These are the pharmacological agent which when administered externally relieves mild or moderate pains without degree of consciousness called as Analgesics are worked against the pain so firstly introduced the Pain sensation.
These are the pharmacological agent which when administered externally , bring loss of all five modalities of sensation with reversible loss of consciousness.
Light
Sound
Taste
Temperature/
Pressure
5. Smell
Diethyl Ether :
Physical Properties :
Colourless ,volatile liq. With pungent odour.
Boil at 350 C , vapor irritant.
Exposed in air , moisture or light , it get convert to ether peroxide and acetic aldehyde , which is irritant in nature
Highly explosive.
Stored in umber colour glass bottle covered with black paper.
10-15 % in inspired air is sufficient for induction of anaesthesia which can be maintained but 4-5 % concentration.
Pharmacological Action
Only a major portion of ether is oxidized in the body and is eliminated through the lungs .
The miscibility of drug with body fluid requires large amount of drug for induction of anesthesia and induction is slow.
Ether irritate the respiratory track and enhance the mucosal secretion.
Drug may causes laryngospasm ,Ether is also known to increase heart rate, blood pressure and blood sugar. It also causes peripheral vasodilation . Ether depresses myocardial contractility.
Advt / Therapeutic effect :
Safest agent in wide margine , also unexperienced hand.
90 mg/100 ml blood Indused anaesthesia
190 mg/100 ml bloodCauses respiratory Track
Not only safe anaesthetics but good analgesic also.
It does not interfere with uterine contractility.
Does not have any effect on liver , kidney , and heat.
No special or complicated apparatus if required.
Eeconomical agent .
general pharmacology is information about drug abd human body mechanism . it shows about route of administration . pharmacological terminologies ADME of bady and their factors. bioavilability of drugs and related factor . general principle of drug action on body . After that descriptioun about mechanism of drug action . factor modifying drug action and dur interaction.
These are the pharmacological agent which when administered externally , bring loss of all five modalities of sensation with reversible loss of consciousness.
Light
Sound
Taste
Temperature/
Pressure
5. Smell
Diethyl Ether :
Physical Properties :
Colourless ,volatile liq. With pungent odour.
Boil at 350 C , vapor irritant.
Exposed in air , moisture or light , it get convert to ether peroxide and acetic aldehyde , which is irritant in nature
Highly explosive.
Stored in umber colour glass bottle covered with black paper.
10-15 % in inspired air is sufficient for induction of anaesthesia which can be maintained but 4-5 % concentration.
Pharmacological Action
Only a major portion of ether is oxidized in the body and is eliminated through the lungs .
The miscibility of drug with body fluid requires large amount of drug for induction of anesthesia and induction is slow.
Ether irritate the respiratory track and enhance the mucosal secretion.
Drug may causes laryngospasm ,Ether is also known to increase heart rate, blood pressure and blood sugar. It also causes peripheral vasodilation . Ether depresses myocardial contractility.
Advt / Therapeutic effect :
Safest agent in wide margine , also unexperienced hand.
90 mg/100 ml blood Indused anaesthesia
190 mg/100 ml bloodCauses respiratory Track
Not only safe anaesthetics but good analgesic also.
It does not interfere with uterine contractility.
Does not have any effect on liver , kidney , and heat.
No special or complicated apparatus if required.
Eeconomical agent .
general pharmacology is information about drug abd human body mechanism . it shows about route of administration . pharmacological terminologies ADME of bady and their factors. bioavilability of drugs and related factor . general principle of drug action on body . After that descriptioun about mechanism of drug action . factor modifying drug action and dur interaction.
Introduction
Pharmacy & therapeutic committee (PTC)
Hospital formulary
Infection control committee
In these days of modern medicine, a large number of drugs are available for the treatment of a disease.
Considering the complexities surrounding their effective use, it is necessary for the hospital to establish a system to bring the best medicinal agents to the attention of the medical staff and help them in proper selection of therapeutic substances.
In order to ensure proper rationality in the use of drugs a “PHARMACY AND THERAPEUTIC COMMITTEE” need to be organized and constituted in a hospital.
It is an advisory group of medical staff and the administration of hospital on matters related to the therapeutic use of drugs.
FUNCTIONS
To advise the medical staff on usage of drugs.
To develop and compile formulary of drugs accepted for use in the hospital.
To plan/establish suitable educational programs.
To review adverse drug reactions.
To make recommendations concerning drugs to be stocked in hospital patient care areas.
To advise the pharmacy in the implementation of effective drug distribution and control procedures.
