UV Curable Gel Formulations for Topical Drug Delivery
•Download as PPTX, PDF•
3 likes•538 views
Uv curable gel fomulations as drug delivery systems
Recommended
More Related Content
What's hot
What's hot (20)
Viewers also liked
Viewers also liked (16)
Similar to UV Curable Gel Formulations for Topical Drug Delivery
Similar to UV Curable Gel Formulations for Topical Drug Delivery (20)
More from Dr Subodh Satheesh
Recently uploaded
Recently uploaded (20)
UV Curable Gel Formulations for Topical Drug Delivery
- 1. MPHARM PART 2 RECENT SEMINAR UV CURABLE GEL FORMULATIONS as drug carriers
- 2. PRESENTED BY SUBODH S SATHEESH 2ND MPHARM ECPS .
- 3. Hello! I am Subodh Hearty welcome to my presentation
- 4. UV CURABLE GELS Let’s start with the first set of slides
- 5. “ Nail diseases Affects the quality of life Topical and oral antifungals Adverse effects and contraindications
- 6. TOPICAL AGENTS ×Overcomes the disadvantages ×Needs to be frequently applied ×Poor patient complaince
- 7. Currently used as cosmetics Glossy cosmetically acceptable film Topical drug carriers Increases drug residence Increases patient complaince UV curable gels
- 8. Materials ×Drug ×Base Resins eg…urethene methaacrylate ×Photoinitiators eg….alpha hydroxy ketone ×Additives eg…pyromellitic glycerol ×Rheology Modifiers eg…bentonite
- 9. ………. ×Drug used amorolfine HCl and terbinafine HCl ×Base resin..dimethyl acrylate ×Solvent inclusion for effective drug loading ×Ethanol and NMP(n methyl 2 pyrollidine)
- 10. Proportion ofexcipients Concentration of photoinitiators and base resins were used as similar as cosmetic gels Formulation with ethanol in 25 to 50% Increased water sensitivity and decreased drug residence Inclusion of ethanol at 25% produced 3%AF and 4% TF and NMP Produced 1% of each
- 11. Preaparation of formulations ×Three types of formulation Drug free solvent containing formulations Drug free solvent free formulation Drug and solvent
- 12. UV curing of formulations ×Formulation was applied to a microscope glass slide using pipette tip ×Placed under a UV nail lamp ×Curing of formulation and formation of film ×Surface wiped with propanol ×Glossy film ×Mass conversion percentage Wt/W0*100
- 13. Characterisation of uv cured film Thickness AK9635D 0–25 mm Digital External Micrometer Maximum drug load XRD and polarised light microscopy DSC Q2000TA SEM FEI Quanta 200F. TGA Discovery TGA model DMA Q800DMA
- 14. … ×Uv cured films adhesivity ×Sensitivity to water ×Drug release from films ×Invitro drug permeation studies ×Analytical methods ×
- 15. RESULTS ...
- 16. THICKNESS ..Solvent-free and drug-free gel 211.1 _ 6.0 Drug-free gel containing ethanol 161.1 _ 7.8 Gel containing ethanol and 3% w/v Amorolfine HCl 163.3 _ 8.7 Gel containing ethanol and 4% w/v Terbinafine HCl 164.4 _ 7.3 Drug-free gel containing NMP 165.6 _ 7.3 Gel containing NMP and 1% w/v Amorolfine HCl 167.8 _ 8.3 Gel containing NMP and 1% w/v Terbinafine HCl 166.7 _ 7.1 Drug-free gel containing ethanol 161.1 _ 7.8
- 17. Percentage of conversion .. Solvent-free and drug-free gel 51.3 Drug-free gel containing ethanol 61.1 Gel containing ethanol and 3% w/v Amorolfine HCl 61.4 Gel containing ethanol and 4% w/v Terbinafine HCl 59.9 Drug-free gel containing NMP 62.7 Gel containing NMP and 1% w/v Amorolfine HCl 63.7 Gel containing NMP and 1% w/v Terbinafine HCl 60.9 Drug-free gel containing ethanol 59.4
- 18. SEM RESULTS …
- 19. Mass after UV curing ×Mass yield and drug yield
- 20. FTIR ×No interactions ×NMP’s incorporation into polymer has produced C=O strech ×Ethanol have no effect
- 21. DMA Results . ×Two transitions represent two polymer chains ×Reaction of monomers ×In NMP more residual solvent has produced plasticizing effect on UV cured film ×Low Tg value
- 22. Film adhesion to substrate .. ×High scores shows low adhesion ×Ethanol dont make much change ×NMP reduces adhesivity ×More NMP on curing
- 23. Water sensitivity values . ×NMP formulations are extremely water sensitive ×Incorporation of NMP in the polymer ×Low water sensitivity of ethanol ×Low water sensitivity ensures longer residence on nail
- 24. Stability ×Accelerated stability studies ×3months ×No changes for uv films ×Polymer films produced crystals
- 25. Drug release ×Curanail is commercially available nail lacquer ×Curanail produced complete drug release by day 10 ×Uv curable produced slow release which indicates greater affinity to films.
- 26. CONCLUSIONS ×Promising topical drug carriers ×Ethanol containing formulations have high stability and water resistance ×Improves topical therapy of nail diseases ×
- 27. REFERENCES Stephen Hilton, laxmi R, Sudaxshina Murdan. UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases. Intl J pharmacy, 2015, 177˗190 Thomas B, Chemistry and Formulation of UV curable gel formulations. Esstech.In 2014 page 234to240 Marjo K Uv curable gel formulations. Tamper J of App Sci. 2011:1(3) 1˗28 Kentaro T, Effects of Curing Conditions and Formulations on Residual Monomer Contents and Temperature Increase of a Model UV Gel Nail Formulation. Journal of Cosmetics, Dermatological Sciences and Applications, 2011, 1, 111-118 Mianz K Uv curable gels in cosmetics. J of cosmetics. 2013,13˗21 ×.
- 28. Thanks! .