The document discusses how nanotechnology can be used for cancer diagnosis and treatment. It describes several nanoscale devices such as nanopores, nanotubes, quantum dots, dendrimers, liposomes, nanoshells, and nanorobots that can help detect genetic mutations associated with cancer, target delivery of drugs to cancer cells, and enable non-invasive cancer diagnosis and treatment with localized heat therapy. The manipulation of matter at the nanoscale allows more precise cancer detection and targeted therapy with fewer side effects than traditional approaches.
DNA Nanotechnology: Concept and its Applications
DNA Nanotechnology # Various 2 and 3 dimensional shapes of DNA nanotechnology # DNA Origami # with their application and Future scope
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to show how nanotechnology for drug deliver is becoming economically feasible.
Introduction
Definition
History
Advantages of nanobiotechnology
Applications of nanobiotechnology
Drawback of nanobiotechnology
New features in the nanobiotechnology
Conclusion
References
DNA Nanotechnology: Concept and its Applications
DNA Nanotechnology # Various 2 and 3 dimensional shapes of DNA nanotechnology # DNA Origami # with their application and Future scope
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to show how nanotechnology for drug deliver is becoming economically feasible.
Introduction
Definition
History
Advantages of nanobiotechnology
Applications of nanobiotechnology
Drawback of nanobiotechnology
New features in the nanobiotechnology
Conclusion
References
This presentation is a simple explain of Bionanoimaging which introduce this area completely. You can use this PPTx File to present in your class and seminars as well. I prepare this file to present in Tabriz University of Medical Sciences when I was a MSc Medical Nanotechnology student. It will be useful for you too.
Nanotechnology and its Application in Cancer TreatmentHasnat Tariq
Nanotechnology
Nanomaterials
Nanostructures
Nanoparticles
Unexpected Optical Properties of Nanoparticles
Synthesis of Nanoparticles
Nanotechnology in Cancer Treatment
Role of Sulfur NPs in Cancer Treatment
Human Tumour Cell Lines Used in Research
Ehrlich ascites carcinoma (EAC)
Sulfur Nanoparticles Preparation
MTT Assay
Sulphorhodamine-B (SRB) Assay
Median lethal dose (LD 50)
Experimental design
FT-IR Characterization of Sulfur Nanoparticles
SEM Characterization of Sulfur Nanoparticles
EDS Characterization of Sulfur Nanoparticles
XRD Characterization of Sulfur Nanoparticles
Chemical Studies on Sulfur Nanoparticles In Vitro
Biochemical investigations
Conclusion
Applications of Nanoparticles in cancer treatment
Nanoshells
Nano X-Ray therapy
Drug Delivery by Nanoparticles
Nanomaterials in biomedical applicationsumeet sharma
An introduction to emerging technology in medicinal science, "nanodrugs" a fruitful combination of nano-science and medical science. In this presentation, use of nano shells for delivery of drugs to targeted cancer cells has been explained. along with In Vivo and In Vitro studies on use of nanomaterials for biomedical application. For any information please feel free to contact me or refer to the references.
Nanotechnology & nanobiotechnology by kk sahuKAUSHAL SAHU
Introduction &definition
a) Nanotechnology
b) Nanobiotechnology
History
Terms related to Nanotechnology
Nanoscale technology
Some Nanoscale related terms
What are Nanosensors
How nanosensors work
DNA Nanotechnology
How Nanotechnology works in different fields
Advantages & application of Nanotechnology
Disadvantages
Conclusion
References
Protein based nanostructures for biomedical applications karoline Enoch
Proteins are kind of natural molecules that show unique
functionalities and properties in biological materials and
manufacturing feld. Tere are numerous nanomaterials
which are derived from protein, albumin, and gelatin. Tese
nanoparticles have promising properties like biodegradability, nonantigenicity, metabolizable, surface modifer, greater
stability during in vivo during storage, and being relatively
easy to prepare and monitor the size of the particles.
These particles have the ability to attach covalently with
drug and ligand
Nanotechnology and potential in Cancer therapy and treatmentladen12
this presentation focuses on new nanotechnology and it possible use in detection and therapy with cancer. it was prepared by final year biochemistry student at NCU.
This presentation is a simple explain of Bionanoimaging which introduce this area completely. You can use this PPTx File to present in your class and seminars as well. I prepare this file to present in Tabriz University of Medical Sciences when I was a MSc Medical Nanotechnology student. It will be useful for you too.