HOSPITAL FORMULARY
Hospital Formulary is defined as a list of drugs used in the hospital.
Formulary system is method whereby the medical staff of an institution, working through the PTC, evaluates, appraises, and selects from among the numerous available drug entities & drug products those that considered most useful in patient care.
A hospital pharmacy is a department within a hospital that prepares, compounds, stocks and dispenses inpatient medications.
What is the role of hospital pharmacist?
Hospital pharmacists work in hospital pharmacy services belong to the MOH as well as the private sector. Pharmacists work in this field are responsible for dispensing of medications, quality testing, formulating and re-formulating dosage forms, monitoring and reporting drug safety, and preparing budges for medications.
The aim of presentation is to provide information related to pharmacy Act, 1948.
Introduction
Definition
Pharmacy Council of India
State pharmacy Council
Registration of pharmacists
Offences and penalties
Asthma is a chronic disease involving the airways in the lungs.
Asthma is a condition in which your airways narrow and swell and may produce extra mucus.
This can make breathing difficult and trigger coughing, a whistling sound (wheezing) when you breathe out, and shortness of breath.
National Pharmaceutical Pricing AuthorityP.N.DESHMUKH
National Pharmaceutical Pricing Authority established by the central government on dated 29 th August 1997 as an independent, autonomous regulator.
Drugs Price Control Order,2013 explained Retail Prices of a scheduled Formulation,Ceiling price of a scheduled formulation,Pharmaceutical
Policy 2002,and National List of Essential Medicines (NLEM).
Community Pharmacy Management
Layouts of Pharmacy stores
Selection of staff for drug store
Arrangement of drugstore
Codification of drugs
Maintains Various registers
Use of computers in Drug store
Definition of Prescription
Parts Prescription
Handling of Prescription
legality & identification of medication related problems like drug interactions.
Patient information leaflets,about disease or drugs,second pharmD ,COMMUNITY ...MerrinJoseph1
DR. Merrin Joseph, Department of pharmacy practice
Patient Counseling ,Second pharm D Community Pharmacy ,Patient information leaflets,about drugs,about drugs,definition,scope,design,layout ,content of leaflets
Introduction
Pharmacy & therapeutic committee (PTC)
Hospital formulary
Infection control committee
In these days of modern medicine, a large number of drugs are available for the treatment of a disease.
Considering the complexities surrounding their effective use, it is necessary for the hospital to establish a system to bring the best medicinal agents to the attention of the medical staff and help them in proper selection of therapeutic substances.
In order to ensure proper rationality in the use of drugs a “PHARMACY AND THERAPEUTIC COMMITTEE” need to be organized and constituted in a hospital.
It is an advisory group of medical staff and the administration of hospital on matters related to the therapeutic use of drugs.
FUNCTIONS
To advise the medical staff on usage of drugs.
To develop and compile formulary of drugs accepted for use in the hospital.
To plan/establish suitable educational programs.
To review adverse drug reactions.
To make recommendations concerning drugs to be stocked in hospital patient care areas.
To advise the pharmacy in the implementation of effective drug distribution and control procedures.
HOSPITAL FORMULARY
Hospital Formulary is defined as a list of drugs used in the hospital.
Formulary system is method whereby the medical staff of an institution, working through the PTC, evaluates, appraises, and selects from among the numerous available drug entities & drug products those that considered most useful in patient care.
A hospital pharmacy is a department within a hospital that prepares, compounds, stocks and dispenses inpatient medications.
What is the role of hospital pharmacist?
Hospital pharmacists work in hospital pharmacy services belong to the MOH as well as the private sector. Pharmacists work in this field are responsible for dispensing of medications, quality testing, formulating and re-formulating dosage forms, monitoring and reporting drug safety, and preparing budges for medications.
The aim of presentation is to provide information related to pharmacy Act, 1948.
Introduction
Definition
Pharmacy Council of India
State pharmacy Council
Registration of pharmacists
Offences and penalties
Asthma is a chronic disease involving the airways in the lungs.
Asthma is a condition in which your airways narrow and swell and may produce extra mucus.
This can make breathing difficult and trigger coughing, a whistling sound (wheezing) when you breathe out, and shortness of breath.
National Pharmaceutical Pricing AuthorityP.N.DESHMUKH
National Pharmaceutical Pricing Authority established by the central government on dated 29 th August 1997 as an independent, autonomous regulator.
Drugs Price Control Order,2013 explained Retail Prices of a scheduled Formulation,Ceiling price of a scheduled formulation,Pharmaceutical
Policy 2002,and National List of Essential Medicines (NLEM).
