Valvular heart disease involves heart valves not functioning properly, affecting blood flow. Common types include valvular stenosis (narrowing of valve openings) and valvular regurgitation (backflow of blood), with various causes such as rheumatic fever and congenital defects. Management may involve medical therapies, surgical interventions like valve replacement, and monitoring for complications.

1. VALVULAR
HEART
DISEASE
NUR HANISAH ZAINOREN

2. What Is Valvular Heart
Disease?
Heart valve disease
occurs when your heart's
valves do not work the
way they should.

3. How Do Heart Valves
Work?
MAINTAIN
ONE-WAY BLOOD FLOW
THROUGH YOUR HEART
 The four heart valves make
sure that blood always flows
freely in a forward direction
and that there is no backward
leakage.

4. Heart
Valves

5. ANY DISEASE OF THESE VALVES ARE CALLED AS
VALVULAR HEART DISEASE!

6. Types of valve disease

7. Valvular Stenosis
THE VALVE OPENING NARROWS
 the valve leaflets may become fused or thickened that the
valve cannot open freely  obstructs the normal flow of blood
EFFECTS:
the chamber behind the stenotic valve is subject to greater stress
 must generate more pressure (work hard) to force blood through
the narrowed opening
 initially, the compensates for the additional workload by
gradual hypertrophy and dilation of the myocardium
 heart failure

8. Valvular Regurgitation
LEAKAGE OR BACKFLOW OF BLOOD RESULTS FROM
INCOMPLETE CLOSURE OF THE VALVE
 due to:
- Scarring and retraction of valve leaflets
OR
- Weakening of supporting structures
EFFECTS:
causes the to pump the same blood twice
(as the blood comes back into the chamber)
 the dilates to accommodate more blood
 ventricular dilation and hypertrophy  eventually leads to
heart failure

9. Principal Causes
•Valve stenosis •Valve regurgitation
• Congenital
• Rheumatic carditis
• Senile degeneration
• Congenital
• Rheumatic carditis
(acute or chronic)
• Infective endocarditis
• Valve ring dilatation
(e.g. dilated cardiomyopathy)
• Syphilitic aortitis
• Traumatic valve rupture
• Damage to chordae and
papillary muscle (e.g. MI)
• Senile degeneration

10. Valvular Heart Disease
1. MITRAL STENOSIS
2. MITRAL REGURGITATION
3. AORTIC STENOSIS
4. AORTIC REGURGITATION
5. TRICUSPID STENOSIS
6. TRICUSPID REGURGITATION
7. PULMONARY STENOSIS
8. PULMONARY REGURGITATION

11. 1. MITRAL STENOSIS

12. Aetiology
 Almost always rheumatic
in origin
 Older people: can be
caused by heavy
calcification of mitral
valve congestion
 Congenital (rare)

14. Pathophysiology
Normal mitral valve
orifice is 5cm2 in
diastole & may be
reduced to 1cm2 in
severe mitral stenosis

15. Pathophysiology

16. Pathophysiology

17. Pathophysiology

18. Pathophysiology

19. Pathophysiology
Atrial fibrillation due to
progressive dilatation
of the LA is very
common.
Its onset often
precipitates
pulmonary oedema
In contrast, a more gradual
rise in left atrial pressure
tends to cause an increase
in pulmonary vascular
resistance  pulmo. HTN 
RVH, TR RHF

20. Pathophysiology
Narrowing of mitral valve
 CO
O2/CO2 exchange
(fatigue, dyspnea,
orthopnea)
Left ventricular
atrophy
pulmonary
congestion
 pulmonary
pressure
 left atrial
pressure
Hypertrophy
left atrium
 blood flow
to left ventricle
Right-sided
failure
Fatigue

21. Clinical features
Symptoms
 Breathlessness, cough (pulmonary congestion)
 Chest pain (pulmonary hypertension)
 Hemoptysis (pulmonary congestion or hypertension)
 Fatigue (low cardiac output)
 Oedema, ascites (right heart failure)
 Palpitation (atrial fibrillation)
 Thromboembolic complications

