The document discusses drugs acting on the central nervous system (CNS). It classifies CNS diseases according to the WHO and describes various types of CNS drugs including anesthetic agents, anxiolytics, antipsychotics, antidepressants, analgesics, psychomotor stimulants, psychotomimetics, cognition enhancers, mood stabilizers, and drugs for neurodegenerative disorders like Alzheimer's and Parkinson's disease. It also discusses the mechanisms and classifications of antipsychotic drugs and provides examples of typical and atypical antipsychotics.
This short presentation demonstrates important adverse effects of common anti-psychotic medications in clinical practice and how to effectively manage the adverse events.
This short presentation demonstrates important adverse effects of common anti-psychotic medications in clinical practice and how to effectively manage the adverse events.
CNS Drugs
CNS Drugs
The drugs which act on the CNS(Central Nervous System) are known as CNS drugs
The CNS consists of cerebrum, cerebellum, medulla and the spinal cord.
CNS depressants
The drugs which have a depressant action on the CNS
Non selective depressants: which produce a generalised depressant action on the CNS. Eg. Hypnotic and sedative, central muscle relaxants
Selective depressants: it selectively depress certain region or portion of the CNS.
They include tranquillizers, Analgesics and anti-convalsants
B. CNS stimulants
the drugs which stimulate and reactivate CNS
used for variety of purposes like treatment of depressive state, maintenance of wakefulness restoration of respiration and blood and restoration of normal reflexes.
C. CNS modifiers(Tranquillizers)
used in treatment of mental disorders.
they produce improvement in the mood and behaviour of the patient
Major tranquillizers: reduce the agitation and disturbed behaviour which are associated with delusion and hallucinations in schizophrenia
Minor tranquillizers: there are antianxiety agents which gives calming effect in patients in anxiety state associated with neurotic personality
This slide contains the definition of CNS drugs.
Their classification based on chemical structure and PHARMACOLOGICAL ACTIVITY
Please find the power point on Management of antipsychotic overdose. I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Antipsychotics, antipsychotic drugs, major tranquilizers, tranquilizersMuthu Venkatachalam
introduction, indication, contraindications and side effects of antipsychotic drugs are explained.
Antipsychotic drugs used in the treatment of schizophrenia including psychosis is described.
Chlorpromazine, Clozapine
CNS Drugs
CNS Drugs
The drugs which act on the CNS(Central Nervous System) are known as CNS drugs
The CNS consists of cerebrum, cerebellum, medulla and the spinal cord.
CNS depressants
The drugs which have a depressant action on the CNS
Non selective depressants: which produce a generalised depressant action on the CNS. Eg. Hypnotic and sedative, central muscle relaxants
Selective depressants: it selectively depress certain region or portion of the CNS.
They include tranquillizers, Analgesics and anti-convalsants
B. CNS stimulants
the drugs which stimulate and reactivate CNS
used for variety of purposes like treatment of depressive state, maintenance of wakefulness restoration of respiration and blood and restoration of normal reflexes.
C. CNS modifiers(Tranquillizers)
used in treatment of mental disorders.
they produce improvement in the mood and behaviour of the patient
Major tranquillizers: reduce the agitation and disturbed behaviour which are associated with delusion and hallucinations in schizophrenia
Minor tranquillizers: there are antianxiety agents which gives calming effect in patients in anxiety state associated with neurotic personality
This slide contains the definition of CNS drugs.
Their classification based on chemical structure and PHARMACOLOGICAL ACTIVITY
Please find the power point on Management of antipsychotic overdose. I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Antipsychotics, antipsychotic drugs, major tranquilizers, tranquilizersMuthu Venkatachalam
introduction, indication, contraindications and side effects of antipsychotic drugs are explained.
Antipsychotic drugs used in the treatment of schizophrenia including psychosis is described.
Chlorpromazine, Clozapine
Neuromuscular monitoring, also known as train of four monitoring, is a technique used during recovery from the application of general anesthesia to objectively determine how well a patient's muscles are able to function. It involves the application of electrical stimulation to nerves and recording of muscle response using, for example, an acceleromyograph. Neuromuscular monitoring is typically used when neuromuscular-blocking drugs have been part of the general anesthesia and the doctor wishes to avoid postoperative residual curarization (PORC) in the patient, that is, the residual paralysis of muscles stemming from these drugs.
