This content is pharmaceutical organic chemistry -1 ,contains about aliphatic amines classification,properties and reactions of aliphatic amines dedicated to all pharmacy & healthcare ,life science students.
This document provides information about carbonyl compounds, specifically aldehydes and ketones. It discusses their IUPAC nomenclature, methods of preparation including oxidation of alcohols and oxidative cleavage of alkenes, and physical and chemical properties. The chemical reactions covered include nucleophilic addition, reduction, condensation, and oxidation reactions. Examples of important aldehydes and ketones are also mentioned along with their structures and uses.
Phenols: methods of preparation, chemical reactionAmbreenKauser2
The document discusses the properties and reactions of phenols. Phenols contain a hydroxyl group directly attached to a benzene ring. They are more acidic than alcohols due to resonance stabilization of the phenoxide ion. Phenols undergo electrophilic aromatic substitution at the ortho- and para-positions. They are also oxidized by strong oxidizing agents. Common phenols include phenol, cresols, and resorcinol. Phenol is used as an antiseptic and in making resins, plastics and drugs. Cresols are used as herbicides, antioxidants and preservatives. Resorcinol is used as an antiseptic and disinfectant.
Definition, Classification, Basicity, Effect of substituents on basicity of amines, Preparation, reaction, Identification test, Structure and Uses of amines
1) Amines act as bases according to both Lewis and Bronsted-Lowry theories due to their ability to donate a lone pair of electrons or accept a proton.
2) The basicity of amines depends on factors such as the stability of the conjugate acid formed, inductive effects, and hydrogen bonding capabilities. In general, aliphatic amines are stronger bases than aromatic amines.
3) Within aliphatic amines, the order of basicity from strongest to weakest is typically tertiary > secondary > primary > ammonia in the gas phase. In aqueous solution, primary amines are stronger bases due to hydrogen bonding of the conjugate acid form.
This document provides information about carbonyl compounds, specifically aldehydes and ketones. It discusses their IUPAC nomenclature, methods of preparation including oxidation of alcohols and oxidative cleavage of alkenes, and physical and chemical properties. The chemical reactions covered include nucleophilic addition, reduction, condensation, and oxidation reactions. Examples of important aldehydes and ketones are also mentioned along with their structures and uses.
Phenols: methods of preparation, chemical reactionAmbreenKauser2
The document discusses the properties and reactions of phenols. Phenols contain a hydroxyl group directly attached to a benzene ring. They are more acidic than alcohols due to resonance stabilization of the phenoxide ion. Phenols undergo electrophilic aromatic substitution at the ortho- and para-positions. They are also oxidized by strong oxidizing agents. Common phenols include phenol, cresols, and resorcinol. Phenol is used as an antiseptic and in making resins, plastics and drugs. Cresols are used as herbicides, antioxidants and preservatives. Resorcinol is used as an antiseptic and disinfectant.
Definition, Classification, Basicity, Effect of substituents on basicity of amines, Preparation, reaction, Identification test, Structure and Uses of amines
1) Amines act as bases according to both Lewis and Bronsted-Lowry theories due to their ability to donate a lone pair of electrons or accept a proton.
2) The basicity of amines depends on factors such as the stability of the conjugate acid formed, inductive effects, and hydrogen bonding capabilities. In general, aliphatic amines are stronger bases than aromatic amines.
3) Within aliphatic amines, the order of basicity from strongest to weakest is typically tertiary > secondary > primary > ammonia in the gas phase. In aqueous solution, primary amines are stronger bases due to hydrogen bonding of the conjugate acid form.
This document discusses the stability and reactivity of conjugated dienes. It begins by explaining that conjugated dienes are more stable than isolated or cumulated dienes due to delocalization of pi electrons. This increased stability is demonstrated by their lower heat of hydrogenation. The document then focuses on the Diels-Alder reaction, where a conjugated diene reacts with an alkene to form a cyclohexene ring. It discusses factors that influence the reaction such as the conformation and substituents of the diene. The document also covers 1,2 and 1,4 additions of electrophiles to conjugated dienes and potential rearrangements of carbocation intermediates.
The document discusses carbocations, which are carbon-containing molecules with a positive charge. It defines different types of carbocations based on the groups attached to the charged carbon atom, such as primary, secondary, tertiary, allylic, benzylic, vinyl, and phenyl carbocations. The document also discusses the structure, stability, and rearrangement of carbocations. Carbocations can rearrange into more stable configurations by shifting bonds to form secondary or tertiary carbocations. The stability of carbocations is affected by the number of carbon groups attached, neighboring electron-withdrawing groups, and hybridization of the charged carbon atom.
