Defined as fracture occurring at or proximal to the surgical neck
It is the commonest fracture affecting the shoulder girdle in adults.
Proximal humeral fracture 80% of all humeral fractures.
In pts above the age of 65 years, proximal humeral fractures are the 2nd most frequent upper extremity fractures
ANATOMY -
The proximal humerus is retroverted 35 to 40 degrees relative to the epicondylar axis.
Most common is fall onto outstretched upper extremity from a standing height, in older & osteoporotic woman.
Younger pts present following high energy trauma with significant soft tissue injury.
Less common with excessive shoulder abduction, direct trauma, electric shock and seizures r seizures
Posterolateral corner injuries of knee joint Samir Dwidmuthe
Missed posterolateral corner injuries of knee joint is a common cause for failure of ACL and PCL reconstruction only next to malpositioned tunnels.
Isolated PLC injuries are uncommon, making up <2% of all acute knee ligamentous injuries. Covey JBJS 2001
Incidence of PLC injuries associated with concomitant ACL and PCL disruptions are much more common (43% to 80%). Ranawat JAAOS 2008
A recent (MRI) analysis of surgical tibialplateau fractures demonstrated an incidence of PLC injuries in 68% of cases. Gardner JOT 2005
Take home message
PLC injuries to be ruled out in every case of ACL& PCL rupture.
Neurovascular integrity to be checked in every case.
Grade I & II can be managed conservatively.
Grade III Acute- Repair.
Grade III Chronic- Anatomic PLC recon.
Beware of varus knee alignment.
Defined as fracture occurring at or proximal to the surgical neck
It is the commonest fracture affecting the shoulder girdle in adults.
Proximal humeral fracture 80% of all humeral fractures.
In pts above the age of 65 years, proximal humeral fractures are the 2nd most frequent upper extremity fractures
ANATOMY -
The proximal humerus is retroverted 35 to 40 degrees relative to the epicondylar axis.
Most common is fall onto outstretched upper extremity from a standing height, in older & osteoporotic woman.
Younger pts present following high energy trauma with significant soft tissue injury.
Less common with excessive shoulder abduction, direct trauma, electric shock and seizures r seizures
Posterolateral corner injuries of knee joint Samir Dwidmuthe
Missed posterolateral corner injuries of knee joint is a common cause for failure of ACL and PCL reconstruction only next to malpositioned tunnels.
Isolated PLC injuries are uncommon, making up <2% of all acute knee ligamentous injuries. Covey JBJS 2001
Incidence of PLC injuries associated with concomitant ACL and PCL disruptions are much more common (43% to 80%). Ranawat JAAOS 2008
A recent (MRI) analysis of surgical tibialplateau fractures demonstrated an incidence of PLC injuries in 68% of cases. Gardner JOT 2005
Take home message
PLC injuries to be ruled out in every case of ACL& PCL rupture.
Neurovascular integrity to be checked in every case.
Grade I & II can be managed conservatively.
Grade III Acute- Repair.
Grade III Chronic- Anatomic PLC recon.
Beware of varus knee alignment.
fractures of the proximal humerus are among the most common fractures of the upper limb and management options are wide according many variables mostly the age.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
1. Acetabular fracture
Dr P. ROHIT RAJ
MBBS MS ORTHO
ASSISTANT PROFESSOR
ORTHOPAEDIC DEPARTMENT
VISHWABHARATHI MEDICAL COLLEGE
2. • Acetabular fractures are a type of pelvic fracture, which may also
involve the ilium, ischium, and/or pubis depending on fracture
configuration.
3. Epidemiology
• Acetabular fractures are uncommon.
• The reported incidence is approximately 3 per 100,000 per year.
• This study reported a 63% to 37% male to female ratio
4. Mechanism
•fractures occur in a bimodal distribution
•high energy trauma in younger patients (e.g.,
motor vehicle accidents)
•low energy trauma in elderly patients (e.g., fall
from standing height)
5.
6.
7. Type of # depends upon position of femoral head in
acetabulum and magnitude of force
A
8. Anatomy
Can be conceptualized as
being built from essentially
six principal components
Anterior column
Posterior column
Anterior wall
Posterior wall
Acetabular dome or tectum
(Latin for roof)
Medial wall
Provides coverage to
approximately 170° of the
femoral head
9.
Ant column
Ant half of the iliac crest
Iliac spines
Ant half of acetabulum
Pubis
Post column
Ischium
Ischial spine
Post half of acetbulum
Dense bone forming schiatic notch
10. Neurovascular structure
Sciatic nerve
Frequently injured with
Post. # dislocation
Sup. Gluteal artery
and Nerve
Corona mortis –
“Circle of Death”
11. Vascular-corona mortis
• anastomosis of external iliac (epigastric) and internal iliac (obturator)
vessels
• at risk with lateral dissection over superior pubic ramus
21. Signs and symptoms
History – cause of injury
ATLS protocol (Advanced
trauma life support)
Visceral injuries common
Associated fractures common
Elderly pt. (underlying cardiac or
neurologic condition)
Assess and document NV status
22. Signs and symptoms
Shortening present if hip is dislocated
Flexion, adduction, and internal rotation
of the hip may not be present
23. Assessment – ATLS
protocol
History
• Mechanism of injury
• Ask for position of hip
• Ask of axial loading or
direct injury
• Low energy trauma
• Underlying illness
• Examination
• Open wounds
• Morel- Lavallee lesions
• Shortening
• Attitude of limb
• Neurological examination
• Document sciatic nerve
• palsy
24. X ray pelvis AP view
Medial roofarc
Judet views
45 degree Iliac oblique view-affected side
touching cassette
Shows Ant wall & post column
Post roof arc
45 degree obturator oblique view-affected
side away from cassette
Shows post wall & ant column
Ant roof arc
27. Landmarks of standardAP radiograph
of hip
1.liopectineal line
2.Ilioischial line
3.Radiographic teardrop
4.Roof of acetabulum.