Community Pharmacy Management
Layouts of Pharmacy stores
Selection of staff for drug store
Arrangement of drugstore
Codification of drugs
Maintains Various registers
Use of computers in Drug store
Definition of Prescription
Parts Prescription
Handling of Prescription
legality & identification of medication related problems like drug interactions.
Patient information leaflets,about disease or drugs,second pharmD ,COMMUNITY ...MerrinJoseph1
DR. Merrin Joseph, Department of pharmacy practice
Patient Counseling ,Second pharm D Community Pharmacy ,Patient information leaflets,about drugs,about drugs,definition,scope,design,layout ,content of leaflets
The term “opiate” refers only to substances with morphine-like activity that are structurally related to morphine. Opioids are sometimes referred to as “narcotic analgesics” and opioid receptor antagonists as “narcotic antagonists”
ANATOMY :
It is the study of structure of whole body as well as its
different individual parts and their relationship amongst
each other.
PHYSIOLOGY :
It deals with the function of the body parts, and
their synchronized working to co-ordination of the
whole body
Surface anatomy : It is the study of the external surface of the body and different marking present .
Gross anatomy : It is the macroscopic study gross organ of the body
Systemic anatomy : It deals with the structure study of different system of the body , such as digestive system , nervous system etc.
Regional Anatomy : It is the study of specific region of the body such as thorax . Abdomen , chest , head etc. from anatomy point of view
Developmental anatomy : It is study of structural feature during development of the fertilized egg to adult form .
Cytology : It is the microscopic study of the structural feature of tissues.
Embryology : Initial eight week developmental study
of structure of fertilized egg.
Teratology: Study of congenital malformations.
Radiological anatomy: Study of anatomy using radiological techniques like: X-rays,CT (computed tomography) scans, MRI (medical resonance imaging).
Applied anatomy: It is anatomical knowledge with clinical application, useful for diagnosis and surgical procedures
Cell Physiology : Deals with the study of different functional characteristics of cell and its organelles .
2) System Physiology : study of function of different organ system of body
3) Cardiovascular Physiology : Study of function of heart and blood vessel
4) Renal Physiology : Deals with study of function of Kidney .
An institution providing medical and surgical treatment and nursing care for sick or injured people.
By WHO "Directory of Hospitals in India, 1988" is to some extent simple and short.
According to this,
definition. "A hospital is an institution which is operated for the medical surgical and/or obstetrical care of in-patients and which is treated as a hospital by the Centrally State Government/Local bodies or licensed by the appropriate authority.
1. Patient care:- patient care involves diagnosis, treatment ofllness or injury preventive medicine, rehabilitation, convalescent care, dental care, personalized services
2. Education services :- The education services are two form:-
a. Medical & allied health profession education: - Teaching of physician nurses, pharmacist, medical technologist, medical social service worker, hospital administration & training, dietician etc.
b. Patient education: - children, general education, social education for rehabilitation health care & also patient counseling.
3.Research: - Research is important to advanced medical knowledge against disease & to improve hospital service. This is important for better health care of patient.
4. Public health care: - public health is important to assist the community to reduce chance of illness & to improve general health population.
joint is site at which bone are together and creating work .
in that discussed definition . structure and function of joint .
disorder of joint briefly discussed
Osseous system II , is the appendicular skeletal system , it representing about the bone of pectoral girdle , pelvic girdle and upper limbs and lower limbs. structure and function of humerus , radius ulna and structure and function of femur , tibia fibula.
It is skeletal system of human body in detail description. In this ppt gives axial skeleton of body cranium thoracic cage and Vertibral coloumn . i gave structure and function of the bone , parts of axial skeleton with diagram
Autocoids are the self treating substance and local hormones . which is create changes in body Phisiology on the situation of to admine poisonous as well as foreign substance.
in this ppt gives Physiology of 5HT , Prostaglandin, and Histamine with their clinical use and adverse effect.
Also discussed about anti histamine , 5 HT antagonist with suitable examples.
It is whole study about animal cell . Componant of cell well described with their function . Structure of organals also seen in presentation . Also gives Homeostatic mechanism of body and how to wor it .
Cell divission frieflys described with their phases And types .
Patient Councelling on Hypertension.pptxSwatiingle7
on that presentation include how to counselling on mild hypertension patient . How to produce it , which medicine gives and what is the side effect with their contraindication . and Informative presentation about primary hypertension. The hypertension is not curable disease but it is preventable as well as live long with this condition .
drug relative to eyes with their meiotic and mydriatic effect.
