This document discusses the use of alcohol and drugs in the treatment of de-addiction. It outlines several mechanisms of action for how alcohol inhibits neuronal activity and ion channels in the brain. Various drugs are mentioned for treating alcohol withdrawal symptoms like anxiety, insomnia, and tremors. These include benzodiazepines, clonidine, propranolol, and ondansetron. Psychosocial therapy is also recommended alongside medical treatment. Disulfiram is discussed as an aversion therapy drug that causes unpleasant reactions if alcohol is consumed.

1. ALCOHOL & DRUG USED IN
TREATMENT OF DE-ADDICTION
Dr. Resu Neha Reddy
MD Pharmacology

12. EuphoriaAnxiety, depressionEmotion,
motivation
Reduce anxiety, inc. sleepMemory, learning impaired

13. Depression – Myocardium
- Vasomotor centre

22. • Bedsores – alcohol hardens
skin

23. Mechanism of Action
 Inhibiting central neuronal nicotinic
cholinergic receptors
 Inhibiting excitatory NMDA and kainate
receptors function
 Promoting the function of 5-HT3 receptors
function
 Ethanol also influences many ion channels
including K+ channels

27. Disulfiram like reaction
C Chlorpropamide
Cephalosporins
G Griseofulvin
M Metronidazole
P Procarbazine

40. Disulfiram aversion therapy

42. Treatment
 Benzodiazepines
– diazepam
– reduce symptoms of alcohol
withdrawal
- Anxiety & insomnia
- Continued and gradually tapered over
several months

43. Treatment
 Clonidine
– Alpha 2 receptor agonist
– reduce release of sympathetic
transmitters
 Propranolol
- Blocks symp. Overactivity – tremors &
tachycardia

45. Treatment
 Ondansetron
 5-HT3 antagonist
 Antiemitic
Being evaluated
Psychosocial therapy

49. Methyl alcohol – denatured ethyl
alcohol
..................................

52. Loading dose - 0.6 g/Kg  Infusion 10
g/hr

56. THANK
YOU...