Medicinal Cannabis in the Treatment of Parkinson'sJames Van Geelen
An overview of the MMJ program in CT, cannabis' benefits in the treatment of parkinson's disease and an introduction to the world of medicinal cannabis.
about the drugs acting on central nervous system, also their physiological effect on the brain and how Neurottransmiters in the brain response to these agents
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
1. DRUGS ACTING ON CNS PRAVINKUMAR AWATE B.PHARM FINAL YEAR (COLLEGE OF PHARMACY, SOLAPUR )
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10. Different between Alzheimer disease and Parkinson’s disease Alzheimer disease Parkinson’s disease Loss of cholinergic neuron in the nucleus basalis of maynert (cerebral cortex) Loss of dopamenergic neuron in substantial nigra and corpus striatum, it visualize by using positron-emission tomography and fluorodopa.
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12. 2) Drug affecting brain cholinergic system: a) Central anticholinergics: e.g. Trihexyphenidyl (Benhexol), Procyclidine, Biperidine. b ) Antihistamines: Orphenadrine, Promethazine
13. A. Levodopa (L-dopa) and carbidopa Levodopa is a metabolic precursor of dopamine. It restores dopamine levels in the extrapyramidal centers (substantia nigra) that atrophy in Parkinsonism. Relief provided by levodopa is only symptomatic and lasts only while the drug is present in the body. 95% of oral dose is decarboxylated in the pheripheral tissue (gut and liver) thus DA formed acts on heart, blood vessel, and CTZ center. The effect of Levodopa on endocrine system is it inhibit the prolactin release. ADR of Levodopa : vomiting and BUN effect (increase blood urea nitrogen). b. Carbidopa: The effects of levodopa on the CNS can be greatly enhanced by coadministering carbidopa a DOPA decarboxylase inhibitor that does not cross the blood- brain barrier and act extracerebrally only. The addition of carbidopa lowers the dose of levodopa needed by 4- to 5-fold and, consequently, decreases the severity of the side effects of peripherally formed dopamine .
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16. B. Bromocriptine Bromocriptine an ergotamine (an alkaloid with vasoconstrictor action) derivative, is a dopamine receptor agonist. The drug produces little response in patients who do not react to levodopa, but it is often used with levodopa in patients responding to drug therapy. Side effects severely limit the utility of the dopamine agonists (Figure) The actions of bromocriptine are similar to those of levodopa, except that hallucinations, confusion, delirium, nausea, and orthostatic hypotension are more common, whereas dyskinesia is less prominent.
17. C. Amantadine It was accidentally discovered that the antiviral drug, amantadine effective in the treatment of influenza, has antiparkinsonism action. It appears to enhance the synthesis, release, or re-uptake of dopamine from the surviving neurons. [Note: If dopamine release is already at a maximum, amantadine has no effect.] The drug may cause restlessness, agitation, confusion, and hallucinations, and at high doses it may induce acute toxic psychosis. Amantadine is less efficacious than levodopa and tolerance develops more readily, but it has fewer side effects. The drug has little effect on tremor but is more effective than the anticholinergics against rigidity and bradykinesia.
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19. D. Deprenyl: Deprenyl, also called selegiline selectively inhibits monoamine oxidase B (which metabolizes dopamine), but does not inhibit monoamine oxidase A (which metabolizes norepinephrine and serotonin). By thus decreasing the metabolism of dopamine, deprenyl has been found to increase dopamine levels in the brain (Figure). Therefore, it enhances the actions of 1evodopa, and when these drugs are administered together, deprenyl substantially reduces the required dose of Levodopa .
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21. E. Antimuscannic agents: The antimuscarinic agents are much less efficacious than levodopa and play only an adjuvant role in antiparkinsonism therapy. All these drugs can induce mood changes and produce xerostomia (dryness of the mouth) and visual problems, as do all muscarinic blockers. They interfere with gastrointestinal peristalsis and cannot be used in patients with glaucoma, prostatic hypertrophy, or pyloric stenosis. Adverse effects are similar to those caused by high doses of atropine, for example, pupillary dilation, confusion, hallucination, urinary retention, and dry mouth.