PHENOL INTRODUCTION, REACTIVITY, ACIDITY, FACTOR AFFECTING ON ACIDITY, PREPARATION, REACTION,COMPARISON OF ACIDITY WITH ALCOHOL AND ACID, USES OF PHENOL, CRESOL, RESORCINOL, NAPTHOL
This document discusses various organic chemistry reactions and processes involving hydrocarbons including alkanes, alkyne, conjugated dienes, and dienes. It covers topics such as the Wurtz reaction, controlled oxidation, isomerization, cyclization, aromatization, ozonolysis, and preparations and synthesis of these hydrocarbon compounds.
Classification, Nomenclature and structural isomerism of organic compound Ganesh Mote
Classification of organic compound, Nomenclature of alkane, alkene, alkyne, alcohol, alkyl halide, aldehyde, ketone, carboxylic acid and its derivatives, amines, ethers, polyfunctional groups and structural isomerism of organic compounds
The aldol condensation reaction involves the reaction of two carbonyl compounds in the presence of a strong base to form a β-hydroxyaldehyde or β-hydroxyketone. The reaction proceeds through the formation of an enolate ion intermediate that acts as a nucleophile, attacking the carbonyl carbon of the other molecule. This forms a carbon-carbon bond between the α-carbon of the donor molecule and the carbonyl carbon of the acceptor molecule. The aldol condensation reaction is useful for synthesizing larger molecules from simple starting materials and plays an important role in biochemical processes such as gluconeogenesis.
This document provides an overview of alkyl halides including their definition, classification, methods of preparation, reactions, and uses. It discusses the SN1 and SN2 substitution reactions in depth, including their mechanisms, stereochemistry, factors affecting the reactions like the leaving group, nucleophile, and solvents. It compares the SN1 and SN2 reactions and provides examples of common alkyl halides and their uses such as ethyl chloride in refrigeration and tetrachloromethane as a refrigerant.
Unit iii heterocyclic compounds as per PCI Syllabus of POC-IIIGanesh Mote
Nomenclature of hetero cyclic compounds, classification of heterocyclic compounds, Reactivity, aromaticity, orbital picture, stability, resonance energy, resonance structure, basicity, method of preparation, reaction and medicinal uses of Pyrrole, furan and thiophene
1. Aromatic acids contain one or more carboxyl groups directly attached to an aromatic ring. The acidity of aromatic acids is influenced by electron withdrawing and donating groups on the ring through inductive or resonance effects.
2. Electron withdrawing groups increase the acidity of benzoic acid by stabilizing the anion through resonance. Electron donating groups decrease acidity by increasing the electron density of the aromatic ring.
3. Aromatic acids undergo various reactions including salt formation, esterification, acylation, reduction, decarboxylation, and electrophilic substitution.
The document discusses various tests to identify primary, secondary, and tertiary amines. It describes the solubility test, litmus test, carbylamine test, nitrous acid test, azo-dye test, and Hinsberg test. The solubility test checks if a compound dissolves in mineral acid, indicating it may be an amine. The litmus test checks if a compound turns red litmus blue, showing it is basic. The carbylamine, nitrous acid, and azo-dye tests identify primary, secondary, and tertiary amines based on their reactions. The Hinsberg test uses precipitation and solubility patterns to distinguish between the three amine types.
Tryptophan is first hydroxylated to form 5-OH-tryptophan in liver. The reaction is analogous to conversion of Phe - to tyrosine. Liver phenyl alanine hydroxylase also can catalyse hydroxylation of tryptophan. In the next step, 5-OH-tryptophan is decarboxylated, by the enzyme 5-OH-tryptophan decarboxylase, in presence of B6-PO4 to form 5-hydroxy tryptamine (5-HT), also called serotonin. The enzyme is present in kidney, liver and stomach. Aromatic-Lamino acid decarboxylase, widely distributed in tissues can also catalyse this reaction.
THIS SLIDE CONTAIN ABOUT QUALITATIVE TEST, STRUCTURE AND USES OF DIFFERENT CARBONYL COMPOUNDS LIKE FORMALDEHYDE, PARALDEHYDE, ACETONE, CHLORAL HYDRATE, HEXAMINE, BENZALDEHYDE, VANILIN AND CINNAMALDEHYDE
1. The document summarizes nucleic acid metabolism and genetic information transfer. It discusses the biosynthesis and catabolism of purine and pyrimidine nucleotides, organization of the mammalian genome, structure and functions of DNA and RNA, DNA replication, transcription, the genetic code, and translation.
