The document discusses the basics of genetics, including that traits are passed from parents to offspring through genes located on chromosomes, and that genes can be dominant or recessive, explaining concepts like Punnett squares and how Gregor Mendel discovered the principles of heredity through experiments with pea plants. It also touches on more advanced genetics topics such as sex-linked traits, codominance, and dihybrid crosses.
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Some is borrowed from a slide show shared on slide share. Heavily edited to create an introduction to Mendel explains what Mendel was doing without assuming the students just get it. For instance, how does the fertilization thing work. I hope it provideds a launching pad.
Genetics: The study of heredity.
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2. GENETICS
Every trait (or characteristic) in your body comes from
instructions from your mother and father
Father Mother
3. GENETICS
The instructions are coded in the DNA as genes. Genes
are located in chromosomes.
Genes
Segments of DNA that
code for specific traits
For example…
Gene for height
Gene for eye-color
This is not an accurate example. It’s just used to illustrate a point.
4. GENETICS
A closer look…
Half of the offspring’s chromosomes are from mommy, and
half are from daddy.
Father Mother
5. GENETICS
A closer look…
Humans have 23 different chromosomes. We get 1 of
each from our parents, for a total of 46 in somatic cells.
6. GENETICS
A closer look…
Homologues
Homologues
Not
homologues
A pair of the same types of
chromosomes are called
homologous chromosomes,
or just homologues.
This picture has 22 pairs of
homologous chromosomes.
7. GENETICS
Chromosomes and their genes are passed to the offspring
(children) through sperm and egg cells (gametes)
Egg cells
23 chromosomes
Sperm cells
Father Mother
23 chromosomes
8. GENETICS
Chromosomes and their genes are passed to the offspring
(children) through sperm and egg cells (gametes)
Father Mother
9. GENETICS
9 months later…
Father Mother
The offspring is born
10. GENETICS
Each gene has alternate forms, called alleles. For
instance, the gene for eye colour may have 2 alleles:
brown or blue
Brown eyes
Blue eyes
Father passed-on: Mother passed-on:
Blue eyes
Brown eyes
11. GENETICS
Some alleles can “mask” the effects of the other allele.
Although the
mother has blue
eyes, the child has
brown eyes.
Father Mother
In this case, brown eyes are “dominant” Blue eyes
Brown eyes
As a result, blue eyes are “recessive”
12. GENETICS
Some alleles can “mask” the effects of the other allele.
Dominant – traits that are
expressed more often.
Alleles that are dominant are usually
represented by a capitalized letter
symbolizing that allele (i.e. B)
Recessive – traits that are
expressed less frequently.
Blue eyes
Brown eyes Alleles that are recessive are usually
represented by a lower-case letter
symbolizing that allele (i.e. b)
13. GENETICS
Dominant and Recessive Alleles:
Daughter’s genetic makeup:
Brown eyes Blue eyes
How can the daughter’s two alleles (genotype) be written?
Let the allele for brown eyes be B, and the allele for blue eyes be b
Bb
Brown eyes Blue eyes
14. GENETICS
Dominant and Recessive Alleles:
Bb
Brown eyes Blue eyes
Notice how the daughter carries the allele for blue eyes, but she does
not have blue eyes.
Thus her phenotype (observable trait) is brown eyes.
15. GENETICS
Homozygous vs. heterozygous
Bb
Brown eyes Blue eyes
Since she carries two different alleles for eye colour, we
can say that she is heterozygous for eye color.
Heterozygous – describes the genotype of an organism that
contains two different alleles (ex. Bb)
16. GENETICS
Homozygous vs. heterozygous
bb
blue eyes Blue eyes
If she had blue eyes, we can say that she is
homozygous for eye color.
Homozygous – describes the genotype of an organism that
contains two alleles that are the same (ex. BB)
17. GENETICS
But wait…
Father Mother
Is this possible?!
18. GENETICS
Yes this is possible
The father could have carried the recessive allele for blue
eyes as well…
Father
bb Mother
Bb bb
…although you can’t tell because he has the dominant
brown eye allele (which “masks” blue eyes)
20. GENETICS
All too complicated?
Let’s take a look at how it all started…
Gregor Mendel (1822-1884)
- Known as the father of genetics
- Worked with pea plants
21. GENETICS
Mendel’s pea plants
He observed 2 traits for each part of the plant
22. GENETICS
Mendel’s pea plants
Mendel came up with the concept of alleles.
He noticed that alleles are hereditary, and that you can predict
the probability of the offspring having certain alleles.
23. GENETICS
Mendel’s pea plants
He also noticed that some traits dominated over others
For instance, if you “crossed” a yellow-pea plant with a
green-pea plant, you generally get a yellow-pea plant
Mendel Video
24. GENETICS
Mendel’s pea plants
What does “crossing” the pea plants mean?
It means to mate a plant with another plant by pollination.
Garden peas are both self-fertilizing and cross-fertilizing.
Self-fertilizing – a plant’s pollen grains fertilize it’s own egg cells in the
ovary
Cross-fertilizing – a plant’s pollen grains fertilize another plant’s egg cells
in the ovary
25. GENETICS
Mendel’s pea plants
This allowed Mendel to mate pea plants with each other as
well as with itself.
For example, you can mate a
purple flower pea plant with itself.
This is called a
Punnett Square MATE!
