This chapter discusses the structure, classification, nomenclature, physical properties and reactions of amines. Amines are classified as primary, secondary or tertiary depending on the number of carbon groups bonded to the nitrogen atom. The chapter describes various amine structures including aliphatic, aromatic, heterocyclic aliphatic and heterocyclic aromatic amines. It also discusses IUPAC nomenclature rules for naming amines and provides examples of common amine names. The chapter notes that amines are polar compounds that can form hydrogen bonds. It describes amines as weak bases and explains how their basicity depends on their structure. The chapter concludes by giving an example reaction of an amine reacting with an acid to
Chemistry of aromatic amines, Classification of amines, Preparation, reactions of amines, synthetic uses of aromatic amines, basicity of aromatic amines and factor affecting basicity amine.
An aromatic amine is an organic compound consisting of an aromatic ring attached to an amine. It is a broad class of compounds that encompasses anilines, but also many more complex aromatic rings and many amine substituents beyond NH2. Such compounds occur widely.Aromatic Amines
Reactivity of Amines
Reaction of Amines
Basicity of Amines
Chemistry of aromatic amines, Classification of amines, Preparation, reactions of amines, synthetic uses of aromatic amines, basicity of aromatic amines and factor affecting basicity amine.
An aromatic amine is an organic compound consisting of an aromatic ring attached to an amine. It is a broad class of compounds that encompasses anilines, but also many more complex aromatic rings and many amine substituents beyond NH2. Such compounds occur widely.Aromatic Amines
Reactivity of Amines
Reaction of Amines
Basicity of Amines
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
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Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
2. Structure & Classification
• Amines are classified as 1°, 2°, or 3° depending on the
number of carbon groups bonded to nitrogen.
• aliphatic amine: All carbons bonded to nitrogen are
derived from alkyl groups.
• aromatic amine: One or more of the groups bonded to
nitrogen are aryl groups.
CH3 -NH2 CH3 -N-CH3
H
CH3 -N-CH3
CH3
Methylamine
(a 1° amine)
Dimethylamine
(a 2° amine)
Trimethylamine
(a 3° amine)
NH2 N-CH3
H
CH2-N-CH3
CH3
Aniline
(a 1° aromatic amine)
N-Methylaniline
(a 2° aromatic amine)
Benzyldimethylamine
(a 3° aliphatic amine)
3. Structure & Classification
• heterocyclic amine: An amine in which the nitrogen
atom is part of a ring.
• heterocyclic aliphatic amine: A heterocyclic amine in
which the ring is saturated (has no C=C bonds).
• heterocyclic aromatic amine: The amine nitrogen is
part of an aromatic ring.
Piperidine
Pyrrolidine Pyridine
(heterocyclic aliphatic amines) (heterocyclic aromatic amines)
N
H
N
H
N N
N
Pyrimidine
N
N
Imidazole
N
N
N
N
H
Purine
H
4. Nomenclature
• IUPAC names
• We derive IUPAC names for aliphatic amines just as we
did for alcohols.
• Drop the final -e of the parent alkane and replace it by -
amine.
• Use a number to locate the amino group on the parent
chain.
CH3 CHCH3
NH2
NH2
H2 N
NH2
1,6-Hexanediamine
Cyclohexanamine
2-Propanamine
5. Nomenclature
• IUPAC names (cont’d)
• IUPAC nomenclature retains the common name aniline
for C6H5NH2, the simplest aromatic amine.
• Name simple derivatives of aniline by using numbers to
locate substituents or, alternatively, use the prefixes
ortho (o), meta (m), and para (p).
• Several derivatives of aniline have common names that
are still widely used; among them is toluidine:
NH2
CH3
NH2
NO2
NH2
3-Methylaniline
(m-Toluidine)
Aniline 4-Nitroaniline
(p-Nitroaniline)
6. Nomenclature
• IUPAC names (cont’d)
• Name unsymmetrical secondary and tertiary amines as
N-substituted primary amines.
• Take the largest group bonded to nitrogen as the
parent amine.
• Name the smaller group(s) bonded to nitrogen, and
show their location on nitrogen by using the prefix N-
(indicating that they are bonded to nitrogen).
N
CH3
CH3
NHCH3
N,N-Dimethyl-
cyclopentanamine
N-Methylaniline
7. Nomenclature
• Common names
• For most aliphatic amines, list the groups bonded to
nitrogen in alphabetical order in one word ending in the
suffix -amine.
Diethylmethylamine
sec-Butylamine
N
NH2
NH2
Cyclohexylamine
NH2
Propylamine
8. Nomenclature
• Amine salts
• When four atoms or groups of atoms are bonded to a
nitrogen atom, as for example CH3NH3
+, nitrogen bears
a positive charge and is associated with an anion as a
salt.
• Name the compound as a salt of the corresponding
amine.
• Replace the ending -amine (or aniline or pyridine or the
like) by -ammonium (or anilinium or pyridinium or the
like) and add the name of the anion.
