This patient has developed a parastomal hernia around their colostomy stoma, which is causing discomfort and leakage. Options for repair include closing the stoma and restoring intestinal continuity, resiting the stoma to a better location, or a local repair using techniques like bowel resection, suture plication, and mesh to reinforce the abdominal wall defect. The elastic garment around their waist is an abdominal binder intended to provide symptomatic relief.
Lecture on principles of bowel anastomosis delivered during Advanced Suturing Workshop 2018 - which was attended by junior doctors learning to perform bowel anastomosis on a bench setting. Encompasses basic sciences, classification, principles and tips on performing bowel anastomosis.
Component separation technique for a very large abdominal wall herniaSanjiv Haribhakti
Component separation technique is an excellent technique for large ventral central defects which can allow a medial shift of approx. For More information visit at Gisurgery.info
Lecture on principles of bowel anastomosis delivered during Advanced Suturing Workshop 2018 - which was attended by junior doctors learning to perform bowel anastomosis on a bench setting. Encompasses basic sciences, classification, principles and tips on performing bowel anastomosis.
Component separation technique for a very large abdominal wall herniaSanjiv Haribhakti
Component separation technique is an excellent technique for large ventral central defects which can allow a medial shift of approx. For More information visit at Gisurgery.info
Knowledge of the basic principles of bowel resection, anastomosis, and the stoma formation, will allow the gynecologist to competently manage many scenarios in which malignancies involve the bowel and require resection for restoration of bowel continuity. In patients with ramified pelvic tumours, a colorectal surgeon may be required as portion of the multidisciplinary approach to ensure complete removal of the cancer (Alves et al., 2004).
The type of the intestinal anastomosis one performs depends on personnel preference but irrespective of the technique availed, principles that ensure a successful outcome include: good vascular supply to segments being specifically approximated, no distal obstruction, and a tension free repair. There are certain bowel disorders like bloating, colic pain etc (Sreeremya, 2018).
Component seperation technique for the repair of very large ventral hernias nikhilameerchetty
Includes all the ventral hernia repairs with the loss of domain and the various methods of component separation technique with their success rate for their repair ,few videos showing the methods of repair in addition to the latest techniques of repair .
Presentation describing surgical technique and principles of anastomosis, factors for good healing in the post operative phase, risk factors for leak and the role of staplers in modern day surgical practice, advantages over hand sewn anastomosis.
Knowledge of the basic principles of bowel resection, anastomosis, and the stoma formation, will allow the gynecologist to competently manage many scenarios in which malignancies involve the bowel and require resection for restoration of bowel continuity. In patients with ramified pelvic tumours, a colorectal surgeon may be required as portion of the multidisciplinary approach to ensure complete removal of the cancer (Alves et al., 2004).
The type of the intestinal anastomosis one performs depends on personnel preference but irrespective of the technique availed, principles that ensure a successful outcome include: good vascular supply to segments being specifically approximated, no distal obstruction, and a tension free repair. There are certain bowel disorders like bloating, colic pain etc (Sreeremya, 2018).
Component seperation technique for the repair of very large ventral hernias nikhilameerchetty
Includes all the ventral hernia repairs with the loss of domain and the various methods of component separation technique with their success rate for their repair ,few videos showing the methods of repair in addition to the latest techniques of repair .
Presentation describing surgical technique and principles of anastomosis, factors for good healing in the post operative phase, risk factors for leak and the role of staplers in modern day surgical practice, advantages over hand sewn anastomosis.
A lecture about the management approaches for abdominal vascular injuries. Injury to the major arteries and veins in the abdomen are technical challenge to the surgeon and are often fatal. All vessels are susceptible to injury with penetrating trauma. Vascular injuries in blunt trauma are far less common and usually involve the renal arteries and veins, though all other vessels, including the aorta, can be injured. Blunt trauma results from deceleration, AP compression or pelvic fractures.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
5. Diagnosis of hollow viscus injury
is difficult, challenges even modern diagnostic
modalities, and requires a high degree of suspicion
Nonoperative management is still possible but
requires compulsive patient monitoring
Outcomes improve if the “evil that lurks within the
abdomen” is diagnosed and treated early
6. Solid Organs and Hollow Structures
Solid: Hollow:
• Liver • Stomach
• Pancreas • Small Intestine
• Spleen • Appendix
• Kidneys • Large Intestine/Colon
• Ovaries • Gallbladder
• Bladder
• Uterus
• Aorta
• Common bile duct
• Fallopian tubes
6
7. What is the "golden hour"?
The first hour after injury provides a
unique opportunity to provide life-
saving interventions. Because more than
half of trauma deaths occur early due to
bleeding or brain injury, rapid
transport, appropriate
triage, evaluation, resuscitation, and
intervention can affect outcomes.
