The document summarizes thoracolumbar spine injuries, including:
- Anatomy of the thoracic and lumbar spine regions which predispose the thoracolumbar junction to injury.
- Epidemiology showing these injuries most commonly affect segments T11-L2 and have bimodal age distribution.
- Classification systems including Denis, McCormack, and TLICS which evaluate morphology, neurology, and ligamentous integrity to determine treatment.
- Treatment principles aim to preserve neurology, minimize compression, stabilize the spine, and rehabilitate the patient either via non-operative or operative means.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
4. Anatomy of Thoracic Spine
• Kyphosis is natural
alignment
• Narrow spinal canal
• Facet orientation
• Rib factor on stability
• Conus at T12-L1
5. Anatomy of Lumbar Spine
• Lordosis is natural
alignment
• Larger vertebral bodies
• Facet orientation
• Cauda equina
6. Transition Zone:
Predisposed to Failure
Little opportunity for force
dispersion
Central loading
of T-L junction
Not anatomically disposed
to transfer force
7. EPIDEMIOLOGY
• Between 5% and 10% of polytrauma patients suffer spinal fractures or
dislocations with 65% to 80% of these injuries occurring within the
thoracic or lumbar regions.
• The vast majority of these injuries affect the motion segments
between T11 and L2 at the thoracolumbar junction
• Thoracolumbar injuries are usually thought to exhibit a bimodal age
distribution, with peaks among males under 40 years of age and again
in the 50 to 70 age group which is made up of a higher percentage of
females compared to the younger age groups
8.
9. The incidence of fractures of the thoracic and lumbar spine increases
sharply in elderly patients younger than 60 years, of 13 fractures per
100,000 which rose to more than 50 fractures/100,000 in patients
above 70 years of age and to above 100 fractures/100,000 for
individuals older than 80 year
Unfortunately, around 20% of patients with thoracolumbar fractures
will develop some type of neurologic deficit. This occurs in nearly 1 in
every 20,000 individuals living in the United States
10. Cause of injury
fall from height RTA Violence Gun shot
injuries
52.3
38.4
5 4.3
Upendra B, Khandwal P
,Chowdhury B, Jayaswal A: Correlation of outcome measures with
epidemiological factors in thoracolumbar spinal trauma. Indain J Orthop 2007
Oct;41(4):290-4.
11. Mechanisms of Injury for Thoracolumbar
Spine Fractures and Dislocations
• axial loading(compression)
• flexion
• extension (lumbar jack injuries) shear
• axial rotation
• Multiple injury: multiple level involvement can occur .
• High Suspicion For Abdominal and thoracic injury
12. • Pathogenic mechanisms fall into three main groups:
LOW-ENERGY INSUFFICIENCY FRACTURES – arising from
• comparatively mild compressive stress in osteoporotic bone
MINOR FRACTURES OF THE VERTEBRAL PROCESSES – due to
• compressive, tensile or torsional strains
HIGH-ENERGY FRACTURES OR FRACTURE-DISLOCATIONS – due
• to major injuries sustained in motor vehicle collisions, falls or diving
from heights, sporting events,
• horse-riding and collapsed buildings
13. Associated Injuries with Thoracolumbar
Spine Fractures and Dislocations
• 50% of individuals with thoracolumbar fractures will be diagnosed
with a nonspinal injury (involvement of one other organ system, 30%;
two systems, 20%; three or more systems
• 45% of patients with “seatbelt” fractures will also sustain some type
of intraabdominal injury such as a laceration of the spleen or liver
14. Signs and Symptoms: Initial Evaluation and
Management of Thoracolumbar Injuries
• Initial Evaluation
Advanced Trauma Life Support (ATLS) protocol
Strict precaution for immobilization in form of spine board and
cervical collar needed.
Urgent transportation to adequately equipped tertiary health centre.
