Introduction to pulmonary drug delivery system,pressurized meter dose inhaller(pMDI),Meter dose inhaller(MDI),Dry powder inhaller(DPI), Advantages of PDDS

1. PULMONARY DRUG DELIVERY
SYSTEM
Presented by
Ujjwal Mandal
1st year,2nd sem.
M.pharm.(Pharmaceutics)

2. CONTENTS
 INTRODUCTION
 ANATOMY OF RESPIRATORY TRACT
 ADVANTAGES OF PDDS
 DISADVANTAGES OF PDDS
 MECHANISM ACTION OF DRUG ABSORPTION
 DEVICES USED FOR PDDS
 CONCLUSION
 REFERENCES
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3. INTRODUCTION
 The pulmonary route has gained increasing importance in the
recent development of drug delivery system , due to its unique
advantages than any others routes. Pulmonary route has been
used to treat various respiratory diseases like asthma, COPD
(Chronic obstructive pulmonary diseases),respiratory infection
etc.
 Using devices like dry powder inhalation (DPI), pressurized
meterd-dose inhalation(pMDI) , Nebulizers for the delivery of
drug.
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4. ANATOMY
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5. ADVANTAGES OF PDDS
Delivery of high concentration drug directly to the diseases
site.
Rapid clinical response.
By pass the barriers like poor gastrointestinal absorption and
first-pass metabolism in the liver.
It is a non-invasive, needle free delivery system.
Suitable for wide range of substance.
Less harsh for low enzymatic environment.
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6. DISADVANTAGES OF PDDS
Aerosol devices might be difficult to use.
Drug absorption may be limited by the physical barrier of the
mucus layer.
Drug can be interaction with the mucus membrane.
Drug particle size matter too much.
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7. ABSORPTION OF DRUG
1. Through intercellular junctions.
2. Transcellular diffusion.
3. Transport mediate absorption.
4. Vesicle Mediate transport.
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8. DEVICES USED FOR PDDS
A. Dry Powder Inhalation (DPI) devices
B. The pressurized Meter Dose Inhalation (pMDI) devices.
C. Nebulizers
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9. DRY POWDER INHALATION DEVICES
(DPI)
 A dry powder inhaler (DPI) is a device that deliver drug molecule to the lungs in
the form of a dry powder. DPI are commonly used to treat respiratory diseases
such as asthma, copd etc.
 The drug formulation must be contain as free flowing powder form, which can be
prepared by spary-drying or micronize blending method & should be deliver by
a suitable inert carrier.
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(https://www.cphi-online.com/46/product/89/54/70/Dry%20powder%20inhalation.jpg)

10. PRESSURIZED METER DOSE INHALATION
(pMDI) DEVICE
 The pressurized meter dose inhaler (pMDI) are use to treat diseases like asthma,
copd etc. The metering valve is designed to deliver a precise aerosol amount
(20-100 micro. L.) at each time.
 The key components of the pMDI device (propellants, formulated solution,
metering valve size and actuator) all play role in the delivery of drug molecule or
in medication.
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(https://img.medscapestatic.com/pi/meds/ckb/92/8692tn.jpg)

11. NEBULIZERS
 Nebulizer is a device, which is used for delivery of drug product into the
pulmonary route.
 It use oxygen, compressed air or ultrasonic power to break up solutions and
suspensions into small aerosol droplet that can be directly inhaled from the
mouth-piece of the device.
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(https://d11zer3aoz69xt.cloudfront.net/media/catalog/product/cache/1/image/1200x/9df78eab335
25d08d6e5fb8d27136e95/b/e/beurer_nebulizer_ih-60__1.jpg)

12. CONCLUSION
 From the Ancient time, we use inhalation therapy
included the use of various leaves from plants, vapour
from aromatic plant like balsam, myrrh etc.
The large surface area of the human lung, along with its
rich blood supply, rapid onset of drug action with high
bioavailability, and other physiological advantages,
make it a potential route for treating asthma, COPD,
and other pulmonary disorders.
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13. REFERENCES
Hillery,Lloyd,’Advanced drug Delivery and targeting :A n
Introduction’ Drug Delivery & Targetting, 3rd Edition,
Taylor & Francis Inc,pp- 244-273
ND Shah, VV Shah and ND Chivate, ‘ Pulmonary Drug
Delivery: A Promising Approach’, Journal of Applied
Pharmaceutical Science;2012
Banker, Rhodes,’ Target Oriented Drug Delivery System
Modern Pharmaceutics’,4th Edition,USA,pp-431-480
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