)
4. C) The endocrine function
Kidneys have primary endocrine function since they produce hormones
(erythropoietin, renin and prostaglandin).
Erythropoietin is secreted in response to a lowered oxygen content in the blood. It
acts on bone marrow, stimulating the production of red blood cells.
Renin the primary stimuli for renin release include reduction of renal perfusion
pressure and hyponatremia.
Renin release is also influenced by angiotension II and ADH.
The kidneys are primarily responsible for producing vitamin D3
6. Location and External Anatomy of Kidneys
Located retroperitoneally
Lateral to T12–L3 vertebrae
Average kidney
12 cm tall, 6 cm wide, 3 cm thick
Hilus
On concave surface
Vessels and nerves enter and exit
Renal capsule surrounds the kidney
14. Mechanisms of Urine Production
Filtration
Filtrate of blood leaves kidney capillaries
Reabsorption
Most nutrients, water, and essential ions reclaimed
Secretion
Active process of removing undesirable molecules
20. THE URETERS
Normal Variations in Ureteral Caliber
The normal ureter is not of uniform caliber, with three
distinct narrowings classically described: the
ureteropelvic junction, crossing of the iliac vessels, and
the ureterovesical junction.
The only true physical restriction of the ureter is as it
makes the intramural passage through the bladder wall
to the ureteral orifice at VUJ.
These three sites of ureteral narrowing are clinically
significant because they are common locations for
urinary calculi to lodge during passage and may restrict
successful passage of rigid endoscopes.
21. Ureteral Segmentation and Nomenclature
The simplest system divides the ureter into the abdominal
ureter extending from renal pelvis to the iliac vessels and
the pelvic ureter extending from the iliac vessels to the
bladder.
Alternatively, the ureter can be divided into upper, middle,
and lower segments .
A- The upper ureter extends from the renal pelvis to the
upper border of the sacrum.
B-The middle ureter comprises the segment from the upper
to the lower border of the sacrum.
C-The lower (distal or pelvic) ureter extends from the lower
border of the sacrum to the bladder.
22. Pain Perception - Somatic Referral
Pain and reflex muscle spasm are typically produced over the distributions of the
subcostal, iliohypogastric, ilioinguinal, and/or genitofemoral nerves, resulting in
flank, groin, or scrotal (or labial) pain and hyperalgesia, depending on the location
of the noxious visceral stimulus
23. Pain Perception-
Stones obstructing the ureteropelvic junction may present
with flank pain without radiation to the groin, due to
distention of the renal capsule. Stones impacted within the
ureter cause abrupt, severe, colicky pain in the flank and
ipsilateral lower abdomen with radiation to the testicles or the
vulva.
24. Urinary Bladder
A collapsible muscular
sac
Stores and expels urine
Full bladder – spherical
Expands into the
abdominal cavity
Empty bladder – lies
entirely within the pelvis
Figure 23.13
25. Figure 23.14
Urinary Bladder
Urachus – closed remnant
of the allantois
Prostate gland
Lies directly inferior to
the bladder
Surrounds the urethra
26. Urinary Bladder
Wall of bladder
Mucosa
Transitional epithelium
Muscular layer
Detrus or muscle
Adventitia
27. Histology of the Urinary Bladder
Figure 24.13 Histology of the bladder.
Lumen of the bladder
Transitional
epithelium
Lamina
propria
Muscular layer
(detrusor)
Micrograph of the bladder
wall (25 )
Epithelium lining the lumen
of the bladder (285 )
Transitional
epithelium
Lamina
propria
Basement
membrane
30. Urethra
In females
Length of 3–4 cm
In males – 16-20 cm in length – three named regions
Prostatic urethra
Passes through the prostate gland
Membranous urethra
Through the urogenital diaphragm
Spongy (penile) urethra
Passes through the length of the penis
31.
32. Embryology of The Urinary System
Embryo develops three pairs of kidneys
Pronephros
Mesonephros
Metanephros
Only metanephros persists to become the adult
kidneys
Metanephric kidney produces urine by fetal third month
Contributes to the volume of amniotic fluid
33. The urinary tract develops from the 3rd week of the embryonic period from
the intermediate mesoderm as well as from the urogenital sinus. The kidneys
develop from the 4th week in three steps:
As a first one, the pronephros, forms that then later atrophies in the 8th week and
is never active functionally.
It is followed by the mesonephros, that is formed between the 6th and 10th
weeks, but is only transitory.
The definitive kidneys develop from a metanephrones (mesodermal origin) and the
ureter bud (that has its origin in the caudal part of the wolffian duct)
34. The urine-excreting part of the kidneys, the
nephron, mainly arises from the
metanephrones (glomerulus, proximal,
intermediate and distal tubules), while the rest
of the upper urinary tract (collecting ducts,
calices, renal pelvis and ureter) develop from
the ureteric bud.
35. The numerous induction mechanisms between ureter bud
and metanephric mesenchyma during the development of
the renal system, as well as the ascent of the kidneys,
originating at the level of the sacrum and moving up to the
diaphragm at the end of the development, make it possible
for a large number of abnormalities to arise.
Many remain asymptomatic whereas others are not
compatible with survival.
36. In males the internal sex organs come from
the mesonephric duct (Wolff) that differentiates
itself into the epididymis, deferent duct, seminal
vesicle and the ejaculatory duct.
The paramesonephric duct (Müller) atrophies. It
leaves behind embryonic remnants such as the
testicular appendage and parts of the prostatic
utricule.
37. In females the paramesonephric duct (Müller) remains in
existence and differentiates itself into the fallopian tube with its
ampullae and, following its fusion at the caudal end, into the
uterus and the upper part of the vagina.
The mesonephric duct (Wolff) with its tubules atrophies and
leaves embryonic remnants such as the ductus longitudinalis
epoöphori (Gartner), epoöphoron and paroöphoron.