This document summarizes information about lymphatic filariasis, which is caused by infection with nematodes Wuchereria bancrofti and Brugia malayi. It affects over 120 million people globally. The life cycle involves transmission between humans and mosquitoes. Adult worms reside in human lymphatic vessels and nodes, producing microfilariae that circulate in blood mostly at night. This can lead to lymphadenitis, lymphangitis, lymphedema, and elephantiasis over time. Diagnosis involves detecting microfilariae or using immunological and molecular tests. Treatment is diethylcarbamazine to kill microfilariae and mosquito control to block transmission.
Concise discussion on Fialrial worms including Morphology, Life cycle, pathogenesis, clinical manifestations and laboratory diagnosis including newer techniques for UG and PG students.
This topic is highly useful for MBBS students.
Strongyloides is a Nematode. Causes Strongyloidiasis.
This topic briefly describes about the mode of transmission, life cycle, clinical features ,complications ,diagnosis, treatment and its prevention.
Concise discussion on Fialrial worms including Morphology, Life cycle, pathogenesis, clinical manifestations and laboratory diagnosis including newer techniques for UG and PG students.
This topic is highly useful for MBBS students.
Strongyloides is a Nematode. Causes Strongyloidiasis.
This topic briefly describes about the mode of transmission, life cycle, clinical features ,complications ,diagnosis, treatment and its prevention.
local names, definition, etiology,epidemiology lifecycle, pathogenesis, clinical findings, necropsy finding, diagnosis,treatment, control and prevention
Filarial worms are thread-like nematodes of which there are at least 8 species for which humans, especially in tropical regions, are the definitive host
local names, definition, etiology,epidemiology lifecycle, pathogenesis, clinical findings, necropsy finding, diagnosis,treatment, control and prevention
Filarial worms are thread-like nematodes of which there are at least 8 species for which humans, especially in tropical regions, are the definitive host
wuchereria bancrofti can causes serious diseases that attack our world . so this presentation gives us some information about this worm , methods of avoiding it and what are diagnostic tests that doctors ask .
Wuchereria Bancrofti, the adult worm or parasites and its embryo microfilariae . The studies of microbiology. Its about Introduction, morphology, life cycle, pathogenesis, diagnosis and treatment
BACTERIAL DISEASES OF FOXES.
All of the information are collected , it's not a research work but I think it will help the students to know about the basic information.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. Arthropod borne Tissue dwelling parasites
arthropods as intermediate hosts
Many affect domestic animals or humans:
Lymphatic filariasis: Wuchereria bancrofti
Brugia spp,
River Blindness: Onchocerca volvulus
3. Life cycle is passed in two hosts.
Humans are the definitive host
Transmitted by
Culex, Aedes, and Anopheles species.
4. Lymphatic filariasis is caused by infection with
nematodes of the family Filarioidea: most of the
infections are caused byWuchereria bancrofti
and most of the remainder by Brugia malayi.
Humans are the exclusive host of infection
with W. bancrofti. Although certain strains of B.
malayi can also infect some animal species
(felines and monkeys)
5. Endemic in 83 countries
1.2 billion at risk
More than 120 million people infected
More than 25 million men suffer from
genital symptoms
More than 15 million people suffer from
lymphoedema or elephantiasis of the leg
6. Habitat : adult male and feamale worm reside
in lynph nodes and lymphatics of man.
Microfilaria are found in blood.
7. Adult worm are long hair like transparent,
creamy white,long, hair like nematodes,
filariform in shape with tapering ends.
Male measures 2.5 to 4 cm in length by 0.1
mm in thickness and female measures 8 to
10 cm in length and 0.3 mm in thickness.
Tail end of male worm is curved ventrally with
two spicules of unequal length, while that of
female worm is narrow and abruptly pointed.
8. The female are viviparous and liberates
sheathed embryos, the microfilariae into
lymph .
10. Transparent and colourless with blunt head
and pointed tail .
Covered by hyaline sheath which is longer
than larva. It can move forwards and
backwards in sheath.
Nuclei appear as granules in the central axis
of microfilaria.
Tail tip is free from nuclei.
11. Found in peripheral blood and often in the
hydrocele fluid and chylous urine.
15. There is a marked periodicity in the circulation
of microfilaria in the blood.
They will be present in high numbers in the
peripheral blood during mid night between
10p to 2am and scanty or absent at day time.
This type of periodicity is called as nocturnal
periodicity.
Body temperature, oxygen,sleeping habits etc
may influence the periodic pattern of the
microfilaria.
16. Completes life cycle in two hosts.
Definitive host: Man.
Intermediate host: Mosquitoes:
Culex quinquefaciatus (50%)
Anopheles (rural areas)
Aedes Species.
17. sheathed microfilariae ingested. After
2-6 hrs penetrate stomach wall to
reach thoracic muscles.
