The document discusses various classes of analgesics including opioids, adjuvant analgesics, and NSAIDs that are used to treat different levels of pain. It describes different opioid medications including natural and synthetic opioids, how they work on opioid receptors in the body, and their uses, benefits, risks, and nursing considerations for administration and monitoring. The goal of pain management is to effectively treat pain while minimizing risks and improving patient quality of life.
Opioid analgesics are the important group of medications used in pain management. The present seminar has been prepared by referring to standard textbooks of pharmacology and presented point wise for easy understanding.
This interesting ppt is the continuation of the Pharmacology of Opioid analgesics I... This impressive ppt highlight the pharmacology, advantages and disadvantages of opioid analgesics other than morphine with illustrations....!!
The term “opiate” refers only to substances with morphine-like activity that are structurally related to morphine. Opioids are sometimes referred to as “narcotic analgesics” and opioid receptor antagonists as “narcotic antagonists”
Opioid analgesics are the important group of medications used in pain management. The present seminar has been prepared by referring to standard textbooks of pharmacology and presented point wise for easy understanding.
This interesting ppt is the continuation of the Pharmacology of Opioid analgesics I... This impressive ppt highlight the pharmacology, advantages and disadvantages of opioid analgesics other than morphine with illustrations....!!
The term “opiate” refers only to substances with morphine-like activity that are structurally related to morphine. Opioids are sometimes referred to as “narcotic analgesics” and opioid receptor antagonists as “narcotic antagonists”
People complaint that fat in milk increases the content of cholesterol in their body in their body in their causing some disease. To get rid of this complaint people can go for skimmed milk. Previously the availability of cattle farm was more and the population was less. To carry out all the day-to-day life activities. Energy is needed. Food gives energy. Hence, it is imitable for any human being to intake food. One of the important factors that must be considered in food is its nutritious value.
Water and wastewater distribution networks are an essential part of the water cycle and a major tool in the preservation of water resources. A smart water network is an integrated set of solutions that enable utilities to remotely and continuously monitor the network, manage maintenance issues and use data to optimise all aspects of the water distribution network. Find out more at http://www.degremont.com.au/municipal/solutions/networks/
Regulatory Aspects of Continuous Pharmaceutical ManufacturingAjaz Hussain
Digital Pharma Manufacturing RoundtableKronberg, Germany, March 17 2017
A story about manufacturing two products, medicinal product and documented data, and a “little secret”
10 years of BRITE: Looking Back to the Future of the Digital Business RevolutionDavid Rogers
Since its inception 10 years ago, the BRITE conference has featured the leading innovators, disruptors, and brand makers pioneering a path for business in the digital age. In this speech, BRITE’s founder, David Rogers (author, "The Digital Transformation Playbook"), looks back at the lessons we’ve learned and the predictions that we heard. And he shares five guiding principles for the future, with a vision for where digital transformation is taking business in the next 10 years.
Web-formation | L'Obeya pour le pilotage de projets Lean DéveloppementXL Groupe
Ronan Hémidy analyse la force d'un Obeya et partage certaines de ses expériences pour optimiser l’impact des Obeyas sur une organisation de Projet(s).
Retrouvez le replay de cette web-conférence sur notre chaîne Youtube : http://buff.ly/2kWIQWD
Historical Texts: visualising digital collectionsJisc
This demo will showcase Jisc Historical Texts and new collections, features and visualisations that have been developed over the last year.
Historical Texts provides access to a wide range of historically significant digital collections that are heavily used in teaching, learning and research including Early English Books Online (EEBO), Eighteenth Century Collections Online (ECCO) and 65,000 texts from the British Library.
A number of innovative visualisations such as hospital maps, wall of images, timelines, and body parts search have been developed to aid the exploration of the content.
The Aviation API Economy: More than SWIM and WaterfallAlex Brooker
Lessons from the SWIM Masterclass, XMAN and recent launch of the IHS Jane’s 2016 award winning Laminar Data platform in March 2016, bringing operational SWIM to a wider market. What is the Aviation API Economy and what is the role of SWIM alongside other ubiquitous web standards and ways of working? When a slow moving industry meets internet speed ideas - what are the challenges and opportunities? How can the latent value within operational data be applied to new use cases? This talk relays some lessons on real world APIs, customer feedback, Agile vs Waterfall, SWIM vs non-SWIM, and Cloud vs Edge.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ocular injury ppt Upendra pal optometrist upums saifai etawah
Opioids
1.