.
8. What is the "golden hour"?
The "golden hour" concept needs to be extended
to several hours in the rural setting, but
with the same structured approach.
9. When Trauma Deaths Occur?
<1 hour 1-3 hours 4 to 6 weeks
“The Trimodal Distribution”
Temple College EMSP
14. Overview:Small bowel Injury
• Seat belts, direct blow or penetrating trauma
• Minimal bleeding
• Peritoneal signs (intoxicated or deeply unconsious
patients – absent)
• US, CT nondiagnostic
• Diagnosis - DPL and laparotomy
• Primary repair or segmental resection and
anastomosis, close mesenteric defects
Klinika Chirurgii Urazowej Grala
15. Management:
Small Bowel Injury Small Bowel
Much less common in blunt than
penetrating
Nonetheless, 3rd most common blunt
abdominal injury
16. Blunt Abdominal Trauma
SMALL BOWEL INJURY
• . Mechanism:
* Crushing of bowel against the spine
* Sudden deceleration sheering of the
bowel from its mesentery at a fixed point
* Bursting of “pseudo-closed-loop” from
sudden increase in intraluminal pressure
21. Seatbelt injuries
.
The three-point shoulder-lap belt is the most effective
restraining system and is associated with the lowest
incidence of abdominal injuries.
However, abdominal injuries are still ascribed to
shoulder-lap and lap-belt systems.
25. pathogensis
o compression of bowel between the belt and the
vertebral column.
o an acute short closed-loop obstruction occurs along
with perforation secondary to the sudden generation
of high intraluminal pressures.
27. Peneterating TRauma
• Small bowel trauma-25-30%
Stab wound
The liver, followed by the small bowel, is the
organ most often damaged by stab wounds
Gunshot Wounds
handguns, rifles, and shotgun
28. Stab wound to right lower quadrant with caecal
evisceration. No colon injury at laparotomy.
29. MCQ
• Small bowel injury is the most common injury
resulting from ___ abdominal trauma.
• penetrating
• blunt
30. MCQ
• Small bowel injury is the most common injury
resulting from ___ abdominal trauma.
• penetrating
• blunt
31. INJURY TO COLON AND RECTUM
Blunt Abdominal Trauma-5% cases
Mechanism: rapid deceleration with steering
wheel compression
• uncommon
• Disruptions of colonic wall or avulsion injury
of mesentery
• Present with hemoperitoneum, peritonitis.
32. INJURY TO COLON AND RECTUM
Peneterating Abdominal Trauma-95%
Large number of colonic injuries are due to
peneterating trauma.
Rectal injuries –assosiatied with pelvic #
34. Operative Management
• Treatment of injury is dictated by location and
severity. In general…
– Antibiotics is administered before skin incision and for 24
hours if injury is confirmed
– Abdominal exploration performed through mid-line
incision sufficient to access entire peritoneal cavity
– After initial control of any significant bleeding is
achieved, inspection commences in a systematic fashion
36. Operative Management
• Injuries to the Small Bowel
– Evaluated intraoperatively by “running the bowel”, from the
ligament of Treitz caudad to the ileocecal valve
Injured Structure AAST Grade Characteristics of Injury AIS-90 Score
Contusion or hematoma without
I devascularization; partial-thickness 2
laceration
Small (<50% of circumference)
II 3
laceration
Small Bowel Large (≥50% of circumference)
III 3
laceration
IV Transection 4
Transection with segmental tissue loss;
V 4
devascularized segment
37. Management:
Sc Small Bowel Injury Scaleale Small Bowel
I Hematoma Contusion without devascularization
Laceration Partial thickness, no perforation
II Laceration <50% circumference
III Laceration >50% circumference without transection
IV Laceration Transection of small bowel
V Laceration Transection with segmental tissue loss
Vascular Devascularized segment
39. Operative Management, cont’d
– Grade I –reapproximation of the seromuscular
layers with interrupted sutures
– Grade II –limited debridement and closure in
either one or two layers
– Grade III –repaired primarily if luminal narrowing
can be avoided; otherwise, resection and
anastamosis
• Small bowel anastomoses usually hand sewn or stapled
– Grade IV and V – resection and anastomosis
42. Management:
Treatment Grade III Small Bowel
No difference in hand-swen vs. stapled (Witzke, J Trauma, 2000)
No difference in 1 vs. 2-layer anastomosis (Burch, Ann Surg, 2000)
43. Management:
Treatment Grade IV Small Bowel
Damage Control:
Can staple both
ends, control other intra-
abdominal
damage, resuscitate in
ICU, and return to OR in
24-48 hrs for delayed
primary anastomosis
(Carillo, J Trauma, 1993)
45. Management:
Postoperative Care Small Bowel
24 hrs perioperative abx if this is the only injury
NG decompression until ileus resolves:
* Multi-injured patients have slower return of bowel fxn
* Can decompress stomach if jejunal feeds used )
* Moderately to severely injured patients do better with enteral feeds
started 24-48 hrs postop
47. Management:
Historical Notes – Backwards as Usual Colon
Gordon-Taylor G. Br J Surg 1942.