2. Key topics covered include the semi-conservative model of DNA replication, the three stages of transcription (initiation, elongation, termination), the genetic code consisting of 64 codons that code for 20 amino acids and 3 stop codons, and an overview of translation or protein synthesis.
3. The summary provides a high-level overview of the major sections and concepts addressed in the original document relating to nucleic acid metabolism and
Tetra substituted alkenes are the most stable, followed by tri, di, and mono substituted alkenes. Within di-substituted alkenes, the trans isomer is more stable than the cis isomer due to less steric hindrance. The degree of stability is directly proportional to the amount of conjugation and substitution on the alkene. Heat of hydrogenation can be used to determine the relative stability and energy of alkene isomers, with less stable isomers requiring more energy for hydrogenation. For example, cis-2-butene requires more energy than trans-2-butene during hydrogenation.
In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C=O. It is common to several classes of organic compounds, as part of many larger functional groups. A compound containing a carbonyl group is often referred to as a carbonyl compound.
Preparation, reactions, Acidity, effect of substituents on acidity, structure and uses of carboxylic acid and identification tests for carboxylic acid, amide and ester
B.Pharm I Year II Sem. SN1 and SN2 reactions, kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations.
SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions.
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene,
dichloromethane, tetrachloromethane and iodoform.
Alcohols, Qualitative tests for Alcohol, Structure and uses of Ethyl alcohol, chlorobutanol, Cetosterylalcohol, Benzyl alcohol, Glycerol, Propylene glycol
This document discusses amines, including their classification, nomenclature, reactions, and uses. Amines are organic compounds derived from ammonia by replacing hydrogen atoms with hydrocarbon groups. They are classified as primary, secondary, or tertiary based on the number of alkyl or aryl groups bonded to the nitrogen atom. Amines can also be aliphatic, aromatic, or heterocyclic. Their nomenclature follows IUPAC rules based on the parent alkane. Common reactions include functioning as a base, undergoing alkylation, reaction with nitrous acid to form diazonium salts, conversion to amides, and Hoffman elimination from quaternary hydroxides. Aromatic amines are mainly used to produce d
This document discusses the stability and reactivity of conjugated dienes. It begins by explaining that conjugated dienes are more stable than isolated or cumulated dienes due to delocalization of pi electrons. This increased stability is demonstrated by their lower heat of hydrogenation. The document then focuses on the Diels-Alder reaction, where a conjugated diene reacts with an alkene to form a cyclohexene ring. It discusses factors that influence the reaction such as the conformation and substituents of the diene. The document also covers 1,2 and 1,4 additions of electrophiles to conjugated dienes and potential rearrangements of carbocation intermediates.
The document discusses carbocations, which are carbon-containing molecules with a positive charge. It defines different types of carbocations based on the groups attached to the charged carbon atom, such as primary, secondary, tertiary, allylic, benzylic, vinyl, and phenyl carbocations. The document also discusses the structure, stability, and rearrangement of carbocations. Carbocations can rearrange into more stable configurations by shifting bonds to form secondary or tertiary carbocations. The stability of carbocations is affected by the number of carbon groups attached, neighboring electron-withdrawing groups, and hybridization of the charged carbon atom.
PHENOL INTRODUCTION, REACTIVITY, ACIDITY, FACTOR AFFECTING ON ACIDITY, PREPARATION, REACTION,COMPARISON OF ACIDITY WITH ALCOHOL AND ACID, USES OF PHENOL, CRESOL, RESORCINOL, NAPTHOL
This document discusses various organic chemistry reactions and processes involving hydrocarbons including alkanes, alkyne, conjugated dienes, and dienes. It covers topics such as the Wurtz reaction, controlled oxidation, isomerization, cyclization, aromatization, ozonolysis, and preparations and synthesis of these hydrocarbon compounds.
Classification, Nomenclature and structural isomerism of organic compound Ganesh Mote
Classification of organic compound, Nomenclature of alkane, alkene, alkyne, alcohol, alkyl halide, aldehyde, ketone, carboxylic acid and its derivatives, amines, ethers, polyfunctional groups and structural isomerism of organic compounds
The aldol condensation reaction involves the reaction of two carbonyl compounds in the presence of a strong base to form a β-hydroxyaldehyde or β-hydroxyketone. The reaction proceeds through the formation of an enolate ion intermediate that acts as a nucleophile, attacking the carbonyl carbon of the other molecule. This forms a carbon-carbon bond between the α-carbon of the donor molecule and the carbonyl carbon of the acceptor molecule. The aldol condensation reaction is useful for synthesizing larger molecules from simple starting materials and plays an important role in biochemical processes such as gluconeogenesis.
