Uploaded byAshok Katta
Vitamin K .
Vitamin K exists in three forms - vitamin K1, K2, and K3. It functions as a coenzyme in the liver to enable the carboxylation of blood clotting factors and proteins involved in bone mineralization. A daily recommended intake of 70-140 μg is needed to support blood coagulation and bone health, with deficiency leading to increased bleeding risks.
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Vitamin K .
- 2. Henrik Dam EdwardDoisy
- 3. Vitamin K Vitamin K Anti-hemorrhagicfactor Specific coenzyme function Required for coagulation
- 4. Chemistry Vitamin K1 Phylloquinone Vitamin K2 Menaquinone VitaminK3 Menadione Naturally occurring Synthetic form
- 5. Vitamin K arenaphthoquinone derivatives. Chemistry
- 6. Chemistry Vitamin K2 • Menaquinone Producedby the intestinal bacteria Vitamin K1 • Phylloquinone Present in plants
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- 9. RDA for VitaminK is… Nutritional Requirement 70–140 μg of vitamin K per day
- 10. Absorption & Transport Dietaryvitamin K is absorbed in the duodenum along with lipids. It is transported to the liver through chylomicron. Stored in Liver
- 11. Functions of VitaminK Role in blood Coagulation Role in Bone
- 12. Functions of VitaminK cont…blood coagulation • It is necessary for coagulation. • It brings about the post translational modification of certain blood clotting factors. (factor II, VII, IX & X) • They all are synthesized as inactive zymogen form in the liver. • Gamma carboxylation of glutamic acid residues. • These are the binding sites for calcium ions.
- 15. Functions of VitaminK Vitamin K is required for proper bone health Bonehealth •Vitamin K is also required for the carboxylation of glutamic acid residues of osteocalcin, a Ca2+ binding protein present in bone
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- 25. Vitamin k -antagonist
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Editor's Notes
- #3 Henrik Dam isolated vitamin K1 in 1929, while Edward Doisy isolated vitamin K2 in 1939. Both of them were awarded Nobel prize in 1943. In 1935 Danish scientist Henrik Dam described a fat-soluble factor that reduced bleeding in chicks fed an extremely low-fat diet. He named this factor vitamin K
- #4 is the only fat soluble vitamin with a specific coenzyme function
- #9 Green leafy vegetables are good dietary sources. Even if the diet does not contain the vitamin, intestinal bacterial synthesis will meet the daily requirements, as long as absorption is normal.
- #13 Factor II (prothrombin); Factor VII (SPCA); Factor IX (Christmas factor); Factor X (Stuart Prower factor).
- #22 In normal adults dietary deficiency will not occurs since the intestinal bacterial synthesis is sufficient to meet the needs of the body. This can result from obstructive jaundice, chronic pancreatitis, sprue, etc.
- #23 The newborns, premature infants have relative vitamin K deficiency. This is due to lack of hepatic stores, limited oral intake And absence of intestinal bacterial flora.
- #24 The newborns, premature infants have relative vitamin K deficiency. This is due to lack of hepatic stores, limited oral intake And absence of intestinal bacterial flora.
- #26 Warfarin and dicoumarol will competitively inhibit the gamma carboxylation system due to structural similarity with vitamin K. Hence they are widely used as anticoagulants for therapeutic purposes.