Nanotechnology and its Application in Cancer TreatmentHasnat Tariq
Nanotechnology
Nanomaterials
Nanostructures
Nanoparticles
Unexpected Optical Properties of Nanoparticles
Synthesis of Nanoparticles
Nanotechnology in Cancer Treatment
Role of Sulfur NPs in Cancer Treatment
Human Tumour Cell Lines Used in Research
Ehrlich ascites carcinoma (EAC)
Sulfur Nanoparticles Preparation
MTT Assay
Sulphorhodamine-B (SRB) Assay
Median lethal dose (LD 50)
Experimental design
FT-IR Characterization of Sulfur Nanoparticles
SEM Characterization of Sulfur Nanoparticles
EDS Characterization of Sulfur Nanoparticles
XRD Characterization of Sulfur Nanoparticles
Chemical Studies on Sulfur Nanoparticles In Vitro
Biochemical investigations
Conclusion
Applications of Nanoparticles in cancer treatment
Nanoshells
Nano X-Ray therapy
Drug Delivery by Nanoparticles
Nanomaterials in biomedical applicationsumeet sharma
An introduction to emerging technology in medicinal science, "nanodrugs" a fruitful combination of nano-science and medical science. In this presentation, use of nano shells for delivery of drugs to targeted cancer cells has been explained. along with In Vivo and In Vitro studies on use of nanomaterials for biomedical application. For any information please feel free to contact me or refer to the references.
Nanotechnology & nanobiotechnology by kk sahuKAUSHAL SAHU
Introduction &definition
a) Nanotechnology
b) Nanobiotechnology
History
Terms related to Nanotechnology
Nanoscale technology
Some Nanoscale related terms
What are Nanosensors
How nanosensors work
DNA Nanotechnology
How Nanotechnology works in different fields
Advantages & application of Nanotechnology
Disadvantages
Conclusion
References
Protein based nanostructures for biomedical applications karoline Enoch
Proteins are kind of natural molecules that show unique
functionalities and properties in biological materials and
manufacturing feld. Tere are numerous nanomaterials
which are derived from protein, albumin, and gelatin. Tese
nanoparticles have promising properties like biodegradability, nonantigenicity, metabolizable, surface modifer, greater
stability during in vivo during storage, and being relatively
easy to prepare and monitor the size of the particles.
These particles have the ability to attach covalently with
drug and ligand
Nanotechnology and potential in Cancer therapy and treatmentladen12
this presentation focuses on new nanotechnology and it possible use in detection and therapy with cancer. it was prepared by final year biochemistry student at NCU.
The engineered nanoparticles are effectively used for cancer treatment due to their targeted drug delivery approach. Download the Aranca report on Technology and Patent Research for current research trends and developments.
Nanotechnology for cancer therapy recent developmentsroshan telrandhe
This paper is an overview of advances and prospects in applications of nanotechnology for cancer treatment. Nanotechnology is an use for prevention, diagnosis, and treatment. nanotechnology offers a promise for the targeted delivery of drugs, genes and protein to tumer tissue and therefore alleviating the toxicity of anticancer agent in healthy tissues. Cancer is one of the leading causes of death worldwide. Nanotechnology is one of the most rapidly growing fields in the 21st centuryThese mainly include arrays of nanocantilevers, nanotubes and nanowires for multiplexing detection, multifunctional injectable nanovectors for therapeutics and diagnostics. This article review current nanotechnology platforms for anticancer drug delivery, including polymeric nanoparticles, liposomes, dendrimers, nanoshells, nuclear acid base nanoparticle [DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO) ] The review increases awarnes of advantages in cancer therapy
The main aim deals with the eradication of cancer cells by providing a steady, possible method of destroying and curing the cancer in an efficient and safe way so that healthy cells are not affected in any manner. This technology also focuses on a main idea that the patient is not affected by cancer again. The purpose of using the RF signal is to save normal cells.
Presentation on Nanoparticles Smart Drug Delivery System For Cancer no company
Nano technology is a rapidly expanding field, encompassing the development of a man-made materials in 5-200 nanometer size range. This dimension vastly exceeds that of standard organic molecules.
Please contact us if you want our services.(We work on every kind of Thesis Presentations (Word, Power point, Excel, Adobe photoshop and Auto-cad).
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Various Approach for the Treatment of Cancer - using Nano-Technologyijsrd.com
the credential part of the paper reviews about the advanced methods for the treatment of cancer using nano devices and nano technology technique. The advanced technology which could be the best to treat cancer is the treatment using nano-technology the molecular scale properties and the interface between the chemical, biological and the physical sciences are the important concerns of nano-technology. The application in the treatment of cancer using nano- technology is promising more than the ordinary treatments. This paper also proposes the use of nano-robots in medical field is the fast, best, and safe method for the treatment of different diseases in the human body. The main stress given in the paper is the comparison of the latest treatment in curing cancer using nano-technology.