This document provides an overview of alkyl halides including their definition, classification, methods of preparation, reactions, and uses. It discusses the SN1 and SN2 substitution reactions in depth, including their mechanisms, stereochemistry, factors affecting the reactions like the leaving group, nucleophile, and solvents. It compares the SN1 and SN2 reactions and provides examples of common alkyl halides and their uses such as ethyl chloride in refrigeration and tetrachloromethane as a refrigerant.
Unit iii heterocyclic compounds as per PCI Syllabus of POC-IIIGanesh Mote
Nomenclature of hetero cyclic compounds, classification of heterocyclic compounds, Reactivity, aromaticity, orbital picture, stability, resonance energy, resonance structure, basicity, method of preparation, reaction and medicinal uses of Pyrrole, furan and thiophene
1. Aromatic acids contain one or more carboxyl groups directly attached to an aromatic ring. The acidity of aromatic acids is influenced by electron withdrawing and donating groups on the ring through inductive or resonance effects.
2. Electron withdrawing groups increase the acidity of benzoic acid by stabilizing the anion through resonance. Electron donating groups decrease acidity by increasing the electron density of the aromatic ring.
3. Aromatic acids undergo various reactions including salt formation, esterification, acylation, reduction, decarboxylation, and electrophilic substitution.
The document discusses various tests to identify primary, secondary, and tertiary amines. It describes the solubility test, litmus test, carbylamine test, nitrous acid test, azo-dye test, and Hinsberg test. The solubility test checks if a compound dissolves in mineral acid, indicating it may be an amine. The litmus test checks if a compound turns red litmus blue, showing it is basic. The carbylamine, nitrous acid, and azo-dye tests identify primary, secondary, and tertiary amines based on their reactions. The Hinsberg test uses precipitation and solubility patterns to distinguish between the three amine types.
Tryptophan is first hydroxylated to form 5-OH-tryptophan in liver. The reaction is analogous to conversion of Phe - to tyrosine. Liver phenyl alanine hydroxylase also can catalyse hydroxylation of tryptophan. In the next step, 5-OH-tryptophan is decarboxylated, by the enzyme 5-OH-tryptophan decarboxylase, in presence of B6-PO4 to form 5-hydroxy tryptamine (5-HT), also called serotonin. The enzyme is present in kidney, liver and stomach. Aromatic-Lamino acid decarboxylase, widely distributed in tissues can also catalyse this reaction.
THIS SLIDE CONTAIN ABOUT QUALITATIVE TEST, STRUCTURE AND USES OF DIFFERENT CARBONYL COMPOUNDS LIKE FORMALDEHYDE, PARALDEHYDE, ACETONE, CHLORAL HYDRATE, HEXAMINE, BENZALDEHYDE, VANILIN AND CINNAMALDEHYDE
1. The document summarizes nucleic acid metabolism and genetic information transfer. It discusses the biosynthesis and catabolism of purine and pyrimidine nucleotides, organization of the mammalian genome, structure and functions of DNA and RNA, DNA replication, transcription, the genetic code, and translation.
2. Key topics covered include the semi-conservative model of DNA replication, the three stages of transcription (initiation, elongation, termination), the genetic code consisting of 64 codons that code for 20 amino acids and 3 stop codons, and an overview of translation or protein synthesis.
3. The summary provides a high-level overview of the major sections and concepts addressed in the original document relating to nucleic acid metabolism and
Tetra substituted alkenes are the most stable, followed by tri, di, and mono substituted alkenes. Within di-substituted alkenes, the trans isomer is more stable than the cis isomer due to less steric hindrance. The degree of stability is directly proportional to the amount of conjugation and substitution on the alkene. Heat of hydrogenation can be used to determine the relative stability and energy of alkene isomers, with less stable isomers requiring more energy for hydrogenation. For example, cis-2-butene requires more energy than trans-2-butene during hydrogenation.
In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C=O. It is common to several classes of organic compounds, as part of many larger functional groups. A compound containing a carbonyl group is often referred to as a carbonyl compound.
