Welcome to "Anatomy of the Heart," an enlightening presentation that takes you on a captivating journey through the intricate structure of the human heart.
In testis, the immature male germ cell (spermatogonia ) produce sperms by spermatogenesis
The spermatogonia ( sing. Spermatogonium ) present on the inside of seminiferous tubules multiply by mitotic division and increase in numbers
Each spermatogonium is diploid and contains 46 chromosomes
Some of the spermatogonia called primary spermatocytes periodically undergo meiosis.A primary spermatocyte completes the first meiotic division (reduction division) leading to formation of two equal, haploid cells called secondary spermatocyte, which have only 23 chromosomes
The secondary spermatocyte undergo the second meiotic division to produce four equal, haploid spermatids
In testis, the immature male germ cell (spermatogonia ) produce sperms by spermatogenesis
The spermatogonia ( sing. Spermatogonium ) present on the inside of seminiferous tubules multiply by mitotic division and increase in numbers
Each spermatogonium is diploid and contains 46 chromosomes
Some of the spermatogonia called primary spermatocytes periodically undergo meiosis.A primary spermatocyte completes the first meiotic division (reduction division) leading to formation of two equal, haploid cells called secondary spermatocyte, which have only 23 chromosomes
The secondary spermatocyte undergo the second meiotic division to produce four equal, haploid spermatids
Bile is a bitter-tasting, dark green to yellowish brown fluid, produced by the liver , it is stored in the gallbladder and upon eating is discharged into the duodenum. .
The principal function of the gallbladder is to serve as a storage reservoir for bile.
The main components of bile are water, bile salts, bile pigments, and cholesterol
Bile salts act as emulsifying agents in the digestion and absorption of fats. Cholesterol and bile pigments from the breakdown of hemoglobin are excreted from the body in the bile.
Physical properties;
Hepatic bile: pH 7.4, colour is golden yellow ,
Bladder bile: pH 6.8, color is green dark to yellow (darker)
Volume of bile produced reaches to one liter of bile per day (depending on body size).
Muscles is a contractile tissue which brings about movement.
Muscle cell responsible for our movement both visible and invisible, example walking, talking, bowel movement ,urination, breathing, heartbeats, the dilation and constriction of the pupils of our eyes and many other.
When we are still sitting or standing muscle cells keep us erect.
CONT...Muscles can be regarded as motors of the body.Muscles comprises about 40% to 50% (approximate) of body weight.There are approximate 650 muscles in body.Alternating contraction and relaxation of cells
A closed system of the heart and blood vessels
The heart pumps blood
Blood vessels allow blood to circulate to all parts of the body
The function of the cardiovascular system is to deliver oxygen and nutrients and to remove carbon dioxide and other waste products
The heart contributes to homeostasis by pumping blood through blood vessels to the tissues of the body to deliver oxygen and nutrients and remove wastes.
Blood to reach body cells and exchange materials with them, it must be pumped continuously by the heart through the body’s blood vessels.
The heart beats about 100,000 times every day, which adds up to about 35 million beats in a year, and approximately 2.5 billion times in an average lifetime.
The left side of the heart pumps blood through an estimated 100,000 km (60,000 mi) of blood vessels, which is equivalent to traveling around the earth’s equator about three times.
The right side of the heart pumps blood through the lungs, enabling blood to pick up oxygen and unload carbon dioxide.
Bile is a bitter-tasting, dark green to yellowish brown fluid, produced by the liver , it is stored in the gallbladder and upon eating is discharged into the duodenum. .
The principal function of the gallbladder is to serve as a storage reservoir for bile.
The main components of bile are water, bile salts, bile pigments, and cholesterol
Bile salts act as emulsifying agents in the digestion and absorption of fats. Cholesterol and bile pigments from the breakdown of hemoglobin are excreted from the body in the bile.
Physical properties;
Hepatic bile: pH 7.4, colour is golden yellow ,
Bladder bile: pH 6.8, color is green dark to yellow (darker)
Volume of bile produced reaches to one liter of bile per day (depending on body size).
Muscles is a contractile tissue which brings about movement.
Muscle cell responsible for our movement both visible and invisible, example walking, talking, bowel movement ,urination, breathing, heartbeats, the dilation and constriction of the pupils of our eyes and many other.