In the presentation discus about spasm of accommodation and cycloplegic action on eye . pharmacological action , dosage also discussed of condition developed on eye i.e. Glaucoma
Briefly describe sedative hypnotic drug with their classification and mechanism , therapeutic effect , adverse effect and dose preparation . this presentation is useful for pharma student .
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
2. • These are the pharmacological agent which when
administered externally relieves mild or moderate pains
without degree of consciousness called as Analgesics are
worked against the pain so firstly introduced the Pain
sensation.
Define PAIN :
Pain is an unpleasant sensation which
inform about structural and functional changes
in body and act as warning signals against
disturbance .
3. 1. Superficial / cutaneous pain :
Arising from skin , superficial mucous membrane and nerve.
2. Deep , non-visceral Pain :
From muscle , joint ligaments
3. Visceral Pain :
It is diffused , not easily localized , is associated with sweating ,
nausea fall in B.P.
4. 1) Severe pain :
Associated with
malignancy , burn
Parturation(childbirth) ,
fracture.
2) Mild Pain :
Associated with
headache , Bodyach , arthralgia
, myalgia , neuralgia .
4. Referred Pain :
deep pain which may sometimes misinterpreted as if
it is coming from some part of the body other than actual site of
stimulation.
5. Psychogenic / Functional pain :
Vegue pain and not related to anatomical part of the body
5. Neurophysiology of Pain :
• Physiologically, pain occurs when
sensory nerve endings
called nociceptors (also referred
to as pain receptors) come into
contact with a painful or noxious
stimulus.
• The resulting nerve impulse
travels from the sensory nerve
ending to the spinal cord, where
the impulse is rapidly shunted to
the brain via nerve tracts in the
spinal cord and brainstem.
• The brain processes the pain
sensation and quickly responds
with a motor response in an
attempt to cease the action causing
the pain.
Pain Process
6. (a) Naturally occurring opium alkaloid
e.g. Morphine , codeine
(b) semisynthetic derivatives :
e.g. Heroine , Dihydromorphine
(c) Synthetic Derivatives :
e.g. Pethidine and methadone
8. Phenanthreen Derivatives
Pharmacological action of drug :
Morphine :
• It is used as sulphate or hydrochoride , most important alkaloid in
Opium.
• Morphine and It’s serrogates produced their major effect on CNS
and GIT.
1. On CNS :
(a) Analgesia :
• Morphine produced analgesia ,drowsiness , changes in mood and
mental clouding .
• Morphine , when administered , externally rilieves severe pain
associated with trauma , fracture , malignancy , burn , parturition,
acute pericardities , pleurisy .by the mechanism of
# To elevate the threshold for Painful stimulus.
# To alter the emotional reaction to pain .
Opioid (Narcotic ) analgesics
9. (b) Euphoria , Sedation , Hypnosis :
• morphine Produced sensation of well being called Euphoria .
If the drug is continuous to compelled it leads to addiction .
• Particularly in pain-free individual , it may produced sence of
anxiety and fear known as dysphoria.
• Sedation induced by morphine is charecterised by drowsiness ,
Decreased Physical activity ,difficult to concentration .
2) Respiration : Morphine Produced depression of
respiration by ,
• By direct depression action on brain steam respiratory centre.
• By reducing sensitivity of the medullary respiratory centre to
increase plasma CO2 concentration .
e.g. a man death from morphine , by due to respiratory attack .
.
10. 3) Pupil :
• Morphine and it’s surrogates cause constriction of pupil
( Miosis ) in man with characteristics pin point pupils .
• The MAO is due to action on Edlinger Westphal nucleus of
occulomotor nerve.
• Morphin produced pin point miosis.
• Miosis or myosis a medical term referring to excessive constriction
of the pupils, as a result of drugs or diseases.
11. 4) Nausea and Vomiting :
• It produced vomiting by stimulation of chemoreceptor trigger
zone (CTZ)in area of postrema medulla.
• Large dose , morphine depress the vomiting Centre . Thus in case
of morphine poisoning , vomiting is absent .
5) Cough :
• Morphine depress the cough reflex by directly depressinig
medullary cough center.
6) On GIT :
• Morphine reduces tone , motility , peristalsis of smooth
muscles of GIT , reduced all digestive enzymes and leads to constipation
12. .
Absorption, fate, Excretion of Morphine :
• When administered orally , absorption is slow and
incomplete.