Preparation, reactions, Acidity, effect of substituents on acidity, structure and uses of carboxylic acid and identification tests for carboxylic acid, amide and ester
B.Pharm I Year II Sem. SN1 and SN2 reactions, kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations.
SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions.
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene,
dichloromethane, tetrachloromethane and iodoform.
Alcohols, Qualitative tests for Alcohol, Structure and uses of Ethyl alcohol, chlorobutanol, Cetosterylalcohol, Benzyl alcohol, Glycerol, Propylene glycol
This document discusses amines, including their classification, nomenclature, reactions, and uses. Amines are organic compounds derived from ammonia by replacing hydrogen atoms with hydrocarbon groups. They are classified as primary, secondary, or tertiary based on the number of alkyl or aryl groups bonded to the nitrogen atom. Amines can also be aliphatic, aromatic, or heterocyclic. Their nomenclature follows IUPAC rules based on the parent alkane. Common reactions include functioning as a base, undergoing alkylation, reaction with nitrous acid to form diazonium salts, conversion to amides, and Hoffman elimination from quaternary hydroxides. Aromatic amines are mainly used to produce d
Amines are organic compounds derived from ammonia that contain an amino group. They can be classified as primary, secondary, or tertiary based on how many carbon groups are bonded to the nitrogen. Amines have unpleasant odors, are polar, and act as weak bases. They undergo reactions like nitration, halogenation, and coupling with diazonium salts to form azo dyes. Amines are used to synthesize nylons through condensation polymerization and are also found in dyes, drugs, and other products.
An aliphatic amine has no aromatic ring attached directly to the nitrogen atom. Aromatic amines have the nitrogen atom connected to an aromatic ring as in the various anilines. The aromatic ring decreases the alkalinity of the amine, depending on its substituents. The presence of an amine group strongly increases the reactivity of the aromatic ring, due to an electron-donating effect.
Amines are organized into four subcategories:
Primary amines—Primary amines arise when one of three hydrogen atoms in ammonia is replaced by an alkyl or aromatic. Important primary alkyl amines include, methylamine, most amino acids, and the buffering agent tris, while primary aromatic amines include aniline.
Secondary amines—Secondary amines have two organic substituents (alkyl, aryl or both) bound to the nitrogen together with one hydrogen. Important representatives include dimethylamine, while an example of an aromatic amine would be diphenylamine.
Tertiary amines—In tertiary amines, nitrogen has three organic substituents. Examples include trimethylamine, which has a distinctively fishy smell, and EDTA.
Cyclic amines—Cyclic amines are either secondary or tertiary amines. Examples of cyclic amines include the 3-membered ring aziridine and the six-membered ring piperidine. N-methylpiperidine and N-phenylpiperidine are examples of cyclic tertiary amines.
It is also possible to have four organic substituents on the nitrogen. These species are not amines but are quaternary ammonium cations and have a charged nitrogen center. Quaternary ammonium salts exist with many kinds of anions.
Amines are organic compounds derived from ammonia by replacing one, two, or all of the hydrogen atoms with alkyl or aryl groups. They are classified as primary, secondary, or tertiary based on the number of hydrogens replaced. Amines are found naturally in proteins, vitamins, alkaloids, and hormones, and are also used synthetically in polymers, dyes, drugs like novocaine and antihistamines. Common methods for synthesizing amines include reduction of nitro compounds, reaction of alkyl halides with ammonia, reduction of nitriles and amides, and the Gabriel and Hoffmann reactions. Amines have properties depending on their structure, with lower aliphatic amines being gases and higher ones
1. Amines are organic compounds derived from ammonia by replacing one or more hydrogen atoms with alkyl groups. This document discusses the nomenclature, preparation, and reactions of amines.
2. Amines are named based on whether they contain one, two, or three alkyl groups bonded to the nitrogen atom (primary, secondary, tertiary). Aromatic amines are named after the parent aromatic compound with the suffix -amine.
3. Amines can be prepared through reduction of nitro compounds, halides, amides, nitriles, or amides via Hoffman degradation. Common reducing agents include lithium aluminum hydride and catalytic hydrogenation.