When we are still sitting or standing muscle cells keep us erect.
CONT...Muscles can be regarded as motors of the body.Muscles comprises about 40% to 50% (approximate) of body weight.There are approximate 650 muscles in body.Alternating contraction and relaxation of cells
A closed system of the heart and blood vessels
The heart pumps blood
Blood vessels allow blood to circulate to all parts of the body
The function of the cardiovascular system is to deliver oxygen and nutrients and to remove carbon dioxide and other waste products
The heart contributes to homeostasis by pumping blood through blood vessels to the tissues of the body to deliver oxygen and nutrients and remove wastes.
Blood to reach body cells and exchange materials with them, it must be pumped continuously by the heart through the body’s blood vessels.
The heart beats about 100,000 times every day, which adds up to about 35 million beats in a year, and approximately 2.5 billion times in an average lifetime.
The left side of the heart pumps blood through an estimated 100,000 km (60,000 mi) of blood vessels, which is equivalent to traveling around the earth’s equator about three times.
The right side of the heart pumps blood through the lungs, enabling blood to pick up oxygen and unload carbon dioxide.
The circulatory system is an organ system that passes nutrients (such as amino acids, electrolytes and lymph), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. Definition of Heart
The upper part of the chest contains the muscular organ known
as the heart. It circulates blood throughout the body by
pumping blood. The cardiovascular system is made up of the
blood vessels and the blood itself, in addition to the heart.
3. INTRODUCTION TO THE HUMAN HEART
Among the most crucial organs necessary for maintaining life is the human heart. It has four
chambers and is a muscular organ. The heart is roughly the size of a clenched hand.
One of the strongest and most active muscles in an individual's body, the heart continues to
beat throughout a person's lifetime.
The majority of animals, excluding humans, have hearts that circulate blood throughout their
bodies. Even invertebrates like grasshoppers have a pumping organ that resembles a heart,
though it does not work in the same manner that the heart of humans does.
The human heart is situated in the thoracic cavity, just to the left of the sternum (breastbone),
between the lungs. It comes from the germ layer of the mesoderm of the embryo.
4. FUNCTION OF HUMAN HEART
The heart of a human being performs an essential job in the body as a strong pump that pumps blood
throughout the entire circulatory system. All of the body's cells depend on it to remove wastes like
carbon dioxide while also providing oxygen, nutrition, and hormones.
The heart's four primary jobs are as follows:
• Blood Circulation: Through systemic circulation, the heart distributes oxygen-rich blood from the
respiratory system to the rest of the body. This makes sure that every tissue and organ gets the oxygen
and nutrients they need to function properly.
• Pulmonary Circulation: The heart helps the lungs circulate blood that has been deoxygenated from
the body and returns oxygenated blood to the heart through the pulmonary system. As a result, the
blood supply is replenished in the lungs, where carbon dioxide can be exchanged for oxygen.
• Contraction and Relaxation: The heart regulates the blood's flow with a series of rhythmic
contractions and relaxations. In order to pump blood out of the heart chambers, the heart contracts
(systole), then relaxes (diastole), allowing blood to return to the chambers.
• Blood Pressure and Regulation: Controlling blood pressure is a crucial function of the heart. Blood
is forced into the blood vessels when the heart contracts, creating pressure. The proper blood pressure
levels are maintained by the coordinated relaxation and contraction of the heart's chambers.
5. • Electrical Conduction: The electrical conduction system inside the heart regulates the heartbeat.
Electrical impulses are started by the sinoatrial (SA) node, which causes the cardiovascular system's
muscles to contract in unison. By ensuring that both ventricles and atria contract in the appropriate
order, effective blood flow is made possible.
• Thermoregulation: The heart plays a role in maintaining body temperature. During physical activity
or exposure to cold, the heart rate can increase to pump more blood and distribute heat throughout the
body.
• Removal of waste products: As the heart circulates blood, it also helps in removing waste products,
such as carbon dioxide and metabolic byproducts, which are then eliminated from the body through
exhalation, urine, and other waste elimination processes.
6. ANATOMY OF HEART
The heart's structure and internal organization are
described in terms of its anatomy. Located in the
chest cavity and slightly skewed to the left, the
human heart is a muscular organ. It weighs between
250 and 350 grammes and has a size similar to that
of a clinched fist.