26. GENETICS
Punnett Square
This means that mating a pea
plant that is heterozygous for
flower colour (Bb) with itself will
produce…
F1 GENOTYPE:
25% BB
50% Bb
25% bb
A 1:2:1 ratio
F1 PHENOTYPE:
75% purple flowers
25% white flowers
F1 stands for filius and filia, which in Latin means
“son” or “daughter”
27. GENETICS Square
Constructing a Simple Punnett
Step 1: Draw a square with a 2 by 2 grid
28. GENETICS Square
Constructing a Simple Punnett
Step 2: Choose a letter for your allele and
record this choice
Let the allele for purple flower be represented by the letter B
29. GENETICS Square
Constructing a Simple Punnett
Step 3: Consider all possible gametes produced by the
first parent. Write the alleles for these gametes across
the top of the square
Bb Let the allele for
purple flower be
represented by the
B b letter B
30. GENETICS Square
Constructing a Simple Punnett
Step 4: Consider all possible gametes produced by the
second parent. Write the alleles for these gametes down
the side of the square
Let the allele for
purple flower be
represented by the
B b letter B
b
bb
b
31. GENETICS Square
Constructing a Simple Punnett
Step 5: Complete the square by writing all possible allele
combinations from the cross
Let the allele for
purple flower be
represented by the
B b letter B
b
b
32. GENETICS Square
Constructing a Simple Punnett
Step 6: Determine the genotypic and phenotypic
proportions of the offspring
Let the allele for
purple flower be
represented by the
letter B
B b
F1 Genotypes:
50% Bb
b Bb bb 50% bb
F1 Phenotypes:
50% of the plants
b Bb bb have purple flowers
50% of the plants
have white flowers
33. GENETICS
A plant that is homozygous for purple flowers is crossed with a plant
that has white flowers. If the purple condition is dominant over the
white condition, what are the genotypes and phenotypes of the F1
generation?
GIVEN: Let the allele for flower color be presented by the letter P
Parent genotypes: PP X pp
Parent gametes: P or P X p or p
Parent # 1 gametes
Results:
P P
Therefore the results of
the PP x pp cross
Parent # 2 Pp Pp indicate that:
gametes p
25% 25% F1 genotypes: 100% are
Pp (or 4 out of 4 are Pp)
Pp Pp
p F1 phenotypes: all plants
25% 25% have purple flowers
34. GENETICS
Sheep ranchers prefer white sheep over black sheep, because black
fur is hard to die and is brittle. The allele for black fur is
recessive. As a result, if a sheep rancher wishes to purchase a
white fur sheep for breeding, how does she/he know if it will make
black fur babies (in other words, how does the rancher know if
her/his sheep is homozygous or heterozygous?)?
A test cross can be performed to determine the genotype of a
dominant phenotype, which involves breeding the unknown
genotype with a homozygous recessive genotype. In this case the
white sheep with an unknown genotype will be bred with a
homozygous recessive black fur sheep.
35. WHY WERE MENDEL’S FINDINGS
IMPORTANT?
Once we find traits that we like in an organism (for
example, a dog), we can maintain these traits by
mating closely related individuals for the purpose of
maintaining or perpetuating these characteristics (this
is called “inbreeding”)
36. WHY WERE MENDEL’S FINDINGS
IMPORTANT?
-We can also mix traits that we like together from
different species (in plants)
-This process is called “hybridization”
37. WHY WERE MENDEL’S FINDINGS
IMPORTANT?
Genetic Screening:
-we can tell if an individual
carries an allele (or two
alleles) for genetic disorders
-Amniocentesis and Chorionic
Villus Sampling (CVS)
38. WHY WERE MENDEL’S FINDINGS
IMPORTANT?
AMNIOCENTESIS:
Looking at fetal
cells from the
amniotic fluid
39. WHY WERE MENDEL’S FINDINGS
IMPORTANT?
CHORIONIC VILLUS
SAMPLING (CVS):
Sampling tiny
fingerlike projections
on the placenta
Can be performed
earlier (10th to 12th
week of pregnancy)
than amniocentesis
40. THE STORY ISN’T AS SIMPLE…
There are often
more than 2
alleles per
This is called
gene…
having multiple
alleles for one
…but each gene
organism can
ONLY have two
different alleles
for a trait at any
one time
We usually
express these
alleles like this:
E1, E2, E3, E4
41. THE STORY ISN’T AS SIMPLE…
Codominance:
Both alleles are
expressed at the
same time
42. THE STORY ISN’T AS SIMPLE…
Incomplete
dominance: two
alleles are equally
dominant
44. SEX-LINKED TRAITS
- Traits that are
controlled by genes
located on the sex
chromosomes
(usually the X
chromosome)
Ex: Duchenne
muscular
dystrophy,
hemophilia,
Charcot-Marie-
Tooth disease and
color blindness
-Usually
represented like
this:
XR Xr
45. SEX-LINKED TRAITS
Females get 2 X chromosomes:
Protected by
other X
chromosome
Males get ONE X chromosome:
Disease!!!
46. SEX-LINKED TRAITS
Females get 2 X chromosomes:
-1 gets turned off (called a
Barr Body)
-some cells have one X
chromosome inactive, while
other cells have the other
inactive
47. GENETICS
Dihybrid cross
So far what we have done
is a monohybrid cross,
which only involves one
trait. What if you wanted
to see how two different
traits are passed on to the
next generation?
Male RrYy x Female RrYy
48. GENETICS
Dihybrid cross
So far what we have done
is a monohybrid cross,
which only involves one
trait. What if you wanted
to see how two different
traits are passed on to the
next generation?
Male RrYy x Female RrYy