This document discusses the structure, classification, naming, physical properties, preparation, and reactions of amines. It begins by describing amines as derivatives of ammonia with hydrogens and/or alkyl groups attached to the nitrogen atom. Amines can be classified as primary, secondary, or tertiary based on the number of alkyl groups. Common methods for preparing amines include SN2 reactions with alkyl halides, reduction of nitro compounds, and reductive amination of aldehydes and ketones. The document notes that amines act as bases and undergo nucleophilic substitution, electrophilic aromatic substitution, and other reactions similar to ammonia. It provides examples of biologically active amines that function as neurotransmitters, hormones
Amines are organic compounds derived from ammonia by replacing one or more hydrogen atoms with alkyl or aryl groups. They can be classified as primary, secondary, or tertiary depending on the number of alkyl/aryl groups attached to the nitrogen atom. Amines exhibit hydrogen bonding and have higher boiling points than comparable alkanes. They act as bases and react with acids to form salts. Primary amines react with nitrous acid to form nitrogen gas and alcohols/alkenes, while secondary amines form nitrosamines. Aromatic amines are used to synthesize azo dyes through diazonium salt formation. Nylon is produced by condensation polymerization of diamines and dic
This document discusses the structure and properties of amines. It begins by defining amines as carbon-hydrogen-nitrogen compounds that are commonly found in living organisms. It then discusses the bonding characteristics of nitrogen atoms in organic compounds and how this relates to the structures of primary, secondary, and tertiary amines. The document also covers the physical properties, basicity, and reactions of amines, including the formation of amine salts. It concludes by discussing heterocyclic and isomeric amines.
Amines are organic compounds derived from ammonia by replacing one or more hydrogen atoms with alkyl or aryl groups. They can be classified as primary, secondary, or tertiary depending on the number of alkyl/aryl groups attached to the nitrogen atom. Aromatic amines have an amine group directly attached to an aromatic ring. Amines can act as bases by accepting protons. Their basicity depends on factors like substitution, with electron-donating groups increasing basicity. Amines undergo reactions like salt formation with acids, nitrosoamine formation with nitrous acid, amide formation with acyl chlorides/anhydrides, and halogenation of aromatic amines.
Chemistry of aromatic amines, Classification of amines, Preparation, reactions of amines, synthetic uses of aromatic amines, basicity of aromatic amines and factor affecting basicity amine.
This document discusses the properties and reactions of amines. It defines amines as organic derivatives of ammonia with one or more alkyl or aryl groups bonded to the nitrogen atom. Amines are classified as primary, secondary, or tertiary depending on the number of alkyl or aryl groups attached to the nitrogen. The document discusses nomenclature, physical properties, basicity, reactions including salt formation and reactions with acids, and uses of amines such as in the synthesis of nylon and azo dyes.
Class 12 Chemistry introduces students to the fascinating realm of amines, a class of organic compounds that plays a vital role in understanding the intricacies of organic chemistry. In this article, we'll unravel the essential aspects covered in Class 12 Chemistry notes on amines, providing a comprehensive overview for students embarking on this academic journey.
This chapter discusses the structure, classification, nomenclature, physical properties and reactions of amines. Amines are classified as primary, secondary or tertiary depending on the number of carbon groups bonded to the nitrogen atom. The chapter describes various amine structures including aliphatic, aromatic, heterocyclic aliphatic and heterocyclic aromatic amines. It also discusses IUPAC nomenclature rules for naming amines and provides examples of common amine names. The chapter notes that amines are polar compounds that can form hydrogen bonds. It describes amines as weak bases and explains how their basicity depends on their structure. The chapter concludes by giving an example reaction of an amine reacting with an acid to
General Chemistry 2 Assignment - Preparation of amine (Group 13 and 18)H Vignes C Pl
The document discusses various methods for reducing nitro compounds and nitriles to amines. Nitro compounds can be reduced to amines through catalytic hydrogenation using metals like platinum or Raney nickel. They can also be reduced using metals like iron, tin, or zinc in acidic solutions. Nitriles can be reduced to amines using lithium aluminium hydride or hydrogen gas over a metal catalyst. Primary amides can be reduced to primary amines through the Hofmann rearrangement, which involves conversion of the amide to an isocyanate intermediate that then hydrolyzes to form the amine.
The document discusses the classification, nomenclature, properties, preparation, and reactions of amines. Amines are classified as primary, secondary, or tertiary depending on the number of alkyl or aryl groups bonded to the nitrogen atom. They are further divided into aliphatic, aromatic, and heterocyclic amines. Amines are named according to IUPAC nomenclature rules. They are weak bases due to resonance stabilization of the conjugate acid. Common methods for preparing amines include reduction of nitriles, amides, imines, and nitro compounds. Amines react with acids to form water-soluble salts and with nitrous acid to undergo proton-transfer and electrophilic aromatic substitution reactions.