Nanotechnology for Cancer therapy: Recent developmentsroshan telrandhe
This paper is an overview of advances and prospects in applications of nanotechnology for cancer treatment. Nanotechnology is an use for prevention, diagnosis, and treatment. nanotechnology offers a promise for the targeted delivery of drugs, genes and protein to tumer tissue and therefore alleviating the toxicity of anticancer agent in healthy tissues. Cancer is one of the leading causes of death worldwide. Nanotechnology is one of the most rapidly growing fields in the 21st centuryThese mainly include arrays of nanocantilevers, nanotubes and nanowires for multiplexing detection, multifunctional injectable nanovectors for therapeutics and diagnostics. This article review current nanotechnology platforms for anticancer drug delivery, including polymeric nanoparticles, liposomes, dendrimers, nanoshells, nuclear acid base nanoparticle [DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO) ] The review increases awarnes of advantages in cancer therapy.
This Presentation discuss about "Drug Development",it is mainly discuss about "Cancer" cure by "Nano Technology".In this Presentation explains how Nano Technology to cure a "Cancer".This Presentation will help for students to know about "Nano Technology".
COMPLICATIONS, MANAGEMENT AND TREATMENT APPROACH OF DIABETES MELLITUSAnas Indabawa
Diabetes describes a group of metabolic diseases in which the person has high blood glucose (blood sugar), either because insulin production is inadequate, or because the body's cells do not respond properly to insulin, or both. Mellitus is Latin for “sweet as honey”.
Pancreas is an elongated, tapered gland that is located behind the stomach and secretes digestive enzymes and the hormones insulin and glucagon.
The Pancreas secretes insulin and Glucagon directly into the blood stream.
It also secretes digestive enzymes into the pancreatic duct, which joins the common bile duct from the liver and drains into the small intestine.
Insulin and Glucagon have opposite effects on liver and other tissues for controlling blood-glucose levels.
Antihypertensive drugs and hypertension managementAnas Indabawa
hypertension can be defined as: A sustained rise in blood pressure.
Blood Pressure is given by two(2) parameters.
Cardiac Output: Given by the rate and stroke volume of the heart.
Total Peripheral Resistance: Given by the blood volume and the level of vasoconstriction
Hypertension is a pathologically increased blood pressure due to an increase in any of these parameters.
Air pollution is the introduction of particulates, biological molecules, or other harmful materials into Earth's atmosphere, causing disease, death to humans, loss of breath, damage to other living organisms such as food crops, or the natural or built environment. Air pollution may come from anthropogenic or natural sources.
Cloves are the aromatic flower buds of a tree in the family Myrtaceae, Syzygium aromaticum. They are native to the Maluku Islands in Indonesia, and are commonly used as a spice. Cloves are commercially harvested primarily in Indonesia, India, Madagascar, Zanzibar, Pakistan, Sri Lanka and Tanzania.
“Nutraceutical” is any substance that may be considered as a food or part of food and provides medical or health benefits, encompassing, prevention and treatment of diseases.
It is the combination of two term "Nutrition" and "pharmaceuticals"
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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Hot Selling Organic intermediates
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Use of Nanotechnology in Diagnosis and Treatment of Cancer
1. Presented by:- ANAS HARUNA INDABAWA
Department of pharmacy, SHIATS, Allahabad
EMAIL:- anasindabawa7@gmail.com
2. Nanotechnology is the creation
of useful materials, devices,
and systems through the
manipulation of matter on this
miniscule scale.
This emerging field involves
scientists from many different
disciplines, including
physicists, chemists, engineers,
information technologists, and
material scientists, as well as
biologists.
Nano refers to the 10-9 power,
or one billionth. For
comparison, a human hair is
about 100,000 nanometers
thick.
There are many interesting
Nano devices being developed
that have a potential to improve
cancer detection, diagnosis, and
treatment
Nanotechnology may be able
to create many new materials
and devices with a vast range
of application, such as
in medicine, electronics,
biomaterials energy production,
and consumer products.
DNA Sample: Approx. 2 nm
Human hair is approximately 1x105 nm
3. There are two basic
approaches for creating Nano
devices. Scientists refer to
these methods as:
The top-down approach
The bottom-up approach.
The top-down approach
involves molding or etching
materials into smaller
components.
The bottom-up approach
involves assembling
structures atom- by-atom or
molecule-by-molecule, and
may prove useful in
manufacturing devices used
in medicine.