Most colonic injuries can be fixed primarily, avoid resection, proximal
colostomies possibly for extensive injury or descending colon injury. 50%
Mortality.
Ogilvie WH. Surg Gynecol Obstet 1944.
Colostomy for colon injuries. 60% Mortality.
, mandating colostomy for all colonic injuries.
Improvement in postoperative care towards the end of WWII led to 5-20%
mortality, credited incorrectly to use of colostomy.
Woodhall, Ochsner. Surgery 1951. Re-introduced primary repair.
48. Management:
Colonic Injury Scale Colon
I Hematoma Contusion without devascularization
Laceration Partial thickness, no perforation
II Laceration <50% circumference
III Laceration >50% circumference without transection
IV Laceration Transection of colon
V Laceration Transection with segmental tissue loss
Vascular Devascularized segment
49. Management:
Intraoperative Diagnosis Colon
Injuries distributed evenly throughout the colon
Sometimes even difficult to diagnose intra-operatively
Explore all:
Blood staining / hematoma on colonic wall
Injured mesentery in proximity to colonic wall (may even need to divide one
or two terminal mesenteric vessels for exposure)
Mobilize all colon in injured areas
Follow trajectories if possible
Milk luminal contents through areas of suspicion
50. Management:
Factors Determining Optimal Tx Colon
1.Shock (preoperative BP < 80/60)
2.Hemorrhage (blood loss > 1L)
3.Multiorgan injury (>2 organ systems)
4.Significant peritoneal spillage
5.Delayed operation (>8 hrs post injury)
6.Nonviable colon (wall destruction or ischemia)
7.Major loss of abdominal wall (close range blast
injury)
8.Location of injury (distal vs. proximal to middle
colic)
55. Management:
Sample Algorithm
Colon
Resection required?
NO YES
Suture Repair Proximal to MCA?
YES
NO
Resection and Evaluate Local
ileocolostomy Conditions:
Resection and
Colocolostomy vs.
Hartmann’s
56.
57. Operative Management, cont’d
– Colonic injuries further categorized as either non-
destructive or destructive
• Destructive - wounds that completely transect the colon (grade IV)
or involve tissue loss and devascularized segments (grade V)
• Patients with destructive colonic injuries who had:
– comorbid medical conditions
– required transfusions of more than 6 units of blood
– in shock
– delayed operation…significantly higher risk for suture line breakdown
when managed with resection and primary anastomosis
58. Operative Management, cont’d
– Non-destructive wounds (grades I-III)
• Seromuscular closure for partial thickness
• Primary closure for full thickness
– Destructive wounds (grades IV-V)
• Repair with resection and primary anastomosis
– Destructive wounds with risk factors
• Resection with end colostomy or resection and primary
anastomosis with proximal diversion
– Proximal diversion
» loop colostomy (with open or closed distal stoma)
» end colostomy (with a mucous fistula or closure of the rectal
stump)
59. Operative Management, cont’d
• Injuries to the Rectum
– Classified according to anatomic criteria
• Anterior and lateral sidewalls of the upper two thirds of the
rectum managed in the same manner as colonic injuries
• Upper two thirds posteriorly and lower one third of the rectum
circumferentially - extraperitoneal
– Upper two thirds - exploration and suture repair, fecal diversion with
loop or end colostomy as adjunctive measure
– Lower one third - explored and repaired if accessible Fecal diversion
recommended
» Wounds difficult to reach - proximal fecal diversion and
presacral drainage
61. The Value of Serial Observation
The Value of Serial Observation
62. Case 1: Troublesome stoma
This 57 year old man was having increasing
discomfort from his stoma and associated leakage
from a stoma appliance that was difficult to apply.
1.What abnormality is shown?.
2. Methods for repair?
3. What is the elastic garment around this
patients waist?
63.
64. ANSWER
1. What abnormality is shown?.
A parastomal hernia
2. Methods for repair?
-consider stoma closure restoring intestinal continuity
-resiting stoma to another area with non attenuated abdominal
wall tissues
-local repair. This may include amputation of some bowel
length, suture plication of the abdominal wall defect, mesh
repair to reinforce the abdominal wall tissues.
3. What is the elastic garment around this patients waist?
-abdominal binder for symptomatic relief