( CH3 CH2 )3 NH+
Cl-
Triethylammonium chloride
9. Physical Properties
• Like ammonia, low-molecular-weight amines have
very sharp, penetrating odors.
• Trimethylamine, for example, is the pungent principle
in the smell of rotting fish.
• Two other particularly pungent amines are 1,4-
butanediamine (putrescine) and 1,5-pentanediamine
(cadaverine).
H2N NH2
1,5-Pentanediamine
(Cadaverine)
NH2
H2N
1,4-Butanediamine
(Putrescine)
10. Physical Properties
• Amines are polar compounds:
• Both 1° and 2° amines have N-H bonds, and can form
hydrogen bonds with one another.
• 3° amines have no N-H bond and cannot form hydrogen
bonds with one another.
11. Physical Properties
• An N-H---N hydrogen bond is weaker than an O-H---O
hydrogen bond, because the difference in
electronegativity between N and H (3.0 - 2.1 = 0.9) is
less than that between O and H (3.5 - 2.1 = 1.4).
• We see the effect of hydrogen bonding between
molecules of comparable molecular weight by
comparing the boiling points of ethane, methanamine,
and methanol.
CH3 OH
CH3 CH3 CH3 NH2
-6.3 65.0
32.0
31.1
MW (amu)
bp (°C)
30.1
-88.6
12. Physical Properties
• All classes of amines form hydrogen bonds with water
and are more soluble in water than are hydrocarbons of
comparable molecular weight.
• Most low-molecular-weight amines are completely
soluble in water.
• Higher-molecular-weight amines are only moderately
soluble in water or are insoluble.
13. Basicity of Amines
• Like ammonia, amines are weak bases, and
aqueous solutions of amines are basic.
• The acid-base reaction between an amine and water
involves transfer of a proton from water to the amine.
CH3-N
H
H
H-O-H CH3-N-H
H
H
O-H
Methylammonium
hydroxide
Methylamine
(a base)
+
+
-
: :
:
:
:
:
14. Basicity of Amines
• The base dissociation constant, Kb, for the
reaction of an amine with water has the following
form, illustrated for the reaction of methylamine
with water to give methylammonium hydroxide.
• pKb is defined as the negative logarithm of Kb
Kb = = 4.37 x 10-4
[ CH3 NH3
+
] [ OH
-
]
[ CH3 NH2 ]
pKb = - log 4.37 x 10 -4
= 3.36
15. Basicity of Amines
• Aliphatic amines have about the same base strength,
and are slightly stronger bases than NH3.
• Aromatic and heterocyclic aromatic amines are
considerably weaker bases than aliphatic amines.
• Note that while aliphatic amines are weak bases by
comparison with inorganic bases such as NaOH, they
are strong bases among organic compounds.
C6 H5 NH2
CH3 CH2 NH2
Aliphatic
Ammonia
Aromatic
3.0 - 4.0
4.74
8.5 - 9.5
Class pKb Example Name
Ethanamine
Aniline
Stronger base
Weaker base
16. Basicity of Amines
• Assume that the amine, RNH2, has a pKb of 3.50 and
that it is dissolved in blood, pH 7.40 (pOH 6.60).
• We first write the base dissociation constant for the
amine and then solve for the ratio of RNH3
+ to RNH2.
• substituting values for Kb and OH- gives:
RNH2 H2 O RNH3
+
OH-
+ +
[RNH3
+
] [OH-
]
[ RNH2 ]
Kb =
[RNH3
+
]
[RNH2 ]
[OH
-
]
Kb
=
[ RNH3
+
]
[ RNH2 ]
3.2 x 10-4
2.5 x 10-7 = = 1300
17. Basicity of Amines
• Given the basicities of amines, we can determine
which form of an amine exists in body fluids, say
blood.
• In a normal, healthy person, the pH of blood is
approximately 7.40, which is slightly basic.
• If an aliphatic amine is dissolved in blood, it is present
predominantly as its protonated (conjugated acid)
form.
HO
HO
NH2
Dopamine
HO
HO
NH3
+
Conjugate acid of dopamine
(the major form present
in blood plasma)
18. Reactions of Amines
• The most important chemical property of amines
is their basicity.
• Amines, whether soluble or insoluble in water, react
quantitatively with strong acids to form water-soluble
salts.
HO H
NH2
HO
HO
HCl
H2 O
HO
HO NH3
+
Cl
-
H
HO
(R)-Norepinephrine hydrochloride
(a water-soluble salt)
+
(R)-Norepinephrine
(only slightly soluble in water)
19. Reactions of Amines
• example: Complete each acid-base reaction and name
the salt formed.
( CH3 CH2 )2 NH HCl
N
CH3 COOH
+
(a)
(b) +
20. Reactions of Amines
• example: Complete each acid-base reaction and name
the salt formed.
• solution:
(CH3 CH2 ) 2 NH HCl
N
CH3 COOH
N
H
(CH3 CH2 ) 2 NH2
+
Cl
-
CH3 COO-
Diethylammonium
chloride
+
Pyridinium acetate
+
(a)
(b) +