Application of Nanotechnology
includes:
Nanomedicine
Nano biotechnology
Green nanotechnology
Energy applications of
nanotechnology
Industrial applications of
nanotechnology
Potential applications of
carbon nanotubes
Nanoart
APPROACHES OF
NANOTECHNOLOGY
4. Cancer, also known as
a malignant tumor or malign
ant neoplasm, is a group of
diseases involving
abnormal cell growth with the
potential to invade or spread
to other parts of the body.
These growths are considered
either benign or malignant.
Each type of cancer is unique
with its own causes,
symptoms, and methods of
treatment. Like with all
groups of disease, some types
of cancer are more common
than others.
Not all tumors are
cancerous; benign tumors do
not spread to other parts of the
body
CAUSES OF CANCER
Any agent that causes cancer is
called a carcinogen and is
described as carcinogenic.
Some of these agents can be:
Chemicals
Diet and exercise
Infection
Radiation
Heredity
Physical agents
Hormone
5. There are over 100 different
known cancers that affect
humans,but the most common
once are:-
Breast cancer
Lung cancer
Colon cancer
Prostate cancer
STAGES OF CANCER
Stage I cancers are localized to
one part of the body; usually
curable.
Stage II cancers are locally
advanced.
Stage III cancers are also locally
advanced.
Stage IV cancers have often
metastasized, or spread to other
organs or throughout the body.
6. Surgery:-Surgery can be used to
diagnose, treat, or even help
prevent cancer in some cases.
Most people with cancer will
have some type of surgery.
Chemotherapy:-Chemotherapy
(chemo) is the use of medicines
or drugs to treat cancer.
Radiation therapy:-Radiation
therapy uses high-energy
particles or waves to destroy or
damage cancer cells. It is one of
the most common treatments for
cancer, either by itself or along
with other forms of treatment.
Immunotherapy:-
Immunotherapy is treatment that
uses your body's own immune
system to help fight cancer.
Targeted therapy:-Targeted
therapy is a newer type of cancer
treatment that uses drugs or other
substances to more precisely
identify and attack cancer cells,
usually while doing little damage
to normal cells.
Stem cell transplant:-
(peripheral blood, bone marrow,
and cord blood transplant) use
treat cancer.
Hyperthermia:-The idea of
using heat to treat cancer has
been around for some time, but
early attempts had mixed results.
Today, newer tools allow more
precise delivery of heat, and
hyperthermia is being studied for
use against many types of cancer.
Blood Product Donation and
Transfusion
7. Nanotechnology can be used
for better cancer diagnosis.
One of the main usage fields of
optical nanoparticles is to allow
better cancer detection.
classical methods that are used
in diagnosis have limitations.
Classified methods such as X-
rays, tomography or
mammography require using
mutagenic agents on cells that
cause cancer, too.
To eliminate these concerns,
optical nanoparticles in
diagnosis is possible technique
that can be used.
This technique works with
special dyes to interact with
tumor cells and optical
nanoparticles can be detected.
NANOPORE
Scientists believe nanopores,
tiny holes that allow DNA to
pass through one strand at a
time, will make DNA
sequencing more efficient.
As DNA passes through a
nanopore, scientists can
monitor the shape and
electrical properties of each
base, or letter, on the strand.
Because these properties are
unique for each of the four
bases that make up the
genetic code, scientists can
use the passage of DNA
through a nanopore to
decipher the encoded
information, including errors
in the code known to be
associated with cancer.
8.
9. NANOTUBE
Another nanodevice that will
help identify DNA changes
associated with cancer is the
nanotube.
Nanotubes are carbon rods
about half the diameter of a
molecule of DNA that not only
can detect the presence of
altered genes, but they may help
researchers pinpoint the exact
location of those changes.
To prepare DNA for nanotube
analysis, scientists must attach a
bulky molecule to regions of the
DNA that are associated with
cancer. They can design tags
that seek out specific mutations
in the DNA and bind to them.
Once the mutation has been
tagged, researchers use a
nanotube tip resembling the
needle on a record player to
trace the physical shape of
DNA and pinpoint the mutated
regions.
The nanotube creates a map
showing the shape of the DNA
molecule, including the tags
identifying important mutations
Since the location of mutations
can influence the effects they
have on a cell, these techniques
will be important in predicting
disease.
10.
11. QUANTUM DOTS
Quantum dots are tiny
crystals that glow when they
are stimulated by ultraviolet
light.
Quantum dots are tiny
crystals that glow when they
are stimulated by ultraviolet
light.