2. Medications that relieve pain without causing
loss of consciousness “Painkillers”
Classes of analgesics:
◦ Opioids (moderate to severe pain)
◦ adjuvant analgesic drugs.
3. An unpleasant
sensory and
emotional
experience
associated with
actual or potential
tissue damage
5. Level of stimulus needed to produce the
sensation of pain
Pain receptors: mu, kappa, and delta.
6. Mu, kappa and delta
Opioid drugs also react with these receptors and
thus relieve pain, so these receptors also called
OPIOID RECEPTORS.
Each receptor family exhibits a different specificity
for the drug(s) it binds.
The analgesic properties of the opioids are primarily
mediated by the μ receptors that modulate
responses to thermal, mechanical, and chemical
nociception.
7. The κ receptors in the dorsal horn also contribute
to analgesia by modulating the response to
chemical and thermal nociception.
8. Body has endogenous pain killers
◦ Enkephalins
◦ Endorphins
The goals of pain management include
reducing and controlling pain, improving
body function and quality of life.
9. Assist primary drugs in relieving pain, this
produce synergistic effects.
◦ NSAIDs
◦ Antidepressants
◦ Anticonvulsants
◦ Corticosteroids
10. Very strong pain relievers
Pain relievers that contain opium, derived from
the opium poppy or chemically related to
opium.
12. They can be classified according to:
◦ Their chemical structure.
◦ Their action at specific receptors.
Of the 20 different natural alkaloids, only three are
clinically useful: morphine, codeine, and papaverine.
Relatively simple synthetic chemical modifications of
these opium alakaloids are produced the three different
chemical classes of opioids: morphine-like drugs,
meperidine-like drugs, and methadone-like
drugs.
15. Main use: to alleviate moderate to severe pain.
Opioids are also used for:
◦ Cough center suppression
◦ Treatment of diarrhea
◦ Balanced anesthesia
16. Control postoperative and other types of pain.
Morphine rapidly enters all body tissues, including
the fetuses of pregnant women.
17.
18. Short duration of action 4 hours.
Given usually I.V OR I.M
Orally given is absorbed buterratic and slow.
Spasm in sphincter of oddi.
Lead to spasm in anal sphincter---constipation.
Cerebral vasodilatation ---increase cerebral pressure.
Release histamine.
Decrease the sensitivity of respiratory center to CO2.
19.
20. Is a weak analgesic compared to
morphine.
It should be used only for mild to
moderate pain.
Dextromethorphan a nonopioid cough
suppressant, is often given instead.
21. Derivative from morphine
Higher addiction potential.
Higher euphoria.
Shorter duration of action.
Higher penetration to the CSF
Compared to morphine.
22.
23.
24. used in Anesthesia.
Used to management Postoperative and
procedural pain.
Rapid onset and short duration.
25. Sufentanil , alfentanil , and remifentanil are three
synthetic opioid agonists related to fentanyl.
They differ in potency and metabolic disposition.
Sufentanil is even more potent than fentanyl,
whereas the other two are less potent and shorter
acting.
These agents are mainly used for their analgesic
and sedative properties during surgical
procedures requiring anesthesia.
26. Used as analgesic.
Used in the controlled withdrawal of dependent
abusers from heroin and morphine.
27. Methadone [METH-a-done] is a synthetic, orally
effective opioid that has variable equianalgesic
potency compared to that of morphine, and the
conversion between the two products is not linear.
Methadone induces less euphoria and has a
longer duration of action.
The actions of methadone are mediated by μ
receptors. In addition, methadone is an antagonist
of the N-methyl-d-aspartate (NMDA)
28. Used for acute pain.
Can be administered orally or I.M.
Meperidine is very lipophilic and has
anticholinergic effects, resulting in an
increased incidence of delirium as
compared to other opioids.
29. Meperidine [me-PER-i-deen] is a lower-potency synthetic opioid
is very lipophilic and has anticholinergic effects, resulting in an increased incidence
of delirium as compared to other opioids.