This document discusses the classification, nomenclature, properties, preparation, and reactions of amines. Amines are classified as primary, secondary, or tertiary depending on the number of alkyl or aryl groups bonded to the nitrogen. They are further divided into aliphatic, aromatic, and heterocyclic amines. Amines are named according to IUPAC nomenclature rules. They are weak bases due to resonance stabilization of the conjugate acid. Common methods for preparing amines include reduction of nitriles, amides, imines, and nitro compounds. Amines react with acids to form salts, and with nitrous acid they undergo protonation or reaction with the nitrosyl cation.
This document discusses amines, which are carbon-hydrogen-nitrogen compounds that occur widely in living organisms. Amines are classified as primary, secondary, or tertiary based on how many hydrocarbon groups are bonded to the nitrogen atom. Primary amines have one hydrocarbon group and two hydrogen atoms bonded to nitrogen. Secondary amines have two hydrocarbon groups and one hydrogen bonded to nitrogen. Tertiary amines have three hydrocarbon groups bonded to nitrogen. Amines behave as weak bases and react with acids to form amine salts. Heterocyclic amines contain nitrogen atoms in aromatic or nonaromatic ring structures. Isomerism in amines can arise from different carbon chain arrangements or positioning of the nitrogen atom.
This document discusses amines, which are carbon-hydrogen-nitrogen compounds that occur widely in living organisms. Amines are classified as primary, secondary, or tertiary based on how many hydrocarbon groups are bonded to the nitrogen atom. Primary amines have one hydrocarbon group and two hydrogen atoms bonded to nitrogen. Secondary amines have two hydrocarbon groups and one hydrogen bonded to nitrogen. Tertiary amines have three hydrocarbon groups bonded to nitrogen. Amines behave as weak bases and react with acids to form amine salts. Heterocyclic amines contain nitrogen atoms in aromatic or nonaromatic ring structures. Isomerism in amines can arise from different carbon chain arrangements or positioning of the nitrogen atom.
A Visual Guide to 1 Samuel | A Tale of Two HeartsSteve Thomason
These slides walk through the story of 1 Samuel. Samuel is the last judge of Israel. The people reject God and want a king. Saul is anointed as the first king, but he is not a good king. David, the shepherd boy is anointed and Saul is envious of him. David shows honor while Saul continues to self destruct.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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Gender and Mental Health - Counselling and Family Therapy Applications and In...PsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
Leveraging Generative AI to Drive Nonprofit InnovationTechSoup
In this webinar, participants learned how to utilize Generative AI to streamline operations and elevate member engagement. Amazon Web Service experts provided a customer specific use cases and dived into low/no-code tools that are quick and easy to deploy through Amazon Web Service (AWS.)
This presentation was provided by Racquel Jemison, Ph.D., Christina MacLaughlin, Ph.D., and Paulomi Majumder. Ph.D., all of the American Chemical Society, for the second session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session Two: 'Expanding Pathways to Publishing Careers,' was held June 13, 2024.
How to Make a Field Mandatory in Odoo 17Celine George
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
3. Definition
• Amines are derivatives
Of ammonia in which one or
more hydrogen atoms have
been replaced by alkyl or aryl
groups
N
H
H
H
Ammonia
N
H
H
CH
3
N
CH
H
CH
3
3
N
CH
CH
CH
3
3
3
Methyl
amine
dimethyl
amine
trimethyl
amine
4. Classification
of amines
• Primary amine:NH2(amino
group)-A amine has only one
alkyl group directly attached to
the nitrogen
• Secondary amine: NH (imino
group)- A amine has two alkyl
group directly attached to the
nitrogen atom.