Latex beads filled with these
crystals can be designed to
bind to specific DNA
sequences. By combining
different sized quantum dots
within a single bead,
scientists can create probes
that release distinct colors
and intensities of light.
When the crystals are
stimulated by UV light, each
bead emits light that serves as
a sort of spectral bar code,
identifying a particular region
of DNA.
To detect cancer, scientists
can design quantum dots that
bind to sequences of DNA
that are associated with the
disease.
When the quantum dots are
stimulated with light, they
emit their unique bar codes,
or labels, making the critical,
cancer-associated DNA
sequences visible.
Another advantage of
quantum dots is that they can
be used in the body,
eliminating the need for
biopsy.
12.
13. spherical, branched polymers
that are silica-coated micelles,
ceramic nanoparticles, and cross-
linked liposomes, can be targeted
to cancer cell.
This is done by attaching
monoclonal antibodies or cell-
surface receptor ligands that bind
specifically to molecules found
on the surfaces of cancer cells.
such as the high-affinity folate
receptor and luteinizing hormone
releasing hormone (LH-RH) or
molecules unique to endothelial
cells that become co-opted by
malignant cells
The nanoparticles are rapidly
taken into cells
14. DENDRIMERS
Dendrimers are highly branched,
star-shaped macromolecules with
nanometer-scale dimensions.
Dendrimers are defined by three
components: a central core, an
interior dendritic structure (the
branches), and an exterior surface
with functional surface groups
The varied combination of these
components yields products of
different shapes and sizes with
shielded interior cores
Applications highlighted in recent
literature include drug delivery,
gene transfection, catalysis, energy
harvesting, photo activity,
molecular weight and size
determination, rheology
modification, and nanoscale
science and technology.
dendrimers have been explored for
the encapsulation
of hydrophobic compounds and for
the delivery of anticancer drugs.
There are three methods for using
dendrimers in drug delivery:-
First, the drug is covalently
attached to the periphery of the
dendrimer to form dendrimer
prodrugs
Second the drug is coordinated to
the outer functional groups via
ionic interactions
Third the dendrimer acts as a
unimolecular micelle by
encapsulating a pharmaceutical
through the formation of a
dendrimer-drug supramolecular
assembly.
15.
16. LIPOSOMES
A liposome is a
spherical vesicle having at least
one lipid bilayer.
The liposome can be used as a
vehicle
for administration of nutrients
and pharmaceutical drugs.
Liposomes can be prepared by
disrupting biological membranes
(such as by sonication).
Liposomes are most often
composed of phospholipids,
especially phosphatidylcholine,
but may also include other lipids,
such as egg
phosphatidylethanolamine, so
long as they are compatible
with lipid bilayer structure.
A liposome design may employ
surface ligands for attaching to
unhealthy tissue.
17. NANOSHELLS
Nanoshells are miniscule
beads coated with gold. By
manipulating the thickness of
the layers making up the
nanoshells
scientists can design these
beads to absorb specific
wavelengths of light.
The most useful nanoshells
are those that absorb near-
infrared light, which can
easily penetrate several
centimeters of human tissue.
The absorption of light by the
nanoshells creates an intense
heat that is lethal to cells.
These gold nanoshells are
shuttled into tumors by the use
of phagocytosis
phagocytes engulf the
nanoshells through the cell
membrane to form an internal
phagosome, or macrophage.
Nanoparticle-based
therapeutics have been
successfully delivered, taken
up passively into tumors
without the assistance of
antibodies.
18.
19. NANOROBOT
A Korean research team has
successfully developed
bacteriobots that can diagnose
and treat cancer.
This bacteria-based robot is
expected to be utilized to
develop new treatments for
cancer and various microrobots
or nanorobots for medical
purposes in the future.
Bacteriobots are made up of
bacteria and 3µm-sized
microstructures filled with
anticancer drugs.
Genetically-modified non-toxic
bacteria move inside tissues or
blood with flagella, and find
tumors by pushing
microstructures and targeting
certain drugs secreted by
cancer cells.
Upon the arrival of bacteriobots in
the tumor region, anticancer drugs
that come from microstructures are
spread onto the surface of tumor
20. Over the past 150 years, many innovative and
groundbreaking techniques have been developed in
order to treat cancer. But these approaches has its own
series of undesirable side effects that are both
dangerous and damaging to the overall health of the
patient.
There have been significant improvements largely due
to breakthroughs, both, in the bottom-up and in the top-
down nanotechnology. we will make early detection,
prevention and treatment with a high degree of
accuracy and ease possible that is effective and can be
made it safe.
Different types of Cancer cells have unique properties
that can be exploited by nanoparticles to target the
Cancer cells