22. Clinical features
Signs
 Atrial fibrillation
 Mitral facies (abnormal flushing of the cheeks that occurs from cutaneous
vasodilation in the setting of severe mitral valve stenosis)
 Auscultation - Loud first heart sound, opening snap
(created by forceful opening of mitral valve)
- Mid-diastolic murmur (apex)
 Crepitations, pulmonary edema, effusions
(raised pulmonary capillary pressure)
 RV heave, loud P2 (pulmonary hypertension)

23. Mitral stenosis
…Lub Hoot…

24. Investigations
 ECG: - right ventricular hypertrophy  tall R waves
 Chest x-ray: - enlarged LA & appendage
- signs of pulmonary venous congestion
 ECHO: - thickened immobile cusps
- reduced valve area
- enlarged LA
- reduced rate of diastolic filling of LV
 Doppler: - pressure gradient across mitral valve
 Cardiac catheterization: - coronary artery disease
- pulmonary artery pressure
- mitral stenosis and regurgitation

25. Management
Medically
 Anticoagulant
To reduce the risk of
systemic embolism
 Digoxin, beta blockers,
or rate limiting calcium
antagonists
To control ventricular rate
in atrial fibrillation
 Diuretic
To control pulmonary
congestion
Surgically
 Mitral balloon
valvuloplasty***
 Mitral valvotomy
 Valve replacement

26. Balloon
mitral
valvuloplasty

27. 2. MITRAL REGURGITATION

28. Mitral regurgitation
Incomplete closure of mitral valve

29. Aetiology
 Rheumatic disease is the principal cause (in
countries where disease is common)
 Mitral valve prolapse
 Dilatation of the LV and mitral valve ring
(e.g. coronary artery disease, cardiomyopathy)
 Damage to valve cusps and chordae
(e.g. rheumatic heart disease, endocarditis)
 Ischaemia or infarction of papillary muscle (MI)

30. Pathophysiology

31. Pathophysiology
Incomplete closure of
mitral valve
 vol. of blood ejected
by left ventricle
 Left atrial pressure
Right-sided heart failure
Left atrial hypertrophy CO
 Pulmonary pressure
Backflow of blood to the
left atrium
 Right ventricular
pressure

32. mitral valve prolapse
 A.k.a ‘floppy’ mitral valve
 One of the most common cause
of mild mitral regurgitation
 Caused by
 congenital anomalies
 degenerative myxomatous
changes
 feature of connective tissue
disorders like Marfan’s syndrome
Mitral regurgitation

33. mitral valve prolapse
 Mildest form:
 Valve remains competent but bulges
back into atrium during systole  mid-
systolic click but no murmur
 In the presence of regurgitant valve:
 Click is followed by a late systolic
murmur, which lengthens as the
regurgitation becomes more severe
 Severe form:
 Progressive elongation of chordae
tendinae increasing regurgitation
Chordal rupture severe regurgitation
Mitral regurgitation

35. Clinical Manifestations
 Fatigue & weakness – due to  CO – predominant complaint
 Exertional dyspnea & cough – pulmonary congestion
 Palpitations – due to atrial fibrillation (occur in 75% of pts.)
 Edema, ascites – Right-sided heart failure
SYMPTOMS

36. Clinical Manifestations
 Atrial fibrillation
 Cardiomegally
 Apical pansystolic murmur +/- thrill
 Soft S1, apical S3
 Signs of pulmonary venous congestion (crepitations, pulmonary
edema, effusions)
 Signs of pulmonary hypertension & right heart failure
SIGNS

37. Mitral regurgitation
…Hoot Dub…

38. Investigations
 ECG: - left atrial hypertrophy
- left ventricular hypertrophy
 Chest x-ray: - enlarged LA,LV
- pulmonary venous congestion
- pulmonary oedema
 ECHO: - dilated LA,LV
- structural abnormalities of mitral valve (e.g. prolapse)
 Doppler: - detects and quantifies regurgitation
 Cardiac catheterization: - dilated LA,LV
- mitral regurgitation
- pulmonary hypertension
- coexisting coronary artery disease

39. Management
Medically
 Vasodilators
(e.g. ACE inhibitors)
 Diuretics
 If atrial fibrillation
presents,
 Anticoagulant
 Digoxin
Surgically
 Mitral valve repair
OR
 Mitral valve
replacement
To treat
mitral valve
prolapse