Resuscitation should begin immediately
15. Complete Spine examination
Thorough history
Inspect and palpate entire spine
Per anal examination :
sphincter tone
bulbocavernous reflex
anal wink
voluntary anal contraction
sensory examination
22. COMPLETE VS INCOMPLETE
Complete
No function below level of injury
Absence of sensation and voluntary movement in
S4/5 distribution
Incomplete
Preservation of sensation in S4/5 distribution and
voluntary control of anal sphincter
24. Antero-posterior view
loss of lateral vertebral body height
changes in horizontal and vertical interpedicular distance
irregular distance between the spinous processes (equivocal sign)
asymmetry of the spinal alignment
subluxation of costotransverse articulations
perpendicular or oblique fractures of the dorsal elements
25. Lateral view
sagittal profile
degree of vertebral body compression
height of the intervertebral space interruption or bulging of the
posterior line of the vertebral body
dislocation of a dorsoapical fragment
26.
27.
28. CT
:
• The axial view allows
an accurate
assessment of the
comminution of the
fracture
• and dislocation
of fragments
into the spinal
canal .
29. • Sagittal and coronal 2D or 3D
reconstructions are helpful for
determining the fracture pattern
30. MRI
:
• In the presence of neurological deficits, MRI is recommended to
identify a possible
• cord lesion or a cord compression that may be
due
to
disc or
fracture fragments
or epidural
hematoma
31. • MRI can be helpful
in determining the
integrity of the
posterior
ligamentous
structures and
thereby
differentiate
between a stable
and an unstable
lesion.
35. Failure under axial load of both
the anterior and middle column
originating at the
level of one or both end plates
of the same vertebrae
36. Burst fractures..
Lateral film:
• Fracture of posterior wall cortex
• Loss of height of posterior vertebral body
• Retropulsion of fragment into canal
AP film
Increase in interpediculate distance
38. Seat-Belt type injuries..
Denis
Failure of both posterior and middle columns under tension forces
generated by flexion with its axis placed in the anterior column
Chance fracture
51. Treatment - Principles
1. To preserve neurological function
2. To minimize a perceived threat of neurological compression
3. To stabilize spine
4. To rehabilitate the patient
52. Medical management
Hemodynamic:
Aim: Maintain MAP >80 mmHg
X 48 hrs OR 24 hrs postoperatively
whichever longer
• Fluids +/- Vasopressors +/-
Inotropes
VTE prophylaxis
Decubitus ulcer prevention
53.
54. Nonoperative management
• Analgesics
• Braces
• physiotherapy
• Indications:
• Mechanically stable fractures
• Neurologically intact
• Acceptable alignment
• Prolonged bed rest:
• Too mechanically unstable to treat with brace, but for some reason surgery is
contraindicated or refused by the patient.
55. Bracing: When out of bed
• Mid-lumbar through Mid-thoracic injuries T7-L3: TLSO
• Upper thoracic injury at T6 or above: CTLSO
• Biomechanics: Limit spinal motion + Load-sharing
• Mode of healing: Secondary
• Duration: 6 wks – 3 months (upto 4-6 months for 3 column burst fractures)
• Restrictions:
• Lifting >10 lbs & Performing bending or twisting activities
• Upright X-ray in brace at regular f/u (2 wk, 6 wk, every 6-8 wk)
• When brace discontinued (wean): Flexion and Extension X-ray (stability)
58. POSTRIOR
SURGERY:PRIMARILY FOR
REALIGNMENT AND
STABILIZATION
Advantages :
avoids the morbidity of anterior exposure in patients who
potentially have concomitant pulmonary or abdominal
injuries.
• shorter operative times
• decreased blood loss
• functional outcomes are similar to those
following anterior surgery
Disadvantages: no direct approach to site of
pathology
59. Initially hooks and wires
were used
Pedicle screws with rods
most commonly used with
rods for stabilisation now.
Sites
1) thoracic : immediately
lateral to middle of facet joint
along superior third of
transverse process
60. 2) lumbar vertebrae:
Intersection of line bisecting the
transverse process and line
passing along lateral aspect of
facet joint
Other methods
mamillary process
pars interarticularis method
63. ANTERIOR
SURGERY
• Indicated for decompression of the
neural elements.
• It provides direct visualization of the
anterior thecal sac and is the most
reliable method of spinal canal
decompression
• Higher morbidity
• Decompression followed by void filling
with autograft/ allograft / cage
insertion
• Fixation by plates and screws/ rods -screw-
staple construct.