The duration of action is slightly shorter than that of morphine and other opioids.
Meperidine also has an active metabolite (normeperidine) that is renally excreted.
Normeperidine has significant neurotoxic actions that can lead to delirium,
hyperreflexia, myoclonus, and possibly seizures.
Due to the short duration of action and the potential for toxicity,meperidine should
only be used for short-term (≤48 hours) management of pain. Other agents are
generally preferred.
Meperidine shouldnot be used in elderly patients or those with renal insufficiency,
hepatic insufficiency, preexisting respiratory compromise, or concomitant or recent
administration of MAOIs.
Serotonin syndrome has also been reported in patients receiving both
meperidine and selective serotonin reuptake inhibitors (SSRIs).
30. partial agonists used for opioid detoxification
Mixed agonist-antagonist
31. Contraindicated in:
Known drug allergy
Severe asthma
Use with extreme caution if:
Respiratory insufficiency
Elevated intracranial pressure
Sleep apnea
32. Euphoria
CNS depression
Nausea and vomiting
Urinary retention
Diaphoresis and flushing
Constipation
33. naloxone I.V (Narcan): half-
life is about 1 hour.
naltrexone oral (Revia), has
longer duration of action.
These drugs are used in the
management of both opioid
overdose and opioid
addiction( block the effect of
any future opioid dose)
34. When treating an opioid overdose or toxicity, the
nurse must recognize the signs and symptoms of
withdrawal.
A gradual dosage reduction after chronic opioid
use, when possible, generally helps to minimize
the risk and severity of withdrawal symptoms.
35.
36.
37. Stimulation of the patient may be adequate to reverse
mild hypoventilation.
Is this is unsuccessful, ventilator assistance using a bag
and mask or endotracheal intubation may be needed to
support respiration.
Administration of opioid anatagonists may also
necessary to reverse severe respiratory depression.
38. Co-administration of opioids with:
◦ Alcohol.
◦ Antihistamines.
◦ Barbiturates.
◦ Benzodiazepine.
Can result in additive respiratory depression,
seizures, and hypotension.
39. Mechanism of action:
It blocks peripheral pain impulses by inhibition of
prostaglandin synthesis.
It also lowers febrile body temperatures by acting on
hypothalamus.
40.
41. Mild to moderate pain
Fever
Alternative for those who cannot take aspirin
products
Contraindications: known allergy, severe liver
disease and G-6-PD
Adverse effects: is generally well tolerated.
Possible adverse effects include rash, nausea
and vomiting.
42. Overdose, causes hepatic necrosis:
hepatotoxicity.
Long-term ingestion of large doses also
causes nephropathy
Recommended antidote: acetylcysteine
regimen : is more effective when given within 10
hours of overdose. It is available as IV and OP
dose.
43. Maximum daily dose for healthy adults is 4000
mg/day
◦ 2000 mg for elderly or those with liver disease
44. It is a centrally acting analgesic.
Weak bond to the mu receptors and inhibit
reuptake of both norepinephrine and serotonin.
Adverse effects are include drowsiness,
dizziness, headache, nausea, constipation and
respiratory depression.
45.
46. Before beginning therapy, perform a thorough
history.
Assess for potential contraindications and drug
interactions
47. Perform a thorough pain assessment, including
pain intensity and character, onset, location,
description, precipitating and relieving factors,
type, remedies, and other pain treatments
◦ Assessment of pain is now being considered a “fifth
vital sign”
◦ Rate pain on a 0 to 10 or similar scale
48. Be sure to medicate patients before the pain
becomes severe so as to provide adequate
analgesia and pain control
Pain management includes pharmacologic and
nonpharmacologic approaches; be sure to
include other interventions as indicated
49. Patients should not take other medications or
over-the-counter preparations without checking
with their physician
Instruct patients to notify physician for signs of
allergic reaction or adverse effects
50. Ensure safety measures, such as keeping side
rails up, to prevent injury
Withhold dose and contact physician if there is
a decline in the patient’s condition or if vital
signs are abnormal, especially if
respiratory rate is less than 10 to 12
breaths/min
51. Monitor for adverse effects.
Monitor for therapeutic effect.