40. 3. AORTIC STENOSIS

41. Aortic Stenosis
Narrowing of the aortic valve

42. Aetiology
 INFANTS, CHILDREN,
ADOLESCENTS
• Congenital aortic stenosis
• Congenital subvalvular
aortic stenosis
• Congenital subvalvular
aortic stenosis
 YOUNG ADULTS TO
MIDDLE-AGED
• Calcification and fibrosis
of congenitally bicuspid
aortic valve
• Rheumatic aortic stenosis
 MIDDLE-AGED TO ELDERLY
• Senile degenerative
aortic stenosis
• Calcification of bicuspid
valve
• Rheumatic aortic stenosis

43. Pathophysiology

44. Pathophysiology
Stiffening/Narrowing of
Aortic Valve
Incomplete emptying of
left atrium
Left ventricular hypertrophy
Pulmonary congestion
Compression of
coronary arteries
Right-sided heart failure
 CO
 Myocardial
O2 needs
Myocardial ischemia
(chest pain)
 O2 supply

45. Clinical features
Symptoms
 Mild or moderate stenosis: usually asymptomatic
 Exertional dyspnea
 Angina (due to demands of
hypertrophied LV)
 Exertional syncope
 Sudden death
 Episodes o acute pulmonary oedema
CARDINAL
SYMPTOMS
CO fails to rise
to meet demand

46. Clinical features
Signs
 Ejection systolic murmur
 Slow-rising carotid pulse
 Thrusting apex beat (LV pressure overload)
 Narrow pulse pressure
 Signs of pulmonary venous congestion (e.g. crepititions)

47. Investigations
 ECG: - left ventricular hypertrophy
- left bundle branch block
 Chest x-ray: - may be normal
- enlarged LV & dilated ascending aorta (PA view)
- calcified valve on lateral view
 ECHO: - calcified valve with restricted opening, hypertrophied LV
 Doppler: - measurement of severity of stenosis
- detection of associated aortic regurgitation
 Cardiac catheterization: - to identify asst. coronary artery disease
- may be used to measure gradient
between LV and aorta

48. Management
 Asymptomatic aortic stenosis  kept under review
 Moderate/severe stenosis  evaluated every 1-2 years
with Doppler echocardiography (to detect progression in severity)
 Symptomatic severe aortic stenosis  valve replacement
 Congenital aortic stenosis  aortic balloon valvuloplasty
 Atrial fibrillation or post valve replacement with a
mechanical prosthesis  anticoagulant
(as the development of angina, syncope,
symptoms of low CO or heart failure
has a poor prognosis and is an indication
for prompt surgery)

49. 4. AORTIC REGURGITATION

50. Causes
 Congenital:
 Bicuspid valve or disproportionate cusps
 Acquired:
 Rheumatic disease
 Infective endocarditis
 Trauma
 Aortic dilatation (marfan’s syndrome, aneurysm,
dissection, syphilis)

51. Pathophysiology

52. Pathophysiology
Incomplete closure of the
aortic valve
Backflow of blood to Left
ventricle
Left ventricular
hypertrophy & dilation
 Left atrial pressure
Left-sided heart failure
(late stage)
Left atrium hypertrophy
 CO
 Pulmonary pressure
Right-sided heart failure
 Right ventricular
pressure

53. Clinical features
Symptoms
 Mild or moderate aortic regurgitation:
 Usually asymptomatic
 Awareness of heartbeat, ‘palpitations’
 Severe aortic regurgitation:
 Breathlessness
 Angina
particularly when lying on the left side,
which results from increased in stroke volume
(because compensatory ventricular
dilatation&hypertrophy occur)

54. Clinical features
 Pulses:
 Large volume or ‘collapsing’ pulse
 Low diastolic and increased pulse pressure
 Bounding peripheral pulse
 Capillary pulsation in nail beds: Quincke’s sign
 Femoral bruit(‘pistol shot’): Duroziez’s sign
 Head nodding with pulse: de Musset’s sign
 Murmurs:
 Early diastolic murmur
 Systolic murmur (increased stroke volume)
 Austin Flint murmur (soft mid-diastolic)
 Other signs:
 Displaced, heaving
apex beat (volume
overload)
 Pre-systolic impulse
 4th heart sound
 Crepitations
(pulmonary venous
congestion)
Signs
characteristic murmur is best heard
to the left sternum during held expiration

