This document discusses various opioid analgesic drugs, including both natural and synthetic opioids. It describes how opioids act through mu, kappa, and delta opioid receptors in the central nervous system and peripheral tissues to produce analgesia, respiratory depression, and other effects. The document categorizes common opioids like morphine, codeine, heroin, pethidine, fentanyl, methadone, and tramadol. For each opioid, it provides details on pharmacological effects, metabolism, excretion, preparations, doses, uses, and adverse drug reactions.
This interesting ppt is the continuation of the Pharmacology of Opioid analgesics I... This impressive ppt highlight the pharmacology, advantages and disadvantages of opioid analgesics other than morphine with illustrations....!!
This interesting ppt is the continuation of the Pharmacology of Opioid analgesics I... This impressive ppt highlight the pharmacology, advantages and disadvantages of opioid analgesics other than morphine with illustrations....!!
These are the pharmacological agent which when administered externally relieves mild or moderate pains without degree of consciousness called as Analgesics are worked against the pain so firstly introduced the Pain sensation.
Opiod analgesics used in Dentistry by Dr. Amit T. Suryawanshi
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. Analgesic
Are drugs which relieve pain without causing
loss of consciousness
OPIATES: product obtained from the opium
poppy.
OPIOID ANALGESIC: naturally occurring
semi synthetic or synthetic drugs which have
action of relief of pain and depression of CNS.
NARCOTICS ANALGESIC: old term for
opioid analgesic
3. Opioid receptors
These opioid acts through receptors
present in CNS and pheripheral tissue.
Following and there functions
1) µ(mu) : analgesia (supraspinal) ,
respiratory depression, euphoria ,sedation
and physical dependence
2) k(kappa) : analgesia (spinal),
dysphoria , sedation
3) δ delta : analgesia( supraspinal and
spinal )and emotional behaviour
4. CLASSIFICATION OF
OPIOID
NATURAL OPIUM
ALKALIODS
a) phenanthrene derivatives
b) benzylisoquinoline derivatives
Morphine , Codeine
Thebaine
Papaverine
Noscapine
Semisynthetic derivative Heroin
dihydromorphine
apomorphine
Synthetic substitutes Pethidine
methadone
fentanyl
tramadol
5. MORPHINE
Natural opium alkaloid
Opium is the milky exudate of unripe capsules of
the poppy plant (Papaver somniferum)
Classified into
Phenanthrene group : morphine , codeine,
thebaine
Benzylisoquinoline group : papaverine,
noscapine and narcine
6. Pharmacological action
ANALGESIC : relieves severe pain like visceral
pain and pain of trauma
mechanism
1) it elevates the pain stimulus
2) alters emotional reaction to pain
3) produce sleep
CNS : in presence of pain it produces euphoria , absence
of pain produces dysphoria. Increased dose produce
sleep
Respiration: depression of respiration by
a) directly depressing the respiratory centre
b) decreasing the sensitivity of respiratory centre to CO2
7. Pupil : constriction of pupil. This effect will block by
atropine. ..addicts have constricted pupil
Emetic action : in small doses produce vomiting due to
stimulation chemoreceptor trigger zone . In large doses
morphine inhibits vomiting.
Antitussive effect: suppresses cough by depressing
cough center
ADH secretion: release of ADH which results in
decrease in urine output
GIT: decreases peristaltic movements .
It produces spasm of intestinal smooth muscles and
spincters .It increases the absorbtion of water leads to
constipation
CVS : normal dose – no effect
toxic dose produces hypotension
8. Absorption, fate and excretion
Absorption from GIT is slow and incomplete.
Quick effect on subcutaneous inj
Metabolised by conjugation with glucuronic acid
Excreted in urine within 24hours
9. preparation and dose
1) Tincture opium – 0.3 to 2ml by
mouth
2) Morphine sulphate - 8 to 20mg by
mouth or injection
3) Morphine hydrochloride - 8 to 20mg
by mouth or injection
10. ADR
CNS: dysphoria and mental clouding
GIT: nausea, vomit, constipation
Tremor, delirium, skin rshes
Acute morphine poisoning- respiratory
depression, miosis, cynosis, reduced body
tempertaure, hypotension,shock and coma
Depression of foetal respirtion
Drug dependence
11. uses
Analgesic
Treat diarrhoeas
Sedation
Pre aneasthetic medication
Acute left ventricular failure
antitussive
12. Codeine
It is phenanthrene alkaloid.
It has antitussive effect..used to treat
cough, nausea, vomiting, miosis,
addiction are less with codeine.
Less potent analgesic when compared
to morphine
13. PETHIDINE
Synthetic compound
It produces same as morphine
1) analgesic effects
2)spasmogenic effect on smooth muscles and
spincters
3) nausea and vomtting
4)sedation and euphoria
5)respiratory depression
But pethidine does not produce miosis and anti
tussive effect
14. Absorption : well on oral and parenteral.
Metabolised : liver
Excrete : urine
ADR: local irritation on parentral administration
dry mouth, nausea, vomiting
euphoria, dysphoria, coma, convulsions
weakness, palpitation, respitaory depression
depression of foetal respiration
addiction and tolerance
Preparation and dose:
1) pethidine hydrochloride tablets: 25 to 100mg
2) pethidine hydrochloride inj : 25 to 100mg by
subcutaneous or i.m inj and 25 to 50mg by i.v
inj
15. Fentanyl
Pethidine congener
It is 80 to 100 times more potent than morphine.
Highly lipid soluble. So it enters brain easily.
Peak analgesic effect produced in 5 min after
inj.
Duration of action slow.
Used as neuroleptanalgesia
16. Methadone
Synthetic opioid
It has analgesic effect, depressant, emetic
similar to morphine
Used in opioid dependence
Mechasim : it acts in tissues
On discontinuation it is slowly released from
tissues. Mid withdrawal symptoms are mild
17. Tramadol
It is centrally acting analgesic.
Use for post operative pain, chronic pain, labour
pain
Addiction is low