• Tertiary amine: N(Tertiary
nitrogen)-A amine has three
alkyl group directly attached to
the nitrogen atom
R NH
2
Primary amine
CH NH
3 2 C H NH
2 5 2 C H NH
6 5 2
methyl
amine
ethyl
amine
aniline
Secondary amine
C H
6 5
NH
R
R NH
CH
HC
3
3
HN
C H
2 5
C H
2 5
HN
C H
6 5
dimethyl
amine
diethyl
amine
diphenyl
amine
3
NCH
3
CH
3
CH
N
R
R R
N
C H
2 5
C H
2 5
C H
2 5
C H
6 5
N
C H
6 5
diphenyl
amine
C H
6 5
Tertiary amines
5. NH OH
4
N
R
R
R
R
. OH
-
N
CH
3
CH
3
CH
3
CH
3
.. OH
-
ammonuim
hydroxide
tetra methyl
ammonuim
hydroxide
tetra alkyl ammonuim
hydroxide
N
C H
2 5
C H
2 5
C H
2 5
C H
2 5
.OH
tetra ethyl ammonuim
hydroxide
6. Nomenclature
common system
Primary amines
CH NH
3 2 C H NH
2 5 2 (CH )CH NH
methyl
amine
ethyl
amine
Iso propyl amine
1
0 0
3 2 2
1
0
1
Secondary amines
C H
5
NH
CH
HC
3
3
HN
C H
2 5
C H
2 5
HN
C H
dimethyl
amine
diethyl
amine
Ethyl propyl
amine
2 2
2
2
3 7
0
0
0
3
NCH
3
CH
3
CH
N
C H
2 5
Tertiary amines
Trimethyl
amine
3
0
0
CH
CH
3
3
ethyldimethylamine
mixed 3
7. IUPAC system
Primary amines
CH NH
3 2 C H NH
2 5 2
3
3
CH
CH
HC
NH2
methamaine
ethanamine propane-2-amine
Secondary amines
NH
CH
HC
3
3
N-methyl metha
namine
CH NH CH CH
323
N-methylethanamine
3
NCH
3
CH
3
CH
N
C H
2 5
Tertiary amines
0
0
CH
CH
3
3
N,N-dimethylethanamine
N,N-dimethylmethanamine
H
C CH CH
HC
NH
323
2
Butan-2 amine
8. Structure of
amines
H H
H
N
O O
107
0
Ammonia
3HC CH3
C
H3
N
O O
108
0
Trimethylamine
Fig:pyramidal shape of dimethylamine & trimethylamine
9. 3HC C3H7
C2H5
N
O O
N
O O
H3C
C3H7C2H5
rapid inversion
Fig:Enantiomers of methyl ethyl n-propyl amine
(I)
(II)
10. Preparation of
amines
• Reduction of nitro compounds
• Reduction of nitriles
• Reduction of oximes
• Reduction of amides
• Reductive amination of aldehydes & ketones
• Reduction of acyl halide
11. Reduction Of Nitro
Compounds
C H NO
2 5 2
+ 6(H) Sn
HCl
C H NH
2 5 2
+ 2H O
2
CH CH NO
3 2 2
LiAlH4
CH CH NH
3 2 2
NO2
CH3
NH2
CH3
H2,NI
NHCOCH3
NO2
NHCOCH3
NH2
H Pt
2
12. Reduction of
oximes
CH CH NOH
3
+ 4(H) CH CH NH
3 2 2
LialH4
+ H O
2
+ 4(H) LialH4 H2N
PROPAN 2 AMINE
3HC
H3C
NOH
propan-2-one oxime
+ H O
2
R
R
O
+ NH OH
2 CR
R
NOH
+ H O
2
13. Reduction of
nitriles &
amides
3HCC N + H2
Ni (CH CH NH)
3
H2
Ni
CH3
H2
C NH2
acetonitrile ethanamine
CH CH C N
3 2
LiAlH4 CH CH CH NH
3 2 2 2
hydrogen cyanide n propylamine
N+-
C
methyl isocyanide
LiAlH4
H
N
dimethylamine
acetamide
3HC NH2
O
CH3
H2
C
NH2
+ H O
2
ethanamine
LIAlH4
Ether
CH3 C NHCH3
O LIAlH4
Ether
CH3
H2
C NH CH3
+ H O
2
14. Reaction of
alkyl halides
• Hofmann”s method
CH3 CH2 I + NH3
CH3 CH2 NH2 + HI
C H
6 5
Cl + 2NH
3
C H
6 5
NH
2
+ NH4Cl
Cuprous salt
473K
15. Reductive amination of
aldehydes & ketones
R C
H
O + NH3
-H2O
(R C
H
NH) R C
H
H
NH2
H2
Ni
imine
schiff"s
bases
Primary aminealdehyde
R C O
R
+ NH3
(R C NH)
R1 H2
Ni
R C
R1
H
NH2
secondary
amine
CH (CH2)5CHO CH (CH2)5 CH NH
2 23 3
NH3
H2-Ni
Heptaldehyde n heptyl amine
O
methyl ethyl ketone
NH3
H2-Ni
NH2
2-amino butane
16. Reduction of acyl halides
R C
O
Cl + NaN3
R C
O
N3 + NaCl
R C
O
N3
Heat
-N2
R N C O + NaCl
H2O
RNH2
+ CO
2