5.Edge of anterior lip of
acetabulum
6.Edge of posterior lip
of acetabulum.
28. Obturator oblique view
• Obturator
foramen
• Anterior column
• Posterior lip or
wall of the
acetabulum
31. Central fracture-dislocation of the acetabulum
• X-ray showing a
fracture of the right
acetabulum with
central dislocation
of the femoral head.
• Right ilioischial and
iliopectineal lines
are completely
disrupted.
35. 3-D CT
Better
understanding of
the fracture
patterns.
Planning the operative
approach
Ability to subtract
unwanted structures
36. Management
The goal of the treatment is
restoration of articular surface,
prevent post traumatic arthritis and
to mobilise the patient as early as
possible
37. Management
Initial treatment – follow ATLS protocols
Operative treatment are usually not
performed as an emergency
Closed reduction of hip
dislocations should be performed
Skeletal traction
Allow soft tissue healing initially
Maintain limb length
Maintain femoral head reduction
38. Patients factors
Age
Pre injury activity level
Medical comorbidities
Associated injuries
Functional demands
39. Non-operative Indications
Hip stable and congruous.
Patient factors
Medical contraindications
Severe osteoporosis in elderly
Undisplaced/Minimally displaced fractures
Fractures with secondary congruence (both-column)
Preexistent arthritis of hip
Local soft tissue problems
Morel Lavelle’ lesion
Open wound
Suprapubic catheter (C/I to Ilioinguinal and Stoppa)
40.
41. Morel Lavalle lesion
Localized area of subcutaneous fat necrosis
over the lateral aspect of the hip
Operating through it has been associated with
a higher rate of postoperative infection
42. Non operative Treatment
Bed rest is necessary in the acute injury
phase only
Mobilization
Patients should begin with touch-down partial
weight-bearing
Gradually progress to full weight bearing when
there is adequate fracture healing, usually by 6
to 12 weeks
68.
Older patients
Intraarticular comminution
Full thickness loss of cartilage
Femoral head impaction
Acetabular dome impaction
Femoral neck #
Preexistent arthritis
69.
70.
71.
72.
73. Post operative care
Suction drain
Antibiotic for 48 – 72 hours
Thromboprophylaxis- Mechanical
compressive device with LMWH
Indomethacin 25 mg tds beginning within 24
hours of surgery and continued for 4 to 6
weeks to prevent HO
Passive motion of the hip on the 2nd or 3rd
day.
Touch down ambulation & crutches on 2nd
to 4th day
Progression to FWB must be tailored to the
individual
75. Complications
Thromboembolism
Risk of PE 1%- 5 %
Use of intermittent compression device plus
a form of chemical anticoagulation (eg-
LMWH or Warfarin) recommended for
prophylaxis
76. Complications
Infection
1-10 % patients
Incidence of infection related to surgeons experience
Other factors -skin necrosis, hematoma formation, and
obesity
Prophylactic antibiotics should be administered within 1
hour before the skin incision and continued for 24-48
hours after surgery
Multiple suction drains should be used
77. Complications
Nerve Injury
Sciatic nerve
Preoperative incidence 12-31 %
Prevalence of postoperative sciatic nerve injury is
2– 16%
Peroneal division commonly involved
Management of sciatic nerve injury is expectant and
prognosis is variable
Iatrogenic injury to the femoral nerve is very rare
with a prevalence of 0.2% to 0.4%
78.
79. Complications
Heterotropic ossification
Incidence varies from 3–69%
Related to extensile surgical exposures, male
gender, associated head injury, significant delays to
surgery, fracture type, the severity of the injury
Rare with ilioinguinal approach
“Significant HO” -loss of active range of motion
>20% of normal.
Indomethacin 25 mg tds for 6 weeks or 75 mg SR
capsule OD for 6 weeks
Radiation therapy- 7–8 Gy in a single dose or 10
Gy in five doses
80.
Class 1 is described as islands of bone within the soft
tissues about the hip
Class 2 includes bone spurs originating from the pelvis
or proximal end of the femur, leaving at least 1 cm
between opposing bone surfaces
Class 3 consists of bone spurs originating
from the pelvis or proximal end of the femur,
reducing the space between opposing bone
surfaces to less than 1 cm
Class 4 shows apparent bone ankylosis of the
hip
81.
82.
83. Complications
Posttraumatic Arthritis
Prevalence of osteoarthritis 4–48%
Quality of the fracture reduction main
determinant
Incidence following perfect reduction was
10%
Anatomical reduction and restoration of joint
congruency is the best prophylaxis