55. Investigations
 ECG: initially normal,
later left ventricular hypertrophy & T-wave inversion
 Chest x-ray: - cardiac dilatation, maybe aortic dilatation
- features of left heart failure
 ECHO: - dilated LV
- hyperdynamic LV
- fluttering anterior mitral leaflet
 Doppler: - detects reflux
 Cardiac catheterization: - dilated LV
- aortic regurgitation
- dilated aortic root

56. Management
 Treatment may be required for underlying conditions,
such as endocarditis or syphilis
 Aortic regurgitation with symptoms aortic valve
replacement (may be combined with aortic root
replacement and coronary bypass surgery)
 Asymptomatic patients  annually follow up with
echocardiography for evidence of increasing
ventricular size
 Systolic BP should be controlled with vasodilating drugs,
such as nifedipine or ACE inhibitors

57. 5. TRICUSPID STENOSIS

58. Tricuspid Stenosis
 usually occurs together with aortic or mitral
stenosis
 may be due to rheumatic heart disease (<5%)
  blood flow from right atrium to right ventricle
  right ventricular output
  left ventricular filling   co
  systemic pressure

59. Tricuspid Stenosis
Symptoms
 symptoms of right-sided
heart failure
- hepatomegaly
- ascites
- peripheral edema
- neck vein
engorgement
  co – fatigue,
hypotension
Signs
 Raised JVP
 Mid-diastolic murmur
(best heard at lower left or
right sternal edge)

60. Tricuspid Stenosis
Management
 Valve replacement
 Valvotomy
 Balloon valvuloplasty

61. 6. TRICUSPID REGURGITATION

62. Tricuspid Regurgitation
 common, and is most frequently ‘functional’ as a
result of enlargement of right ventricle
 an insufficient tricuspid valve allows blood to flow
back into the right atrium  venous congestion & 
right ventricular output   blood flow towards the
lungs

63. primary
 Rheumatic heart disease
 Endocarditis, particularly
in injection drug-users
 Ebstein’s congenital
anomaly
secondary
 Right ventricular
dilatation due to chronic
left heart failure
(‘functional tricuspid
regurgitation’)
 Right ventricular
infarction
 Pulmonary hypertension
(e.g. cor pulmonale)
Tricuspid Regurgitation
causes

64. Tricuspid Regurgitation
Symptoms
 Usually non-specific
 Tiredness (reduced
forward flow)
 Oedema
 Hepatic enlargement
(venous congestion)
Signs
 Raised JVP
 Pansystolic murmur (left
sternal edge)
 Pulsatile liver

65. Tricuspid Regurgitation
Management
 Correction of the cause of right ventricular
overload (if TR is due to right ventricular dilatation)
 Use of diuretic and vasodilator treatment of CCF
 Valve repair
 Valve replacement

66. 7. PULMONARY STENOSIS

67. Pulmonary Stenosis
Symptoms
 Fatigue, dyspnea on
exertion, cyanosis
 Poor weight gain or
failure to thrive in infants
 Hepatomegaly,
ascites, edema
Signs
 Ejection systolic murmur
(loudest at the left upper
sternum & radiating towards
the left shoulder)
 Murmur often preceded by
an ejection sound (click)
 May be wide splitting of
second heart sound (delay in
ventricular ejection
 May be a thrill (best felt when
patient leans forward and
breathes out)

68. Investigations
 ECG: - right ventricular hypertrophy
 Chest x-ray: - post-stenotic dilatation in the pulmonary artery
 Doppler echocardiography is the definitive investigation

69. Management
 Mild to modearate isolated pulmonary stenosis is
relatively common and does not usually progress or
require treatment
 Severe pulmonary stenosis  percutaneous pulmonary
balloon valvuloplasty
OR
surgical valvotomy

70. 8. PULMONARY REGURGITATION

71. Pulmonary Regurgitation
 A rare condition
 Usually associated with pulmonary hypertension
which may be
• Secondary of the disease of left side of the heart
• Primary pulmonary vascular disease
• Eisenmenger’s syndrome
 Blood flows back into right ventricle  right ventricle
and atrium hypertrophy  symptoms of right-sided
heart failure
 Trivial PR is a frequent finding in normal individuals and has
no clinical significance

72. Reference
 For videos of
heart murmurs:
https://www.youtu
be.com/playlist?list
=PLB7F86984222A1F
7C

73. THANK YOU