• Morphine exist in Plasma , partly bound to plasma proteins
and partly free .
• It is conjugated with glucouronic acid and excreted through
urine.
Side Effect :
• Euphoria followed dysphoria .
• Constipation
• Mental clouding
• Nausea, vomiting
• Headache, Fatigue.
13. Therapeutic Uses / Applications :
1. For relief Pain
2. It is good analgesics to relieve severe types of pain associated
in Myocardial infarction, fracture of long bone , burns,
terrminal stage of malignancy , pulmonary embolism ,acute
pericardities .
3. Preanaesthetic agent
4. Valuable agent in acute left ventricular failure
5. Tincture of opium used for constipation .
Preparations :
• Tincture of Opium I.P. 0.3 to 2.0 ml orally
• Morphine sulphate injection , I.P. 10 mg ampoule
10 to 20 mg subcutaneously
14. Morphine should not be used in following condition ;
Head ach / brain injury
Undignosed abdominal pain
With phenothiazine mono amino oxidase inhibitors
Hypovlumic shock
In old patient and infant
Contraindication :
15. Causes :
• Clinically overdoses
• Accidental or intentional overdosing
addiction by addict .
Symptoms :
• Pin point miosis
• Respiratory depression
• Nausea and Vomiting
• Clammy , Pale skin
16. (a)Symptomatic
• If intoxication by mouth , gastric lavage is advised
• If respiration is badly hampered , artificially respiration is
achieved
(b) Drug treatment :
• Pure antagonist Naloxone
Trade name Narcan
Dose 0.4 mg I/V
• Partial antagonist Nalophine
Trade name Lethidrone
Dose 10 mg I/V
17. Codeine :
• Much less potent analgesic than morphine .
• No depression of respiration and less addiction liability .
• It is most commonly used as an antitussive .
Papaverine :
• Devoid of Narcotics and analgesic activity .
• Has relaxant action on smooth muscle.
Noscopine :
• Has significant anti-tussive action.
• It has wide application in therapy of cough .
Other Phenanthrene Alkaloid of Opium :
Benzyl Isoquinoline Alkaloids of Opium
18. Non-narcotic / Non opioid / NSAID/
antipyretics
Non narcotics analgesics are Non narcotics analgesics are drug which produced
relief from pain and lower elevated body temperature , the also possess anti-
inflammatory activity.
Classification
1. Salicylic acid derivatives : e.g. Acetyl Salicylic
acid ,
sodium salicylate
2. Para amimo phenol derivatives : e.g.
Paracetamol
3. Pyrozole derivatives : e.g. Oxyphenbutazone
4. Indole derivatives : e.g. Indomethacin
19. Pharmacology of NSAID
Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and
diclofanac are the most commonly prescribed drugs for arthritis,
inflammation, and cardiovascular protection. However, they cause
gastrointestinal complications such as ulcers and erosions. The
pathophysiology of these complications has mostly been ascribed to NSAID’s
action on the cyclooxygenase (COX) inhibition and the subsequent
prostaglandin (PG) deficiency. Here’s some Pharmacology mnemonics.
Beneficial effects of inhibition of prostaglandin synthesis by NSAIDs (remember of
5 A’s)
Analgesia
Antipyretic
Anti-inflammatory
Antithrombotic
Arteriosus (NSAIDs for closure of patent ductus arteriosus)
20. 1. On respiration
Direct action on medullary respiratory Centre.
Indirect action by increasing plasma carbon-dioxide concentration.
2. On GIT :
Salicylates ingestion causes dyspepsia high incidence o nausea ,
vomiting , epigastric distress , belching , frank gastric bleeding and
ulcer.
3. On blood system :
Salicylates reduce platelets aggregation , promotes fibrinolysis
,prolongs bleeding time , interfere with the formation of endoperoxide
thromboxane, the chemical mediators essential for Platelets
aggregation.
Other Pharmacological action
21. 4. Uricosuric effect :
Salicylates in small dose 1 – 2 gm./day increase plasma urate level by
interfering urate secretion by distal tubules
Salicylates in large doses 5 mg/day inhibit reabsorption of urate by
proximal tubule .
This result urcosuria.
5. Hepatic and renal effect :
Increase secretion of bile
Large dose Acute hepatic necrosis
High dose Increase urine cell count , Tracess of albumin .
6 Metabolic effect :
Hyperpyrexia due to large dose .
22. Side effects of NSAIDs (remember of NSAID):
Swelling
Damage of Stomach Wall (ulcer)
All Allergy
Impaired renal function