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27. Psychotomimetics (Psychedelic, Psychodisleptic, and hallucinogen): -Drugs produce psychosis like states. Note: -Antidepressants and Antimanic drugs are collectively known as drugs for affective disorders. Tranquillizers :-Drugs which reduce mental tension and produce calmness without inducing sleep but this term not used now a days.
28. Antipsychotic drugs:- It is also known as antischizophrenic drugs. Schizophrenia (Bleuler) is a defect in selective attention. Crow classified schizophrenias into two types based on symptoms: 1) Positive symptoms:- a) Delusion (mistaken belief) b) Hallucination (see same think which not actually present) c) Thought disorder. d) Abnormal behaviors (aggressive and serotypes) 2) Negative symptoms:- a) Withdrawal from social contact b) Flattening of emotional responses
29. Schizophrenia - symptoms Positive Symptoms Hallucinations Delusions (bizarre, persecutory) Disorganized Thought Perception disturbances Inappropriate emotions Abnormal behaviors (aggressive and serotypes ) Negative Symptoms Blunted emotions Anhedonia Lack of feeling Cognition New Learning Memory Mood Symptoms Loss of motivation Social withdrawal Insight Demoralization Suicide FUNCTION €
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31. Classifications of Antipsychotic drugs:- 1) Phenothiazines a) Aliphatic side chain Chlorpromazines, Promazines, Triflupromazine. b) Piperidine side chain Thioridazine, Mezoridazine, Piperacetazine c) Piperazine Side chain Trifluoperazine, Fluphenazine, Perphenazine. 2) Butyrophenones Haloperidol, Droperidol, Penfluridol, Trifluoperidol. 3) Thioxanthenes Thiothixene, Flupenthixol. 4) Other heterocyclics (RPL) Pimozide, Loxapine, Reserpine. 5) Atypical Neuroleptics (CROSSQ) Clozapine, Risperidone, Olanzapine, Sulpiride, Sertindole, Quetiapine.
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33. Mechanism of action: Dopamine receptor-blocking activity : All of the neuroleptic drugs block dopamine receptors in the brain and in the periphery. Five types of dopamine receptors: D1 and D5 receptors activate adenylyl cyclase, and D2, D3 and D4 receptors inhibit adenylylcyclase. Typical neuroleptic drugs correlates closely with their relative ability to block D2 receptors in the mesolimbic system of the brain.on other hand, the atypical drug clozapine has a high affinity for D4 receptor result in minimal ability to cause extrapyramidal side effects. The actions of the neuroleptic drugs are antagonized by agents that raise dopamine concentration, for example, L-dopa and amphetamines.
34. Serotonin receptor-blocking activity in brain: The newer "atypical" agents appear to exert part of their unique action through inhibition of serotonin (5-HT) receptors. Thus, clozapine has high affinity for D1 and D4, 5-HT2, muscarinic and alfa-adrenergic receptors, but it is also a dopamine D2-receptor antagonist. Another new agent, risperidone blocks 5-HT2 receptors to a greater extent than it does D2 receptors. Both of these drugs exhibit a low incidence of extra pyramidal side effects.
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36. Actions :- The antipsychotic actions of neuroleptic drugs reflect blockade at dopamine and/or serotonin receptors. However, many of these agents also block cholinergic, adrenergic, and histamine receptors, causing a variety of side effects. Antipsychotic actions: The neuroleptic drugs reduce the hallucinations and agitation associated with schizophrenia by blocking dopamine receptors in the mesolimbic system of the brain. In contrast to the central nervous system (CNS) depressants, such as barbiturates, the neuroleptics do not depress intellectual function of the patient, and motor incoordination is minimal.
37. Extrapyramidal effects: Parkinsonian symptoms, akathisia (motor restlessness), and tardive dyskinesia (inappropriate postures of the neck, trunk, and limbs) occur with chronic treatment. Blocking of dopamine receptors in the nigrostriatal pathway probably causes these unwanted parkinsonian symptoms. Clozapine and risperidone exhibit a low incidence of these symptoms .
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49. Parkinsonian effects: The inhibitory effects of dopaminergic neurons are normally balanced by the excitatory actions of cholinergic neurons. Blocking dopamine receptors alters this balance, causing a relative excess of cholinergic influence and resulting in extrapyramidal motor effects.