66. COMBINED
APPROACH
Advantages:
• maximization of canal clearance,
• immediate circumferential
stability optimized fusion
rates.
Disadvantage
• superadded morbidity of two
procedure
Usually opted as 2 stage procedure : post ct
scan shows increased deformity or has
residual neurological deficit
67. COMPRESSION FRACTURE
• <10% vertebral height loss :no need external
support.
• <30% to 40% height loss and <20 degrees to 25
degrees kyphosis : Jewett brace for 6 to 8
weeks.
• In fractures below T5, a plaster jacket or TLSO can be
used.
• In higher fractures, a cervical component should be
added to the brace.
• 50% height loss or >30 degrees kyphosis suggests
PLC disruption, and posterior stabilization is
recommended.
• An MRI scan should be used to examine the integrity of
the PLC
68.
69. BURST FRACTURE
Failure of anterior and middle column
Axial compression
+/- failure of posterior column
Compression or tensile force
Most common at T/Ljunction
70. BURST
FRACTURE
• Stable :
• No PLC injury without neurologicdeficit
Radiographic criteria for non operative
• less than 25 degrees to 30 degrees of kyphosis, less than 50% height loss,
• absence of interspinous process widening, less than 50% canal compromise
MRI evidence of discontinuity or continuity ofthe
PLC
TLSO( hyperextension) Brace applied for 3 months
X-ray and clinical follow-up examinations are
scheduled at 2 weeks, 1 month, 2 months,
and 3 months. At the 3-month follow-up, x-
rays are made out of the brace to ensure
stable alignment.
71. UNSTABLE BURST
FRACTURE
Need operative stabilization
Posterior instrumentation and fusion:
PLC disruption in neurologically intact
patients.
<50% height loss: short-segment stabilization
>greater than 50% or extensive comminution:
pedicle screws are placed two levels above and
below the fractured vertebra.
72.
73. Neurological deficit :
Complete injury
Early stabilization
Neurological outcome not changed by
decompression
Incomplete injury
Stabilization and decompression beneficial .
Improvement may occur
76. SEAT BELT / CHANCE
INJURY
Associated with intra-abdominal pathology.
Purely Osseous injuries can be treated
nonoperatively
If the injury is ligamentous orosseoligamentous,
surgical stabilization is indicated
Single-segment posterior fusion is usually
adequate.
Surgeons should check that the pedicles at
adjacent levels are intact prior to surgery.
If not : longer fixation is required
In about 15% of cases, there is associated burst
fracture configuration.
In about 5% of cases, there is an associated
herniated disc : Anterior decompression
77.
78. FRACTURE
DISLOCATION
High energy trauma
There is a high incidence ofcomplete
neurologic deficit
Goal:
Stabilization for early mobilization
Long posterior pedicle screw constructs are best
for thoracolumbar fracture- dislocations.
Up to 50% dural tears have been noted.
Short-segment spinal fixation may not
provide adequate stabilization
79. GUN SHOT
WOUNDS
Rare injury
Transabdominal bullets :
higher source of
contamination
Complete injury more
common than incomplete
Retained bullets may
cause to lead toxicity
81. Postoperative protocol
• Posterior stabilization: Postoperative mobilization on orthosis on D1
and continued upto 8-12 weeks
• Anterior stabilization: Bed rest until chest tube removed TLSO
worn all time when spine is >30 degrees from horizontal plane
TLSO used for 12-16 weeks
82. Complications
• Of injuries:
1. Skin problems
2. VTE
3. Urosepsis
4. Sinus bradycardia
5. Orthostatic hypotension
6. Autonomic dysreflexia
7. Major depressive disorder
• Of fixation:
1. Dural tear
2. Iatrogenic neural injury
3. Pseudoarthrosis
4. Failure of fixation
5. Iatrogenic flat back
6. Infection
7. Medical complications
83. REFERENCES
1. Apley and Solomon’s System of Orthopedics and Trauma – 10th
Edition
2. Campbell’s Operative Orthopedics – 14th Edition
3. Rockwood and Greens Fractures in Adults – 9th Edition
4. AOSpine Masters Series – Volume 6