The heart has four chambers, each of which plays a
particular role in blood flow. The top chambers are
known as atria (plural: atrium), and the lower
chambers are known as ventricles. These chambers
are separated into two pairs.
• Atria: There are four chambers in the heart, and
each one contributes differently to blood flow.
The upper chambers are called atria, and the
lower chambers are called ventricles. There are
two pairs of these chambers.
7. • Ventricles: The right and left ventricles and the other two ventricles make up the heart. The heart's
ventricles are in charge of pumping blood away. Deoxygenated blood is pumped from the right
ventricle through the pulmonary artery, which connects to the lungs. The largest artery in the body,
known as the aorta, is used by the left ventricle to pump blood and oxygen to the rest of the body.
There are septa, which are muscular walls that divide the heart's chambers. In contrast to the
interventricular septum, which divides the ventricles, the interatrial septum separates the atria.
The heart's valves guarantee one-way blood flow. The atrioventricular (AV) valves divide the ventricles
and atria. In contrast to the mitral (bicuspid) valve, which is situated between the left atrium and left
ventricle, the tricuspid valve is found between the right atrium and right ventricle. The pulmonary valve
and aortic valve, two semilunar valves, protect the ventricles' entry points into the arteries.
The pulmonary veins and superior and inferior vena cava, which transport oxygenated blood from the
lungs to the left atrium and deoxygenated blood from the body to the right atrium, respectively, are
connected to the heart.
The pericardium, the protective double-layered membrane that surrounds the heart and aids in stabilising
it and lubricating its motions, helps maintain the heart in place.
Understanding the heart's structure is essential to understanding how the body circulates blood and how
the heart works.
8. BLOOD CIRCULATION
• The circulatory system is a complicated network of blood vessels that circulates blood throughout the
body. Deoxygenated blood returns to the heart and reaches the right atrium via the superior and inferior
vena cava. It then enters the right ventricle via the tricuspid valve. When the right ventricle contracts,
deoxygenated blood is forced via the pulmonary valve and into the pulmonary artery, where it is sent to
the lungs.
• The lungs oxygenate the blood by absorbing oxygen and exhaling carbon dioxide. The pulmonary
veins return oxygenated blood to the heart and enter the left atrium. After going through the mitral
valve, the left ventricle is reached. The aorta, the body's biggest artery, receives oxygenated blood as a
result of the left ventricle's contractions. The aorta's split into smaller arteries allows oxygenated blood
to reach all organs and tissues.
9. BLOOD SUPPLY TO THE HEART
• Regardless of its role in blood circulation, the heart requires a steady supply of oxygen and nutrients to
function properly. The coronary arteries play an important part in this. The left coronary artery and its
branches supply the left side of the heart, whereas the right coronary artery and its branches supply the
right side of the heart.
• Coronary artery disease develops when the coronary arteries constrict or become occluded as a result
of plaque buildup. This condition restricts blood supply to the heart muscle, resulting in symptoms
such as angina (chest discomfort) or, in extreme cases, a heart attack (myocardial infarction). Timely
intervention, such as medication, lifestyle changes, or surgical procedures such as angioplasty or
coronary bypass surgery, can help restore blood flow while avoiding further complications.
10. COMMON DISORDERS OF HEART
The human heart is prone to a variety of illnesses that can impair its structure and function. Among the
most frequent heart conditions are:
• Coronary Artery Disease (CAD): This condition develops when the coronary arteries constrict or
obstruct, resulting in less blood reaching the heart muscle.
• Heart Failure: Chronic illness known as heart failure affects the heart's ability to pump blood
effectively. Numerous underlying conditions, such as coronary artery disease, excessive blood
pressure, or past heart attacks, may be the cause.
• Arrythmias: Heart rhythm irregularities are known as arrhythmias. A fast heartbeat (tachycardia), a
slow heartbeat (bradycardia), or an irregular heartbeat (atrial fibrillation) are some of their
symptoms.
• Valvular Heart Disease: Valvular heart disease is caused by defective or damaged heart valves,
which impair the heart's capacity to regulate blood flow adequately.
• Congenital Heart Defects: These are structural heart defects that are present at birth. They can
range from simple flaws that have no effect on health to severe disorders that necessitate surgical
intervention.