This document discusses dry powder inhalers (DPIs) for pulmonary drug delivery. It covers the ideal characteristics of DPIs including being easy to use, delivering multiple doses, minimizing moisture and adhesion, and providing accurate, uniform and consistent delivery. The document discusses DPI design considerations like capsule opening mechanisms, airflow, and mouthpiece design. It also addresses issues with single and multiple dose devices. Additionally, it outlines drug delivery mechanisms for DPIs and factors that affect their performance like humidity, particle size, and physical properties of powders. Common DPI technologies are also presented along with current trends in DPI development.

1. SUBODH S SATHEESH
2ND MPHARM
DEPT OF PHARMACEUTICS
ECPS
Department of pharmaceutics
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2. Introduction
 COPD
 Pulmonary dosage forms
 Inhaler technology
 PMDI
 Dry powder inhalers
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3. Ideal characters
 Easy to use
 Multiple doses
 Moisture
 Accurate and uniform
 Consistent
 Minimize adhesion
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4. Design
 Capsule opening mechanism
 Airflow
 Retention of capsule debris
 Mouthpiece design
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5. Issues with design
 Single dose devices
 Multiple dose devices
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6. Mechanism
 Impaction
 Diffusion
 Sedimentation
 Interception
 Electrostatic precipitation
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7. Drug delivery
 Invitro
 Invivo
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8. Inhalation devices
 Nebulizers
 Pressurized metered dose inhalers
 Dry powder inhalers
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9. Factors affecting DPI devices
 Humidity
 Interparticulate forces
 Particle size
 Physical properties of powders
 Carrier and size
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10. characterization
 Crystallinity
 Polymorphism
 Moisture content
 Particle size
 Forces of interaction
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11. Micronization
 Fluid energy mill
 Ball mill
 Pin mill
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12. Evaluation
 Appearance
 Colour
 Sieve analysis
 Moisture content
 Spray pattern
 Flow properties
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13. Current trends
 Twisthaler
 Handihaler
 Turbuhalers
 Easyhaler
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14. CONCLUSION
 Drug delivery to lungs
 Improves aerosol delivery systems
 High patient compatibility
 High dose carrying capacity
 Treatment of asthma and COPD
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15. Bibliography
 Frijilink H W, Dry powder inhaler for pulmonary drug delivery
IJPR 2015; 1(1);67-86.
 Nithi yadav, Alka lohani, Dry powder inhalers. A review, Indo
global journal of pharmaceutical sciences, 2014;3(2);141-171
 Newman SP, Evolution of dry powder inhalers formulation and
perfomance. Respiratory care 2013 1209-1223
 Mark copley, accessing Dry powder inhalers. Copley scientific
2012;(3):1027-1028
 Sahane SP, Nikhar AK. Dry powder inhalers, IJPC 2011;(3)
1143-1149.
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