On 10-
11th day
3rd stage
infective
larva is
fully
formed
Mosquito injects 3rd stage larva in
man through skin which enter into
lymphatics &settle in L.N
In 1 yr they
are sexually
mature.
After
fertilization
female
produces
microfilariae
18.
19. The infections are mainly classified into two
forms
1.BANCROFTIAN FILARIASIS.
2.OCCULT FILARIASIS.
3. TROPICAL PULMONARY EOSINOPHILIA
20. The pathogenic effect is produced by adult
worms of Wuchereria.
LYMPH NODES BECOME ENLARGED FIRM
AND FIBROTIC.
m/s- lymph nodes show lymphocytes, plasma
cells, polymorphs and eosinophils.
Adult worms can be seen in lumen of
lymphatic vessels.
In chronic disease dead worms with fibrotic
and calcified tissue is seen.
21. Lymphangitis with swelling. Redness and pain .
Mechanical irritation
Liberation of metabolites
Absorption of toxic products.
Secondary bacterial infections.
chronic inflammation leads to damaged and
incompetent lymph valves.
Increased pemeability of wall of lymphatics.
22. Lymphatic obstruction- due to dead
worms, obliterative endolymphangitis,
exessive fibrosis of lymphatic vessels and
afferent lymph nodes.
23. Repeated leakage of lymph in tissues lead to
lymphoedema and swelling of the limbs,
breasts and genitalia.
Non-pitting edema and verrucous growth
occurs with secondary bacterial and fungal
infection.
in males, hydrocele, orchitis, epidydimitis are
common.
Chyluria – lymph getting in urine can occur .
Lymphangiovarices occur in inguinal,
scrotal, testicular, abdominal sites
24.
25. Bouts of fever, headache, malaise,pain
and lymphangitis and lymphadenitis of
axilla or groin region are common during
incubation period. Blood examination may
show high eosinophilia.
26. Occult filariasis is believed to be the result of
hyper responsiveness to filarial antigens
derived from mf.
Massive eosinophilia , generalised L.N.
enlargement, helatospenomegaly and
pulmonary symptoms.
Eosinophilic granulomas develop.
27. Malaise, fever , wt loss and respiratory
symptoms- dry nocturnal cough, dyspnoea
and wheezing, with marked increase in
eosinophil count.
X-ray shows diffused miliary mottling and and
increased broncoalveolar markings.
Total serum IgE is increased and antibodies to
filaria of high titre.
Associated with W. bancrofti and Brugia malayi
infections.
28. Detection of microfilariae.
Detection of adult worm.
Immunodiagnosis.
DNA probes.
29. Filariasis is usually diagnosed by identifying
microfilariae on Giemsa stained, thin and thick
strict windows of the time of day must be observed.
Membrane fitration , centrifugation and
sedimentation tecniques used for suboptimal times.
Anticoagulated blood mounts can be seen for
microfilaria.
Acridine orange –microhaematocrit tecnique can be
used.
The DEC(diethylcarbamazine)
(2mg/kg)provocation test is performed to obtain
satisfying numbers of parasites in daytime samples
30. Lymph node aspirate and chylus fluid
may also yield microfilariae.
Detection of adult worm – in biopsied L.N
X-ray can show calcified adult worms.
Antibody tests —Serologic tests for filarial
antibodies which detect elevated levels of
IgGand IgEare available
31. Polymerase chain reaction (PCR) , DNA probes
and antigenic assays, which detect circulating
filarial antigens, are also available for making
the diagnosis.
32. DEC Diethyl Carbomazine citrate (DEC)
Dose: 6mg/Kg/12 days
34. Habitat- L.N and lymphatic vessels. And
microfilaria in blood of man.
Morphology – resembles W. bancrofti, though
smaller in size.
Sheathed larva like wuchreria.
Secondary kinks present, cephalic space is
longer.
Nuclear column appears blurred in giemsa
staining.
2 discrete nuclie at tip of tail.
Show nocturnal periodicity.
35.
36. Life cycle is similar but I.H are Mansonia,
anopheles and aedes.
Pathogenicity- similar to bancroftian filariasis
but elephantiasis is restricted to legs and no
chyluria or involvement of male genetalia.
Can cause TPE
Lab diagnosis- demonstration of microfilaria.
And adult worms.
37. Brugia malayi
The adult females of B malayi
resembles to W. bancrofti
Brugia timori
Similar to B. malayi .
38. Brugia timori microfilaria differ by failure of
the sheath to stain with giemsa and long
cephalic space. Greater no of nuclie in tail (5-
8)
Lesions are few and mild.
Lymphangitis , lymphadenitis and
elephantiasis below the knee.
Lab dia and tratment similar to B. MALAYI
INFECTION.