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Process design.cancer treatment using nanoparticles. ppt
Nanoparticles show promise for improving cancer detection and treatment. They are small enough to enter cells and interact with DNA and proteins. Quantum dots and nanoshells can be used to detect cancer signatures. Nanoshells coated with cancer-targeting molecules can selectively heat and destroy cancer cells when exposed to near-infrared light, protecting healthy cells. While challenges remain around toxicity and delivery, nanoparticles may enable cheaper, less toxic cancer therapies compared to chemotherapy and improve outcomes.
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Process design.cancer treatment using nanoparticles. ppt
- 1. PROCESS DESIGN: USING NANOPARTICLESIN CANCER TREATMENT HA NOI UNIVERSITY OF SCIENCE AND TECHNOLOGY **** AdVANCEd training PROGRAM **** Name : Hoàng Văn Tiến Class : MSE-K54 ID Student : 20092697
- 2. CONTENT • Problem • Propertiesand characteristic of nanoparticles • Use of nanoparticles in cancer treatment • Applications and promises • Summary
- 3. HOW MANY PEOPLEDIE FROM CANCER IN THE WORLD EACH YEAR ? • Approximately 7.6 million people die from cancer each year (according to an article titled "ACS Report Focuses on Global Cancer Toll" which was published by the American Cancer Society-2012) • Viet Nam: -240.000 – 250.000 people are being cancer -150.000 new each year -75.000 dead (2010 ) •
- 4. PROBLEM Estimated cancer prevalencein the United States as of January 1, 2009 Males Females All invasive cancer sites 12,549,000 5,809,000 6,740,000 Brain and other nervous system 135,000 71,000 65,000 Breast 2,762,000 14,000 2,747,000 Cervix 248,000 0 248,000 Colon & rectum 1,140,000 559,000 581,000 Endometrial cancer and Uterine sarcoma 590,000 0 590,000
- 6. What Is NanoBiotechnology? Nanodevices Nanopores Dendrimers Nanotubes Quantumdots Nanoshells Tennis ballA periodWhite blood cell Water molecule
- 7. Nanoparticles Are Small Enoughto Enter Cells Cell White blood cell Water molecule Nanodevices Nanoparticles -Most animal cells are 10,000 to 20,000 nanometers in diameter. nanoscale devices (less than 100 nanometers) can enter cells and the organelles inside them to interact with DNA and proteins. Tools developed through nanotechnology may be able to detect disease in a very small amount of cells or tissue. They may also be able to enter and monitor cells within a living body.
- 8. Manufacturing Nanodevices Scattered X- rays Atoms incrystal Detector NanodevicesCrystal White blood cell CrystalX-ray beam
- 11. Nanodevices Can ImproveCancer Detection and Diagnosis ImagingNanoBiotechnology Physical Exam, Symptoms
- 12. Quantum Dots Ultraviolet light off White bloodcell Water molecule Nanodevices Quantum dots Quantum dots emit light Ultraviolet light on Quantum dots Quantum dot bead
- 13. Quantum Dots Can FindCancer Signatures Cancer cells Healthy cells Quantum dot beads Quantum dot beads Healthy cells Cancer cells
- 14. Improving Cancer Treatment NanotechnologyTreatmentTraditional Treatment Intact noncancerous cells Noncancerous cells Toxins Nanodevices Cancer cells Dead noncancerous cells Noncancerous cells Drugs Dead cancer cells Dead cancer cells Toxins Cancer cells
- 15. Nanoshells Nanoshell White blood cell Water molecule Nanodevices Nanoshells Gold Near-infrared lightonNear-infrared light off Nanoshell absorbs heat
- 16. − Nanoshells havemetallic outer layer and silica core − Selectively attracted to cancer shells either through a phenomena called enhanced permeation retention or due to some molecules coated on the shells − The nanoshells are heated with an external energy source killing the cancer cells Thermal ablation of cancer cells
- 17. Nanoshells as CancerTherapy Nanoshells Dead cancer cells Nanoshells Cancer cells Healthy cells Intact healthy cells Near-infrared light Healthy cells Cancer cells
- 18. - quantum dotsto antibodies that guided them to prostate tumor sites in living mice, where they clumped together and were visible using a simple mercury lamp.
- 19. APPLICATIONS AND PROMISES •Cantilevers Can Make Cancer Tests Faster and More Efficient • Kill the cancer cells without affect to other cells • Can deliver more of the active ingredient and control more precisely how quickly it is released compared with current leading cancer drugs.
- 20. • Cancer treatmentby grammar rays(US) : 15.000 – 25.000 USD ((300.000.000 – 500.000.000 vnd) • Many new drug treatments cost nearly $100,000 a year • $93,000 for vacxin which can adds four months' survival, on average, for men with incurable prostate tumors.
- 21. POTENTIALS • More cheaperthan the traditional methods ( drug ,vacxin , UV ….) • Low effect to the body (compare with Chemotherapy, Radiation Therapy…) • Cancer treatment (until now) : tumor's natural recruitment of monocytes, Liver Cancer Treatment, Lung Cancer Treatment, Vaginal Cancer Treatment , Leukemia Treatment Overview…. • Bright futures in uses
- 22. CHALENGES • Nanostructures canbe so small that the body may clear them too rapidly for them to be effective in detection or imaging. • Larger nanoparticles may accumulate in vital organs, creating a toxicity problem. • Difficult to approximate amount of nanopartiles • Cytotoxic Effect
- 23. REFERENCES • http://www.sciencedirect.com/science/article/pii/S1470204506707938 • http://triplehelixblog.com/2011/09/nanorobots-novel-technology-for-cancer- therapy/ •http://www.nanotec.or.th/en/?p=3667 • Applications of gold nanoparticles in cancer nanotechnology -Weibo Cai ,Ting Gao,Hao Hong, Jiangtao Sun • http://cancer.gov/cancertopics/understand • en.wikipedia.org/wiki/Alternative_cancer_treatmentsingcancer • Anti-Cancer Drug Loaded Iron–Gold Core–Shell Nanoparticles (Fe@Au) for Magnetic Drug Targeting-Sibnath Kayal and Raju Vijayaraghavan Ramanujan∗School of Materials Science and Engineering, Nanyang Technological University, 639798, Singapore